GVIIJ[(Btr)2W,(Scc)24(Eac),Y25D] (P08812) Protein Card

General Information
Name GVIIJ[(Btr)2W,(Scc)24(Eac),Y25D] (named by ConoServer)
Alternative name(s) [Y25D]GVIIJ[SSEA]
Organism synthetic construct
Protein Type Synthetic
Parent GVIIJ

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family mu conotoxin

Sequence
GWCGDOGATCGKLRLYCCSGFCD(Eac)DTKTCKDKSSA
Modified residues
positionsymbolname
6O4-Hydroxyproline
24Eac2-aminoethanethiol (cysteamine) cysteine
Sequence evidence protein level
Average Mass 3767.26
Monoisotopic Mass 3764.48
Isoelectric Point 10.08
Extinction Coefficient [280nm] 6990.00

Activity

Kd: Voltage-Gated Sodium Channels

TargetOrganismKdRef
Nav1.2R. norvegicus3.00 nM+/-0.88Green,B.R. et al. (2016)

References
Green,B.R., Gajewiak,J., Chhabra,S., Skalicky,J.J., Zhang,M.M., Rivier,J.E., Bulaj,G., Olivera,B.M., Yoshikami,D. and Norton,R.S. (2016) Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. J. Biol. Chem. 291:7205-7220

Internal links
Nucleic acids
Structure

External links

Tools