Conorphin-T[N1(BzP),del2-3,R4r,R5r,I7(Chg)] (P08863) Protein Card

General Information
Name Conorphin-T[N1(BzP),del2-3,R4r,R5r,I7(Chg)] (named by ConoServer)
Alternative name(s) 48
Organism synthetic construct
Protein Type Synthetic
Parent Conorphin-T[ribbon]

Classification
Conopeptide class conorphin
Gene superfamily
Pharmacological family

Sequence
(BzP)rrQ(Chg)CC(nh2)
Modified residues
positionsymbolname
1BzPBenzoyl proline
2rD-arginine
3rD-arginine
5Chgcyclohexaglycine
8nh2C-term amidation
Sequence evidence protein level
Average Mass 1002.22
Monoisotopic Mass 1001.47
Isoelectric Point 8.60
Extinction Coefficient [280nm] 250.00

Activity

EC50: Opioid receptors

TargetOrganismEC50Ref
κsynthetic construct(cAMP inhibition assay)0.62 nM+/-0.31Brust A. et al. (2016)
(ERK 1/2 phosphorylation assay)0.39 nM+/-0.23Brust A. et al. (2016)

Ki: Opioid receptors

TargetOrganismKiCompetitorAgonistRef
κsynthetic construct(cAMP inhibition assay)0.48 nM+/-0.22Brust A. et al. (2016)

References
Brust A., Croker D. E., Colless B., Ragnarsson L., Andersson A., Jain K., Garcia-Caraballo S., Castro J., Brierley S. M., Alewood P. F., Lewis R. J. (2016) Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J. Med. Chem.

Internal links
Nucleic acids
Structure

External links

Tools