Conorphin-T[N1(BzP),del2-3,R4r,R5r,I7(Cha),insC_CH2] (P08871) Protein Card

General Information
Name Conorphin-T[N1(BzP),del2-3,R4r,R5r,I7(Cha),insC_CH2] (named by ConoServer)
Alternative name(s) 55
Organism synthetic construct
Protein Type Synthetic
Parent Conorphin-T[ribbon]

Classification
Conopeptide class conorphin
Gene superfamily
Pharmacological family

Sequence
(BzP)rrQ(Cha)CC(CH3N)(nh2)
Modified residues
positionsymbolname
1BzPBenzoyl proline
2rD-arginine
3rD-arginine
5ChaCyclohexylalanine
8CH3NMethanimine
9nh2C-term amidation
Sequence evidence protein level
Average Mass NA
Monoisotopic Mass NA
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

Ki: Opioid receptors

TargetOrganismKiCompetitorAgonistRef
κsynthetic construct15.8 nM+/-9.7Brust A. et al. (2016)

References
Brust A., Croker D. E., Colless B., Ragnarsson L., Andersson A., Jain K., Garcia-Caraballo S., Castro J., Brierley S. M., Alewood P. F., Lewis R. J. (2016) Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J. Med. Chem.

Internal links
Nucleic acids
Structure

External links

Tools