conomarphin-Ac1[O6P] (P08910) Protein Card

General Information
Name conomarphin-Ac1[O6P] (named by ConoServer)
Alternative name(s) conotoxin-Ac1-O6P
Organism Conus achatinus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor conomarphin-Ac1 precursor (4216)
Notes Liu et al., 2020 reported that the inhibition of 10 µM conomarphin-Ac1[O6P] to NaV,Kv,CaV,NMDAR is 2.69%,5.71%,17.89% and 14.37% respectively.

Classification
Conopeptide class conomarphin
Gene superfamily M superfamily
Pharmacological family

Sequence
NYYLYPAROENSwwT
Modified residues
positionsymbolname
9O4-Hydroxyproline
13wD-tryptophan
14wD-tryptophan
Sequence evidence protein level
Average Mass 1976.14
Monoisotopic Mass 1974.89
Isoelectric Point 7.88
Extinction Coefficient [280nm] 15470.00

Activity

Percentage inhibition: Ionotropic glutamate receptors

TargetOrganism% inhibitionConcentrationRef
GluN2AH. sapiens210 uMLiu,X. et al. (2020)
GluN2BH. sapiens11+/-210 uMLiu,X. et al. (2020)

References
Liu,X., Yao,G., Wang,K., Liu,Y., Wan,X. and Jiang,H (2020) Structural and Functional Characterization of Conotoxins from Conus achatinus Targeting NMDAR Marine drugs 18

Internal links
Protein Precursor conomarphin-Ac1 precursor (4216)
Nucleic acids
Structure

External links

Tools