PeIA[L15(Nle)] (P08979) Protein Card

General Information
Name PeIA[L15(Nle)] (named by ConoServer)
Alternative name(s) [Nle15]PeIA
Organism synthetic construct
Protein Type Synthetic
Parent PeIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACSVNHPE(Nle)C(nh2)
Modified residues
positionsymbolname
15NleNorleucine
17nh2C-term amidation
Sequence evidence Unknown
Average Mass 1651.86
Monoisotopic Mass 1650.62
Isoelectric Point 6.81
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus21.1 nM[18.5-24.1]ACh (100 μM)Hone,A.J. et al. (2019)
α3β4R. norvegicus1.49 μM[1.34-1.65]ACh (300 μM)Hone,A.J. et al. (2020)
α6/α3β2β3R. norvegicus13.2 nM[10.9-15.9]ACh (100 μM)Hone,A.J. et al. (2019)

References
Hone,A.J., Fisher,F., Christensen,S., Gajewiak,J., Larkin,D., Whiteaker,P. and McIntosh,J.M. (2019) PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors J. Med. Chem. 62:6262-6275
Hone,A.J., Rueda-Ruzafa,L., Gordon,T.J., Gajewiak,J., Christensen,S., Dyhring,T., Albillos,A. and McIntosh,J.M. (2020) Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists Journal of Neurochemistry

Internal links
Nucleic acids
Structure

External links

Tools