PeIA[S9H,V10L,N11(Aad)] (P08984) Protein Card

General Information
Name PeIA[S9H,V10L,N11(Aad)] (named by ConoServer)
Alternative name(s) PeIA-5415
Organism synthetic construct
Protein Type Synthetic
Parent PeIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACHL(Aad)HPELC(nh2)
Modified residues
positionsymbolname
11Aadalpha-aminoadipic acid
17nh2C-term amidation
Sequence evidence Unknown
Average Mass 1763.00
Monoisotopic Mass 1761.68
Isoelectric Point 7.10
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus3.01 nM[2.4-3.78]Ach (100 uM)Hone,A.J. et al. (2019)
α6/α3β2β3R. norvegicus155 nM[122-197]Ach (100 uM)Hone,A.J. et al. (2019)

References
Hone,A.J., Fisher,F., Christensen,S., Gajewiak,J., Larkin,D., Whiteaker,P. and McIntosh,J.M. (2019) PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors J. Med. Chem. 62:6262-6275

Internal links
Nucleic acids
Structure

External links

Tools