PeIA[S9H,V10(Nle),N11(Api)] (P08986) Protein Card

General Information
Name PeIA[S9H,V10(Nle),N11(Api)] (named by ConoServer)
Alternative name(s) PeIA-5416
Organism synthetic construct
Protein Type Synthetic
Parent PeIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACH(Nle)(Api)HPELC(nh2)
Modified residues
positionsymbolname
10NleNorleucine
11Apialpha-aminopimelic acid
17nh2C-term amidation
Sequence evidence Unknown
Average Mass 1777.03
Monoisotopic Mass 1775.70
Isoelectric Point 7.10
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus1.33 nM[1.17-1.53]ACh (100 uM)Hone,A.J. et al. (2019)
α3β4R. norvegicus168 nM[155-201]ACh (300 uM)Hone,A.J. et al. (2019)
α4β2R. norvegicus1930 nM[1520-2451]ACh (100 uM)Hone,A.J. et al. (2019)
α6/α3β2β3R. norvegicus286 nM[220-373]ACh (100 uM)Hone,A.J. et al. (2019)
α6/α3β4R. norvegicus120 nM[102-141]ACh (300 uM)Hone,A.J. et al. (2019)
α7R. norvegicus18.7 nM[14.5-24.2]ACh (300 uM)Hone,A.J. et al. (2019)

References
Hone,A.J., Fisher,F., Christensen,S., Gajewiak,J., Larkin,D., Whiteaker,P. and McIntosh,J.M. (2019) PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors J. Med. Chem. 62:6262-6275

Internal links
Nucleic acids
Structure

External links

Tools