PeIA[S9H,V10L,N11(Api),L15I] (P08988) Protein Card

General Information
Name PeIA[S9H,V10L,N11(Api),L15I] (named by ConoServer)
Alternative name(s) PeIA-5413
Organism synthetic construct
Protein Type Synthetic
Parent PeIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACHL(Api)HPEIC(nh2)
Modified residues
positionsymbolname
11Apialpha-aminopimelic acid
17nh2C-term amidation
Sequence evidence Unknown
Average Mass 1777.03
Monoisotopic Mass 1775.70
Isoelectric Point 7.10
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus0.57 nM[0.44-0.74]Ach (100 uM)Hone,A.J. et al. (2019)
α3β4R. norvegicus341 nM[317-366]Ach (300 uM)Hone,A.J. et al. (2019)
α4β2R. norvegicus572 nM[501-652]Ach (100 uM)Hone,A.J. et al. (2019)
α6/α3β2β3R. norvegicus58.2 nM[51.4-65.8]Ach (100 uM)Hone,A.J. et al. (2019)
α6/α3β4R. norvegicus77.3 nM[57.3-104]Ach (300 uM)Hone,A.J. et al. (2019)
α7R. norvegicus34.5 nM[28.8-41.4]Ach (300 uM)Hone,A.J. et al. (2019)

References
Hone,A.J., Fisher,F., Christensen,S., Gajewiak,J., Larkin,D., Whiteaker,P. and McIntosh,J.M. (2019) PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors J. Med. Chem. 62:6262-6275

Internal links
Nucleic acids
Structure

External links

Tools