PeIA[S9H,V10L,N11(Api)] (P08990) Protein Card

General Information
Name PeIA[S9H,V10L,N11(Api)] (named by ConoServer)
Alternative name(s) PeIA-5355
Organism synthetic construct
Protein Type Synthetic
Parent PeIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACHL(Api)HPELC(nh2)
Modified residues
positionsymbolname
11Apialpha-aminopimelic acid
17nh2C-term amidation
Sequence evidence Unknown
Average Mass 1777.03
Monoisotopic Mass 1775.70
Isoelectric Point 7.10
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus0.38 nM[0.36-0.44]Ach (100 uM)Hone,A.J. et al. (2019)
α3β4R. norvegicus501 nM[425-592]Ach (300 uM)Hone,A.J. et al. (2019)
α4β2R. norvegicus280 nM[251-313]Ach (100 uM)Hone,A.J. et al. (2019)
α6/α3β2β3R. norvegicus22.3 nM[19.9-24.9]Ach (100 uM)Hone,A.J. et al. (2019)
α6/α3β4R. norvegicus43.1 nM[37.5-49.6]Ach (300 uM)Hone,A.J. et al. (2019)
α7R. norvegicus31.6 nM[29.2-34.3]Ach (300 uM)Hone,A.J. et al. (2019)

References
Hone,A.J., Fisher,F., Christensen,S., Gajewiak,J., Larkin,D., Whiteaker,P. and McIntosh,J.M. (2019) PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors J. Med. Chem. 62:6262-6275

Internal links
Nucleic acids
Structure

External links

Tools