Vc1.1[Y10(F(4-F))] (P09008) Protein Card

General Information
Name Vc1.1[Y10(F(4-F))] (named by ConoServer)
Alternative name(s) CX-6
Organism synthetic construct
Protein Type Synthetic
Parent Vc1.1

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCN(F(4-F))DHPEIC(nh2)
Modified residues
positionsymbolname
10F(4-F)4-fluoro-phenylalanine
17nh2C-term amidation
Average Mass 1826.98
Monoisotopic Mass 1825.64
Isoelectric Point 4.80
Extinction Coefficient [280nm] NA

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α9α10H. sapiens01 μMACh(6 μM)Chu,X. et al. (2019)

References
Chu,X., Tae,H.S., Xu,Q., Jiang,T., Adams,D.J. and Yu,R (2019) α-Conotoxin Vc1.1 Structure-Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement ACS Chem Neurosci 10:4328-4336

Internal links
Nucleic acids
Structure

External links

Tools