MilIA[N10K] (P09017) Protein Card

General Information
Name MilIA[N10K]
Organism synthetic construct
Protein Type Synthetic
Parent MilIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
DMCCHPACMKHFNC(nh2)
Modified residues
positionsymbolname
15nh2C-term amidation
Sequence evidence protein level
Average Mass 1634.95
Monoisotopic Mass 1633.55
Isoelectric Point 8.53
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α1β1δεH. sapiens>100 uMACh(200 µM)Peigneur,S. et al. (2019)
α1β1γδH. sapiens3842 nM+/-1480.8ACh(200 µM)Peigneur,S. et al. (2019)
α2β4H. sapiens>10 uMACh(200 µM)Peigneur,S. et al. (2019)
α4β2H. sapiens>10 uMACh(200 µM)Peigneur,S. et al. (2019)
α4β4H. sapiens>10 uMACh(200 µM)Peigneur,S. et al. (2019)
α7H. sapiens>10 uMACh(100 µM)Peigneur,S. et al. (2019)
α9α10H. sapiens>10 uMACh(500 µM)Peigneur,S. et al. (2019)

References
Peigneur,S., Devi,P., Seldeslachts,A., Ravichandran,S., Quinton,L. and Tytgat,J. (2019) Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi Mar Drugs 17:535

Internal links
Nucleic acids
Structure

External links

Tools