PeIA[S9H,V10I,N11(Api),L15(Nle)] (P09045) Protein Card

General Information
Name PeIA[S9H,V10I,N11(Api),L15(Nle)] (named by ConoServer)
Alternative name(s) PeIA-5441
Organism synthetic construct
Protein Type Synthetic
Parent PeIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACHI(Api)HPE(Nle)C(nh2)
Modified residues
positionsymbolname
11Apialpha-aminopimelic acid
15NleNorleucine
17nh2C-term amidation
Sequence evidence Unknown
Average Mass 1777.03
Monoisotopic Mass 1775.70
Isoelectric Point 7.10
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus1.9 nM[1.6-2.3]ACh (100 μM)Hone,A.J. et al. (2020)
α3β4R. norvegicus316 nM[253-394]ACh (300 μM)Hone,A.J. et al. (2020)
α4β2R. norvegicus548 nM[442-648]ACh (100 μM)Hone,A.J. et al. (2020)
α4β4R. norvegicus>10 μMACh (300 μM)Hone,A.J. et al. (2020)
α6/α3β2β3R. norvegicus44.2 nM[39.2-49.7]ACh (100 μM)Hone,A.J. et al. (2020)
α6/α3β4R. norvegicus77.7 nM[69.2-87.1]ACh (300 μM)Hone,A.J. et al. (2020)
α7R. norvegicus42.9 nM[37.8-48.7]ACh (300 μM)Hone,A.J. et al. (2020)
α9α10R. norvegicus>10 μMACh (300 μM)Hone,A.J. et al. (2020)

References
Hone,A.J., Rueda-Ruzafa,L., Gordon,T.J., Gajewiak,J., Christensen,S., Dyhring,T., Albillos,A. and McIntosh,J.M. (2020) Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists Journal of Neurochemistry

Internal links
Nucleic acids
Structure

External links

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