PeIA[S9R,V10I,N11(Api),L15(Nle)] (P09046) Protein Card

General Information
Name PeIA[S9R,V10I,N11(Api),L15(Nle)] (named by ConoServer)
Alternative name(s) PeIA-5469
Organism synthetic construct
Protein Type Synthetic
Parent PeIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACRI(Api)HPE(Nle)C(nh2)
Modified residues
positionsymbolname
11Apialpha-aminopimelic acid
15NleNorleucine
17nh2C-term amidation
Sequence evidence Unknown
Average Mass 1796.08
Monoisotopic Mass 1794.74
Isoelectric Point 8.42
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus8.5 nM[7.8-9.4]ACh (100 μM)Hone,A.J. et al. (2020)
α3β4R. norvegicus>10 μMACh (300 μM)Hone,A.J. et al. (2020)
α4β2R. norvegicus>10 μMACh (100 μM)Hone,A.J. et al. (2020)
α4β4R. norvegicus>10 μMACh (300 μM)Hone,A.J. et al. (2020)
α6/α3β2β3R. norvegicus2110 nM[1250-3581]ACh (100 μM)Hone,A.J. et al. (2020)
α6/α3β4R. norvegicus>10 μMACh (300 μM)Hone,A.J. et al. (2020)
α7R. norvegicus6.5 nM[5.5-7.6]ACh (300 μM)Hone,A.J. et al. (2020)
α9α10R. norvegicus>10 μMACh (300 μM)Hone,A.J. et al. (2020)

References
Hone,A.J., Rueda-Ruzafa,L., Gordon,T.J., Gajewiak,J., Christensen,S., Dyhring,T., Albillos,A. and McIntosh,J.M. (2020) Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists Journal of Neurochemistry

Internal links
Nucleic acids
Structure

External links

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