ImI precursor (P00093) Protein Card

General Information
Name ImI precursor
Organism Conus imperialis
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Precursor

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Pharmacological family

Sequence
IVRR
GCCSDPRCAWRC
G
Sequence region
[5-16]mature peptideImI

References
McIntosh,J.M., Yoshikami,D., Mahe,E., Nielsen,D.B., Rivier,J.E., Gray,W.R. and Olivera,B.M. (1994) A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI J. Biol. Chem. 269:16733-16739
Maslennikov,I.V., Shenkarev,Z.O., Zhmak,M.N., Ivanov,V.T., Methfessel,C., Tsetlin,V.I. and Arseniev,A.S. (1999) NMR spatial structure of alpha-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors FEBS Lett. 444:275-280
Rogers,J.P., Luginbuhl,P., Shen,G.S., McCabe,R.T., Stevens,R.C. and Wemmer,D.E. (1999) NMR solution structure of alpha-conotoxin ImI and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors Biochemistry 38:3874-3882
Lamthanh,H., Jegou-Matheron,C., Servent,D., Menez,A. and Lancelin,J.M. (1999) Minimal conformation of the alpha-conotoxin ImI for the alpha7 neuronal nicotinic acetylcholine receptor recognition: correlated CD, NMR and binding studies FEBS Lett. 454:293-298
Johnson,D.S., Martinez,J., Elgoyhen,A.B., Heinemann,S.F. and McIntosh,J.M. (1995) alpha-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric alpha 7 and alpha 9 receptors Mol. Pharmacol. 48:194-199
Rogers,J.P., Luginbuhl,P., Pemberton,K., Harty,P., Wemmer,D.E. and Stevens,R.C. (2000) Structure-activity relationships in a peptidic alpha7 nicotinic acetylcholine receptor antagonist J. Mol. Biol. 304:911-926
Ellison,M.A., McIntosh,J.M. and Olivera,B.M. (2003) alpha-Conotoxins ImI and ImII: similar alpha 7 nicotinic receptor antagonists act at different sites J. Biol. Chem. 278:757-764
Gouda,H. and Hirono,S. (1999) Solution structure of alpha-conotoxin ImI determined by two-dimensional NMR spectroscopy Biochim. Biophys. Acta 1431:384-394
Gehrmann,J., Daly,N.L., Alewood,P.F. and Craik,D.J. (1999) Solution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonance J. Med. Chem. 42:2364-2372

Internal links
Nucleic acids Conus imperialis alpha-conotoxin ImI precursor, gene, exon 2 and partial cds
Structure

External links
UniProtKB/Swiss-Prot P50983
Ncbi P50983, AAN78128

Tools