Reference List

The references are sorted by year then first author.
Each reference is followed by a 'P' link and a 'NA' link that search the corresponding protein sequences and nucleic acid sequences, respectively.


Yang,M. and Zhou,M
Insertions and Deletions Play an Important Role in the Diversity of Conotoxins Protein J. (2020) 39: 190-195 [P, NA]
Xu,Q., Tae,H.S., Wang,Z., Jiang,T., Adams,D.J. and Yu,R.
Rational Design of α-Conotoxin RegIIA Analogues Specifically Inhibiting the Human α3β2 Nicotinic Acetylcholine Receptor through Computational Scanning ACS Chem Neurosci (2020) [P, NA]
Xu, P., Kaas, Q., Wu, Y., Zhu, X., Li, X., Harvey, P.J., Zhangsun, D., Craik, D.J. and Luo, S
Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA Journal of Medicinal Chemistry (2020) [P, NA]
Wilson,D.T., Bansal,P.S., Carter,D.A., Vetter,I., Nicke,A., Dutertre,S. and Daly,N.L.
Characterisation of a Novel A-Superfamily Conotoxin Biomedicines (2020) 8: 128-0 [P, NA]
Sun,Z., Bao,J., Zhangsun,M., Dong,S., Zhangsun,D. and Luo,S.
αO-Conotoxin GeXIVA Inhibits the Growth of Breast Cancer Cells via Interaction with α9 Nicotine Acetylcholine Receptors Mar Drugs (2020) 18: 195-0 [P, NA]
Rybin, M.J., O’Brien, H., Ramiro, I.B.L., Azam, L., McIntosh, J.M., Olivera, B.M., Safavi-Hemami, H. and Yoshikami, D.
αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish Toxins (Basel) (2020) 12 [P, NA]
Osipov,A.V., Terpinskaya,T.I., Yanchanka,T., Balashevich,T., Zhmak,M.N., Tsetlin,V.I. and Utkin,Y.N
α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors Mar Drugs (2020) 18 [P, NA]
Mohan,M.K., Abraham,N., R P,R., Jayaseelan,B.F., Ragnarsson,L., Lewis,R.J. and Sarma,S.P
Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors J. Biol. Chem. (2020) 295: 7096-7112 [P, NA]
Liu,X., Yao,G., Wang,K., Liu,Y., Wan,X. and Jiang,H
Structural and Functional Characterization of Conotoxins from Conus achatinus Targeting NMDAR Marine drugs (2020) 18 [P, NA]
Liang,J., Tae,H.S., Xu,X., Jiang,T., Adams,D.J. and Yu,R
Dimerization of α-Conotoxins as a Strategy to Enhance the Inhibition of the Human α7 and α9α10 Nicotinic Acetylcholine Receptors J. Med. Chem (2020) 63: 2974-2985 [P, NA]
Li,X., Wang,S., Zhu,X., Zhangsun,D., Wu,Y. and Luo,S
Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB Mar Drugs (2020) 18 [P, NA]
Kumar,S., Vijayasarathy,M., Venkatesha,M.A., Sunita,P. and Balaram,P.
Cone Snail Analogs of the Pituitary Hormones Oxytocin/Vasopressin and Their Carrier Protein Neurophysin. Proteomic and Transcriptomic Identification of Conopressins and Conophysins Biochim Biophys Acta Proteins Proteom (2020) 1868: 140391-0 [P, NA]
Hone,A.J., Rueda-Ruzafa,L., Gordon,T.J., Gajewiak,J., Christensen,S., Dyhring,T., Albillos,A. and McIntosh,J.M.
Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists Journal of Neurochemistry (2020) [P, NA]
Giribaldi,J., Ragnarsson,L., Pujante,T., Enjalbal,C., Wilson,D., Daly,N.L., Lewis,R.J. and Dutertre,S
Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from Conus miliaris Marine drugs (2020) 18 [P, NA]
Dutt,M., Giacomotto,J., Ragnarsson,L., Andersson,A., Brust,A., Deakan,Z., Alewood,P.F. and Lewis,R.J.
Re-evaluating the nirvana cabal deployed by piscivorous cone snails Toxicon (2020) 177 [P, NA]
Bao,N., Lecaer,J.P., Nghia,N.D. and Vinh,P.T.K.
Isolation and structural identification of a new T1-conotoxin with unique disulfide connectivities derived from Conus bandanus J Venom Anim Toxins Incl Trop Dis (2020) 26 [P, NA]
AlSharari,S.D., Toma,W., Mahmood,H.M., Michael McIntosh,J. and Imad Damaj,M.
The α9α10 nicotinic acetylcholine receptors antagonist α-conotoxin RgIA reverses colitis signs in murine dextran sodium sulfate model Eur. J. Pharmacol. (2020) 173320 [P, NA]

Ziegman, R., Brust, A., Jha, P., Cardoso, F.C., Lewis, R.J. and Alewood, P.F.
‘Messy’Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency Marine drugs (2019) 17: 165-0 [P, NA]
Zhang, H., Fu, Y., Wang, L., Liang, A., Chen, S. and Xu, A.
Identifying novel conopepetides from the venom ducts of Conus litteratus through integrating transcriptomics and proteomics Journal of proteomics (2019) 192: 346-357 [P, NA]
Zazueta-Favela,D., Donis-Maturano,L., Licea-Navarro,A.F., Bernáldez-Sarabia,J., Dan,K.W.L., Cota-Arce,J.M., Escobedo,G. and De León-Nava,M.A.
Marine peptides as immunomodulators: Californiconus californicus-derived synthetic conotoxins induce IL-10 production by regulatory T cells (CD4+Foxp3+) Immunopharmacol Immunotoxicol (2019) 41: 463-468 [P, NA]
You,S., Li,X., Xiong,J., Zhu,X., Zhangsun,D., Zhu,X. and Luo,S.
α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice Mar Drugs (2019) 17: 490-0 [P, NA]
Yao, G., Peng, C., Zhu, Y., Fan, C., Jiang, H., Chen, J., Cao, Y. and Shi, Q.
High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing Marine drugs (2019) 17: 193-0 [P, NA]
Xu, X., Liang, J., Zhang, Z., Jiang, T. and Yu, R.
Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations Marine drugs (2019) 17: 303-0 [P, NA]
Weese,D.A. and Duda,T.F. Jr.
Effects of Predator-Prey Interactions on Predator Traits: Differentiation of Diets and Venoms of a Marine Snail Toxins (Basel) (2019) 11: 299-0 [P, NA]
Wang, H., Li, X., Zhangsun, D., Yu, G., Su, R. and Luo, S.
The α9α10 Nicotinic Acetylcholine Receptor Antagonist αO-Conotoxin GeXIVA[1,2] Alleviates and Reverses Chemotherapy-Induced Neuropathic Pain Marine drugs (2019) 17: 265-0 [P, NA]
Vijayasarathy, M. and Balaram, P.
Cone snail prolyl-4-hydroxylase α-subunit sequences derived from transcriptomic data and mass spectrometric analysis of variable proline hydroxylation in C. amadis venom Journal of proteomics (2019) 194: 37-48 [P, NA]
Van Hout, M., Valdes, A., Christensen, S.B., Tran, P.T., Watkins, M., Gajewiak, J., Jensen, A.A., Olivera, B.M. and McIntosh, J.M.
α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors Neuropharmacology (2019) 157: 107691-0 [P, NA]
utt, M., Giacomotto, J., Ragnarsson, L., Andersson, Å., Brust, A., Dekan, Z., Alewood, P.F. and Lewis, R.J.
The α1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa Sci Rep (2019) 9: 17841-0 [P, NA]
Ren, J., Zhu, X., Xu, P., Li, R., Fu, Y., Dong, S., Zhangsun, D., Wu, Y. and Luo, S.
d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability Marine drugs (2019) 17: 142-0 [P, NA]
Phuong,M.A., Alfaro,M.E., Mahardika,G.N., Marwoto,R.M., Prabowo,R.E., von Rintelen,T., Vogt,P.W.H., Hendricks,J.R. and Puillandre,N.
Lack of Signal for the Impact of Conotoxin Gene Diversity on Speciation Rates in Cone Snails Syst. Biol. (2019) 68: 781-796 [P, NA]
Peigneur,S., Devi,P., Seldeslachts,A., Ravichandran,S., Quinton,L. and Tytgat,J.
Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi Mar Drugs (2019) 17: 535-0 [P, NA]
Patil, N.A., Karas, J.A., Wade, J.D., Hossain, M.A. and Tailhades, J.
Rapid Photolysis-Mediated Folding of Disulfide-Rich Peptides Chemistry–A European Journal (2019) 25: 8599-8603 [P, NA]
Pardos-Blas,J.R., Irisarri,I., Abalde,S., Tenorio,M.J. and Zardoya,R.
Conotoxin Diversity in the Venom Gland Transcriptome of the Magician Marine drugs (2019) 17: 453-0 [P, NA]
Pan,X., Li,Z., Huang,X., Huang,G., Gao,S., Shen,H., Liu,L., Lei,J. and Yan,N.
Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA. Science (2019) eaaw2999 [P, NA]
Oroz-Parra,I., Álvarez-Delgado,C., Cervantes-Luevano,K., Dueñas-Espinoza,S. and Licea-Navarro,A.F.
Proapoptotic Index Evaluation of Two Synthetic Peptides Derived from the Coneshell Californiconus californicus in Lung Cancer Cell Line H1299 Mar Drugs (2019) 18: 10-0 [P, NA]
Ning,J., Ren,J., Xiong,Y., Wu,Y., Zhangsun,M., Zhangsun,D., Zhu,X. and Luo,S.
Identification of Crucial Residues in α-Conotoxin EI Inhibiting Muscle Nicotinic Acetylcholine Receptor Toxins (Basel) (2019) 11: 603-0 [P, NA]
Nielsen, L.D., Foged, M.M., Albert, A., Bertelsen, A.B., Søltoft, C.L., Robinson, S.D., Petersen, S.V., Purcell, A.W., Olivera, B.M., Norton, R.S. and Vasskog, T.
The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework Journal of Biological Chemistry (2019) 294: 8745-8759 [P, NA]
Neves,J.L.B., Imperial,J.S., Morgenstern,D., Ueberheide,B., Gajewiak,J., Antunes,A., Robinson,S.D., Espino,S., Watkins,M., Vasconcelos,V. and Olivera,B.M.
Characterization of the First Conotoxin from Conus ateralbus, a Vermivorous Cone Snail from the Cabo Verde Archipelago Mar Drugs (2019) 17: 432-0 [P, NA]
Mendoza,C.B., Masacupan,D.J.M., Batoctoy,D.C.R., Yu,E.T., Lluisma,A.O. and Salvador-Reyes,L.A.
Conomarphins cause paralysis in mollusk: Critical and tunable structural elements for bioactivity. J. Pept. Sci. (2019) 25 [P, NA]
Möller, C., Davis, W.C., Clark, E., DeCaprio, A. and Mari, F.
Conodipine-P1-3, the First Phospholipases A2 Characterized from Injected Cone Snail Venom Molecular & Cellular Proteomics (2019) 18: 876-891 [P, NA]
Liu, C., Wu, P., Zhu, H., Grieco, P., Yu, R., Gao, X., Wu, G., Wang, D., Xu, H. and Qi, W.
Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects Molecules (2019) 24: 337-0 [P, NA]
Kondasinghe, T.D., Saraha, H.Y., Jackowski, S.T. and Stockdill, J.L.
Raising the bar on-bead: Efficient on-resin synthesis of α-conotoxin LvIA Tetrahedron letters (2019) 60: 23-28 [P, NA]
Jin, A.H., Dutertre, S., Dutt, M., Lavergne, V., Jones, A., Lewis, R.J. and Alewood, P.F.
Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis Marine drugs (2019) 17: 177-0 [P, NA]
Jin, A.H., Cristofori-Armstrong, B., Rash, L.D., Román-González, S.A., Espinosa, R.A., Lewis, R.J., Alewood, P.F. and Vetter, I
Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels Biochemical pharmacology (2019) 164: 342-348 [P, NA]
Huynh,P.N., Giuvelis,D., Christensen,S., Tucker,K.L. and McIntosh,J.M.
RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats Mar Drugs (2019) 18: 12-0 [P, NA]
Hone,A.J., Fisher,F., Christensen,S., Gajewiak,J., Larkin,D., Whiteaker,P. and McIntosh,J.M.
PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors J. Med. Chem. (2019) 62: 6262-6275 [P, NA]
Hernández-Sámano,A.C., Falcón,A., Zamudio,F., Batista,C.V.F., Michel-Morfín,J.E., Landa-Jaime,V., López-Vera,E., Jeziorski,M.C. and Aguilar,M.B.
αD-Conotoxins in Species of the Eastern Pacific: The Case of Conus princeps from Mexico. Toxins (Basel) (2019) 11: 405-0 [P, NA]
Finol-Urdaneta, R.K., McArthur, J.R., Korkosh, V.S., Huang, S., McMaster, D., Glavica, R., Tikhonov, D.B., Zhorov, B.S. and French, R.J.
Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA Marine drugs (2019) 17: 510-527 [P, NA]
Fassio, G., Modica, M.V., Mary, L., Zaharias, P., Fedosov, A.E., Gorson, J., Kantor, Y.I., Holford, M. and Puillandre, N.
Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus Toxins (2019) 11: 623-0 [P, NA]
El Hamdaoui,Y., Wu,X., Clark,R.J., Giribaldi,J., Anangi,R., Craik,D.J., King,G.F., Dutertre,S., Kaas,Q., Herzig,V. and Nicke,A.
Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR. Front Pharmacol (2019) 10: 577-0 [P, NA]
Dutt, M., Giacomotto, J., Ragnarsson, L., Andersson, Å., Brust, A., Dekan, Z., Alewood, P.F. and Lewis, R.J.
The α 1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa Scientific reports (2019) 9: 17841-0 [P, NA]
Dutt, M., Dutertre, S., Jin, A.H., Lavergne, V., Alewood, P.F. and Lewis, R.J.
Venomics reveals venom complexity of the piscivorous cone snail, Conus tulipa Marine drugs (2019) 17: 71-0 [P, NA]
Cordeiro,S., Finol-Urdaneta,R.K., Köpfer,D., Markushina,A., Song,J., French,R.J., Kopec,W., de Groot,B.L., Giacobassi,M.J., Leavitt,L.S., Raghuraman,S., Teichert,R.W., Olivera,B.M. and Terlau,H
Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channels Proceedings of the National Academy of Sciences (2019) 116: 1059-1064 [P, NA]
Chu,X., Tae,H.S., Xu,Q., Jiang,T., Adams,D.J. and Yu,R
α-Conotoxin Vc1.1 Structure-Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement ACS Chem Neurosci (2019) 10: 4328-4336 [P, NA]
Bernáldez-Sarabia, J., Figueroa-Montiel, A., Dueñas, S., Cervantes-Luévano, K., Beltrán, J.A., Ortiz, E., Jiménez, S., Possani, L.D., Paniagua-Solís, J.F., Gonzalez-Canudas, J. and Licea-Navarro, A.
The Diversified O-Superfamily in Californiconus californicus Presents a Conotoxin with Antimycobacterial Activity Toxins (2019) 11: 128-0 [P, NA]
Ahorukomeye, P., Disotuar, M.M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S.D., Salcedo, P.F., Smith, N.A., Smith, B.J., Schlegel, A. and Forbes, B.E.
Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor eLife (2019) 8 [P, NA]

Yu,R., Tae,H.S., Tabassum,N., Shi,J., Jiang,T. and Adams,D.J.
Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor Subtype J. Med. Chem. (2018) 61: 4628-4634 [P, NA]
Yu,J., Zhu,X., Yang,Y., Luo,S. and Zhangsun,D.
Expression in Escherichia coli of fusion protein comprising α-conotoxin TxIB and preservation of selectivity to nicotinic acetylcholine receptors in the purified product Chem Biol Drug Des (2018) 91: 349-358 [P, NA]
Yu, J., Zhu, X., Zhang, L., Kudryavtsev, D., Kasheverov, I., Lei, Y., Zhangsun, D., Tsetlin, V. and Luo, S.
Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists Neuropharmacology (2018) 139: 226-237 [P, NA]
Yu, J., Zhu, X., Harvey, P.J., Kaas, Q., Zhangsun, D., Craik, D.J. and Luo, S.
Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist Journal of medicinal chemistry (2018) 61: 9256-9265 [P, NA]
Wu, X., Tae, H.S., Huang, Y.H., Adams, D.J., Craik, D.J. and Kaas, Q.
Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Biochemical pharmacology (2018) 155: 288-297 [P, NA]
Wilson,D. and Daly,N.L.
Nuclear Magnetic Resonance seq (NMRseq): A New Approach to Peptide Sequence Tags Toxins (Basel) (2018) 10: 437-0 [P, NA]
Vijayasarathy,M. and Balaram,P
Mass spectrometric identification of bromotryptophan containing conotoxin sequences from the venom of C. amadis Toxicon (2018) 144: 68-74 [P, NA]
Vijayasarathy, M., Basheer, S.M. and Balaram, P.
Cone Snail Glutaminyl Cyclase Sequences from Transcriptomic Analysis and Mass Spectrometric Characterization of Two Pyroglutamyl Conotoxins Journal of proteome research (2018) 17: 2695-2703 [P, NA]
Sousa,S.R., McArthur,J.R., Brust,A., Bhola,R.F., Rosengren,K.J., Ragnarsson,L., Dutertre,S., Alewood,P.F., Christie,M.J., Adams,D.J., Vetter,I. and Lewis,R.J.
Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Sci Rep (2018) 8: 13397-0 [P, NA]
Sadeghi M, Carstens BB, Callaghan BP, Daniel JT, Tae HS, O Donnell T, Castro J, Brierley SM, Adams DJ, Craik DJ, Clark RJ
Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1. ACS Chem. Biol. (2018) 13: 1577-1587 [P, NA]
Phuong, M.A. and Mahardika, G.N.
Targeted Sequencing of Venom Genes from Cone Snail Genomes Improves Understanding of Conotoxin Molecular Evolution Molecular biology and evolution (2018) 35: 1210-1224 [P, NA]
Paul George,A.A., Heimer,P., Maaß,A., Hamaekers,J., Hofmann-Apitius,M., Biswas,A. and Imhof,D.
Insights into the Folding of Disulfide-Rich μ-Conotoxins ACS Omega (2018) 3: 12330-12340 [P, NA]
Ning,J., Li,R., Ren,J., Zhangsun,D., Zhu,X., Wu,Y. and Luo,S.
Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor Mar Drugs (2018) 16: 507-0 [P, NA]
Mei, D., Zhao, L., Chen, B., Zhang, X., Wang, X., Yu, Z., Ni, X. and Zhang, Q.
α-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to α7-nAChR overexpressed non-small cell lung cancer Drug Delivery (2018) 25: 493-503 [P, NA]
Möller, C., Dovell, S., Melaun, C. and Marí, F.
Definition of the R-superfamily of conotoxins: Structural convergence of helix-loop-helix peptidic scaffolds Peptides (2018) 107: 75-82 [P, NA]
Liu,Z., Bartels,P., Sadeghi,M., Du,T., Dai,Q., Zhu,C., Yu,S., Wang,S., Dong,M., Sun,T. and Guo,J.
A novel α-conopeptide Eu1.6 inhibits N-type (Ca V 2.2) calcium channels and exhibits potent analgesic activity Scientific reports (2018) 8: 1004-0 [P, NA]
Li, Q., Watkins, M., Robinson, S., Safavi-Hemami, H. and Yandell, M.
Discovery of Novel Conotoxin Candidates Using Machine Learning Toxins (2018) 10: 503-0 [P, NA]
Hone, A.J., Talley, T.T., Bobango, J., Melo, C.H., Hararah, F., Gajewiak, J., Christensen, S., Harvey, P.J., Craik, D.J. and McIntosh, J.M.
Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors Journal of Biological Chemistry (2018) 293: 17838-17852 [P, NA]
Himaya, S.W.A., Mari, F. and Lewis, R.J.
Accelerated proteomic visualization of individual predatory venoms of Conus purpurascens reveals separately evolved predation-evoked venom cabals Scientific reports (2018) 8: 1-8 [P, NA]
Heimer, P., Tietze, A.A., Bäuml, C.A., Resemann, A., Mayer, F.J., Suckau, D., Ohlenschläger, O., Tietze, D. and Imhof, D.
Conformational μ-conotoxin PIIIA isomers revisited: Impact of cysteine pairing on disulfide-bond assignment and structure elucidation Analytical chemistry (2018) 90: 3321-3327 [P, NA]
Harvey,P.J., Kurniawan,N.D., Finol-Urdaneta,R.K., McArthur,J.R., Van Lysebetten,D., Dash,T.S., Hill,J.M., Adams,D.J., Durek,T. and Craik,D.J.
NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency Molecules (2018) 23: 2715-0 [P, NA]
Grau, V., Richter, K., Hone, A.J. and McIntosh, J.M.
Conopeptides [V11L; V16D] ArIB and RgIA4: powerful tools for the identification of novel nicotinic acetylcholine receptors in monocytes Frontiers in pharmacology (2018) 9 [P, NA]
Giribaldi, J., Wilson, D., Nicke, A., El Hamdaoui, Y., Laconde, G., Faucherre, A., Moha Ou Maati, H., Daly, N., Enjalbal, C. and Dutertre, S.
Synthesis, structure and biological activity of CIA and CIB, two α-conotoxins from the predation-evoked venom of Conus catus Toxins (2018) 10: 222-0 [P, NA]
Gao,B., Peng,C., Zhu,Y., Sun,Y., Zhao,T., Huang,Y. and Shi,Q.
High Throughput Identification of Novel Conotoxins from the Vermivorous Oak Cone Snail (Conus quercinus) by Transcriptome Sequencing Int J Mol Sci (2018) 19: 3901-0 [P, NA]
Franco,A., Dovell,S., Möller,C., Grandal,M., Clark,E. and Marí,F.
Structural plasticity of mini-M conotoxins - expression of all mini-M subtypes by Conus regius. FEBS J. (2018) 285: 887-902 [P, NA]
Figueroa-Montiel, A., Bernáldez, J., Jiménez, S., Ueberhide, B., González, L. and Licea-Navarro, A.
Antimycobacterial activity: A new pharmacological target for conotoxins found in the first reported conotoxin from Conasprella ximenes Toxins (2018) 10: 51-0 [P, NA]
Espino, S.S., Robinson, S.D., Safavi-Hemami, H., Gajewiak, J., Yang, W., Olivera, B.M. and Liu, Q.
Conopeptides promote itch through human itch receptor hMgprX1 Toxicon (2018) 154: 28-34 [P, NA]
Chen, F., Huang, W., Jiang, T. and Yu, R.
Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-Gated Sodium Channels from Binding Energy Calculations Marine drugs (2018) 16: 153-0 [P, NA]
Chen J, Liang L, Ning H, Cai F, Liu Z, Zhang L, Zhou L, Dai Q
Cloning, Synthesis and Functional Characterization of a Novel α-Conotoxin Lt1.3 Marine drugs (2018) 16: 112-0 [P, NA]
Castro J, Grundy L, Deiteren A, Harrington AM, O Donnell T, Maddern J, Moore J, Garcia-Caraballo S, Rychkov GY, Yu R, Kaas Q, Craik DJ, Adams DJ, Brierley SM
Cyclic analogues of α‐conotoxin Vc1. 1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain British journal of pharmacology (2018) 175: 2384-2398 [P, NA]
Cai,F., Xu,N., Liu,Z., Ding,R., Yu,S., Dong,M., Wang,S., Shen,J., Tae,H.S., Adams,D.J., Zhang,X. and Dai,Q.
Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity J. Med. Chem. (2018) 61: 10198-10205 [P, NA]
Armstrong,D.A., Kaas,Q. and Rosengren,K.J.
Prediction of disulfide dihedral angles using chemical shifts. Chem Sci (2018) 9: 6548-6556 [P, NA]
Abalde, S., Tenorio, M.J., Afonso, C.M. and Zardoya, R.
Conotoxin diversity in Chelyconus ermineus (Born, 1778) and the convergent origin of piscivory in the Atlantic and Indo-Pacific cones Genome biology and evolution (2018) 10: 2643-2662 [P, NA]

Yang,M., Zhao,S., Min,X., Shao,M., Chen,Y., Chen,Z. and Zhou,M.
A novel μ-conotoxin from worm-hunting Conus tessulatus that selectively inhibit rat TTX-resistant sodium currents. Toxicon (2017) 130: 11-18 [P, NA]
Xu,M., Zhu,X., Yu,J., Yu,J., Luo,S. and Wang,X.
The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes. Protein Cell (2017) 8: 675-685 [P, NA]
Tabassum, N., Tae, H.S., Jia, X., Kaas, Q., Jiang, T., Adams, D.J. and Yu, R.
Role of CysI-CysIII Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors ACS omega (2017) 2: 4621-4631 [P, NA]
Robinson,S.D., Li,Q., Bandyopadhyay,P.K., Gajewiak,J., Yandell,M., Papenfuss,A.T., Purcell,A.W., Norton,R.S. and Safavi-Hemami,H.
Hormone-like peptides in the venoms of marine cone snails. Gen. Comp. Endocrinol. (2017) 244: 11-18 [P, NA]
Reyes-Guzman, E.A., Vega-Castro, N., Reyes-Montaño, E.A. and Recio-Pinto, E.
Antagonistic action on NMDA/GluN2B mediated currents of two peptides that were conantokin-G structure-based designed BMC neuroscience (2017) 18: 44-0 [P, NA]
Reimers,C., Lee,C.H., Kalbacher,H., Tian,Y., Hung,C.H., Schmidt,A., Prokop,L., Kauferstein,S., Mebs,D., Chen,C.C. and Gründer,S.
Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain. Proc. Natl. Acad. Sci. U.S.A. (2017) 114 [P, NA]
Lu, J., Zhang, K., Wang, S., Sun, T., Yu, S., Dai, Q. and Liu, Z.
Cloning, expression and functional characterization of a D-superfamily conotoxin Lt28. 1 with previously undescribed cysteine pattern Peptides, 94, pp.64-70 (2017) 94: 64-70 [P, NA]
Li,Q., Barghi,N., Lu,A., Fedosov,A.E., Bandyopadhyay,P.K., Lluisma,A.O., Concepcion,G.P., Yandell,M., Olivera,B.M. and Safavi-Hemami,H.
Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus. Genome Biol Evol (2017) 9: 2211-2225 [P, NA]
Leipold,E., Ullrich,F., Thiele,M., Tietze,A.A., Terlau,H., Imhof,D. and Heinemann,S.H.
Subtype-specific block of voltage-gated K+ channels by μ-conopeptides Biochem. Biophys. Res. Commun. (2017) 482: 1135-1140 [P, NA]
Leffler,A.E., Kuryatov,A., Zebroski,H.A., Powell,S.R., Filipenko,P., Hussein,A.K., Gorson,J., Heizmann,A., Lyskov,S., Tsien,R.W., Poget,S.F., Nicke,A., Lindstrom,J., Rudy,B., Bonneau,R. and Holford,M.
Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. Proc. Natl. Acad. Sci. U.S.A. (2017) 114 [P, NA]
Jin, A.H., Dekan, Z., Smout, M.J., Wilson, D., Dutertre, S., Vetter, I., Lewis, R.J., Loukas, A., Daly, N.L. and Alewood, P.F.
Conotoxin Φ‐MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti‐Apoptotic Activity Angewandte Chemie International Edition (2017) 56: 14973-14976 [P, NA]
Hoggard, M.F., Rodriguez, A.M., Cano, H., Clark, E., Tae, H.S., Adams, D.J., Godenschwege, T.A. and Marí, F
In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens Neuropharmacology (2017) 127: 253-259 [P, NA]
Gao,B., Peng,C., Lin,B., Chen,Q., Zhang,J. and Shi,Q.
Screening and Validation of Highly-Efficient Insecticidal Conotoxins from a Transcriptome-Based Dataset of Chinese Tubular Cone Snail Toxins (Basel) (2017) 9: 214-0 [P, NA]
El-Aziz,T.M.A., Ravelet,C., Molgo,J., Fiore,E., Pale,S., Amar,M., Al-Khoury,S., Dejeu,J., Fadl,M., Ronjat,M., Taiwe,G.S., Servent,D., Peyrin,E. and De Waard,M
Efficient functional neutralization of lethal peptide toxins in vivo by oligonucleotides Sci Rep (2017) 78: 7202-0 [P, NA]
Echterbille,J., Gilles,N., Araóz,R., Mourier,G., Amar,M., Servent,D., De Pauw,E. and Quinton,L.
Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon (2017) 130: 1-10 [P, NA]
Drane,S.B., Robinson,S.D., MacRaild,C.A., Chhabra,S., Chittoor,B., Morales,R.A., Leung,E.W., Belgi,A., Espino,S.S., Olivera,B.M., Robinson,A.J., Chalmers,D.K. and Norton,R.S.
Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue. Toxicon (2017) 129: 113-122 [P, NA]
Christensen, S.B., Hone, A.J., Roux, I., Kniazeff, J., Pin, J.P., Upert, G., Servent, D., Glowatzki, E. and McIntosh, J.M.
RgIA4 potently blocks mouse α9α10 nAChRs and provides long lasting protection against oxaliplatin-induced cold allodynia Frontiers in cellular neuroscience (2017) 11: 219-0 [P, NA]
Chittoor,B., Krishnarjuna,B., Morales,R.A.V., MacRaild,C.A., Sadek,M., Leung,E.W.W., Robinson,S.D., Pennington,M.W. and Norton,R.S.
The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering. Biochemistry (2017) 56: 2455-2466 [P, NA]
Campos-Lira, E., Carrillo, E., Aguilar, M.B., Gajewiak, J., Gómez-Lagunas, F. and López-Vera, E
Conorfamide-Sr3, a structurally novel specific inhibitor of the Shaker K+ channel Toxicon (2017) 138: 53-58 [P, NA]
Abraham,N., Healy,M., Ragnarsson,L., Brust,A., Alewood,P.F. and Lewis,R.J.
Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Sci Rep (2017) 7: 45466-0 [P, NA]

Zhu,X., Bi,J., Yu,J., Li,X., Zhang,Y., Zhangsun,D. and Luo,S.
Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli. Mar Drugs (2016) 14 [P, NA]
Yuan,Y., Balsara,R.D., Zajicek,J., Kunda,S. and Castellino,F.J.
Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors. Biochemistry (2016) 55: 7112-7122 [P, NA]
Wang,F., Yan,Z., Liu,Z., Wang,S., Wu,Q., Yu,S., Ding,J. and Dai,Q.
Molecular basis of toxicity of N-type calcium channel inhibitor MVIIA. Neuropharmacology (2016) 101: 137-145 [P, NA]
Robinson,S.D., Chhabra,S., Belgi,A., Chittoor,B., Safavi-Hemami,H., Robinson,A.J., Papenfuss,A.T., Purcell,A.W. and Norton,R.S.
A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin Fold. Structure (2016) 24: 293-299 [P, NA]
Prashanth,J.R., Dutertre,S., Jin,A.H., Lavergne,V., Hamilton,B., Cardoso,F.C., Griffin,J., Venter,D.J., Alewood,P.F. and Lewis,R.J.
The role of defensive ecological interactions in the evolution of conotoxins. Mol. Ecol. (2016) 25: 598-615 [P, NA]
Peng, C., Yao, G., Gao, B.M., Fan, C.X., Bian, C., Wang, J., Cao, Y., Wen, B., Zhu, Y., Ruan, Z. and Zhao, X.
High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing Gigascience (2016) 5: 17-0 [P, NA]
Menting,J.G., Gajewiak,J., MacRaild,C.A., Chou,D.H., Disotuar,M.M., Smith,N.A., Miller,C., Erchegyi,J., Rivier,J.E., Olivera,B.M., Forbes,B.E., Smith,B.J., Norton,R.S., Safavi-Hemami,H. and Lawrence,M.C.
A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin. Nat. Struct. Mol. Biol. (2016) 23: 916-920 [P, NA]
Lin,B., Xu,M., Zhu,X., Wu,Y., Liu,X., Zhangsun,D., Hu,Y., Xiang,S.H., Kasheverov,I.E., Tsetlin,V.I., Wang,X. and Luo,S.
From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR. Sci Rep (2016) 6: 22349-0 [P, NA]
Lebbe,E.K., Ghequire,M.G., Peigneur,S., Mille,B.G., Devi,P., Ravichandran,S., Waelkens,E., D Souza,L., De Mot,R. and Tytgat,J.
Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. Mar Drugs (2016) 14 [P, NA]
Kwon,S., Bosmans,F., Kaas,Q., Cheneval,O., Conibear,A.C., Rosengren,K.J., Wang,C.K., Schroeder,C.I. and Craik,D.J.
Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnol. Bioeng. (2016) 113: 2202-2212 [P, NA]
Kasheverov,I.E., Chugunov,A.O., Kudryavtsev,D.S., Ivanov,I.A., Zhmak,M.N., Shelukhina,I.V., Spirova,E.N., Tabakmakher,V.M., Zelepuga,E.A., Efremov,R.G. and Tsetlin,V.I.
High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method. Sci Rep (2016) 6: 36848-0 [P, NA]
Han, P., Wang, K., Dai, X., Cao, Y., Liu, S., Jiang, H., Fan, C., Wu, W. and Chen, J.
The Role of Individual Disulfide Bonds of μ-Conotoxin GIIIA in the Inhibition of Nav1. 4 Marine drugs (2016) 14: 213-0 [P, NA]
Green,B.R., Gajewiak,J., Chhabra,S., Skalicky,J.J., Zhang,M.M., Rivier,J.E., Bulaj,G., Olivera,B.M., Yoshikami,D. and Norton,R.S.
Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. J. Biol. Chem. (2016) 291: 7205-7220 [P, NA]
Espino,S.S., Dilanyan,T., Imperial,J.S., Aguilar,M.B., Teichert,R.W., Bandyopadhyay,P. and Olivera,B.M.
Glycine-rich conotoxins from the Virgiconus clade. Toxicon (2016) 113: 11-17 [P, NA]
Deuis,J.R., Dekan,Z., Inserra,M.C., Lee,T.H., Aguilar,M.I., Craik,D.J., Lewis,R.J., Alewood,P.F., Mobli,M., Schroeder,C.I., Henriques,S.T. and Vetter,I.
Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8. J. Biol. Chem. (2016) 291: 11829-11842 [P, NA]
De León-Nava,M.A., Romero-Núñez,E., Luna-Nophal,A., Bernáldez-Sarabia,J., Sánchez-Campos,L.N., Licea-Navarro,A.F., Morales-Montor,J. and Muñiz-Hernández,S.
In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii. Mar Drugs (2016) 14 [P, NA]
Cuny,H., Kompella,S.N., Tae,H.S., Yu,R. and Adams,D.J.
Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins. J. Biol. Chem. (2016) 291: 23779-23792 [P, NA]
Carstens,B.B., Berecki,G., Daniel,J.T., Lee,H.S., Jackson,K.A., Tae,H.S., Sadeghi,M., Castro,J., O
Structure-Activity Studies of Cysteine-Rich a-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew. Chem. Int. Ed. Engl (2016) 55: 4692-4696 [P, NA]
Carstens, B.B., Swedberg, J., Berecki, G., Adams, D.J., Craik, D.J. and Clark, R.J.
Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α‐conotoxin Peptide Science (2016) 106: 864-875 [P, NA]
Brust A., Croker D. E., Colless B., Ragnarsson L., Andersson A., Jain K., Garcia-Caraballo S., Castro J., Brierley S. M., Alewood P. F., Lewis R. J.
Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J. Med. Chem. (2016) [P, NA]
Bernáldez,J., Jiménez,S., González,L.J., Ferro,J.N., Soto,E., Salceda,E., Chávez,D., Aguilar,M.B. and Licea-Navarro,A.
A New Member of Gamma-Conotoxin Family Isolated from Conus princeps Displays a Novel Molecular Target. Toxins (Basel) (2016) 8: 39-0 [P, NA]

Zhou,M., Wang,L., Wu,Y., Liu,J., Sun,D., Zhu,X., Feng,Y., Qin,M., Chen,S. and Xu,A.
Soluble expression and sodium channel activity of lt16a, a novel framework XVI conotoxin from the M-superfamily. Toxicon (2015) 98: 5-11 [P, NA]
Zhang,M.M., Gajewiak,J., Azam,L., Bulaj,G., Olivera,B.M. and Yoshikami,D.
Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ. Biochemistry (2015) 54: 3911-3920 [P, NA]
Yu,R., Seymour,V.A., Berecki,G., Jia,X., Akcan,M., Adams,D.J., Kaas,Q. and Craik,D.J.
Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Sci Rep (2015) 5: 13264-0 [P, NA]
Xu,S., Zhang,T., Kompella,S.N., Yan,M., Lu,A., Wang,Y., Shao,X., Chi,C., Adams,D.J., Ding,J. and Wang,C.
Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci Rep (2015) 5: 14261-0 [P, NA]
Wilson,M.J., Zhang,M.M., Gajewiak,J., Azam,L., Rivier,J.E., Olivera,B.M. and Yoshikami,D.
Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ. J. Neurophysiol. (2015) 113: 2289-2301 [P, NA]
Wang, S., Zhao, C., Liu, Z., Wang, X., Liu, N., Du, W. and Dai, Q.
Structural and functional characterization of a novel α-conotoxin Mr1. 7 from Conus marmoreus targeting neuronal nAChR α3β2, α9α10 and α6/α3β2β3 subtypes Marine drugs (2015) 13: 3259-3275 [P, NA]
Wan, J., Huang, J.X., Vetter, I., Mobli, M., Lawson, J., Tae, H.S., Abraham, N., Paul, B., Cooper, M.A., Adams, D.J. and Lewis, R.J.
α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors Journal of the American Chemical Society (2015) 137: 3209-3212 [P, NA]
Safavi-Hemami,H., Gajewiak,J., Karanth,S., Robinson,S.D., Ueberheide,B., Douglass,A.D., Schlegel,A., Imperial,J.S., Watkins,M., Bandyopadhyay,P.K., Yandell,M., Li,Q., Purcell,A.W., Norton,R.S., Ellgaard,L. and Olivera,B.M.
Specialized insulin is used for chemical warfare by fish-hunting cone snails. Proc. Natl. Acad. Sci. U.S.A. (2015) 112: 1743-1748 [P, NA]
Robinson,S.D., Safavi-Hemami,H., Raghuraman,S., Imperial,J.S., Papenfuss,A.T., Teichert,R.W., Purcell,A.W., Olivera,B.M. and Norton,R.S.
Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom. J Proteomics (2015) 114: 38-47 [P, NA]
Ren,Z., Wang,L., Qin,M., You,Y., Pan,W., Zhou,L., Sun,D. and Xu,A.
Pharmacological characterization of conotoxin lt14a as a potent non-addictive analgesic. Toxicon (2015) 96: 57-67 [P, NA]
Novel M-Superfamily and T-Superfamily conotoxins and contryphans from the vermivorous snail Conus figulinus. J. Pept. Sci. (2015) 21: 29-39 [P, NA]
Mueller,A., Starobova,H., Inserra,M.C., Jin,A.H., Deuis,J.R., Dutertre,S., Lewis,R.J., Alewood,P.F., Daly,N.L. and Vetter,I.
α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochem. Pharmacol. (2015) 94: 155-163 [P, NA]
Luo,S., Zhangsun,D., Harvey,P.J., Kaas,Q., Wu,Y., Zhu,X., Hu,Y., Li,X., Tsetlin,V.I., Christensen,S., Romero,H.K., McIntyre,M., Dowell,C., Baxter,J.C., Elmslie,K.S., Craik,D.J. and McIntosh,J.M.
Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. Proc. Natl. Acad. Sci. U.S.A. (2015) 112 [P, NA]
Li,L., Liu,N., Ding,R., Wang,S., Liu,Z., Li,H., Zheng,X. and Dai,Q.
A novel 4/6-type alpha-conotoxin ViIA selectively inhibits nAchR α3β2 subtype. Acta Biochim. Biophys. Sin. (Shanghai) (2015) 47: 1023-1028 [P, NA]
Kunda,S., Yuan,Y., Balsara,R.D., Zajicek,J. and Castellino,F.J.
Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors. J. Biol. Chem. (2015) 290: 18156-18172 [P, NA]
Kompella,S.N., Hung,A., Clark,R.J., Marí,F. and Adams,D.J.
Alanine scan of α-conotoxin RegIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist J. Biol. Chem. (2015) 290: 1039-1048 [P, NA]
Kompella,S.N., Cuny,H., Hung,A. and Adams,D.J.
Molecular Basis for Differential Sensitivity of α-Conotoxin RegIIA at Rat and Human Neuronal Nicotinic Acetylcholine Receptors Mol. Pharmacol. (2015) 88: 993-1001 [P, NA]
Kancherla,A.K., Meesala,S., Jorwal,P., Palanisamy,R., Sikdar,S.K. and Sarma,S.P.
A Disulfide Stabilized β-Sandwich Defines the Structure of a New Cysteine Framework M-Superfamily Conotoxin. ACS Chem. Biol. (2015) 10: 1847-1860 [P, NA]
Jin,A.H., Vetter,I., Himaya,S.W., Alewood,P.F., Lewis,R.J. and Dutertre,S.
Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom Proteomics (2015) 15: 4030-4040 [P, NA]
Jin,A.H., Israel,M.R., Inserra,M.C., Smith,J.J., Lewis,R.J., Alewood,P.F., Vetter,I. and Dutertre,S.
δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proc. Biol. Sci. (2015) 282 [P, NA]
Jennifer R. Deuis, Ella Whately, Andreas Brust, Marco C. Inserra, Naghmeh H. Asvadi, Richard J. Lewis, Paul F. Alewood, Peter J. Cabot, Irina Vetter
Activation of κ opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia ACS Chemical Neuroscience (2015) 6: 1751-1758 [P, NA]
Himaya, S.W.A., Jin, A.H., Dutertre, S., Giacomotto, J., Mohialdeen, H., Vetter, I., Alewood, P.F. and Lewis, R.J.
Comparative venomics reveals the complex prey capture strategy of the piscivorous cone snail Conus catus. Journal of proteome research (2015) 14: 4372-4381 [P, NA]
Christensen,S.B., Bandyopadhyay,P.K., Olivera,B.M. and McIntosh,J.M.
αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors Biochem. Pharmacol. (2015) 96: 349-356 [P, NA]
Aman,J.W., Imperial,J.S., Ueberheide,B., Zhang,M.M., Aguilar,M., Taylor,D., Watkins,M., Yoshikami,D., Showers-Corneli,P., Safavi-Hemami,H., Biggs,J., Teichert,R.W. and Olivera,B.M.
Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus. Proc. Natl. Acad. Sci. U.S.A. (2015) 112: 5087-5092 [P, NA]
Aman,J.W., Imperial,J.S., Ueberheide,B., Zhang,M.M., Aguilar,M., Taylor,D., Watkins,M., Yoshikami,D., Showers-Corneli,P., Safavi-Hemami,H., Biggs,J. and Olivera,B.M.
Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus. Proc. Natl. Acad. Sci. U.S.A. (2015) 112: 5087-5092 [P, NA]
Akcan,M., Clark,R.J., Daly,N.L., Conibear,A.C., de Faoite,A., Heghinian,M.D., Sahil,T., Adams,D.J., Marí,F. and Craik,D.J.
Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins. Biopolymers (2015) 104: 682-692 [P, NA]

Wu,Y., Wu,X., Yu,J., Zhu,X., Zhangsun,D. and Luo,S.
Influence of disulfide connectivity on structure and bioactivity of α-conotoxin TxIA Molecules (2014) 19: 966-979 [P, NA]
Wang,S., Du,T., Liu,Z., Wang,S., Wu,Y., Ding,J., Jiang,L. and Dai,Q.
Characterization of a T-superfamily conotoxin TxVC from Conus textile that selectively targets neuronal nAChR subtypes. Biochem. Biophys. Res. Commun. (2014) 454: 151-156 [P, NA]
Wang,C.K., King,G.J., Northfield,S.E., Ojeda,P.G. and Craik,D.J.
Racemic and quasi-racemic X-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angew. Chem. Int. Ed. Engl. (2014) 53: 11236-11241 [P, NA]
Stock,P., Ljaschenko,D., Heckmann,M. and Dudel,J.
Agonists binding nicotinic receptors elicit specific channel-opening patterns at αγ and αδ sites. J. Physiol. (Lond.) (2014) 592: 2501-2517 [P, NA]
Robinson,S.D., Safavi-Hemami,H., McIntosh,L.D., Purcell,A.W., Norton,R.S. and Papenfuss,A.T.
Diversity of Conotoxin Gene Superfamilies in the Venomous Snail, Conus victoriae. PLoS ONE (2014) 9 [P, NA]
Puillandre,N., Stöcklin,R., Favreau,P., Bianchi,E., Perret,F., Rivasseau,A., Limpalaër,L. and Bouchet,P.
When everything converges: integrative taxonomy with shell, DNA and venomic data reveals Conus conco, a new species of cone snails (Gastropoda: Conoidea). Mol. Phylogenet. Evol. (2014) 80: 186-192 [P, NA]
Puillandre,N., Bouchet,P., Duda,T.F. Jr., Kauferstein,S., Kohn,A.J., Olivera,B.M., Watkins,M. and Meyer,C.
Molecular phylogeny and evolution of the cone snails (Gastropoda, Conoidea) Mol. Phylogenet. Evol. (2014) 78: 290-303 [P, NA]
Platt,R.J., Curtice,K.J., Twede,V.D., Watkins,M., Gruszczyński,P., Bulaj,G., Horvath,M.P. and Olivera,B.M.
From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes. Toxicon (2014) 81: 67-79 [P, NA]
Nguyen,B., Le Caer,J.P., Aráoz,R., Thai,R., Lamthanh,H., Benoit,E. and Molgó,J.
Isolation, purification and functional characterization of alpha-BnIA from Conus bandanus venom. Toxicon (2014) 91: 155-163 [P, NA]
Nepravishta,R., Mandaliti,W., Melino,S., Eliseo,T. and Paci,M.
Structure of the cyclic peptide [W8S]contryphan Vn: effect of the tryptophan/serine substitution on trans-cis proline isomerization. Amino Acids (2014) 46: 2841-2853 [P, NA]
Luo,S., Zhangsun,D., Schroeder,C.I., Zhu,X., Hu,Y., Wu,Y., Weltzin,M.M., Eberhard,S., Kaas,Q., Craik,D.J., McIntosh,J.M. and Whiteaker,P.
A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors. FASEB J. (2014) 28: 1842-1853 [P, NA]
Lu,A., Yang,L., Xu, S. and Wang,C.
Various conotoxin diversifications revealed by a venomic study of Conus flavidus. Mol. Cell Proteomics (2014) 13: 105-118 [P, NA]
Lebbe,E.K., Peigneur,S., Maiti,M., Mille,B.G., Devi,P., Ravichandran,S., Lescrinier,E., Waelkens,E., D'Souza,L. and Tytgat,J.
Discovery of a new subclass of α-conotoxins in the venom of Conus australis. Toxicon (2014) 91: 145-154 [P, NA]
Lebbe,E.K., Peigneur,S., Maiti,M., Devi,P., Ravichandran,S., Lescrinier,E., Ulens,C., Waelkens,E., D'Souza,L. and Tytgat,J.
Structure-Function Elucidation of a New α-Conotoxin, Lo1a, from Conus longurionis. J. Biol. Chem. (2014) 289: 9573-9583 [P, NA]
Jin,A.H., Vetter,I., Dutertre,S., Abraham,N., Emidio,N.B., Inserra,M., Murali,S.S., Christie,M.J., Alewood,P.F. and Lewis,R.J.
MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors. Biochemistry (2014) 53: 1-3 [P, NA]
Jia,X., Kwon,S., Wang,C.I., Huang,Y.H., Chan,L.Y., Tan,C.C., Rosengren,K.J., Mulvenna,J.P., Schroeder,C.I. and Craik,D.J.
Semienzymatic cyclization of disulfide-rich peptides using Sortase A. J. Biol. Chem. (2014) 289: 6627-6638 [P, NA]
Green,B.R., Zhang,M.M., Chhabra,S., Robinson,S.D., Wilson,M.J., Redding,A., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S.
Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3. FEBS J. (2014) 281: 2885-2898 [P, NA]
Gajewiak,J., Azam,L., Imperial,J., Walewska,A., Green,B.R., Bandyopadhyay,P.K., Raghuraman,S., Ueberheide,B., Bern,M., Zhou,H.M., Minassian,N.A., Hagan,R.H., Flinspach,M., Liu,Y., Bulaj,G., Wickenden,A.D., Olivera,B.M., Yoshikami,D. and Zhang,M.M.
A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ. Proc. Natl. Acad. Sci. U.S.A. (2014) 111: 2758-2763 [P, NA]
Dutertre,S., Jin,A.H., Vetter,I., Hamilton,B., Sunagar,K., Lavergne,V., Dutertre,V., Fry,B.G., Antunes,A., Venter,D.J., Alewood,P.F. and Lewis,R.J.
Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails Nat Commun (2014) 5: 3521- [P, NA]
α-Conotoxin M1 (CTx) blocks αδ binding sites of adult nicotinic receptors while ACh binding at αε sites elicits only small and short quantal synaptic currents. Physiol Rep (2014) 2 [P, NA]
Chhabra,S., Belgi,A., Bartels,P., van Lierop,B.J., Robinson,S.D., Kompella,S.N., Hung,A., Callaghan,B.P., Adams,D.J., Robinson,A.J. and Norton,R.S.
Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets. J. Med. Chem. (2014) 57: 9933-9944 [P, NA]
Chen,S., Gopalakrishnan,R., Schaer,T., Marger,F., Hovius,R., Bertrand,D., Pojer,F. and Heinis,C.
Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides Nat Chem (2014) 6: 1009-1016 [P, NA]
Chen,L., Dürr,K.L. and Gouaux,E.
X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism. Science (2014) 345: 1021-1026 [P, NA]
Berecki, G., Daly, N.L., Huang, Y.H., Vink, S., Craik, D.J., Alewood, P.F. and Adams, D.J.
Effects of arginine 10 to lysine substitution on ω‐conotoxin CVIE and CVIF block of Cav 2.2 channels British journal of pharmacology (2014) 171: 3313-3327 [P, NA]
Banerjee,J., Yongye,A.B., Chang,Y.P., Gyanda,R., Medina-Franco,J.L. and Armishaw,C.J.
Design and synthesis of α-conotoxin GID analogues as selective α4β2 nicotinic acetylcholine receptor antagonists. Biopolymers (2014) 102: 78-87 [P, NA]

Zhou,M., Wang,L., Wu,Y., Zhu,X., Feng,Y., Chen,Z., Li,Y., Sun,D., Ren,Z. and Xu,A.
Characterizing the evolution and functions of the M-superfamily conotoxins. Toxicon (2013) 76: 150-159 [P, NA]
Zhang,M.M., Wilson,M.J., Azam,L., Gajewiak,J., Rivier,J.E., Bulaj,G., Olivera,B.M. and Yoshikami,D.
Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins. Br. J. Pharmacol. (2013) 168: 1597-1610 [P, NA]
Yu,R., Kompella,S.N., Adams,D.J., Craik,D.J. and Kaas,Q.
Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor. J. Med. Chem. (2013) [P, NA]
Wu,Y., Wang,L., Zhou,M., You,Y., Zhu,X., Qiang,Y., Qin,M., Luo,S., Ren,Z. and Xu,A.
Molecular evolution and diversity of Conus peptide toxins, as revealed by gene structure and intron sequence analyses. PLoS ONE (2013) 8 [P, NA]
van Lierop,B.J., Robinson,S.D., Kompella,S.N., Belgi,A., McArthur,J.R., Hung,A., MacRaild,C.A., Adams,D.J. and Robinson,A.J.
Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. ACS Chem. Biol. (2013) 8: 1815-1821 [P, NA]
Sonti,R., Gowd,K.H., Rao,K.N., Ragothama,S., Rodriguez,A., Perez,J.J. and Balaram,P.
Conformational diversity in contryphans from Conus venom: cis-trans isomerisation and aromatic/proline interactions in the 23-membered ring of a 7-residue peptide disulfide loop. Chemistry (2013) 19: 15175-15189 [P, NA]
Ragnarsson,L., Wang,C.I., Andersson,A., Fajarningsih,D., Monks,T., Brust,A., Rosengren,K.J. and Lewis,R.J.
Conopeptide ρ-TIA defines a new allosteric site on the extracellular surface of the α1B-adrenoceptor. J. Biol. Chem. (2013) 288: 1814-1827 [P, NA]
Quinton,L., Servent,D., Girard,E., Molgó,J., Le Caer,J.P., Malosse,C., Haidar,E.A., Lecoq,A., Gilles,N. and Chamot-Rooke,J.
Identification and functional characterization of a novel α-conotoxin (EIIA) from Conus ermineus. Anal Bioanal Chem (2013) [P, NA]
Petrel,C., Hocking,H.G., Reynaud,M., Upert,G., Favreau,P., Biass,D., Paolini-Bertrand,M., Peigneur,S., Tytgat,J., Gilles,N., Hartley,O., Boelens,R., Stocklin,R. and Servent,D.
Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor. Biochem. Pharmacol. (2013) [P, NA]
Peigneur,S., Van Der Haegen,A., Möller,C., Waelkens,E., Diego-García,E., Marí,F., Naudé,R. and Tytgat,J.
Unraveling the peptidome of the South African cone snails Conus pictus and Conus natalis. Peptides (2013) 41: 8-16 [P, NA]
McDougal,O.M., Granum,D.M., Swartz,M., Rohleder,C. and Maupin,C.M.
pKa determination of histidine residues in α-conotoxin MII peptides by 1H NMR and constant pH molecular dynamics simulation. J Phys Chem B (2013) 117: 2653-2661 [P, NA]
Luo,S., Zhangsun,D., Zhu,X., Wu,Y., Hu,Y., Christensen,S., Harvey,P.J., Akcan,M., Craik,D.J. and McIntosh,J.M.
Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors. J. Med. Chem. (2013) 56: 9655-9663 [P, NA]
Luo,S., Zhangsun,D., Wu,Y., Zhu,X., Hu,Y., McIntyre,M., Christensen,S., Akcan,M., Craik,D.J. and McIntosh,J.M.
Characterization of a novel α-conotoxin from conus textile that selectively targets α6/α3β2β3 nicotinic acetylcholine receptors. J. Biol. Chem. (2013) 288: 894-902 [P, NA]
Luo,S., Christensen,S., Zhangsun,D., Wu,Y., Hu,Y., Zhu,X., Chhabra,S., Norton,R.S. and McIntosh,J.M.
A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily. PLoS ONE (2013) 8 [P, NA]
Lavergne,V., Dutertre,S., Jin,A.H., Lewis,R.J., Taft,R.J. and Alewood,P.F.
Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies BMC Genomics (2013) 14: 708- [P, NA]
Lavergne,V., Dutertre,S., Jin,A.H., Lewis,R.J. and Alewood,P.F.
Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. BMC Genomics (2013) 14: 708- [P, NA]
Kuang,Z., Zhang,M.M., Gupta,K., Gajewiak,J., Gulyas,J., Balaram,P., Rivier,J.E., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S.
Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency. ACS Chem. Biol. (2013) 8: 1344-1351 [P, NA]
Kapono,C.A., Thapa,P., Cabalteja,C.C., Guendisch,D., Collier,A.C. and Bingham,J.P.
Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus. Toxicon (2013) [P, NA]
Jin,A.H., Dutertre,S., Kaas,Q., Lavergne,V., Kubala,P. and Alewood,P.F.
Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Mol. Cell Proteomics (2013) 12: 3824-3833 [P, NA]
Inserra,M.C., Kompella,S.N., Vetter,I., Brust,A., Daly,N.L., Cuny,H., Craik,D.J., Alewood,P.F., Adams,D.J. and Lewis,R.J.
Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochem. Pharmacol. (2013) 86: 791-799 [P, NA]
Hone,A.J., Ruiz,M., Scadden,M., Christensen,S., Gajewiak,J., Azam,L. and McIntosh,J.M.
Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors. J. Biol. Chem. (2013) 288: 25428-25439 [P, NA]
Hocking,H.G., Gerwig,G.J., Dutertre,S., Violette,A., Favreau,P., Stöcklin,R., Kamerling,J.P. and Boelens,R.
Structure of the O-glycosylated conopeptide CcTx from Conus consors venom. Chemistry (2013) 19: 870-879 [P, NA]
Grishin,A.A., Cuny,H., Hung,A., Clark,R.J., Brust,A., Akondi,K., Alewood,P.F., Craik,D.J. and Adams,D.J.
Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. J. Biol. Chem. (2013) 288: 34428-34442 [P, NA]
Gao,B., Zhangsun,D., Wu,Y., Lin,B., Zhu,X. and Luo,S.
Expression, renaturation and biological activity of recombinant conotoxin GeXIVAWT. Appl. Microbiol. Biotechnol. (2013) 97: 1223-1230 [P, NA]
Dutertre,S., Jin,A.H., Kaas,Q., Jones,A., Alewood,P.F. and Lewis,R.J.
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Mol. Cell Proteomics (2013) 12: 312-329 [P, NA]
Braga,M.C., Nery,A.A., Ulrich,H., Konno,K. and Pimenta,D.C.
α -RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom. Int J Pept (2013) 2013: 543028- [P, NA]
Bernáldez,J., Román-González,S.A., Martínez,O., Jiménez,S., Vivas,O., Arenas,I., Corzo,G., Arreguín,R., García,D.E., Possani,L.D. and Licea,A.
A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits CaV2.2 Channels and Displays an Anti-Nociceptive Activity. Mar Drugs (2013) 11: 1188-1202 [P, NA]
Akcan,M., Cao,Y., Chongxu,F. and Craik,D.J.
The three-dimensional solution structure of mini-M conotoxin BtIIIA reveals a disconnection between disulfide connectivity and peptide fold. Bioorg. Med. Chem. (2013) 21: 3590-3596 [P, NA]
Aguilar,M.B., Zugasti-Cruz,A., Falcón,A., Batista,C.V., Olivera,B.M. and Heimer de la Cotera,E.P.
A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico. Peptides (2013) [ahead of print] [P, NA]
Aguilar,M.B., Ortiz,E., Kaas,Q., López-Vera,E., Becerril,B., Possani,L.D. and de la Cotera,E.P.
Precursor De13.1 from Conus delessertii defines the novel G gene superfamily. Peptides (2013) [ahead of print] [P, NA]

Zhang,B., Huang,F. and Du,W.
Solution structure of a novel α-conotoxin with a distinctive loop spacing pattern. Amino Acids (2012) 43: 389-396 [P, NA]
Yu,R., Kaas,Q. and Craik,D.J.
Delineation of the unbinding pathway of α-conotoxin ImI from the α7 nicotinic acetylcholine receptor. J Phys Chem B (2012) 116: 6097-6105 [P, NA]
Ye,M., Khoo,K.K., Xu,S., Zhou,M., Boonyalai,N., Perugini,M.A., Chi,C., Galea,C.A., Wang,C. and Norton,R.S.
A Helical Conotoxin From Conus Imperialis Has A Novel Cysteine Framework And Defiines A New Superfamily J Biol Chem (2012) 287: 14973-14983 [P, NA]
Violette,A., Leonardi,A., Piquemal,D., Terrat,Y., Biass,D., Dutertre,S., Noguier,F., Ducancel,F., Stöcklin,R., Križaj,I. and Favreau,P.
Recruitment of glycosyl hydrolase proteins in a cone snail venomous arsenal: further insights into biomolecular features of Conus venoms. Mar Drugs (2012) 10: 258-280 [P, NA]
Violette,A., Biass,D., Dutertre,S., Koua,D., Piquemal,D., Pierrat,F. and Favreau,P.
Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach. J Proteomics (2012) 75: 5215-5225 [P, NA]
Vetter,I., Dekan,Z., Knapp,O., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochem. Pharmacol. (2012) 84: 540-548 [P, NA]
Van Der Haegen A, Peigneur S, Dyubankova N, Möller C, Marí F, Diego-García E, Naudé R, Lescrinier E, Herdewijn P, Tytgat J
Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity Peptides (2012) 34: 106-113 [P, NA]
Tietze,A.A., Tietze,D., Ohlenschläger,O., Leipold,E., Ullrich,F., Kühl,T., Mischo,A., Buntkowsky,G., Görlach,M., Heinemann,S.H. and Imhof,D.
Structurally diverse μ-conotoxin PIIIA isomers block sodium channel NaV 1.4. Angew. Chem. Int. Ed. Engl. (2012) 51: 4058-4061 [P, NA]
Terrat,Y., Biass,D., Dutertre,S., Favreau,P., Remm,M., Stöcklin,R., Piquemal,D. and Ducancel,F.
High-resolution picture of a venom gland transcriptome: case study with the marine snail Conus consors. Toxicon (2012) 59: 34-46 [P, NA]
Steiner,A.M., Woycechowsky,K.J., Olivera,B.M. and Bulaj,G.
Reagentless oxidative folding of disulfide-rich peptides catalyzed by an intramolecular diselenide. Angew. Chem. Int. Ed. Engl. (2012) 51: 5580-5584 [P, NA]
Schroeder,C.I., Nielsen,K.J., Adams,D.A., Loughnan,M., Thomas,L., Alewood,P.F., Lewis,R.J. and Craik,D.J.
Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers (2012) 98: 345-356 [P, NA]
Schroeder,C.I., Adams,D., Thomas,L., Alewood,P.F. and Lewis,R.J.
N- and C-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers (2012) 98: 161-165 [P, NA]
Safavi-Hemami,H., Gorasia,D.G., Steiner,A.M., Williamson,N.A., Karas,J.A., Gajewiak,J., Olivera,B.M., Bulaj,G. and Purcell,A.W.
Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails. J. Biol. Chem. (2012) 287: 34288-34303 [P, NA]
Puillandre,N., Koua,D., Favreau,P., Olivera,B.M. and Stocklin,R.
Molecular phylogeny, classification and evolution of conopeptides J. Mol. Evol. (2012) 74: 297-309 [P, NA]
Platt,R.J., Han,T.S., Green,B.R., Smith,M.D., Skalicky,J., Gruszczynski,P., White,H.S., Olivera,B., Bulaj,G. and Gajewiak,J.
Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. J. Biol. Chem. (2012) 287: 20727-20736 [P, NA]
Pérez-Alvarez,A., Hernández-Vivanco,A., McIntosh,J.M. and Albillos,A.
Native α6β4* nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland. FASEB J. (2012) 26: 346-354 [P, NA]
Olivera,B.M., Watkins,M., Bandyopadhyay,P., Imperial,J.S., de la Cotera,E.P., Aguilar,M.B., Vera,E.L., Concepcion,G.P. and Lluisma,A.
Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes. Ann. N. Y. Acad. Sci. (2012) 1267: 61-70 [P, NA]
Napier,I.A., Klimis,H., Rycroft,B.K., Jin,A.H., Alewood,P.F., Motin,L., Adams,D.J. and Christie,M.J.
Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain. Neuropharmacology (2012) 62: 2202-2207 [P, NA]
Markgraf,R., Leipold,E., Schirmeyer,J., Paolini-Bertrand,M., Hartley,O. and Heinemann,S.H.
Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC. Br. J. Pharmacol. (2012) 167: 576-586 [P, NA]
Lluisma,A.O., Milash,B.A., Moore,B., Olivera,B.M. and Bandyopadhyay,P.K.
Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome. Mar Genomics (2012) 5: 43-51 [P, NA]
Liu,Z., Li,H., Liu,N., Wu,C., Jiang,J., Yue,J. and Dai,Q.
Diversity and evolution of conotoxins in Conus virgo, Conus eburneus, Conus imperialis and Conus marmoreus from the South China Sea. Toxicon (2012) 60: 982-989 [P, NA]
Knapp,O., Nevin,S.T., Yasuda,T., Lawrence,N., Lewis,R.J. and Adams,D.J.
Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB. Br. J. Pharmacol. (2012) 166: 2148-2160 [P, NA]
Khoo,K.K., Gupta,K., Green,B.R., Zhang,M.M., Watkins,M., Olivera,B.M., Balaram,P., Yoshikami,D., Bulaj,G. and Norton,R.S.
Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels. Biochemistry (2012) 51: 9826-9835 [P, NA]
Kaas,Q., Yu,R., Jin,A.H., Dutertre,S. and Craik,D.J.
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Res (2012) 40 : 325-330 [P, NA]
Hu,H., Bandyopadhyay,P.K., Olivera,B.M. and Yandell,M.
Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct. BMC Genomics (2012) 13: 284-0 [P, NA]
Hone,A.J., Scadden,M., Gajewiak,J., Christensen,S., Lindstrom,J. and McIntosh,J.M.
α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptors. Mol. Pharmacol. (2012) 82: 972-982 [P, NA]
Gowd,K.H., Han,T.S., Twede,V., Gajewiak,J., Smith,M.D., Watkins,M., Platt,R.J., Toledo,G., White,H.S., Olivera,B.M. and Bulaj,G.
Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits. Biochemistry (2012) 51: 4685-4692 [P, NA]
Franco,A., Kompella,S.N., Akondi,K.B., Melaun,C., Daly,N.L., Luetje,C.W., Alewood,P.F., Craik,D.J., Adams,D.J. and Marí,F.
RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs. Biochem. Pharmacol. (2012) 83: 419-426 [P, NA]
Favreau P, Benoit E, Hocking HG, Carlier L, D hoedt D, Leipold E, Markgraf R, Schlumberger S, Córdova MA, Gaertner H, Paolini-Bertrand M, Hartley O, Tytgat J, Heinemann SH, Bertrand D, Boelens R, Stöcklin R, Molgó J
A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors Br J Pharmacol (2012) 166: 1654-1668 [P, NA]
Dobson,R., Collodoro,M., Gilles,N., Turtoi,A., De Pauw,E. and Quinton,L.
Secretion and maturation of conotoxins in the venom ducts of Conus textile. Toxicon (2012) 60: 1370-1379 [P, NA]
Chang,D. and Duda,T.F. Jr.
Extensive and continuous duplication facilitates rapid evolution and diversification of gene families. Mol. Biol. Evol. (2012) 29: 2019-2029 [P, NA]
Bhatia,S., Kil,Y.J., Ueberheide,B., Chait,B.T., Tayo,L., Cruz,L., Lu,B., Yates,J.R. 3rd. and Bern,M.
Constrained de novo sequencing of conotoxins. J. Proteome Res. (2012) 11: 4191-4200 [P, NA]
Beissner,M., Dutertre,S., Schemm,R., Danker,T., Sporning,A., Grubmüller,H. and Nicke,A.
Efficient binding of 4/7 α-conotoxins to nicotinic α4β2 receptors is prevented by Arg185 and Pro195 in the α4 subunit Mol. Pharmacol (2012) 82: 711-718 [P, NA]
Balsara,R., Li,N., Weber-Adrian,D., Huang,L. and Castellino,F.J.
Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors. Neuropharmacology (2012) 62: 2227-2238 [P, NA]

Yu,R., Craik,D.J. and Kaas,Q.
Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PLoS Comput. Biol. (2011) 7 [P, NA]
Ye,M., Hong,J., Zhou,M., Huang,L., Shao,X., Yang,Y., Sigworth,F.J., Chi,C., Lin,D. and Wang,C.
A novel conotoxin, qc16a, with a unique cysteine framework and folding. Peptides (2011) 32: 1159-1165 [P, NA]
Wilson,M.J., Zhang,M.M., Azam,L., Olivera,B.M., Bulaj,G. and Yoshikami,D.
NaV{beta} Subunits Modulate the Inhibition of NaV1.8 by the Analgesic Gating Modifier {micro}O-Conotoxin MrVIB. J. Pharmacol. Exp. Ther. (2011) 338: 687-693 [P, NA]
Wilson,M.J., Yoshikami,D., Azam,L., Gajewiak,J., Olivera,B.M., Bulaj,G. and Zhang,M.M.
μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc. Natl. Acad. Sci. U.S.A. (2011) 108: 10302-10307 [P, NA]
Van Der Haegen,A., Peigneur,S. and Tytgat,J.
Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity. FEBS J. (2011) 278: 3408-3418 [P, NA]
Sun,D., Ren,Z., Zeng,X., You,Y., Pan,W., Zhou,M., Wang,L. and Xu,A.
Structure-function relationship of conotoxin lt14a, a potential analgesic with low cytotoxicity. Peptides (2011) 32: 300-305 [P, NA]
Safavi-Hemami,H., Siero,W.A., Kuang,Z., Williamson,N.A., Karas,J.A., Page,L.R., MacMillan,D., Callaghan,B., Kompella,S.N., Adams,D.J., Norton,R.S., and Purcell,A.W.
Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? J. Biol. Chem. (2011) 286: 22546-22557 [P, NA]
Pucci,L., Grazioso,G., Dallanoce,C., Rizzi,L., De Micheli,C., Clementi,F., Bertrand,S., Bertrand,D., Longhi,R., De Amici,M. and Gotti,C.
Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors. FASEB J. (2011) 25: 3775-3789 [P, NA]
McArthur,J.R., Singh,G., O Mara,M.L., McMaster,D., Ostroumov,V., Tieleman,D.P. and French,R.J
Orientation of {micro}-Conotoxin PIIIA in a Sodium Channel Vestibule, Based on Voltage Dependence of Its Binding. Mol. Pharmacol. (2011) 80: 219-227 [P, NA]
McArthur,J.R., Singh,G., McMaster,D., Winkfein,R., Tieleman,D.P. and French,R.J.
Interactions of key charged residues contributing to selective block of neuronal sodium channels by μ-conotoxin KIIIA. Mol. Pharmacol. (2011) 80: 573-584 [P, NA]
Möller,C. and Marí,F.
9.3 KDa components of the injected venom of Conus purpurascens define a new five-disulfide conotoxin framework. Biopolymers (2011) 96: 158-165 [P, NA]
Lovelace,E.S., Gunasekera,S., Alvarmo,C., Clark,R.J., Nevin,S.T., Grishin,A.A., Adams,D.J., Craik,D.J., and Daly,N.L.
Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization. Antioxid. Redox Signal. (2011) 14: 87-95 [P, NA]
Leipold,E., Markgraf,R., Miloslavina,A., Kijas,M., Schirmeyer,J. , Imhof,D., and Heinemann,S.H
Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels. Neuropharmacology (2011) 61: 105-111 [P, NA]
Klimis,H., Adams,D.J., Callaghan,B., Nevin,S., Alewood,P.F., Vaughan,C.W., Mozar,C.A. and Christie,M.J.
A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain. Pain (2011) 152: 259-266 [P, NA]
Khoo,K.K., Wilson,M.J., Smith,B.J., Zhang,M.M., Gulyas,J., Yoshikami,D., Rivier,J.E., Bulaj,G. and Norton,R.S.
Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA. J. Med. Chem. (2011) 54: 7558-7566 [P, NA]
Kauferstein,S., Porth,C., Kendel,Y., Wunder,C., Nicke,A., Kordis,D., Favreau,P., Koua,D., Stöcklin,R. and Mebs,D.
Venomic study on cone snails (Conus spp.) from South Africa. Toxicon (2011) 57: 28-34 [P, NA]
Imperial,J., Hillyard,D.R., Watkins,M., Olivera,B.M., Wagstaff,J.D., Jones,R.M., Mccabe,R.T., Cruz,L.J., Layer,R.T., Griffen,D. and Craig,A.G.
Contulakin-G, Analogs Thereof and Uses Therefor Patent: JP 2011024579-A (2011) [P, NA]
Hu,H., Bandyopadhyay,P.K. and Yandell,M.
Characterization of the Conus bullatus genome and its venom-duct transcriptome. BMC Genomics (2011) 12: 60- [P, NA]
Halai,R., Callaghan,B., Daly,N.L., Clark,R.J., Adams,D.J. and Craik,D.J.
Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor. J. Med. Chem. (2011) 54: 6984-6992 [P, NA]
Gilly, W.F., Richmond, T.A., Duda, T.F., Elliger, C., Lebaric, Z., Schulz, J., Bingham, J.P. and Sweedler, J.V.,
Gilly, W.F., Richmond, T.A., Duda, T.F., Elliger, C., Lebaric, Z., Schulz, J., Bingham, J.P. and Sweedler, J.V., 2011. A diverse family of novel peptide toxins from an unusual cone snail, Conus californicus Journal of Experimental Biology (2011) 214: 147-161 [P, NA]
Elliger,C.A., Richmond,T.A., Lebaric,Z.N., Pierce,N.T., Sweedler,J.V. and Gilly,W.F.
Diversity of conotoxin types from Conus californicus reflects a diversity of prey types and a novel evolutionary history. Toxicon (2011) 57: 311-322 [P, NA]
Dekan,Z., Vetter,I., Daly,N.L., Craik,D.J., Lewis,R.J. and Alewood,P.F.
α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure J. Am. Chem. Soc. (2011) 133: 15866-15869 [P, NA]
de Araujo,A.D., Callaghan,B., Nevin,S.T., Daly,N.L., Craik,D.J., Moretta,M., Hopping,G., Christie,M.J., Adams,D.J. and Alewood,P.F.
Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angew. Chem. Int. Ed. Engl. (2011) 50: 6527-6529 [P, NA]
Daly,N.L., Callaghan,B., Clark,R.J., Nevin,S.T., Adams,D.J. and Craik,D.J.
Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels. J. Biol. Chem. (2011) 286: 10233-10237 [P, NA]
Bruce,C., Fitches,E.C., Chougule,N., Bell,H.A. and Gatehouse,J.A.
Recombinant conotoxin, TxVIA, produced in yeast has insecticidal activity. Toxicon (2011) 58: 93-100 [P, NA]
Bernaldez,J., López,O., Licea,A., Salceda,E., Arellano,R.O., Vega,R. and Soto,E.
Electrophysiological characterization of a novel small peptide from the venom of Conus californicus that targets voltage-gated neuronal Ca2+ channels. Toxicon (2011) 57: 60-67 [P, NA]
Armishaw,C.J., Jensen,A.A., Balle,L.D., Scott,K.C., Sørensen,L. and Strømgaard,K.
Improving the stability of α-conotoxin AuIB through N-to-C cyclization: the effect of linker length on stability and activity at nicotinic acetylcholine receptors. Antioxid. Redox Signal. (2011) 14: 65-76 [P, NA]

Zhang,L., Shao,X., Chi,C. and Wang,C.
Two short D-Phe-containing cysteine-free conopeptides from Conus marmoreus. Peptides (2010) 31: 177-179 [P, NA]
Xu,J., Wang,Y., Zhang,B. and Du,W.
Stereochemistry of 4-hydroxyproline affects the conformation of conopeptides. Chem. Commun. (Camb.) (2010) 46: 5467-5469 [P, NA]
Wu,X.C., Zhou,M., Peng,C., Shao,X.X. and Chi,C.W.
Novel conopeptides in a form of disulfide-crosslinked dimer. Peptides (2010) 31: 1001-1006 [P, NA]
Wu,X., Shao,X., Guo,Z.Y. and Chi,C.W.
Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus. Acta Biochim. Biophys. Sin. (Shanghai) (2010) 42: 502-505 [P, NA]
Puillandre,N. and Olivera,B.M.
Evolution of Conus Peptide Genes: Duplication and Positive Selection in the A-Superfamily. J Mol Evol (2010) [P, NA]
Peng,C., Ye,M., Wang,Y., Shao,X., Yuan,D., Liu,J., Hawrot,E. and Chi,C.
A new subfamily of conotoxins belonging to the A-superfamily. Peptides (2010) 31: 2009-2016 [P, NA]
Peng,C., Chen,W., Sanders,T., Chew,G., Liu,J., Hawrot,E. and Chi,C.
Chemical synthesis and characterization of two α4/7-conotoxins. Acta Biochim. Biophys. Sin. (Shanghai) (2010) 42: 745-753 [P, NA]
Möller,C., Melaun,C., Castillo,C., Díaz,M.E., Renzelman,C.M., Estrada,O., Kuch,U., Lokey,S. and Marí,F.
Functional hypervariability and gene diversity of cardioactive neuropeptides. J. Biol. Chem. (2010) 285: 40673-40680 [P, NA]
Luo,S., Akondi,K.B., Zhangsun,D., Wu,Y., Zhu,X., Hu,Y., Christensen,S., Dowell,C., Daly,N.L., Craik,D.J., Wang,C.I., Lewis,R.J., Alewood,P.F. and Michael McIntosh,J.
Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor. J. Biol. Chem. (2010) 285: 12355-12366 [P, NA]
Liu,Z., Yu,Z., Liu,N., Zhao,C., Hu,J. and Dai,Q.
cDNA cloning of conotoxins with framework XII from several Conus species. Acta Biochim. Biophys. Sin. (Shanghai) (2010) 42: 656-661 [P, NA]
Lee,S., Kim,Y., Back,S.K., Choi,H.W., Lee,J.Y., Jung,H.H., Ryu,J.H., Suh,H.W., Na,H.S., Kim,H.J. and Kim,J.I.
Analgesic effect of highly reversible ω-conotoxin FVIA on N type Ca2+ channels. Mol Pain (2010) 6: 97-0 [P, NA]
Kaas,Q., Westermann, J. and Craik,D.J.
Conopeptide characterization and classifications: an analysis using ConoServer. Toxicon (2010) 55: 1491-1509 [P, NA]
Jimenez,E.C. and Olivera,B.M.
Divergent M- and O-superfamily peptides from venom of fish-hunting Conus parius. Peptides (2010) 31: 1678-1683 [P, NA]
Gupta,K. and Balaram,P.
Disulfide bond assignments by mass spectrometry of native natural peptides: cysteine pairing in disulfide bonded conotoxins. Anal. Chem. (2010) 82: 8313-8319 [P, NA]
Grishin,A.A., Wang,C.I., Muttenthaler,M., Alewood,P.F., Lewis,R.J. and Adams,D.J.
Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors. J. Biol. Chem. (2010) 285: 22254-22263 [P, NA]
Gowd,K.H., Watkins,M., Twede,V.D., Bulaj,G.W. and Olivera,B.M.
Characterization of conantokin Rl-A: molecular phylogeny as structure/function study. J. Pept. Sci. (2010) 16: 375-382 [P, NA]
Clark,R.J., Jensen,J., Nevin,S.T., Callaghan,B.P. and Craik,D.J.
The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angew. Chem. Int. Ed. Engl. (2010) 49: 6545-6548 [P, NA]
Chen,P., Dendorfer,A., Finol-Urdaneta,R.K., Terlau,H. and Olivera,B.M.
Biochemical characterization of kM-RIIIJ, a KV1.2 channel blocker: Evaluation of cardioprotective effects of kM-conotoxins. J Biol Chem (2010) 285: 14882-14889 [P, NA]
Biggs,J.S., Watkins,M., Puillandre,N., Ownby,J.P., Lopez-Vera,E., Christensen,S., Moreno,K.J., Bernaldez,J., Licea-Navarro,A. and Olivera,B.M.
Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. Mol. Phylogenet. Evol. (2010) 56: 1-12 [P, NA]
Berecki,G., Motin,L., Haythornthwaite,A., Vink,S., Bansal,P., Drinkwater,R., Wang,C.I., Moretta,M., Lewis,R.J., Alewood,P.F. and Adams,D.J.
Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Mol. Pharmacol. (2010) 77: 139-148 [P, NA]
Azam,L., Maskos,U., Changeux,J.P., Dowell,C.D., Christensen,S., De Biasi,M. and McIntosh,J.M.
α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. FASEB J. (2010) 24: 5113-5123 [P, NA]
Armishaw,C.J., Singh,N., Medina-Franco,J.L., Clark,R.J., Scott,K.C., Houghten,R.A. and Jensen,A.A.
A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists. J. Biol. Chem. (2010) 285: 1809-1821 [P, NA]

Zamora-Bustillos,R., Aguilar,M.B., Falcón,A. and Heimer de la Cotera,E.P.
Identification, by RT-PCR, of four novel T-1-superfamily conotoxins from the vermivorous snail Conus spurius from the Gulf of Mexico. Peptides (2009) 30: 1396-1404 [P, NA]
Zamora-Bustillos,R., Aguilar,M.B. and Falcón,A.
Identification, by molecular cloning, of a novel type of I(2)-superfamily conotoxin precursor and two novel I(2)-conotoxins from the worm-hunter snail Conus spurius from the Gulf of México Peptides (2009) 31: 384-393 [P, NA]
Yuan,D.D., Liu,L., Shao,X.X., Peng,C., Chi,C.W. and Guo,Z.Y.
New conotoxins define the novel I3-superfamily. Peptides (2009) 30: 861-865 [P, NA]
Wang,L., Liu,J., Pi,C., Zeng,X., Zhou,M., Jiang,X., Chen,S., Ren,Z. and Xu,A.
Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents. Arch. Toxicol. (2009) [P, NA]
Walker,C.S., Jensen,S., Ellison,M., Matta,J.A., Lee,W.Y., Imperial,J.S., Duclos,N., Brockie,P.J., Madsen,D.M., Isaac,J.T., Olivera,B. and Maricq,A.V.
A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors. Curr. Biol. (2009) 19: 900-908 [P, NA]
Ueberheide,B.M., Fenyö,D., Alewood,P.F. and Chait,B.T.
Rapid sensitive analysis of cysteine rich peptide venom components. Proc. Natl. Acad. Sci. U.S.A. (2009) 106: 6910-6915 [P, NA]
Twede,V.D., Teichert,R.W., Walker,C.S., Gruszczynski,P., Kazmierkiewicz,R., Bulaj,G. and Olivera,B.M.
Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor. Biochemistry (2009) 48: 4063-4073 [P, NA]
Twede,V.D., Miljanich,G., Olivera,B.M. and Bulaj,G.
Neuroprotective and cardioprotective conopeptides: an emerging class of drug leads. Curr Opin Drug Discov Devel (2009) 12: 231-239 [P, NA]
Turner,M., Eidemiller,S., Martin,B., Narver,A., Marshall,J., Zemp,L., Cornell,K.A., McIntosh,J.M. and McDougal,O.M.
Structural basis for alpha-conotoxin potency and selectivity. Bioorg. Med. Chem. (2009) 17: 5894-5899 [P, NA]
Quinton,L., Gilles,N. and De Pauw,E.
TxXIIIA, an atypical homodimeric conotoxin found in the Conus textile venom. J Proteomics (2009) 72: 219-226 [P, NA]
Peng,C., Chen,W., Han,Y., Sanders,T., Chew,G., Liu,J., Hawrot,E., Chi,C. and Wang,C.
Characterization of a novel alpha4/4-conotoxin, Qc1.2, from vermivorous Conus quercinus. Acta Biochim. Biophys. Sin. (Shanghai) (2009) 41: 858-864 [P, NA]
Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL
Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. J Biol Chem. (2009) 284: 4944-4951 [P, NA]
MacRaild,C.A., Illesinghe,J., van Lierop,B.J., Townsend,A.L., Chebib,M., Livett,B.G., Robinson,A.J. and Norton,R.S.
Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an alpha-conotoxin containing a nonreducible cystine analogue. J. Med. Chem. (2009) 52: 755-762 [P, NA]
Loughnan,M.L., Nicke,A., Lawrence,N. and Lewis,R.J.
Novel alphaD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry (2009) 48: 3717-3729 [P, NA]
Liu,Z., Xu,N., Hu,J., Zhao,C., Yu,Z. and Dai,Q.
Identification of novel I-superfamily conopeptides from several clades of Conus species found in the South China Sea. Peptides (2009) 30: 1782-1787 [P, NA]
Lewis RJ
Conotoxins: molecular and therapeutic targets. Prog. Mol. Subcell. Biol. (2009) 46: 45-65 [P, NA]
Khoo,K.K., Feng,Z.P., Smith,B.J., Zhang,M.M., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S.
Structure of the Analgesic mu-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion. Biochemistry (2009) 6: 1210-1219 [P, NA]
Kauferstein,S., Kendel,Y., Nicke,A., Coronas,F.I., Possani,L.D., Favreau,P., Krizaj,I., Wunder,C., Kauert,G. and Mebs,D.
New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors. Toxicon (2009) 54: 295-301 [P, NA]
Kasheverov,I.E., Zhmak,M.N., Fish,A., Rucktooa,P., Khruschov,A.Y., Osipov,A.V., Ziganshin,R.H., D'hoedt,D., Bertrand,D., Sixma,T.K., Smit,A.B. and Tsetlin,V.I.
Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor. J. Neurochem. (2009) 111: 934-944 [P, NA]
Huang,F. and Du,W.
Solution Structure of Hyp10Pro variant of conomarphin, a cysteine-free and D-amino-acid containing conopeptide. Toxicon (2009) [P, NA]
Hone,A.J., Whiteaker,P., Christensen,S., Xiao,Y., Meyer,E.L. and McIntosh,J.M.
A novel fluorescent alpha-conotoxin for the study of alpha7 nicotinic acetylcholine receptors. J. Neurochem. (2009) 111: 80-89 [P, NA]
Holford,M., Zhang,M.M., Gowd,K.H., Azam,L., Green,B.R., Watkins,M., Ownby,J.P., Yoshikami,D., Bulaj,G. and Olivera,B.M.
Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon (2009) 53: 90-98 [P, NA]
Han TS, Zhang MM, Walewska A, Gruszczynski P, Robertson CR, Cheatham TE 3rd, Yoshikami D, Olivera BM, Bulaj G
Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics. ChemMedChem (2009) 4: 406-414 [P, NA]
Halai,R., Clark,R.J., Nevin,S.T., Jensen,J.E., Adams,D.J. and Craik,D.J.
Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor. J. Biol. Chem. (2009) [P, NA]
Duda,T.F. Jr., Chang,D., Lewis,B.D. and Lee,T.
Geographic variation in venom allelic composition and diets of the widespread predatory marine gastropod Conus ebraeus. PLoS ONE (2009) 4 [P, NA]
Duda,T.F. Jr. and Lee,T.
Ecological release and venom evolution of a predatory marine snail at Easter Island. PLoS ONE (2009) 4 [P, NA]
Davis,J., Jones,A. and Lewis,R.J.
Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS. Peptides (2009) 30: 1222-1227 [P, NA]
Brust,A., Palant,E., Croker,D.E., Colless,B., Drinkwater,R., Patterson,B., Schroeder,C.I., Wilson,D., Nielsen,C.K., Smith,M.T., Alewood,D., Alewood,P.F. and Lewis,R.J.
chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. J. Med. Chem. (2009) 52: 6991-7002 [P, NA]
Biass,D., Dutertre,S., Gerbault,A., Menou,J.L., Offord,R., Favreau,P. and Stöcklin,R.
Comparative proteomic study of the venom of the piscivorous cone snail Conus consors. J Proteomics (2009) 72: 210-218 [P, NA]
Armishaw,C., Jensen,A.A., Balle,T., Clark,R.J., Harpsøe,K., Skonberg,C., Liljefors,T. and Strømgaard,K.
Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives. J. Biol. Chem. (2009) 284: 9498-9512 [P, NA]
Aguilar,M.B., Flores-Torres,A., Batista,C.V., Falcon,A., Lopez-Vera,E. and de la Cotera,E.P.
Structural characterization of five post-translationally modified isomorphs of a novel putative delta-conotoxin from the vermivorous snail Conus delessertii from the Mexican Caribbean Sea. Peptides (2009) 30: 458-466 [P, NA]

Zugasti-Cruz,A., Aguilar,M.B., Falcón,A., Olivera,B.M. and Heimer de la Cotera,E.P.
Two new 4-Cys conotoxins (framework 14) of the vermivorous snail Conus austini from the Gulf of Mexico with activity in the central nervous system of mice. Peptides (2008) 29: 179-185 [P, NA]
Yuan,D.D., Liu,L., Shao,X.X., Peng,C., Chi,C.W. and Guo,Z.Y.
Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus. Peptides (2008) 29: 1521-1525 [P, NA]
Yao,S., Zhang,M.M., Yoshikami,D., Azam,L., Olivera,B.M., Bulaj,G. and Norton,R.S.
Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA. Biochemistry (2008) 47: 10940-10949 [P, NA]
Whiteaker,P., Marks,M.J., Christensen,S., Dowell,C., Collins,A.C. and McIntosh,J.M.
Synthesis and characterization of 125I-alpha-conotoxin ArIB[V11L;V16A], a selective alpha7 nicotinic acetylcholine receptor antagonist. J. Pharmacol. Exp. Ther. (2008) 325: 910-919 [P, NA]
Wang,Y., Shao,X., Li,M., Wang,S., Chi,C. and Wang,C.
mr1e, a conotoxin from Conus marmoreus with a novel disulfide pattern. Acta Biochim. Biophys. Sin. (Shanghai) (2008) 40: 391-396 [P, NA]
Wang,Q., Jiang,H., Han,Y.H., Yuan,D.D. and Chi,C.W.
Two different groups of signal sequence in M-superfamily conotoxins. Toxicon (2008) 51: 813-822 [P, NA]
Wang,L., Pi,C., Liu,J., Chen,S., Peng,C., Sun,D., Zhou,M., Xiang,H., Ren,Z. and Xu,A.
Identification and characterization of a novel O-superfamily conotoxin from Conus litteratus. J. Pept. Sci. (2008) 14: 1077-1083 [P, NA]
Walewska A, Skalicky JJ, Davis DR, Zhang MM, Lopez-Vera E, Watkins M, Han TS, Yoshikami D, Olivera BM, Bulaj G
NMR-based mapping of disulfide bridges in cysteine-rich peptides: application to the mu-conotoxin SxIIIA J Am Chem Soc (2008) 130: 14280-14286 [P, NA]
Schroeder,C.I., Ekberg,J., Nielsen,K.J., Adams,D., Loughnan,M.L., Thomas,L., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Neuronally mu-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. J. Biol. Chem. (2008) 283: 21621-21628 [P, NA]
Romeo,C., Di Francesco,L., Oliverio,M., Palazzo,P., Massilia,G.R., Ascenzi,P., Polticelli,F. and Schininà,M.E.
Conus ventricosus venom peptides profiling by HPLC-MS: a new insight in the intraspecific variation. J Sep Sci (2008) 31: 488-498 [P, NA]
Remigio,E.A. and Duda,T.F. Jr.
Evolution of ecological specialization and venom of a predatory marine gastropod. Mol. Ecol. (2008) 17: 1156-1162 [P, NA]
Peng,C., Liu,L., Shao,X., Chi,C. and Wang,C.
Identification of a novel class of conotoxins defined as V-conotoxins with a unique cysteine pattern and signal peptide sequence. Peptides (2008) 29: 985-991 [P, NA]
Peng,C., Han,Y., Sanders,T., Chew,G., Liu,J., Hawrot,E., Chi,C. and Wang,C.
alpha4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors. Peptides (2008) 29: 1700-1707 [P, NA]
Motin,L. and Adams,D.J.
omega-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn. Neuropharmacology (2008) 55: 860-864 [P, NA]
Lluisma,A.O., López-Vera,E., Bulaj,G., Watkins,M. and Olivera,B.M.
Characterization of a novel psi-conotoxin from Conus parius Reeve. Toxicon (2008) 51: 174-180 [P, NA]
Liu,L., Wu,X., Yuan,D., Chi,C. and Wang,C.
Identification of a novel S-superfamily conotoxin from vermivorous Conus caracteristicus. Toxicon (2008) 51: 1331-1337 [P, NA]
Kaas,Q., Westermann,J.C., Halai,R. and Craik,D.J.
ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24: 445-446 [P, NA]
Innocent,N., Livingstone,P.D., Hone,A., Kimura,A., Young,T., Whiteaker,P., McIntosh,J.M. and Wonnacott,S.
Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors. J. Pharmacol. Exp. Ther. (2008) 327: 529-537 [P, NA]
Imperial,J.S., Chen,P., Sporning,A., Terlau,H., Daly,N.L., Craik,D.J. and Olivera,B.M.
Tyrosine-rich conopeptides affect voltage-gated K+ channels. J. Biol. Chem. (2008) 283: 23026-23032 [P, NA]
Han,Y., Huang,F., Jiang,H., Liu,L., Wang,Q., Wang,Y., Shao,X., Chi,C., Du,W. and Wang,C.
Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus. FEBS J. (2008) 275: 1976-1987 [P, NA]
Gowd,K.H., Twede,V., Watkins,M., Krishnan,K.S., Teichert,R.W., Bulaj,G. and Olivera,B.M.
Conantokin-P, an unusual conantokin with a long disulfide loop. Toxicon (2008) 52: 203-213 [P, NA]
Gowd,K.H., Dewan,K.K., Iengar,P., Krishnan,K.S. and Balaram,P.
Probing peptide libraries from Conus achatinus using mass spectrometry and cDNA sequencing: identification of delta and omega-conotoxins. J Mass Spectrom (2008) 43: 791-805 [P, NA]
Fiedler,B., Zhang,M.M., Buczek,O., Azam,L., Bulaj,G., Norton,R.S., Olivera,B.M. and Yoshikami,D.
Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochem. Pharmacol. (2008) 75: 2334-2344 [P, NA]
Ellison,M., Feng,Z.P., Park,A.J., Zhang,X., Olivera,B.M., McIntosh,J.M. and Norton,R.S.
Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues. J. Mol. Biol. (2008) 377: 1216-1227 [P, NA]
Dutertre,S., Croker,D., Daly,N.L., Andersson,A., Muttenthaler,M., Lumsden,N.G., Craik,D.J., Alewood,P.F., Guillon,G. and Lewis,R.J.
Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. J. Biol. Chem. (2008) 283: 7100-7108 [P, NA]
Duda,T.F. Jr., Bolin,M.B., Meyer,C.P. and Kohn,A.J.
Hidden diversity in a hyperdiverse gastropod genus: discovery of previously unidentified members of a Conus species complex. Mol. Phylogenet. Evol. (2008) 49: 867-876 [P, NA]
Duda,T.F. Jr. and Remigio,E.A.
Variation and evolution of toxin gene expression patterns of six closely related venomous marine snails. Mol. Ecol. (2008) 17: 3018-3032 [P, NA]
Clark,R.J., Daly,N.L., Halai,R., Nevin,S.T., Adams,D.J. and Craik,D.J.
The three-dimensional structure of the analgesic alpha-conotoxin, RgIA. FEBS Lett. (2008) 582: 597-602 [P, NA]
Chen,P., Garrett,J.E., Watkins,M. and Olivera,B.M.
Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins. Toxicon (2008) 52: 139-145 [P, NA]
Callaghan,B., Haythornthwaite,A., Berecki,G., Clark,R.J., Craik,D.J. and Adams,D.J.
Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation. J. Neurosci. (2008) 28: 10943-10951 [P, NA]
Buczek,O., Jimenez,E.C., Yoshikami,D., Imperial,J.S., Watkins,M., Morrison,A. and Olivera,B.M.
I(1)-superfamily conotoxins and prediction of single D-amino acid occurrence. Toxicon (2008) 51: 218-229 [P, NA]
Biggs,J.S., Olivera,B.M. and Kantor,Y.I.
alpha-Conopeptides specifically expressed in the salivary gland of Conus pulicarius. Toxicon (2008) 52: 101-105 [P, NA]
Benoit,E., Favreau,P., Schlumberger,S., Cordova,M.A., Tytgat,J., Stocklin, R. abd and R. Stocklin and Molgo J.
A new mu-conotoxin from Conus consors that atypically targets sodium channels in unmyelinated and myelinated nerve fibers Abstract Book, 16th European Section Meeting of the International Society on Toxinology (2008) [P, NA]
Azam,L., Yoshikami,D., and McIntosh,J.M.
Amino acid residues that confer high selectivity of the alpha6 nicotinic acetylcholine receptor subunit to alpha-conotoxin MII[S4A,E11A,L15A]. J. Biol. Chem. (2008) 283: 11625-11632 [P, NA]
Aguilar,M.B., Luna-Rami­rez,K.S., Echeverria,D., Falcon,A., Olivera,B.M., Heimer de la Cotera,E.P. and Maillo,M.
Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks. Peptides (2008) 29: 186-195 [P, NA]

Zhang,M.M., Green,B.R., Catlin,P., Fiedler,B., Azam,L., Chadwick,A., Terlau,H., McArthur,J.R., French,R.J., Gulyas,J., Rivier,J.E., Smith,B.J., Norton,R.S., Olivera,B.M., Yoshikami,D. and Bulaj,G.
Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J. Biol. Chem. (2007) 282: 30699-30706 [P, NA]
Yuan,D.D., Han,Y.H., Wang,C.G. and Chi,C.W.
From the identification of gene organization of alpha conotoxins to the cloning of novel toxins Toxicon (2007) 49: 1135-1149 [P, NA]
Whiteaker, P., Christensen,S., Yoshikami,D., Dowell,C., Watkins,M., Gulyas,J., Rivier,J., Olivera,B.M. and McIntosh,J.M.
Discovery, Synthesis, and Structure Activity of a Highly Selective alpha7 Nicotinic Acetylcholine Receptor Antagonist Biochemistry (2007) 46: 6628-6638 [P, NA]
Watkins, M., Hillyard, D.R., McIntosh, M.J., Jones, R.M. and Olivera, B.M.
Alpha-conotoxin peptides Patent: EP 1852440-A 07-NOV-2007; University of Utah Research Foundation (US); (2007) [P, NA]
Thakur,S.S. and Balaram,P.
Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom. Rapid Commun. Mass Spectrom. (2007) 21: 3420-3426 [P, NA]
Teichert,R.W., Jimenez,E.C., Twede,V., Watkins,M., Hollmann,M., Bulaj,G. and Olivera,B.M.
Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. J. Biol. Chem. (2007) 282: 36905-36913 [P, NA]
Teichert,R.W., Jacobsen,R., Terlau,H., Yoshikami,D. and Olivera,B.M.
Discovery and characterization of the short kappaA-conotoxins: a novel subfamily of excitatory conotoxins Toxicon (2007) 49: 318-328 [P, NA]
Peng,C., Wu,X., Han,Y., Yuan,D., Chi,C. and Wang,C.
Identification of six novel T-1 conotoxins from Conus pulicarius by molecular cloning. Peptides (2007) 28: 2116-2124 [P, NA]
Nevin,S.T., Clark,R.J., Klimis,H., Christie,M.J., Craik,D.J. and Adams,D.J.
Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Mol. Pharmacol. (2007) 72: 1406-1410 [P, NA]
Moller,C. and Mari,F.
A vasopressin/oxytocin-related conopeptide with gamma-carboxyglutamate at position 8 Biochem. J. (2007) 404: 413-419 [P, NA]
Mandal,A.K., Ramasamy,M.R., Sabareesh,V., Openshaw,M.E., Krishnan,K.S. and Balaram,P.
Sequencing of T-superfamily conotoxins from Conus virgo: pyroglutamic acid identification and disulfide arrangement by MALDI mass spectrometry. J. Am. Soc. Mass Spectrom. (2007) 18: 1396-1404 [P, NA]
Luo,S., Zhangsun,D., Feng,J., Wu,Y., Zhu,X. and Hu,Y.
Diversity of the O-superfamily conotoxins from Conus miles J. Pept. Sci. (2007) 13: 44-53 [P, NA]
Luna-Ramirez,K.S., Aguilar,M.B., Falcon,A., Heimer de la Cotera,E.P., Olivera,B.M. and Maillo,M.
An O-conotoxin from the vermivorous Conus spurius active on mice and mollusks Peptides (2007) 28: 24-30 [P, NA]
Liu,L., Chew,G., Hawrot,E., Chi,C. and Wang,C.
Two potent alpha3/5 conotoxins from piscivorous Conus achatinus. Acta Biochim. Biophys. Sin. (Shanghai) (2007) 39: 438-444 [P, NA]
Liu,J., Wu,Q., Pi,C., Zhao,Y., Zhou,M., Wang,L., Chen,S. and Xu,A.
Isolation and characterization of a T-superfamily conotoxin from Conus litteratus with targeting tetrodotoxin-sensitive sodium channels. Peptides (2007) 28: 2313-2319 [P, NA]
Lewis,R.J., Schroeder,C.I., Ekberg,J., Nielsen,K.J., Loughnan,M., Thomas,L., Adams,D.A., Drinkwater,R., Adams,D.J. and Alewood,P.F.
Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels Mol. Pharmacol. (2007) 71: 676-685 [P, NA]
López-Vera,E., Jacobsen,R.B., Ellison,M., Olivera,B.M. and Teichert,R.W.
A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors Toxicon (2007) 49: 1193-1199 [P, NA]
López-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano Cassulini,R., Batista,C.V., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B. and Wanke,E.
Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. (2007) 274: 3972-3985 [P, NA]
Korukottu,J., Bayrhuber,M., Montaville,P., Vijayan,V., Jung,Y.S., Becker,S. and Zweckstetter,M.
Fast high-resolution protein structure determination by using unassigned NMR data. Angew. Chem. Int. Ed. Engl. (2007) 46: 1176-1179 [P, NA]
Kang,T.S., Radic,Z., Talley,T.T., Jois,S.D., Taylor,P. and Kini,R.M.
Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins. Biochemistry (2007) 46: 3338-3355 [P, NA]
Jin,A.H., Brandstaetter,H., Nevin,S.T., Tan,C.C., Clark,R.J., Adams,D.J., Alewood,P.F., Craik,D.J. and Daly,N.L.
Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics. BMC Struct. Biol. (2007) 7: 28-0 [P, NA]
Jimenez,E.C., Olivera,B.M. and Teichert,R.W.
AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists. Biochemistry (2007) 46: 8717-8724 [P, NA]
Dutertre,S., Ulens,C., Büttner,R., Fish,A., van Elk,R., Kendel,Y., Hopping,G., Alewood,P.F., Schroeder,C., Nicke,A., Smit,A.B., Sixma,T.K. and Lewis,R.J.
AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. EMBO J. (2007) 26: 3858-3867 [P, NA]
Du,W.H., Han,Y.H., Huang,F.J., Li,J., Chi,C.W. and Fang,W.H.
Solution structure of an M-1 conotoxin with a novel disulfide linkage FEBS J. (2007) 274: 2596-2602 [P, NA]
Cortez,L., Marino-Buslje,C., de Jiménez Bonino,M.B. and Hellman,U.
Interactions between alpha-conotoxin MI and the Torpedo marmorata receptor alpha-delta interface. Biochem. Biophys. Res. Commun. (2007) 355: 275-279 [P, NA]
Buczek,O., Wei,D., Babon,J.J., Yang,X., Fiedler,B., Chen,P., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S.
Structure and sodium channel activity of an excitatory I1-superfamily conotoxin. Biochemistry (2007) 46: 9929-9940 [P, NA]
Bordia,T., Grady,S.R., McIntosh,J.M. and Quik,M.
Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson Mol. Pharmacol. (2007) 72: 52-61 [P, NA]
Biggs,J.S., Rosenfeld,Y., Shai,Y. and Olivera,B.M.
Conolysin-Mt: a conus peptide that disrupts cellular membranes. Biochemistry (2007) 46: 12586-12593 [P, NA]
Aguilar,M.B., López-Vera,E., Heimer de la Cotera,E.P., Falcón,A., Olivera,B.M. and Maillo,M.
I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius. Peptides (2007) 28: 18-23 [P, NA]

Zugasti-Cruz,A., Maillo,M., Lopez-Vera,E., Falcon,A., Heimer de la Cotera,E.P., Olivera,B.M. and Aguilar,M.B.
Amino acid sequence and biological activity of a gamma-conotoxin-like peptide from the worm-hunting snail Conus austini Peptides (2006) 27: 506-511 [P, NA]
Zorn,S., Leipold,E., Hansel,A., Bulaj,G., Olivera,B.M., Terlau,H. and Heinemann,S.H.
The muO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3 FEBS Lett. (2006) 580: 1360-1364 [P, NA]
Zhangsun, D., Luo, S., Wu, Y., Zhu, X., Hu, Y. and Xie, L.
Novel O-superfamily conotoxins identified by cDNA cloning from three vermivorous Conus species. Chem Biol Drug Des. (2006) 68: 256-265 [P, NA]
Zhang,M.M., Fiedler,B., Green,B.R., Catlin,P., Watkins,M., Garrett,J.E., Smith,B.J., Yoshikami,D., Olivera,B.M. and Bulaj,G.
Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels Biochemistry (2006) 45: 3723-3732 [P, NA]
Watkins,M. and Olivera,B.M.
Genes expressed in a turrid venom duct: divergence and similarity to conotoxins. J. Mol. Evol. (2006) 62: 247-256 [P, NA]
Wang,C.Z., Zhang,H., Jiang,H., Lu,W., Zhao,Z.Q. and Chi,C.W.
A novel conotoxin from Conus striatus, mu-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels Toxicon (2006) 47: 122-132 [P, NA]
Vincler,M., Wittenauer,S., Parker,R., Ellison,M., Olivera,B.M. and McIntosh,J.M.
Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors. Proc. Natl. Acad. Sci. U.S.A. (2006) 103: 17880-17884 [P, NA]
Ulens,C., Hogg,R.C., Celie,P.H., Bertrand,D., Tsetlin,V., Smit,A.B. and Sixma,T.K.
Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP Proc. Natl. Acad. Sci. U.S.A. (2006) 103: 3615-3620 [P, NA]
Teichert,R.W., Lopez-Vera,E., Gulyas,J., Watkins,M., Rivier,J. and Olivera,B.M.
Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor Biochemistry (2006) 45: 1304-1312 [P, NA]
Talley,T.T., Olivera,B.M., Han,K.H., Christensen,S.B., Dowell,C., Tsigelny,I., Ho,K.Y., Taylor,P. and McIntosh,J.M.
Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors J. Biol. Chem. (2006) 281: 24678-24686 [P, NA]
Shiembob,D.L., Roberts,R.L., Luetje,C.W. and McIntosh,J.M.
Determinants of alpha-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor beta subunit. Biochemistry (2006) 45: 11200-11207 [P, NA]
Sabareesh,V., Gowd,K.H., Ramasamy,P., Sudarslal,S., Krishnan,K.S., Sikdar,S.K. and Balaram,P.
Characterization of contryphans from Conus loroisii and Conus amadis that target calcium channels Peptides (2006) 27: 2647-2654 [P, NA]
Quinton,L., Le Caer,J.P., Vinh,J., Gilles,N. and Chamot-Rooke,J.
Fourier transform mass spectrometry: a powerful tool for toxin analysis Toxicon (2006) 47: 715-726 [P, NA]
Pi,C., Liu,Y., Peng,C., Jiang,X., Liu,J., Xu,B., Yu,X., Yu,Y., Jiang,X., Wang,L., Dong,M., Chen,S. and Xu,A.L.
Analysis of expressed sequence tags from the venom ducts of Conus striatus: focusing on the expression profile of conotoxins Biochimie (2006) 88: 131-140 [P, NA]
Pi,C., Liu,J., Peng,C., Liu,Y., Jiang,X., Zhao,Y., Tang,S., Wang,L., Dong,M., Chen,S. and Xu,A.
Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus Genomics (2006) 88: 809-819 [P, NA]
Peng,C., Tang,S., Pi,C., Liu,J., Wang,F., Wang,L., Zhou,W. and Xu,A.
Discovery of a novel class of conotoxin from Conus litteratus, lt14a, with a unique cysteine pattern Peptides (2006) 27: 2174-2181 [P, NA]
Conus peptides: biodiversity-based discovery and exogenomics. J. Biol. Chem. (2006) 281: 31173-31177 [P, NA]
Nair,S.S., Nilsson,C.L., Emmett,M.R., Schaub,T.M., Gowd,K.H., Thakur,S.S., Krishnan,K.S., Balaram,P. and Marshall,A.G.
De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry Anal. Chem. (2006) 78: 8082-8088 [P, NA]
Mondal,S., Babu,R.M., Bhavna,R. and Ramakumar,S.
I-conotoxin superfamily revisited J. Pept. Sci. (2006) 12: 679-685 [P, NA]
Luo,S., Zhangsun,D., Zhang,B., Quan,Y. and Wu,Y.
Novel alpha-conotoxins identified by gene sequencing from cone snails native to Hainan, and their sequence diversity J. Pept. Sci. (2006) 12: 693-704 [P, NA]
Luo,S., Zhangsun,D., Zhang,B., Chen,X. and Feng,J.
Direct cDNA cloning of novel conotoxins of the T-superfamily from Conus textile Peptides (2006) 27: 2640-2646 [P, NA]
Luo,S., Zhangsun,D., Wu,Y., Zhu,X., Xie,L., Hu,Y., Zhang,J. and Zhao,X.
Identification and molecular diversity of T-superfamily conotoxins from Conus lividus and Conus litteratus Chem Biol Drug Des (2006) 68: 97-106 [P, NA]
Luo,S., Zhangsun,D., Lin,Q., Xie,L., Wu,Y. and Zhu,X.
Sequence diversity of O-superfamily conopetides from Conus marmoreus native to Hainan Peptides (2006) 27: 3058-3068 [P, NA]
Lovelace,E.S., Armishaw,C.J., Colgrave,M.L., Wahlstrom,M.E., Alewood,P.F., Daly,N.L. and Craik,D.J.
Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter J. Med. Chem. (2006) 49: 6561-6568 [P, NA]
Loughnan,M., Nicke,A., Jones,A., Schroeder,C.I., Nevin,S.T., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum J. Biol. Chem. (2006) 281: 24745-24755 [P, NA]
Kelley,W.P., Schulz,J.R., Jakubowski,J.A., Gilly,W.F. and Sweedler,J.V.
Two toxins from Conus striatus that individually induce tetanic paralysis. Biochemistry (2006) 45: 14212-14222 [P, NA]
Kasheverov,I.E., Chiara,D.C., Zhmak,M.N., Maslennikov,I.V., Pashkov,V.S., Arseniev,A.S., Utkin,Y.N., Cohen,J.B. and Tsetlin,V.I.
alpha-Conotoxin GI benzoylphenylalanine derivatives. (1)H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor FEBS J. (2006) 273: 1373-1388 [P, NA]
Kang,T.S., Jois,S.D. and Kini,R.M.
Solution structures of two structural isoforms of CMrVIA chi/lambda-conotoxin Biomacromolecules (2006) 7: 2337-2346 [P, NA]
Jiang,H., Xu,C.Q., Wang,C.Z., Fan,C.X., Zhao,T.Y., Chen,J.S. and Chi,C.W.
Two novel O-superfamily conotoxins from Conus vexillum Toxicon (2006) 47: 425-436 [P, NA]
Jiang,H., Wang,C.Z., Xu,C.Q., Fan,C.X., Dai,X.D., Chen,J.S. and Chi,C.W.
A novel M-superfamily conotoxin with a unique motif from Conus vexillum Peptides (2006) 27: 682-689 [P, NA]
Jakubowski,J.A., Kelley,W.P. and Sweedler,J.V.
Screening for post-translational modifications in conotoxins using liquid chromatography/mass spectrometry: an important component of conotoxin discovery Toxicon (2006) 47: 688-699 [P, NA]
Imperial,J.S., Bansal,P.S., Alewood,P.F., Daly,N.L., Craik,D.J., Sporning,A., Terlau,H., Lopez-Vera,E., Bandyopadhyay,P.K. and Olivera,B.M.
A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins Biochemistry (2006) 45: 8331-8340 [P, NA]
Han,Y.H., Wang,Q., Jiang,H., Liu,L., Xiao,C., Yuan,D.D., Shao,X.X., Dai,Q.Y., Cheng,J.S. and Chi,C.W.
Characterization of novel M-superfamily conotoxins with new disulfide linkage FEBS J. (2006) 273: 4972-4982 [P, NA]
Franco,A., Pisarewicz,K., Moller,C., Mora,D., Fields,G.B. and Mari,F.
Hyperhydroxylation: a new strategy for neuronal targeting by venomous marine molluscs Prog. Mol. Subcell. Biol. (2006) 43: 83-0 [P, NA]
Ellison,M., Haberlandt,C., Gomez-Casati,M.E., Watkins,M., Elgoyhen,A.B., McIntosh,J.M. and Olivera,B.M.
Alpha-RgIA: a novel conotoxin that specifically and potently blocks the alpha9alpha10 nAChR Biochemistry (2006) 45: 1511-1517 [P, NA]
Dy,C.Y., Buczek,P., Imperial,J.S., Bulaj,G. and Horvath,M.P.
Structure of conkunitzin-S1, a neurotoxin and Kunitz-fold disulfide variant from cone snail. Acta Crystallogr. D Biol. Crystallogr. (2006) 62: 980-990 [P, NA]
Dutertre,S., Lumsden,N.G., Alewood,P.F. and Lewis,R.J.
Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail. FEBS Lett. (2006) 580: 3860-3866 [P, NA]
Drinkwater,R.D., Lewis,R.J., Alewood,P.F. and Nielsen,K.J.
Omega.conotoxin peptides Patent: US 7101849 05-SEP-2006 (2006) [P, NA]
Czerwiec,E., Kalume,D.E., Roepstorff,P., Hambe,B., Furie,B., Furie,B.C. and Stenflo,J.
Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile. FEBS J. (2006) 273: 2779-2788 [P, NA]
Croker D., Dutertre S., Alewood P., and Lewis R.
Discovery and pharmacology of conopressin-T, a novel vasopressin-like peptide from Conus tulipa. Acta Pharmacologica Sinica (2006) 27: 351-351 [P, NA]
Craik,D.J., Daly,N.L. and Nielsen,K.J.
Cyclized conotoxin peptides Patent: US 7001883-A 29 21-FEB-2006; The University of Queensland; Queensland; AU; (2006) [P, NA]
Clark,R.J., Fischer,H., Nevin,S.T., Adams,D.J. and Craik,D.J.
The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1 J. Biol. Chem. (2006) 281: 23254-23263 [P, NA]
Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H.
NMR structure determination of alpha-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold Biochem. Biophys. Res. Commun. (2006) 349: 1228-1234 [P, NA]
Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H.
Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes Biochem. Biophys. Res. Commun. (2006) 345: 248-254 [P, NA]
Chen,W.H., Han,Y.H., Wang,Q., Miao,X.W., Ou,L. and Shao,X.X.
cDNA cloning of two novel T-superfamily conotoxins from Conus leopardus Acta Biochim. Biophys. Sin. (Shanghai) (2006) 38: 287-291 [P, NA]
Chen,W.H., Han,Y.H., Wang,Q., Miao,X.W., Ou,L. and Shao,X.X.
cDNA cloning of two novel T-superfamily conotoxins from Conus leopardus Acta Biochim. Biophys. Sin. (Shanghai) (2006) 38: 287-291 [P, NA]
Bulaj,G., Zhang,M.M., Green,B.R., Fiedler,B., Layer,R.T., Wei,S., Nielsen,J.S., Low,S.J., Klein,B.D., Wagstaff,J.D., Chicoine,L., Harty,T.P., Terlau,H., Yoshikami,D. and Olivera,B.M.
Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity Biochemistry (2006) 45: 7404-7414 [P, NA]
Bulaj,G., West,P.J., Garrett,J.E., Watkins,M., Zhang,M.-M., Norton,R.S., Smith,B.J., Yoshikami,D. and Olivera,B.M.
Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity. Biochemistry (2006) 45: 3116-0 [P, NA]
Armishaw,C.J., Daly,N.L., Nevin,S.T., Adams,D.J., Craik,D.J. and Alewood,P.F.
Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists J. Biol. Chem. (2006) 281: 14136-14143 [P, NA]
Aguilar,M.B., Lezama-Monfil,L., Maillo,M., Pedraza-Lara,H., Lopez-Vera,E. and Heimer de la Cotera,E.P.
A biologically active hydrophobic T-1-conotoxin from the venom of Conus spurius Peptides (2006) 27: 500-505 [P, NA]

Zhao,T.-Y., Cao,Y., Dai,X.-D., Fan,C.-X. and Chen,J.-S.
Purification, sequence and disulfide bonding pattern of a novel conotoxin BtIIIB Acta Chim. Sin. (2005) 63: 163-0 [P, NA]
Wen,L., Yang,S., Qiao,H., Liu,Z., Zhou,W., Zhang,Y. and Huang,P.
SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons Br. J. Pharmacol. (2005) 145: 728-739 [P, NA]
Vianna Braga,M.C., Konno,K., Portaro,F.C., de Freitas,J.C., Yamane,T., Olivera,B.M. and Pimenta,D.C.
Mass spectrometric and high performance liquid chromatography profiling of the venom of the Brazilian vermivorous mollusk Conus regius: feeding behavior and identification of one novel conotoxin Toxicon (2005) 45: 113-122 [P, NA]
Teichert,R.W., Rivier,J., Torres,J., Dykert,J., Miller,C. and Olivera,B.M.
A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor J. Neurosci. (2005) 25: 732-736 [P, NA]
Teichert,R.W., Jimenez,E.C. and Olivera,B.M.
Alpha S-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors Biochemistry (2005) 44: 7897-7902 [P, NA]
Satkunanathan,N., Livett,B., Gayler,K., Sandall,D., Down,J. and Khalil,Z.
Alpha-conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones Brain Res. (2005) 1059: 149-158 [P, NA]
Sarma,S.P., Kumar,G.S., Sudarslal,S., Iengar,P., Ramasamy,P., Sikdar,S.K., Krishnan,K.S. and Balaram,P.
Solution structure of delta-Am2766: a highly hydrophobic delta-conotoxin from Conus amadis that inhibits inactivation of neuronal voltage-gated sodium channels. Chem. Biodivers. (2005) 2: 535-556 [P, NA]
Pisarewicz,K., Mora,D., Pflueger,F.C., Fields,G.B. and Mari,F.
Polypeptide chains containing D-gamma-hydroxyvaline J. Am. Chem. Soc. (2005) 127: 6207-6215 [P, NA]
Olivera,B.M., McIntosh,J.M., Yoshikami,D., Cartier,G.E. and Luo,S.
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Olivera,B.M., Layer,R.T., McIntosh,J.M., Nielsen,J.S. and Jones,R.M.
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Nilsson,K.P., Lovelace,E.S., Caesar,C.E., Tynngard,N., Alewood,P.F., Johansson,H.M., Sharpe,I.A., Lewis,R.J., Daly,N.L. and Craik,D.J.
Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter Biopolymers (2005) 80: 815-823 [P, NA]
Nielsen,C.K., Lewis,R.J., Alewood,D., Drinkwater,R., Palant,E., Patterson,M., Yaksh,T.L., McCumber,D. and Smith,M.T.
Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain Pain (2005) 118: 112-124 [P, NA]
Mondal,S., Vijayan,R., Shichina,K., Babu,R.M. and Ramakumar,S.
I-superfamily conotoxins: sequence and structure analysis In Silico Biol. (Gedrukt) (2005) 5: 557-571 [P, NA]
Moller,C., Rahmankhah,S., Lauer-Fields,J., Bubis,J., Fields,G.B. and Mari,F.
A novel conotoxin framework with a helix-loop-helix (Cs alpha/alpha) fold Biochemistry (2005) 44: 15986-15996 [P, NA]
McIntosh,J.M., Plazas,P.V., Watkins,M., Gomez-Casati,M.E., Olivera,B.M. and Elgoyhen,A.B.
A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors J. Biol. Chem. (2005) 280: 30107-30112 [P, NA]
Lima,V., Mueller,A., Kamikihara,S.Y., Raymundi,V., Alewood,D., Lewis,R.J., Chen,Z., Minneman,K.P. and Pupo,A.S.
Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta Eur. J. Pharmacol. (2005) 508: 183-192 [P, NA]
Leipold,E., Hansel,A., Olivera,B.M., Terlau,H. and Heinemann,S.H.
Molecular interaction of delta-conotoxins with voltage-gated sodium channels FEBS Lett. (2005) 579: 3881-3884 [P, NA]
Lang,P.M., Burgstahler,R., Haberberger,R.V., Sippel,W. and Grafe,P.
A conus peptide blocks nicotinic receptors of unmyelinated axons in human nerves Neuroreport (2005) 16: 479-483 [P, NA]
Kauferstein,S., Melaun,C. and Mebs,D.
Direct cDNA cloning of novel conopeptide precursors of the O-superfamily Peptides (2005) 26: 361-367 [P, NA]
Huang,X., Dong,F. and Zhou,H.X.
Electrostatic recognition and induced fit in the kappa-PVIIA toxin binding to Shaker potassium channel. J. Am. Chem. Soc. (2005) 127: 6836-6849 [P, NA]
Hansen,S.B., Sulzenbacher,G., Huxford,T., Marchot,P., Taylor,P. and Bourne,Y.
Structures Of Aplysia Achbp Complexes With Nicotinic Agonists And Antagonists Reveal Distinctive Binding Interfaces And Conformations Embo J. (2005) 24: 3635-0 [P, NA]
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Sequence diversity of T-superfamily conotoxins from Conus marmoreus Toxicon (2005) 45: 481-487 [P, NA]
Gowd,K.H., Sabareesh,V., Sudarslal,S., Iengar,P., Franklin,B., Fernando,A., Dewan,K., Ramaswami,M., Sarma,S.P., Sikdar,S., Balaram,P. and Krishnan,K.S.
Novel peptides of therapeutic promise from Indian Conidae Ann. N. Y. Acad. Sci. (2005) 1056: 462-0 [P, NA]
Dutertre,S., Nicke,A., and Lewis,R.J.
Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor. J. Biol. Chem. (2005) 280: 30460-30468 [P, NA]
Corpuz,G.P., Jacobsen,R.B., Jimenez,E.C., Watkins,M., Walker,C., Colledge,C., Garrett,J.E., McDougal,O., Li,W., Gray,W.R., Hillyard,D.R., Rivier,J., McIntosh,J.M., Cruz,L.J. and Olivera,B.M.
Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms Biochemistry (2005) 44: 8176-8186 [P, NA]
Clark,R.J., Fischer,H., Dempster,L., Daly,N.L., Rosengren,K.J., Nevin,S.T., Meunier,F.A., Adams,D.J. and Craik,D.J.
Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII Proc. Natl. Acad. Sci. U.S.A. (2005) 102: 13767-13772 [P, NA]
Chi,S.W., Lee,S.H., Kim,D.H., Kim,J.S., Olivera,B.M., McIntosh,J.M. and Han,K.H.
Solution structure of alpha-conotoxin PIA, a novel antagonist of alpha6 subunit containing nicotinic acetylcholine receptors Biochem. Biophys. Res. Commun. (2005) 338: 1990-1997 [P, NA]
Celie,P.H., Kasheverov,I.E., Mordvintsev,D.Y., Hogg,R.C., van Nierop,P., van Elk,R., van Rossum-Fikkert,S.E., Zhmak,M.N., Bertrand,D., Tsetlin,V., Sixma,T.K. and Smit,A.B.
Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant Nat. Struct. Mol. Biol. (2005) 12: 582-588 [P, NA]
Bulaj,G., West,P.J., Garrett,J.E., Watkins,M., Zhang,M.M., Norton,R.S., Smith,B.J., Yoshikami,D. and Olivera,B.M.
Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels Biochemistry (2005) 44: 7259-7265 [P, NA]
Buczek,O., Yoshikami,D., Watkins,M., Bulaj,G., Jimenez,E.C. and Olivera,B.M.
Characterization of D-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily FEBS J. (2005) 272: 4178-4188 [P, NA]
Buczek,O., Yoshikami,D., Bulaj,G., Jimenez,E.C. and Olivera,B.M.
Post-translational amino acid isomerization: a functionally important D-amino acid in an excitatory peptide J. Biol. Chem. (2005) 280: 4247-4253 [P, NA]
Brown,M.A., Begley,G.S., Czerwiec,E., Stenberg,L.M., Jacobs,M., Kalume,D.E., Roepstorff,P., Stenflo,J., Furie,B.C. and Furie,B.
Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation Biochemistry (2005) 44: 9150-9159 [P, NA]
Bingham,J.P., Broxton,N.M., Livett,B.G., Down,J.G., Jones,A. and Moczydlowski,E.G.
Optimizing the connectivity in disulfide-rich peptides: alpha-conotoxin SII as a case study Anal. Biochem. (2005) 338: 48-61 [P, NA]
Bayrhuber,M., Vijayan,V., Ferber,M., Graf,R., Korukottu,J., Imperial,J., Garrett,J.E., Olivera,B.M., Terlau,H., Zweckstetter,M. and Becker,S.
Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization. J. Biol. Chem. (2005) 280: 23766-23770 [P, NA]
Azam,L., Dowell,C., Watkins,M., Stitzel,J.A., Olivera,B.M. and McIntosh,J.M.
Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors J. Biol. Chem. (2005) 280: 80-87 [P, NA]
Aguilar,M.B., López-Vera,E., Ortiz,E., Becerril,B., Possani,L.D., Olivera,B.M. and Heimer de la Cotera,E.P.
A novel conotoxin from Conus delessertii with posttranslationally modified lysine residues Biochemistry (2005) 44: 11130-11136 [P, NA]
Aguilar,M.B., López-Vera,E., Imperial,J.S., Falcón,A., Olivera,B.M. and de la Cotera,E.P.
Putative gamma-conotoxins in vermivorous cone snails: the case of Conus delessertii Peptides (2005) 26: 23-27 [P, NA]

Watkins,M., Olivera,B.M., Hillyard,D.R., McIntosh,M.J. and Jones,R.M.
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Wang,C.Z., Ou,Z.L. and Chi,C.W.
Gene cloning and functional studies of alpha conotoxin SII (Unpublished) [P, NA]

Walker,C.S., Shetty,R., Jimenez,E.C., McIntosh,J.M., Olivera,B.M., Watkins,M., Jones,R.M. and Shen,G.S.
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Volpon,L., Lamthanh,H., Barbier,J., Gilles,N., Molgo,J., Menez,A. and Lancelin,J.M.
NMR solution structures of delta-conotoxin EVIA from Conus ermineus that selectively acts on vertebrate neuronal Na+ channels J. Biol. Chem. (2004) 279: 21356-21366 [P, NA]
Teichert,R.W., Rivier,J., Dykert,J., Cervini,L., Gulyas,J., Bulaj,G., Ellison,M. and Olivera,B.M.
AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors Toxicon (2004) 44: 207-214 [P, NA]
Santos,A.D., McIntosh,J.M., Hillyard,D.R., Cruz,L.J. and Olivera,B.M.
The A-superfamily of conotoxins: structural and functional divergence J. Biol. Chem. (2004) 279: 17596-17606 [P, NA]
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Mu-conopeptides Patent: US 6727226-A 80 27-APR-2004; University of Utah Research Foundation and Cognetix, Inc.; Salt Lake City, UT (2004) [P, NA]
Olivera,B.M., Cartier,G.E., Watkins,M., Hillyard,D.R., McIntosh,J.M., Layer,R.T. and Jones,R.M.
O-superfamily conotoxin peptides Patent: US 6762165-A 282 13-JUL-2004; University of Utah Research Foundation and Cognetix, Inc.; Salt Lake City, UT (2004) [P, NA]
Mould,J., Yasuda,T., Schroeder,C.I., Beedle,A.M., Doering,C.J., Zamponi,G.W., Adams,D.J. and Lewis,R.J.
The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels J. Biol. Chem. (2004) 279: 34705-34714 [P, NA]
Mould,J., Yasuda,T., Schroeder,C.I., Beedle,A.M., Doering,C.J., Zamponi,G.W., Adams,D.J. and Lewis,R.J.
The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. J. Biol. Chem. (2004) 279: 34705-34714 [P, NA]
Ziconotide: neuronal calcium channel blocker for treating severe chronic pain Curr. Med. Chem. (2004) 11: 3029-3040 [P, NA]
McIntosh,J.M., Olivera,B.M., Cruz,L.J., Corpuz,G.P., Jones,R.M. and Garrett,J.E.
Conotoxin peptides Patent: US 6767896 27-JUL-2004 (2004) [P, NA]
McIntosh,J.M., Azam,L., Staheli,S., Dowell,C., Lindstrom,J.M., Kuryatov,A., Garrett,J.E., Marks,M.J. and Whiteaker,P.
Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors. Mol. Pharmacol. (2004) 65: 944-952 [P, NA]
McDougal,O.M. and Dale Poulter,C.
Three-dimensional structure of the mini-M conotoxin mr3a Biochemistry (2004) 43: 425-429 [P, NA]
Loughnan,M.L., Nicke,A., Jones,A., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone J. Med. Chem. (2004) 47: 1234-1241 [P, NA]
Kauferstein,S., Huys,I., Kuch,U., Melaun,C., Tytgat,J. and Mebs,D.
Novel conopeptides of the I-superfamily occur in several clades of cone snails Toxicon (2004) 44: 539-548 [P, NA]
Jimenez,E.C., Watkins,M. and Olivera,B.M.
Multiple 6-bromotryptophan residues in a sleep-inducing peptide Biochemistry (2004) 43: 12343-12348 [P, NA]
Jakubowski,J.A., Keays,D.A., Kelley,W.P., Sandall,D.W., Bingham,J.P., Livett,B.G., Gayler,K.R. and Sweedler,J.V.
Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry J Mass Spectrom (2004) 39: 548-557 [P, NA]
Jakubowski,J.A. and Sweedler, J.V.
Sequencing and mass profiling highly modified conotoxins using global reduction/alkylation followed by mass spectrometry Anal. Chem. (2004) 76: 6541-6547 [P, NA]
Hansson,K., Ma,X., Eliasson,L., Czerwiec,E., Furie,B., Furie,B.C., Rorsman,P. and Stenflo,J.
The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. J. Biol. Chem. (2004) 279: 32453-32463 [P, NA]
Hansson,K., Ma,X., Eliasson,L., Czerwiec,E., Furie,B., Furie,B.C., Rorsman,P. and Stenflo,J.
The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. J. Biol. Chem. (2004) 279: 32453-32463 [P, NA]
Hansson,K., Furie,B., Furie,B.C. and Stenflo,J.
Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern Biochem. Biophys. Res. Commun. (2004) 319: 1081-1087 [P, NA]
Grant,M.A., Hansson,K., Furie,B.C., Furie,B., Stenflo,J. and Rigby,A.C.
The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M J. Biol. Chem. (2004) 279: 32464-32473 [P, NA]
Everhart,D., Cartier,G.E., Malhotra,A., Gomes,A.V., McIntosh,J.M. and Luetje,C.W.
Determinants of potency on alpha-conotoxin MII, a peptide antagonist of neuronal nicotinic receptors Biochemistry (2004) 43: 2732-2737 [P, NA]
Ellison,M., Gao,F., Wang,H.L., Sine,S.M. and Olivera,B.M.
Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. Biochemistry (2004) 43: 16019-16026 [P, NA]
Eliseo,T., Cicero,D.O., Romeo,C., Schinina,M.E., Massilia,G.R., Polticelli,F., Ascenzi,P. and Paci,M.
Solution structure of the cyclic peptide contryphan-Vn, a Ca2+-dependent K+ channel modulator Biopolymers (2004) 74: 189-198 [P, NA]
Duda,T.F. Jr. and Palumbi,S.R.
Gene expression and feeding ecology: evolution of piscivory in the venomous gastropod genus Conus. Proc. Biol. Sci. (2004) 271: 1165-1174 [P, NA]
Daly,N.L., Ekberg,J.A., Thomas,L., Adams,D.J., Lewis,R.J. and Craik,D.J.
Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons J. Biol. Chem. (2004) 279: 25774-25782 [P, NA]
Craig,A.G., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J., Cruz,L.J., Wagstaff,J.D., Layer,R.T., Jones,R.M. and McCabe,R.T.
Contulakin-G, analogs thereof and uses therefor Patent: US 6696408 24-FEB-2004 (2004) [P, NA]
Chierici,S., Jourdan,M., Figuet,M. and Dumy,P.
A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a [small delta]-conotoxin EVIA peptide analog Org. Biomol. Chem. (2004) 2: 2437-2441 [P, NA]
Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H.
Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors Biochem. J. (2004) 380: 347-352 [P, NA]
Chen,Z., Rogge,G., Hague,C., Alewood,D., Colless,B., Lewis,R.J. and Minneman,K.P.
Subtype-selective noncompetitive or competitive inhibition of human alpha1-adrenergic receptors by rho-TIA J. Biol. Chem. (2004) 279: 35326-35333 [P, NA]
Barbier,J., Lamthanh,H., Le Gall,F., Favreau,P., Benoit,E., Chen,H., Gilles,N., Ilan,N., Heinemann,S.H., Gordon,D., Menez,A. and Molgo,J.
A delta-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels but not in skeletal and cardiac muscles J. Biol. Chem. (2004) 279: 4680-4685 [P, NA]
Al-Sabi,A., Lennartz,D., Ferber,M., Gulyas,J., Rivier,J.E., Olivera,B.M., Carlomagno,T. and Terlau,H.
KappaM-conotoxin RIIIK, structural and functional novelty in a K+ channel antagonist. Biochemistry (2004) 43: 8625-8635 [P, NA]

Yan,Y.B., Tu,G.Z., Luo,X.C., Dai,Q.Y., Huang,P.T. and Zhang,R.Q.
Three dimensional solution structure of omega-conotoxin SO3 determined by NMR Chin. Sci. Bull. (2003) 48: 1097-0 [P, NA]
Yan,Y., Tu,G., Luo,X., Dai,Q., Huang,P. and Zhang,R.
Three-Dimensional Solution Structure Of W-Conotoxin So3 Determined By 1h Nmr Chin.Sci.Bull. (2003) 48: 1097-0 [P, NA]
Williams,A.J., Ling,G., Berti,R., Moffett,J.R., Yao,C., Lu,X.M. and Tortella,F.C.
Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats. Exp Brain Res (2003) 153: 16-26 [P, NA]
Wang,C.Z., Jiang,H., Ou,Z.L., Chen,J.S. and Chi,C.W.
cDNA cloning of two A-superfamily conotoxins from Conus striatus Toxicon (2003) 42: 613-619 [P, NA]
Walker,C., Shetty,R., Olivera,B.M., Hooper,D., Jacobsen,R., Steele,D. and Jones,R.M.
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Walker,C., Shetty,R., Olivera,B.M., Hooper,D., Jacobsen,R., Steele,D. and Jones,R.
Tau-conotoxin peptides Patent: US 6630573 07-OCT-2003 (2003) [P, NA]
Van Wagoner,R.M., Jacobsen,R.B., Olivera,B.M. and Ireland,C.M.
Characterization and three-dimensional structure determination of psi-conotoxin Piiif, a novel noncompetitive antagonist of nicotinic acetylcholine receptors Biochemistry (2003) 42: 6353-6362 [P, NA]
Van Wagoner,R.M. and Ireland,C.M.
An improved solution structure for psi-conotoxin PiiiE. Biochemistry (2003) 42: 6347-6352 [P, NA]
Sudarslal,S., Majumdar,S., Ramasamy,P., Dhawan,R., Pal,P.P., Ramaswami,M., Lala,A.K., Sikdar,S.K., Sarma,S.P., Krishnan,K.S. and Balaram,P.
Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail FEBS Lett. (2003) 553: 209-212 [P, NA]
Sharpe,I.A., Thomas,L., Loughnan,M., Motin,L., Palant,E., Croker,D.E., Alewood,D., Chen,S., Graham,R.M., Alewood,P.F., Adams,D.J. and Lewis,R.J.
Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA J. Biol. Chem. (2003) 278: 34451-34457 [P, NA]
Sharpe,I.A., Palant,E., Schroeder,C.I., Kaye,D.M., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship J. Biol. Chem. (2003) 278: 40317-40323 [P, NA]
Sandall,D.W., Satkunanathan,N., Keays,D.A., Polidano,M.A., Liping,X., Pham,V., Down,J.G., Khalil,Z., Livett,B.G. and Gayler,K.R.
A novel alpha-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo Biochemistry (2003) 42: 6904-6911 [P, NA]
Olivera,B.M., Layer,R.T., Watkins,M., Hillyard,D.R., Mcintosh,M.J., Jones,R.M. and Schoenfeld,R.
Alpha Conotoxin Peptides JP 2003525582-A 3 02-SEP-2003 (2003) [P, NA]
Nicke,A., Samochocki,M., Loughnan,M.L., Bansal,P.S., Maelicke,A. and Lewis,R.J.
Alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors. FEBS Lett. (2003) 554: 219-223 [P, NA]
Nicke,A., Loughnan,M.L., Millard,E.L., Alewood,P.F., Adams,D.J., Daly,N.L., Craik,D.J. and Lewis,R.J.
Isolation, Structure, and Activity of GID, a Novel alpha 4/7-Conotoxin with an Extended N-terminal Sequence J. Biol. Chem. (2003) 278: 3137-3144 [P, NA]
Massilia,G.R., Eliseo,T., Grolleau,F., Lapied,B., Barbier,J., Bournaud,R., Molgo,J., Cicero,D.O., Paci,M., Schinina,M.E., Ascenzi,P. and Polticelli,F.
Contryphan-Vn: a modulator of Ca2+-dependent K+ channels Biochem. Biophys. Res. Commun. (2003) 303: 238-246 [P, NA]
Malmberg,A.B., Gilbert,H., McCabe,R.T. and Basbaum,A.I.
Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T Pain (2003) 101: 109-116 [P, NA]
Makino,K., Oshima,K., Kurokawa,K., Yokoyama,K., Uda,T., Tagomori,K., Iijima,Y., Najima,M., Nakano,M., Yamashita,A., Kubota,Y., Kimura,S., Yasunaga,T., Honda,T., Shinagawa,H., Hattori,M. and Iida,T.
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Hydrophobic amino acids define the carboxylation recognition site in the precursor of the gamma-carboxyglutamic-acid-containing conotoxin epsilon-TxIX from the marine cone snail Conus textile. Biochemistry (1999) 38: 14660-14666 [P, NA]
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Three-dimensional solution structure of conotoxin psi-PIIIE, an acetylcholine gated ion channel antagonist Biochemistry (1998) 37: 1215-1220 [P, NA]
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A novel post-translational modification involving bromination of tryptophan. Identification of the residue, L-6-bromotryptophan, in peptides from Conus imperialis and Conus radiatus venom J. Biol. Chem. (1997) 272: 4689-4698 [P, NA]

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Zhao,D. and Huang,P.
Conus imperialis conotoxin ImIIA precursor mRNA (Unpublished) [P, NA]

Yuan, D., Liu, L., Chi, C. and Guo, Z.
New conotoxins define a novel I3-superfamily Unpublished (0) [P, NA]
Walker,C., Shetty,R., Olivera,B.M., Hooper,D., Jacobsen,R., Steele,D. and Jones,R.M.
Tau-conotoxin peptides (Unpublished) [P, NA]

Peng, C., Wu, X., Wang, Y., Shao, X., Chi, C. and Wang, C.
Identification and characterization of a new four-Cys conotoxin (framework 14) from the vermivorous Conus pulicarius, pu14a, a novel antagonist of nicotinic acetylcholine receptors Unpublished (0) [P, NA]
Peng, C., Wu, X., Han, Y., Yuan, D., Chi, C. and Wang, C.
Identification of six novel T-1 conotoxins from the venom ducts of Conus pulicarius by molecular cloning Unpublished (0) [P, NA]
Luo,S., Zhangsun,D., Zhang,B. and Lin,Q.
Hainan O-superfamily peptides (Unpublished) [P, NA]
Luo,S., Zhangsun,D., Zhang,B. and Lin,Q.
Novel O-superfamily conotoxins, and their coding polynucleotides and use (Unpublished) [P, NA]
Luo,S., Zhangsun,D. and Zhang,B.
Hainan O-superfamily peptides (Unpublished) [P, NA]
Luo,S., Zhang,B. and Zhangsun,D.
C11GB conotoxin scaffold VI/VII precursor (Unpublished) [P, NA]
Luo,S., Zhang,B. and Zhangsun,D.
A11GB conotoxin scaffold VI/VII precursor (Unpublished) [P, NA]
Luo,S. and Zhangsun,D.
Hainan O-superfamily peptides (Unpublished) [P, NA]
Lu,B.S., Yu,F., Wang,J.H., Zhao,D., Zhao,S.Q. and Huang,P.T.
Cloning of alpha-conotoxin sequences from Conus textile venom duct (Unpublished) [P, NA]

Liu, L., Chi, C.W. and Wang, C.G.
cDNA of S-superfamily conotoxin precursor from Conus caracteristicus Unpublished (0) [P, NA]
Jiang, X., Pi, C. and Liu, Y.
A Novel Class of Conotoxin cDNAs with a Distinctive Cysteine Arrangement Unpublished (0) [P, NA]
Duda,T.F. Jr. and Palumbi,S.R.
Convergent evolution of venoms and feeding ecologies among polyphyletic piscivorous Conus species (Unpublished) [P, NA]
Duda,T.F. Jr.
Positive selection and patterns of divergence of orthologous toxin genes among related venomous predatory gastropods (Unpublished) [P, NA]
Duda,T.F. and Palumbi,S.R.
Molecular evolution of four-loop conotoxin precursors from fish-eating Conus (Unpublished) [P, NA]
Physico-chemical and pharmacological study of new toxins from the piscivorous cone snail Conus consors Thesis (1999) () [P, NA]
Physico-chemical and pharmacological study of new toxins from the piscivorous cone snail Conus consors Thesis (1999) () [P, NA]
Physico-chemical and pharmacological study of new toxins from the piscivorous cone snail Conus consors Thesis (1999) () [P, NA]