GVIIIA (P02582) Protein Card

General Information
Name GVIIIA
Alternative name(s) G8a
Organism Conus geographus (Geography cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor GVIIIA precursor (1724)

Classification
Conopeptide class conotoxin
Gene superfamily S superfamily
Cysteine framework VIII
Pharmacological family sigma conotoxin

Sequence
GCTRTCGGOKCTGTCTCTNSSKCGCRYNVHPSG(BTr)GCG
CACS(nh2)
Modified residues
positionsymbolname
9O4-Hydroxyproline
34BTrBromotryptophan
42nh2C-term amidation
Sequence evidence protein level
Average Mass 4192.48
Monoisotopic Mass 4188.42
Isoelectric Point 11.81
Extinction Coefficient [280nm] 1490.00

Activity

IC50: 5-HT3 receptors

TargetOrganismIC50AgonistRef
5-HT3AM. musculus53nM+/-3zacopride (1 nM)England,L.J. et al. (1998)

Ki: 5-HT3 receptors

TargetOrganismKiCompetitorAgonistRef
5-HT3AM. musculus4.8nM+/-0.3zacopride (1 nM)England,L.J. et al. (1998)

References
England,L.J., Imperial,J., Jacobsen,R., Craig,A.G., Gulyas,J., Akhtar,M., Rivier,J., Julius,D. and Olivera,B.M. (1998) Inactivation of a serotonin-gated ion channel by a polypeptide toxin from marine snails Science 281:575-578

Internal links
Protein Precursor GVIIIA precursor (1724)
Nucleic acids
Structure

External links

Tools