EpI (P00405) Protein Card

General Information
Name EpI
Organism Conus episcopatus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor EpI precursor (2925)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCNMNNPD(sTy)C(nh2)
Modified residues
positionsymbolname
15sTySulfotyrosine
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1866.00
Monoisotopic Mass 1864.53
Isoelectric Point 4.50
Extinction Coefficient [280nm] 1490.00

References
Hu,S.H., Loughnan,M., Miller,R., Weeks,C.M., Blessing,R.H., Alewood,P.F., Lewis,R.J. and Martin,J.L. (1998) The 1.1 A resolution crystal structure of [Tyr15]EpI, a novel alpha-conotoxin from Conus episcopatus, solved by direct methods Biochemistry 37:11425-11433
Loughnan,M., Bond,T., Atkins,A., Cuevas,J., Adams,D.J., Broxton,N.M., Livett,B.G., Down,J.G., Jones,A., Alewood,P.F. and Lewis,R.J. (1998) alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors J. Biol. Chem. 273:15667-15674
Nicke,A., Samochocki,M., Loughnan,M.L., Bansal,P.S., Maelicke,A. and Lewis,R.J. (2003) Alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors. FEBS Lett. 554:219-223

Internal links
Protein Precursor EpI precursor (2925)
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P56638
Ncbi P56638

Tools