Reference List

The references are sorted by year then first author.
Each reference is followed by a 'P' link and a 'NA' link that search the corresponding protein sequences and nucleic acid sequences, respectively.


Chen J, Liang L, Ning H, Cai F, Liu Z, Zhang L, Zhou L, Dai Q
Cloning, Synthesis and Functional Characterization of a Novel α-Conotoxin Lt1.3 Marine drugs (2018) 16: 112-0 [P, NA]
Franco,A., Dovell,S., Möller,C., Grandal,M., Clark,E. and Marí,F.
Structural plasticity of mini-M conotoxins - expression of all mini-M subtypes by Conus regius. FEBS J. (2018) 285: 887-902 [P, NA]
Möller,C., Dovell,S., Melaun,C. and Marí,F.
Definition of the R-superfamily of conotoxins: Structural convergence of helix-loop-helix peptidic scaffolds. Peptides (2018) 107: 75-82 [P, NA]
Sadeghi M, Carstens BB, Callaghan BP, Daniel JT, Tae HS, O Donnell T, Castro J, Brierley SM, Adams DJ, Craik DJ, Clark RJ
Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1. ACS Chem. Biol. (2018) 13: 1577-1587 [P, NA]
Sousa,S.R., McArthur,J.R., Brust,A., Bhola,R.F., Rosengren,K.J., Ragnarsson,L., Dutertre,S., Alewood,P.F., Christie,M.J., Adams,D.J., Vetter,I. and Lewis,R.J.
Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Sci Rep (2018) 8: 13397-0 [P, NA]

Abraham,N., Healy,M., Ragnarsson,L., Brust,A., Alewood,P.F. and Lewis,R.J.
Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Sci Rep (2017) 7: 45466-0 [P, NA]
Chittoor,B., Krishnarjuna,B., Morales,R.A.V., MacRaild,C.A., Sadek,M., Leung,E.W.W., Robinson,S.D., Pennington,M.W. and Norton,R.S.
The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering. Biochemistry (2017) 56: 2455-2466 [P, NA]
Drane,S.B., Robinson,S.D., MacRaild,C.A., Chhabra,S., Chittoor,B., Morales,R.A., Leung,E.W., Belgi,A., Espino,S.S., Olivera,B.M., Robinson,A.J., Chalmers,D.K. and Norton,R.S.
Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue. Toxicon (2017) 129: 113-122 [P, NA]
Echterbille,J., Gilles,N., Araóz,R., Mourier,G., Amar,M., Servent,D., De Pauw,E. and Quinton,L.
Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon (2017) 130: 1-10 [P, NA]
Leffler,A.E., Kuryatov,A., Zebroski,H.A., Powell,S.R., Filipenko,P., Hussein,A.K., Gorson,J., Heizmann,A., Lyskov,S., Tsien,R.W., Poget,S.F., Nicke,A., Lindstrom,J., Rudy,B., Bonneau,R. and Holford,M.
Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. Proc. Natl. Acad. Sci. U.S.A. (2017) 114 [P, NA]
Li,Q., Barghi,N., Lu,A., Fedosov,A.E., Bandyopadhyay,P.K., Lluisma,A.O., Concepcion,G.P., Yandell,M., Olivera,B.M. and Safavi-Hemami,H.
Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus. Genome Biol Evol (2017) 9: 2211-2225 [P, NA]
Xu,M., Zhu,X., Yu,J., Yu,J., Luo,S. and Wang,X.
The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes. Protein Cell (2017) 8: 675-685 [P, NA]
Yang,M., Zhao,S., Min,X., Shao,M., Chen,Y., Chen,Z. and Zhou,M.
A novel μ-conotoxin from worm-hunting Conus tessulatus that selectively inhibit rat TTX-resistant sodium currents. Toxicon (2017) 130: 11-18 [P, NA]

Bernáldez,J., Jiménez,S., González,L.J., Ferro,J.N., Soto,E., Salceda,E., Chávez,D., Aguilar,M.B. and Licea-Navarro,A.
A New Member of Gamma-Conotoxin Family Isolated from Conus princeps Displays a Novel Molecular Target. Toxins (Basel) (2016) 8: 39-0 [P, NA]
Brust A., Croker D. E., Colless B., Ragnarsson L., Andersson A., Jain K., Garcia-Caraballo S., Castro J., Brierley S. M., Alewood P. F., Lewis R. J.
Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J. Med. Chem. (2016) [P, NA]
Carstens,B.B., Berecki,G., Daniel,J.T., Lee,H.S., Jackson,K.A., Tae,H.S., Sadeghi,M., Castro,J., O
Structure-Activity Studies of Cysteine-Rich a-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew. Chem. Int. Ed. Engl (2016) 55: 4692-4696 [P, NA]
Cuny,H., Kompella,S.N., Tae,H.S., Yu,R. and Adams,D.J.
Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins. J. Biol. Chem. (2016) 291: 23779-23792 [P, NA]
De León-Nava,M.A., Romero-Núñez,E., Luna-Nophal,A., Bernáldez-Sarabia,J., Sánchez-Campos,L.N., Licea-Navarro,A.F., Morales-Montor,J. and Muñiz-Hernández,S.
In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii. Mar Drugs (2016) 14 [P, NA]
Deuis,J.R., Dekan,Z., Inserra,M.C., Lee,T.H., Aguilar,M.I., Craik,D.J., Lewis,R.J., Alewood,P.F., Mobli,M., Schroeder,C.I., Henriques,S.T. and Vetter,I.
Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8. J. Biol. Chem. (2016) 291: 11829-11842 [P, NA]
Espino,S.S., Dilanyan,T., Imperial,J.S., Aguilar,M.B., Teichert,R.W., Bandyopadhyay,P. and Olivera,B.M.
Glycine-rich conotoxins from the Virgiconus clade. Toxicon (2016) 113: 11-17 [P, NA]
Green,B.R., Gajewiak,J., Chhabra,S., Skalicky,J.J., Zhang,M.M., Rivier,J.E., Bulaj,G., Olivera,B.M., Yoshikami,D. and Norton,R.S.
Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. J. Biol. Chem. (2016) 291: 7205-7220 [P, NA]
Kasheverov,I.E., Chugunov,A.O., Kudryavtsev,D.S., Ivanov,I.A., Zhmak,M.N., Shelukhina,I.V., Spirova,E.N., Tabakmakher,V.M., Zelepuga,E.A., Efremov,R.G. and Tsetlin,V.I.
High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method. Sci Rep (2016) 6: 36848-0 [P, NA]
Kwon,S., Bosmans,F., Kaas,Q., Cheneval,O., Conibear,A.C., Rosengren,K.J., Wang,C.K., Schroeder,C.I. and Craik,D.J.
Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnol. Bioeng. (2016) 113: 2202-2212 [P, NA]
Lebbe,E.K., Ghequire,M.G., Peigneur,S., Mille,B.G., Devi,P., Ravichandran,S., Waelkens,E., D Souza,L., De Mot,R. and Tytgat,J.
Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. Mar Drugs (2016) 14 [P, NA]
Lin,B., Xu,M., Zhu,X., Wu,Y., Liu,X., Zhangsun,D., Hu,Y., Xiang,S.H., Kasheverov,I.E., Tsetlin,V.I., Wang,X. and Luo,S.
From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR. Sci Rep (2016) 6: 22349-0 [P, NA]
Menting,J.G., Gajewiak,J., MacRaild,C.A., Chou,D.H., Disotuar,M.M., Smith,N.A., Miller,C., Erchegyi,J., Rivier,J.E., Olivera,B.M., Forbes,B.E., Smith,B.J., Norton,R.S., Safavi-Hemami,H. and Lawrence,M.C.
A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin. Nat. Struct. Mol. Biol. (2016) 23: 916-920 [P, NA]
Penggang Han, Kang Wang, Xiandong Dai, Ying Cao, Shangyi Liu, Hui Jiang, Chongxu Fan, Wenjian Wu and Jisheng Chen
The Role of Individual Disulfide Bonds of μ-Conotoxin GIIIA in the Inhibition of NaV1.4 Marine drugs (2016) 14: 213-0 [P, NA]
Prashanth,J.R., Dutertre,S., Jin,A.H., Lavergne,V., Hamilton,B., Cardoso,F.C., Griffin,J., Venter,D.J., Alewood,P.F. and Lewis,R.J.
The role of defensive ecological interactions in the evolution of conotoxins. Mol. Ecol. (2016) 25: 598-615 [P, NA]
Robinson,S.D., Chhabra,S., Belgi,A., Chittoor,B., Safavi-Hemami,H., Robinson,A.J., Papenfuss,A.T., Purcell,A.W. and Norton,R.S.
A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin Fold. Structure (2016) 24: 293-299 [P, NA]
Wang,F., Yan,Z., Liu,Z., Wang,S., Wu,Q., Yu,S., Ding,J. and Dai,Q.
Molecular basis of toxicity of N-type calcium channel inhibitor MVIIA. Neuropharmacology (2016) 101: 137-145 [P, NA]
Yuan,Y., Balsara,R.D., Zajicek,J., Kunda,S. and Castellino,F.J.
Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors. Biochemistry (2016) 55: 7112-7122 [P, NA]
Zhu,X., Bi,J., Yu,J., Li,X., Zhang,Y., Zhangsun,D. and Luo,S.
Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli. Mar Drugs (2016) 14 [P, NA]

Akcan,M., Clark,R.J., Daly,N.L., Conibear,A.C., de Faoite,A., Heghinian,M.D., Sahil,T., Adams,D.J., Marí,F. and Craik,D.J.
Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins. Biopolymers (2015) 104: 682-692 [P, NA]
Aman,J.W., Imperial,J.S., Ueberheide,B., Zhang,M.M., Aguilar,M., Taylor,D., Watkins,M., Yoshikami,D., Showers-Corneli,P., Safavi-Hemami,H., Biggs,J. and Olivera,B.M.
Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus. Proc. Natl. Acad. Sci. U.S.A. (2015) 112: 5087-5092 [P, NA]
Aman,J.W., Imperial,J.S., Ueberheide,B., Zhang,M.M., Aguilar,M., Taylor,D., Watkins,M., Yoshikami,D., Showers-Corneli,P., Safavi-Hemami,H., Biggs,J., Teichert,R.W. and Olivera,B.M.
Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus. Proc. Natl. Acad. Sci. U.S.A. (2015) 112: 5087-5092 [P, NA]
Jennifer R. Deuis, Ella Whately, Andreas Brust, Marco C. Inserra, Naghmeh H. Asvadi, Richard J. Lewis, Paul F. Alewood, Peter J. Cabot, Irina Vetter
Activation of K-Opoid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia ACS Chemical Neuroscience (2015) 6: 1751-1758 [P, NA]
Jin,A.H., Israel,M.R., Inserra,M.C., Smith,J.J., Lewis,R.J., Alewood,P.F., Vetter,I. and Dutertre,S.
δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proc. Biol. Sci. (2015) 282 [P, NA]
Kancherla,A.K., Meesala,S., Jorwal,P., Palanisamy,R., Sikdar,S.K. and Sarma,S.P.
A Disulfide Stabilized β-Sandwich Defines the Structure of a New Cysteine Framework M-Superfamily Conotoxin. ACS Chem. Biol. (2015) 10: 1847-1860 [P, NA]
Kunda,S., Yuan,Y., Balsara,R.D., Zajicek,J. and Castellino,F.J.
Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors. J. Biol. Chem. (2015) 290: 18156-18172 [P, NA]
Li,L., Liu,N., Ding,R., Wang,S., Liu,Z., Li,H., Zheng,X. and Dai,Q.
A novel 4/6-type alpha-conotoxin ViIA selectively inhibits nAchR α3β2 subtype. Acta Biochim. Biophys. Sin. (Shanghai) (2015) 47: 1023-1028 [P, NA]
Luo,S., Zhangsun,D., Harvey,P.J., Kaas,Q., Wu,Y., Zhu,X., Hu,Y., Li,X., Tsetlin,V.I., Christensen,S., Romero,H.K., McIntyre,M., Dowell,C., Baxter,J.C., Elmslie,K.S., Craik,D.J. and McIntosh,J.M.
Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. Proc. Natl. Acad. Sci. U.S.A. (2015) 112 [P, NA]
Mueller,A., Starobova,H., Inserra,M.C., Jin,A.H., Deuis,J.R., Dutertre,S., Lewis,R.J., Alewood,P.F., Daly,N.L. and Vetter,I.
α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochem. Pharmacol. (2015) 94: 155-163 [P, NA]
Novel M-Superfamily and T-Superfamily conotoxins and contryphans from the vermivorous snail Conus figulinus. J. Pept. Sci. (2015) 21: 29-39 [P, NA]
Ren,Z., Wang,L., Qin,M., You,Y., Pan,W., Zhou,L., Sun,D. and Xu,A.
Pharmacological characterization of conotoxin lt14a as a potent non-addictive analgesic. Toxicon (2015) 96: 57-67 [P, NA]
Robinson,S.D., Li,Q., Bandyopadhyay,P.K., Gajewiak,J., Yandell,M., Papenfuss,A.T., Purcell,A.W., Norton,R.S., Safavi-Hemami,H.
Hormone-like peptides in the venoms of marine cone snails Gen. Comp. Endocrinol. (2015) [In press, corrected proof] [P, NA]
Robinson,S.D., Safavi-Hemami,H., Raghuraman,S., Imperial,J.S., Papenfuss,A.T., Teichert,R.W., Purcell,A.W., Olivera,B.M. and Norton,R.S.
Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom. J Proteomics (2015) 114: 38-47 [P, NA]
Safavi-Hemami,H., Gajewiak,J., Karanth,S., Robinson,S.D., Ueberheide,B., Douglass,A.D., Schlegel,A., Imperial,J.S., Watkins,M., Bandyopadhyay,P.K., Yandell,M., Li,Q., Purcell,A.W., Norton,R.S., Ellgaard,L. and Olivera,B.M.
Specialized insulin is used for chemical warfare by fish-hunting cone snails. Proc. Natl. Acad. Sci. U.S.A. (2015) 112: 1743-1748 [P, NA]
Wilson,M.J., Zhang,M.M., Gajewiak,J., Azam,L., Rivier,J.E., Olivera,B.M. and Yoshikami,D.
Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ. J. Neurophysiol. (2015) 113: 2289-2301 [P, NA]
Xu,S., Zhang,T., Kompella,S.N., Yan,M., Lu,A., Wang,Y., Shao,X., Chi,C., Adams,D.J., Ding,J. and Wang,C.
Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci Rep (2015) 5: 14261-0 [P, NA]
Yu,R., Seymour,V.A., Berecki,G., Jia,X., Akcan,M., Adams,D.J., Kaas,Q. and Craik,D.J.
Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Sci Rep (2015) 5: 13264-0 [P, NA]
Zhang,M.M., Gajewiak,J., Azam,L., Bulaj,G., Olivera,B.M. and Yoshikami,D.
Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ. Biochemistry (2015) 54: 3911-3920 [P, NA]
Zhou,M., Wang,L., Wu,Y., Liu,J., Sun,D., Zhu,X., Feng,Y., Qin,M., Chen,S. and Xu,A.
Soluble expression and sodium channel activity of lt16a, a novel framework XVI conotoxin from the M-superfamily. Toxicon (2015) 98: 5-11 [P, NA]

Banerjee,J., Yongye,A.B., Chang,Y.P., Gyanda,R., Medina-Franco,J.L. and Armishaw,C.J.
Design and synthesis of α-conotoxin GID analogues as selective α4β2 nicotinic acetylcholine receptor antagonists. Biopolymers (2014) 102: 78-87 [P, NA]
Chen,L., Dürr,K.L. and Gouaux,E.
X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism. Science (2014) 345: 1021-1026 [P, NA]
Chen,S., Gopalakrishnan,R., Schaer,T., Marger,F., Hovius,R., Bertrand,D., Pojer,F. and Heinis,C.
Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides Nat Chem (2014) 6: 1009-1016 [P, NA]
Chhabra,S., Belgi,A., Bartels,P., van Lierop,B.J., Robinson,S.D., Kompella,S.N., Hung,A., Callaghan,B.P., Adams,D.J., Robinson,A.J. and Norton,R.S.
Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets. J. Med. Chem. (2014) 57: 9933-9944 [P, NA]
α-Conotoxin M1 (CTx) blocks αδ binding sites of adult nicotinic receptors while ACh binding at αε sites elicits only small and short quantal synaptic currents. Physiol Rep (2014) 2 [P, NA]
Dutertre,S., Jin,A.H., Vetter,I., Hamilton,B., Sunagar,K., Lavergne,V., Dutertre,V., Fry,B.G., Antunes,A., Venter,D.J., Alewood,P.F. and Lewis,R.J.
Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails Nat Commun (2014) 5: 3521- [P, NA]
Gajewiak,J., Azam,L., Imperial,J., Walewska,A., Green,B.R., Bandyopadhyay,P.K., Raghuraman,S., Ueberheide,B., Bern,M., Zhou,H.M., Minassian,N.A., Hagan,R.H., Flinspach,M., Liu,Y., Bulaj,G., Wickenden,A.D., Olivera,B.M., Yoshikami,D. and Zhang,M.M.
A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ. Proc. Natl. Acad. Sci. U.S.A. (2014) 111: 2758-2763 [P, NA]
Green,B.R., Zhang,M.M., Chhabra,S., Robinson,S.D., Wilson,M.J., Redding,A., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S.
Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3. FEBS J. (2014) 281: 2885-2898 [P, NA]
Jia,X., Kwon,S., Wang,C.I., Huang,Y.H., Chan,L.Y., Tan,C.C., Rosengren,K.J., Mulvenna,J.P., Schroeder,C.I. and Craik,D.J.
Semienzymatic cyclization of disulfide-rich peptides using Sortase A. J. Biol. Chem. (2014) 289: 6627-6638 [P, NA]
Jin,A.H., Vetter,I., Dutertre,S., Abraham,N., Emidio,N.B., Inserra,M., Murali,S.S., Christie,M.J., Alewood,P.F. and Lewis,R.J.
MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors. Biochemistry (2014) 53: 1-3 [P, NA]
Lebbe,E.K., Peigneur,S., Maiti,M., Devi,P., Ravichandran,S., Lescrinier,E., Ulens,C., Waelkens,E., D'Souza,L. and Tytgat,J.
Structure-Function Elucidation of a New α-Conotoxin, Lo1a, from Conus longurionis. J. Biol. Chem. (2014) 289: 9573-9583 [P, NA]
Lebbe,E.K., Peigneur,S., Maiti,M., Mille,B.G., Devi,P., Ravichandran,S., Lescrinier,E., Waelkens,E., D'Souza,L. and Tytgat,J.
Discovery of a new subclass of α-conotoxins in the venom of Conus australis. Toxicon (2014) 91: 145-154 [P, NA]
Lu,A., Yang,L., Xu, S. and Wang,C.
Various conotoxin diversifications revealed by a venomic study of Conus flavidus. Mol. Cell Proteomics (2014) 13: 105-118 [P, NA]
Luo,S., Zhangsun,D., Schroeder,C.I., Zhu,X., Hu,Y., Wu,Y., Weltzin,M.M., Eberhard,S., Kaas,Q., Craik,D.J., McIntosh,J.M. and Whiteaker,P.
A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors. FASEB J. (2014) 28: 1842-1853 [P, NA]
Nepravishta,R., Mandaliti,W., Melino,S., Eliseo,T. and Paci,M.
Structure of the cyclic peptide [W8S]contryphan Vn: effect of the tryptophan/serine substitution on trans-cis proline isomerization. Amino Acids (2014) 46: 2841-2853 [P, NA]
Nguyen,B., Le Caer,J.P., Aráoz,R., Thai,R., Lamthanh,H., Benoit,E. and Molgó,J.
Isolation, purification and functional characterization of alpha-BnIA from Conus bandanus venom. Toxicon (2014) 91: 155-163 [P, NA]
Platt,R.J., Curtice,K.J., Twede,V.D., Watkins,M., Gruszczyński,P., Bulaj,G., Horvath,M.P. and Olivera,B.M.
From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes. Toxicon (2014) 81: 67-79 [P, NA]
Puillandre,N., Stöcklin,R., Favreau,P., Bianchi,E., Perret,F., Rivasseau,A., Limpalaër,L. and Bouchet,P.
When everything converges: integrative taxonomy with shell, DNA and venomic data reveals Conus conco, a new species of cone snails (Gastropoda: Conoidea). Mol. Phylogenet. Evol. (2014) 80: 186-192 [P, NA]
Robinson,S.D., Safavi-Hemami,H., McIntosh,L.D., Purcell,A.W., Norton,R.S. and Papenfuss,A.T.
Diversity of Conotoxin Gene Superfamilies in the Venomous Snail, Conus victoriae. PLoS ONE (2014) 9 [P, NA]
Stock,P., Ljaschenko,D., Heckmann,M. and Dudel,J.
Agonists binding nicotinic receptors elicit specific channel-opening patterns at αγ and αδ sites. J. Physiol. (Lond.) (2014) 592: 2501-2517 [P, NA]
Wang,C.K., King,G.J., Northfield,S.E., Ojeda,P.G. and Craik,D.J.
Racemic and quasi-racemic X-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angew. Chem. Int. Ed. Engl. (2014) 53: 11236-11241 [P, NA]
Wang,S., Du,T., Liu,Z., Wang,S., Wu,Y., Ding,J., Jiang,L. and Dai,Q.
Characterization of a T-superfamily conotoxin TxVC from Conus textile that selectively targets neuronal nAChR subtypes. Biochem. Biophys. Res. Commun. (2014) 454: 151-156 [P, NA]

Aguilar,M.B., Ortiz,E., Kaas,Q., López-Vera,E., Becerril,B., Possani,L.D. and de la Cotera,E.P.
Precursor De13.1 from Conus delessertii defines the novel G gene superfamily. Peptides (2013) [ahead of print] [P, NA]
Aguilar,M.B., Zugasti-Cruz,A., Falcón,A., Batista,C.V., Olivera,B.M. and Heimer de la Cotera,E.P.
A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico. Peptides (2013) [ahead of print] [P, NA]
Akcan,M., Cao,Y., Chongxu,F. and Craik,D.J.
The three-dimensional solution structure of mini-M conotoxin BtIIIA reveals a disconnection between disulfide connectivity and peptide fold. Bioorg. Med. Chem. (2013) [ahead of print] [P, NA]
Bernáldez,J., Román-González,S.A., Martínez,O., Jiménez,S., Vivas,O., Arenas,I., Corzo,G., Arreguín,R., García,D.E., Possani,L.D. and Licea,A.
A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits CaV2.2 Channels and Displays an Anti-Nociceptive Activity. Mar Drugs (2013) 11: 1188-1202 [P, NA]
Braga,M.C., Nery,A.A., Ulrich,H., Konno,K. and Pimenta,D.C.
α -RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom. Int J Pept (2013) 2013: 543028- [P, NA]
Dutertre,S., Jin,A.H., Kaas,Q., Jones,A., Alewood,P.F. and Lewis,R.J.
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Mol. Cell Proteomics (2013) 12: 312-329 [P, NA]
Gao,B., Zhangsun,D., Wu,Y., Lin,B., Zhu,X. and Luo,S.
Expression, renaturation and biological activity of recombinant conotoxin GeXIVAWT. Appl. Microbiol. Biotechnol. (2013) 97: 1223-1230 [P, NA]
Grishin,A.A., Cuny,H., Hung,A., Clark,R.J., Brust,A., Akondi,K., Alewood,P.F., Craik,D.J. and Adams,D.J.
Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. J. Biol. Chem. (2013) 288: 34428-34442 [P, NA]
Hocking,H.G., Gerwig,G.J., Dutertre,S., Violette,A., Favreau,P., Stöcklin,R., Kamerling,J.P. and Boelens,R.
Structure of the O-glycosylated conopeptide CcTx from Conus consors venom. Chemistry (2013) 19: 870-879 [P, NA]
Hone,A.J., Ruiz,M., Scadden,M., Christensen,S., Gajewiak,J., Azam,L. and McIntosh,J.M.
Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors. J. Biol. Chem. (2013) 288: 25428-25439 [P, NA]
Inserra,M.C., Kompella,S.N., Vetter,I., Brust,A., Daly,N.L., Cuny,H., Craik,D.J., Alewood,P.F., Adams,D.J. and Lewis,R.J.
Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochem. Pharmacol. (2013) 86: 791-799 [P, NA]
Jin,A.H., Dutertre,S., Kaas,Q., Lavergne,V., Kubala,P. and Alewood,P.F.
Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Mol. Cell Proteomics (2013) 12: 3824-3833 [P, NA]
Kapono,C.A., Thapa,P., Cabalteja,C.C., Guendisch,D., Collier,A.C. and Bingham,J.P.
Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus. Toxicon (2013) [P, NA]
Kuang,Z., Zhang,M.M., Gupta,K., Gajewiak,J., Gulyas,J., Balaram,P., Rivier,J.E., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S.
Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency. ACS Chem. Biol. (2013) 8: 1344-1351 [P, NA]
Lavergne,V., Dutertre,S., Jin,A.H., Lewis,R.J. and Alewood,P.F.
Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. BMC Genomics (2013) 14: 708- [P, NA]
Lavergne,V., Dutertre,S., Jin,A.H., Lewis,R.J., Taft,R.J. and Alewood,P.F.
Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies BMC Genomics (2013) 14: 708- [P, NA]
Luo,S., Christensen,S., Zhangsun,D., Wu,Y., Hu,Y., Zhu,X., Chhabra,S., Norton,R.S. and McIntosh,J.M.
A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily. PLoS ONE (2013) 8 [P, NA]
Luo,S., Zhangsun,D., Wu,Y., Zhu,X., Hu,Y., McIntyre,M., Christensen,S., Akcan,M., Craik,D.J. and McIntosh,J.M.
Characterization of a novel α-conotoxin from conus textile that selectively targets α6/α3β2β3 nicotinic acetylcholine receptors. J. Biol. Chem. (2013) 288: 894-902 [P, NA]
Luo,S., Zhangsun,D., Zhu,X., Wu,Y., Hu,Y., Christensen,S., Harvey,P.J., Akcan,M., Craik,D.J. and McIntosh,J.M.
Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors. J. Med. Chem. (2013) 56: 9655-9663 [P, NA]
McDougal,O.M., Granum,D.M., Swartz,M., Rohleder,C. and Maupin,C.M.
pKa determination of histidine residues in α-conotoxin MII peptides by 1H NMR and constant pH molecular dynamics simulation. J Phys Chem B (2013) 117: 2653-2661 [P, NA]
Peigneur,S., Van Der Haegen,A., Möller,C., Waelkens,E., Diego-García,E., Marí,F., Naudé,R. and Tytgat,J.
Unraveling the peptidome of the South African cone snails Conus pictus and Conus natalis. Peptides (2013) 41: 8-16 [P, NA]
Petrel,C., Hocking,H.G., Reynaud,M., Upert,G., Favreau,P., Biass,D., Paolini-Bertrand,M., Peigneur,S., Tytgat,J., Gilles,N., Hartley,O., Boelens,R., Stocklin,R. and Servent,D.
Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor. Biochem. Pharmacol. (2013) [P, NA]
Quinton,L., Servent,D., Girard,E., Molgó,J., Le Caer,J.P., Malosse,C., Haidar,E.A., Lecoq,A., Gilles,N. and Chamot-Rooke,J.
Identification and functional characterization of a novel α-conotoxin (EIIA) from Conus ermineus. Anal Bioanal Chem (2013) [P, NA]
Ragnarsson,L., Wang,C.I., Andersson,A., Fajarningsih,D., Monks,T., Brust,A., Rosengren,K.J. and Lewis,R.J.
Conopeptide ρ-TIA defines a new allosteric site on the extracellular surface of the α1B-adrenoceptor. J. Biol. Chem. (2013) 288: 1814-1827 [P, NA]
Sonti,R., Gowd,K.H., Rao,K.N., Ragothama,S., Rodriguez,A., Perez,J.J. and Balaram,P.
Conformational diversity in contryphans from Conus venom: cis-trans isomerisation and aromatic/proline interactions in the 23-membered ring of a 7-residue peptide disulfide loop. Chemistry (2013) 19: 15175-15189 [P, NA]
van Lierop,B.J., Robinson,S.D., Kompella,S.N., Belgi,A., McArthur,J.R., Hung,A., MacRaild,C.A., Adams,D.J. and Robinson,A.J.
Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. ACS Chem. Biol. (2013) 8: 1815-1821 [P, NA]
Wu,Y., Wang,L., Zhou,M., You,Y., Zhu,X., Qiang,Y., Qin,M., Luo,S., Ren,Z. and Xu,A.
Molecular evolution and diversity of Conus peptide toxins, as revealed by gene structure and intron sequence analyses. PLoS ONE (2013) 8 [P, NA]
Yu,R., Kompella,S.N., Adams,D.J., Craik,D.J. and Kaas,Q.
Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor. J. Med. Chem. (2013) [P, NA]
Zhang,M.M., Wilson,M.J., Azam,L., Gajewiak,J., Rivier,J.E., Bulaj,G., Olivera,B.M. and Yoshikami,D.
Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins. Br. J. Pharmacol. (2013) 168: 1597-1610 [P, NA]
Zhou,M., Wang,L., Wu,Y., Zhu,X., Feng,Y., Chen,Z., Li,Y., Sun,D., Ren,Z. and Xu,A.
Characterizing the evolution and functions of the M-superfamily conotoxins. Toxicon (2013) 76: 150-159 [P, NA]

Balsara,R., Li,N., Weber-Adrian,D., Huang,L. and Castellino,F.J.
Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors. Neuropharmacology (2012) 62: 2227-2238 [P, NA]
Bhatia,S., Kil,Y.J., Ueberheide,B., Chait,B.T., Tayo,L., Cruz,L., Lu,B., Yates,J.R. 3rd. and Bern,M.
Constrained de novo sequencing of conotoxins. J. Proteome Res. (2012) 11: 4191-4200 [P, NA]
Chang,D. and Duda,T.F. Jr.
Extensive and continuous duplication facilitates rapid evolution and diversification of gene families. Mol. Biol. Evol. (2012) 29: 2019-2029 [P, NA]
Dobson,R., Collodoro,M., Gilles,N., Turtoi,A., De Pauw,E. and Quinton,L.
Secretion and maturation of conotoxins in the venom ducts of Conus textile. Toxicon (2012) 60: 1370-1379 [P, NA]
Favreau P, Benoit E, Hocking HG, Carlier L, D hoedt D, Leipold E, Markgraf R, Schlumberger S, Córdova MA, Gaertner H, Paolini-Bertrand M, Hartley O, Tytgat J, Heinemann SH, Bertrand D, Boelens R, Stöcklin R, Molgó J
A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors Br J Pharmacol (2012) 166: 1654-1668 [P, NA]
Franco,A., Kompella,S.N., Akondi,K.B., Melaun,C., Daly,N.L., Luetje,C.W., Alewood,P.F., Craik,D.J., Adams,D.J. and Marí,F.
RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs. Biochem. Pharmacol. (2012) 83: 419-426 [P, NA]
Gowd,K.H., Han,T.S., Twede,V., Gajewiak,J., Smith,M.D., Watkins,M., Platt,R.J., Toledo,G., White,H.S., Olivera,B.M. and Bulaj,G.
Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits. Biochemistry (2012) 51: 4685-4692 [P, NA]
Hone,A.J., Scadden,M., Gajewiak,J., Christensen,S., Lindstrom,J. and McIntosh,J.M.
α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptors. Mol. Pharmacol. (2012) 82: 972-982 [P, NA]
Hu,H., Bandyopadhyay,P.K., Olivera,B.M. and Yandell,M.
Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct. BMC Genomics (2012) 13: 284-0 [P, NA]
Kaas,Q., Yu,R., Jin,A.H., Dutertre,S. and Craik,D.J.
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Res (2012) 40 : 325-330 [P, NA]
Khoo,K.K., Gupta,K., Green,B.R., Zhang,M.M., Watkins,M., Olivera,B.M., Balaram,P., Yoshikami,D., Bulaj,G. and Norton,R.S.
Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels. Biochemistry (2012) 51: 9826-9835 [P, NA]
Knapp,O., Nevin,S.T., Yasuda,T., Lawrence,N., Lewis,R.J. and Adams,D.J.
Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB. Br. J. Pharmacol. (2012) 166: 2148-2160 [P, NA]
Liu,Z., Li,H., Liu,N., Wu,C., Jiang,J., Yue,J. and Dai,Q.
Diversity and evolution of conotoxins in Conus virgo, Conus eburneus, Conus imperialis and Conus marmoreus from the South China Sea. Toxicon (2012) 60: 982-989 [P, NA]
Lluisma,A.O., Milash,B.A., Moore,B., Olivera,B.M. and Bandyopadhyay,P.K.
Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome. Mar Genomics (2012) 5: 43-51 [P, NA]
Markgraf,R., Leipold,E., Schirmeyer,J., Paolini-Bertrand,M., Hartley,O. and Heinemann,S.H.
Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC. Br. J. Pharmacol. (2012) 167: 576-586 [P, NA]
Napier,I.A., Klimis,H., Rycroft,B.K., Jin,A.H., Alewood,P.F., Motin,L., Adams,D.J. and Christie,M.J.
Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain. Neuropharmacology (2012) 62: 2202-2207 [P, NA]
Olivera,B.M., Watkins,M., Bandyopadhyay,P., Imperial,J.S., de la Cotera,E.P., Aguilar,M.B., Vera,E.L., Concepcion,G.P. and Lluisma,A.
Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes. Ann. N. Y. Acad. Sci. (2012) 1267: 61-70 [P, NA]
Pérez-Alvarez,A., Hernández-Vivanco,A., McIntosh,J.M. and Albillos,A.
Native α6β4* nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland. FASEB J. (2012) 26: 346-354 [P, NA]
Platt,R.J., Han,T.S., Green,B.R., Smith,M.D., Skalicky,J., Gruszczynski,P., White,H.S., Olivera,B., Bulaj,G. and Gajewiak,J.
Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. J. Biol. Chem. (2012) 287: 20727-20736 [P, NA]
Puillandre,N., Koua,D., Favreau,P., Olivera,B.M. and Stocklin,R.
Molecular phylogeny, classification and evolution of conopeptides J. Mol. Evol. (2012) 74: 297-309 [P, NA]
Safavi-Hemami,H., Gorasia,D.G., Steiner,A.M., Williamson,N.A., Karas,J.A., Gajewiak,J., Olivera,B.M., Bulaj,G. and Purcell,A.W.
Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails. J. Biol. Chem. (2012) 287: 34288-34303 [P, NA]
Schroeder,C.I., Adams,D., Thomas,L., Alewood,P.F. and Lewis,R.J.
N- and C-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers (2012) 98: 161-165 [P, NA]
Schroeder,C.I., Nielsen,K.J., Adams,D.A., Loughnan,M., Thomas,L., Alewood,P.F., Lewis,R.J. and Craik,D.J.
Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers (2012) 98: 345-356 [P, NA]
Steiner,A.M., Woycechowsky,K.J., Olivera,B.M. and Bulaj,G.
Reagentless oxidative folding of disulfide-rich peptides catalyzed by an intramolecular diselenide. Angew. Chem. Int. Ed. Engl. (2012) 51: 5580-5584 [P, NA]
Terrat,Y., Biass,D., Dutertre,S., Favreau,P., Remm,M., Stöcklin,R., Piquemal,D. and Ducancel,F.
High-resolution picture of a venom gland transcriptome: case study with the marine snail Conus consors. Toxicon (2012) 59: 34-46 [P, NA]
Tietze,A.A., Tietze,D., Ohlenschläger,O., Leipold,E., Ullrich,F., Kühl,T., Mischo,A., Buntkowsky,G., Görlach,M., Heinemann,S.H. and Imhof,D.
Structurally diverse μ-conotoxin PIIIA isomers block sodium channel NaV 1.4. Angew. Chem. Int. Ed. Engl. (2012) 51: 4058-4061 [P, NA]
Van Der Haegen A, Peigneur S, Dyubankova N, Möller C, Marí F, Diego-García E, Naudé R, Lescrinier E, Herdewijn P, Tytgat J
Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity Peptides (2012) 34: 106-113 [P, NA]
Vetter,I., Dekan,Z., Knapp,O., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochem. Pharmacol. (2012) 84: 540-548 [P, NA]
Violette,A., Biass,D., Dutertre,S., Koua,D., Piquemal,D., Pierrat,F. and Favreau,P.
Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach. J Proteomics (2012) 75: 5215-5225 [P, NA]
Violette,A., Leonardi,A., Piquemal,D., Terrat,Y., Biass,D., Dutertre,S., Noguier,F., Ducancel,F., Stöcklin,R., Križaj,I. and Favreau,P.
Recruitment of glycosyl hydrolase proteins in a cone snail venomous arsenal: further insights into biomolecular features of Conus venoms. Mar Drugs (2012) 10: 258-280 [P, NA]
Ye,M., Khoo,K.K., Xu,S., Zhou,M., Boonyalai,N., Perugini,M.A., Chi,C., Galea,C.A., Wang,C. and Norton,R.S.
A Helical Conotoxin From Conus Imperialis Has A Novel Cysteine Framework And Defiines A New Superfamily J Biol Chem (2012) 287: 14973-14983 [P, NA]
Yu,R., Kaas,Q. and Craik,D.J.
Delineation of the unbinding pathway of α-conotoxin ImI from the α7 nicotinic acetylcholine receptor. J Phys Chem B (2012) 116: 6097-6105 [P, NA]
Zhang,B., Huang,F. and Du,W.
Solution structure of a novel α-conotoxin with a distinctive loop spacing pattern. Amino Acids (2012) 43: 389-396 [P, NA]

Armishaw,C.J., Jensen,A.A., Balle,L.D., Scott,K.C., Sørensen,L. and Strømgaard,K.
Improving the stability of α-conotoxin AuIB through N-to-C cyclization: the effect of linker length on stability and activity at nicotinic acetylcholine receptors. Antioxid. Redox Signal. (2011) 14: 65-76 [P, NA]
Bernaldez,J., López,O., Licea,A., Salceda,E., Arellano,R.O., Vega,R. and Soto,E.
Electrophysiological characterization of a novel small peptide from the venom of Conus californicus that targets voltage-gated neuronal Ca2+ channels. Toxicon (2011) 57: 60-67 [P, NA]
Bruce,C., Fitches,E.C., Chougule,N., Bell,H.A. and Gatehouse,J.A.
Recombinant conotoxin, TxVIA, produced in yeast has insecticidal activity. Toxicon (2011) 58: 93-100 [P, NA]
Daly,N.L., Callaghan,B., Clark,R.J., Nevin,S.T., Adams,D.J. and Craik,D.J.
Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels. J. Biol. Chem. (2011) 286: 10233-10237 [P, NA]
de Araujo,A.D., Callaghan,B., Nevin,S.T., Daly,N.L., Craik,D.J., Moretta,M., Hopping,G., Christie,M.J., Adams,D.J. and Alewood,P.F.
Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angew. Chem. Int. Ed. Engl. (2011) 50: 6527-6529 [P, NA]
Elliger,C.A., Richmond,T.A., Lebaric,Z.N., Pierce,N.T., Sweedler,J.V. and Gilly,W.F.
Diversity of conotoxin types from Conus californicus reflects a diversity of prey types and a novel evolutionary history. Toxicon (2011) 57: 311-322 [P, NA]
Halai,R., Callaghan,B., Daly,N.L., Clark,R.J., Adams,D.J. and Craik,D.J.
Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor. J. Med. Chem. (2011) 54: 6984-6992 [P, NA]
Hu,H., Bandyopadhyay,P.K. and Yandell,M.
Characterization of the Conus bullatus genome and its venom-duct transcriptome. BMC Genomics (2011) 12: 60- [P, NA]
Imperial,J., Hillyard,D.R., Watkins,M., Olivera,B.M., Wagstaff,J.D., Jones,R.M., Mccabe,R.T., Cruz,L.J., Layer,R.T., Griffen,D. and Craig,A.G.
Contulakin-G, Analogs Thereof and Uses Therefor Patent: JP 2011024579-A (2011) [P, NA]
Kauferstein,S., Porth,C., Kendel,Y., Wunder,C., Nicke,A., Kordis,D., Favreau,P., Koua,D., Stöcklin,R. and Mebs,D.
Venomic study on cone snails (Conus spp.) from South Africa. Toxicon (2011) 57: 28-34 [P, NA]
Khoo,K.K., Wilson,M.J., Smith,B.J., Zhang,M.M., Gulyas,J., Yoshikami,D., Rivier,J.E., Bulaj,G. and Norton,R.S.
Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA. J. Med. Chem. (2011) 54: 7558-7566 [P, NA]
Klimis,H., Adams,D.J., Callaghan,B., Nevin,S., Alewood,P.F., Vaughan,C.W., Mozar,C.A. and Christie,M.J.
A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain. Pain (2011) 152: 259-266 [P, NA]
Leipold,E., Markgraf,R., Miloslavina,A., Kijas,M., Schirmeyer,J. , Imhof,D., and Heinemann,S.H
Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels. Neuropharmacology (2011) 61: 105-111 [P, NA]
Lovelace,E.S., Gunasekera,S., Alvarmo,C., Clark,R.J., Nevin,S.T., Grishin,A.A., Adams,D.J., Craik,D.J., and Daly,N.L.
Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization. Antioxid. Redox Signal. (2011) 14: 87-95 [P, NA]
Möller,C. and Marí,F.
9.3 KDa components of the injected venom of Conus purpurascens define a new five-disulfide conotoxin framework. Biopolymers (2011) 96: 158-165 [P, NA]
McArthur,J.R., Singh,G., McMaster,D., Winkfein,R., Tieleman,D.P. and French,R.J.
Interactions of key charged residues contributing to selective block of neuronal sodium channels by μ-conotoxin KIIIA. Mol. Pharmacol. (2011) 80: 573-584 [P, NA]
McArthur,J.R., Singh,G., O Mara,M.L., McMaster,D., Ostroumov,V., Tieleman,D.P. and French,R.J
Orientation of {micro}-Conotoxin PIIIA in a Sodium Channel Vestibule, Based on Voltage Dependence of Its Binding. Mol. Pharmacol. (2011) 80: 219-227 [P, NA]
Pucci,L., Grazioso,G., Dallanoce,C., Rizzi,L., De Micheli,C., Clementi,F., Bertrand,S., Bertrand,D., Longhi,R., De Amici,M. and Gotti,C.
Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors. FASEB J. (2011) 25: 3775-3789 [P, NA]
Safavi-Hemami,H., Siero,W.A., Kuang,Z., Williamson,N.A., Karas,J.A., Page,L.R., MacMillan,D., Callaghan,B., Kompella,S.N., Adams,D.J., Norton,R.S., and Purcell,A.W.
Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? J. Biol. Chem. (2011) 286: 22546-22557 [P, NA]
Sun,D., Ren,Z., Zeng,X., You,Y., Pan,W., Zhou,M., Wang,L. and Xu,A.
Structure-function relationship of conotoxin lt14a, a potential analgesic with low cytotoxicity. Peptides (2011) 32: 300-305 [P, NA]
Van Der Haegen,A., Peigneur,S. and Tytgat,J.
Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity. FEBS J. (2011) 278: 3408-3418 [P, NA]
Wilson,M.J., Yoshikami,D., Azam,L., Gajewiak,J., Olivera,B.M., Bulaj,G. and Zhang,M.M.
μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc. Natl. Acad. Sci. U.S.A. (2011) 108: 10302-10307 [P, NA]
Wilson,M.J., Zhang,M.M., Azam,L., Olivera,B.M., Bulaj,G. and Yoshikami,D.
NaV{beta} Subunits Modulate the Inhibition of NaV1.8 by the Analgesic Gating Modifier {micro}O-Conotoxin MrVIB. J. Pharmacol. Exp. Ther. (2011) 338: 687-693 [P, NA]
Ye,M., Hong,J., Zhou,M., Huang,L., Shao,X., Yang,Y., Sigworth,F.J., Chi,C., Lin,D. and Wang,C.
A novel conotoxin, qc16a, with a unique cysteine framework and folding. Peptides (2011) 32: 1159-1165 [P, NA]
Yu,R., Craik,D.J. and Kaas,Q.
Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PLoS Comput. Biol. (2011) 7 [P, NA]

Armishaw,C.J., Singh,N., Medina-Franco,J.L., Clark,R.J., Scott,K.C., Houghten,R.A. and Jensen,A.A.
A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists. J. Biol. Chem. (2010) 285: 1809-1821 [P, NA]
Azam,L., Maskos,U., Changeux,J.P., Dowell,C.D., Christensen,S., De Biasi,M. and McIntosh,J.M.
α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. FASEB J. (2010) 24: 5113-5123 [P, NA]
Berecki,G., Motin,L., Haythornthwaite,A., Vink,S., Bansal,P., Drinkwater,R., Wang,C.I., Moretta,M., Lewis,R.J., Alewood,P.F. and Adams,D.J.
Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Mol. Pharmacol. (2010) 77: 139-148 [P, NA]
Biggs,J.S., Watkins,M., Puillandre,N., Ownby,J.P., Lopez-Vera,E., Christensen,S., Moreno,K.J., Bernaldez,J., Licea-Navarro,A. and Olivera,B.M.
Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. Mol. Phylogenet. Evol. (2010) 56: 1-12 [P, NA]
Chen,P., Dendorfer,A., Finol-Urdaneta,R.K., Terlau,H. and Olivera,B.M.
Biochemical characterization of kM-RIIIJ, a KV1.2 channel blocker: Evaluation of cardioprotective effects of kM-conotoxins. J Biol Chem (2010) 285: 14882-14889 [P, NA]
Clark,R.J., Jensen,J., Nevin,S.T., Callaghan,B.P. and Craik,D.J.
The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angew. Chem. Int. Ed. Engl. (2010) 49: 6545-6548 [P, NA]
Gowd,K.H., Watkins,M., Twede,V.D., Bulaj,G.W. and Olivera,B.M.
Characterization of conantokin Rl-A: molecular phylogeny as structure/function study. J. Pept. Sci. (2010) 16: 375-382 [P, NA]
Grishin,A.A., Wang,C.I., Muttenthaler,M., Alewood,P.F., Lewis,R.J. and Adams,D.J.
Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors. J. Biol. Chem. (2010) 285: 22254-22263 [P, NA]
Gupta,K. and Balaram,P.
Disulfide bond assignments by mass spectrometry of native natural peptides: cysteine pairing in disulfide bonded conotoxins. Anal. Chem. (2010) 82: 8313-8319 [P, NA]
Jimenez,E.C. and Olivera,B.M.
Divergent M- and O-superfamily peptides from venom of fish-hunting Conus parius. Peptides (2010) 31: 1678-1683 [P, NA]
Kaas,Q., Westermann, J. and Craik,D.J.
Conopeptide characterization and classifications: an analysis using ConoServer. Toxicon (2010) 55: 1491-1509 [P, NA]
Lee,S., Kim,Y., Back,S.K., Choi,H.W., Lee,J.Y., Jung,H.H., Ryu,J.H., Suh,H.W., Na,H.S., Kim,H.J. and Kim,J.I.
Analgesic effect of highly reversible ω-conotoxin FVIA on N type Ca2+ channels. Mol Pain (2010) 6: 97-0 [P, NA]
Liu,Z., Yu,Z., Liu,N., Zhao,C., Hu,J. and Dai,Q.
cDNA cloning of conotoxins with framework XII from several Conus species. Acta Biochim. Biophys. Sin. (Shanghai) (2010) 42: 656-661 [P, NA]
Luo,S., Akondi,K.B., Zhangsun,D., Wu,Y., Zhu,X., Hu,Y., Christensen,S., Dowell,C., Daly,N.L., Craik,D.J., Wang,C.I., Lewis,R.J., Alewood,P.F. and Michael McIntosh,J.
Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor. J. Biol. Chem. (2010) 285: 12355-12366 [P, NA]
Möller,C., Melaun,C., Castillo,C., Díaz,M.E., Renzelman,C.M., Estrada,O., Kuch,U., Lokey,S. and Marí,F.
Functional hypervariability and gene diversity of cardioactive neuropeptides. J. Biol. Chem. (2010) 285: 40673-40680 [P, NA]
Peng,C., Chen,W., Sanders,T., Chew,G., Liu,J., Hawrot,E. and Chi,C.
Chemical synthesis and characterization of two α4/7-conotoxins. Acta Biochim. Biophys. Sin. (Shanghai) (2010) 42: 745-753 [P, NA]
Peng,C., Ye,M., Wang,Y., Shao,X., Yuan,D., Liu,J., Hawrot,E. and Chi,C.
A new subfamily of conotoxins belonging to the A-superfamily. Peptides (2010) 31: 2009-2016 [P, NA]
Puillandre,N. and Olivera,B.M.
Evolution of Conus Peptide Genes: Duplication and Positive Selection in the A-Superfamily. J Mol Evol (2010) [P, NA]
Wu,X., Shao,X., Guo,Z.Y. and Chi,C.W.
Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus. Acta Biochim. Biophys. Sin. (Shanghai) (2010) 42: 502-505 [P, NA]
Wu,X.C., Zhou,M., Peng,C., Shao,X.X. and Chi,C.W.
Novel conopeptides in a form of disulfide-crosslinked dimer. Peptides (2010) 31: 1001-1006 [P, NA]
Xu,J., Wang,Y., Zhang,B. and Du,W.
Stereochemistry of 4-hydroxyproline affects the conformation of conopeptides. Chem. Commun. (Camb.) (2010) 46: 5467-5469 [P, NA]
Zhang,L., Shao,X., Chi,C. and Wang,C.
Two short D-Phe-containing cysteine-free conopeptides from Conus marmoreus. Peptides (2010) 31: 177-179 [P, NA]

Aguilar,M.B., Flores-Torres,A., Batista,C.V., Falcon,A., Lopez-Vera,E. and de la Cotera,E.P.
Structural characterization of five post-translationally modified isomorphs of a novel putative delta-conotoxin from the vermivorous snail Conus delessertii from the Mexican Caribbean Sea. Peptides (2009) 30: 458-466 [P, NA]
Armishaw,C., Jensen,A.A., Balle,T., Clark,R.J., Harpsøe,K., Skonberg,C., Liljefors,T. and Strømgaard,K.
Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives. J. Biol. Chem. (2009) 284: 9498-9512 [P, NA]
Biass,D., Dutertre,S., Gerbault,A., Menou,J.L., Offord,R., Favreau,P. and Stöcklin,R.
Comparative proteomic study of the venom of the piscivorous cone snail Conus consors. J Proteomics (2009) 72: 210-218 [P, NA]
Brust,A., Palant,E., Croker,D.E., Colless,B., Drinkwater,R., Patterson,B., Schroeder,C.I., Wilson,D., Nielsen,C.K., Smith,M.T., Alewood,D., Alewood,P.F. and Lewis,R.J.
chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. J. Med. Chem. (2009) 52: 6991-7002 [P, NA]
Davis,J., Jones,A. and Lewis,R.J.
Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS. Peptides (2009) 30: 1222-1227 [P, NA]
Duda,T.F. Jr. and Lee,T.
Ecological release and venom evolution of a predatory marine snail at Easter Island. PLoS ONE (2009) 4 [P, NA]
Duda,T.F. Jr., Chang,D., Lewis,B.D. and Lee,T.
Geographic variation in venom allelic composition and diets of the widespread predatory marine gastropod Conus ebraeus. PLoS ONE (2009) 4 [P, NA]
Halai,R., Clark,R.J., Nevin,S.T., Jensen,J.E., Adams,D.J. and Craik,D.J.
Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor. J. Biol. Chem. (2009) [P, NA]
Han TS, Zhang MM, Walewska A, Gruszczynski P, Robertson CR, Cheatham TE 3rd, Yoshikami D, Olivera BM, Bulaj G
Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics. ChemMedChem (2009) 4: 406-414 [P, NA]
Holford,M., Zhang,M.M., Gowd,K.H., Azam,L., Green,B.R., Watkins,M., Ownby,J.P., Yoshikami,D., Bulaj,G. and Olivera,B.M.
Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon (2009) 53: 90-98 [P, NA]
Hone,A.J., Whiteaker,P., Christensen,S., Xiao,Y., Meyer,E.L. and McIntosh,J.M.
A novel fluorescent alpha-conotoxin for the study of alpha7 nicotinic acetylcholine receptors. J. Neurochem. (2009) 111: 80-89 [P, NA]
Huang,F. and Du,W.
Solution Structure of Hyp10Pro variant of conomarphin, a cysteine-free and D-amino-acid containing conopeptide. Toxicon (2009) [P, NA]
Kasheverov,I.E., Zhmak,M.N., Fish,A., Rucktooa,P., Khruschov,A.Y., Osipov,A.V., Ziganshin,R.H., D'hoedt,D., Bertrand,D., Sixma,T.K., Smit,A.B. and Tsetlin,V.I.
Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor. J. Neurochem. (2009) 111: 934-944 [P, NA]
Kauferstein,S., Kendel,Y., Nicke,A., Coronas,F.I., Possani,L.D., Favreau,P., Krizaj,I., Wunder,C., Kauert,G. and Mebs,D.
New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors. Toxicon (2009) 54: 295-301 [P, NA]
Khoo,K.K., Feng,Z.P., Smith,B.J., Zhang,M.M., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S.
Structure of the Analgesic mu-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion. Biochemistry (2009) 6: 1210-1219 [P, NA]
Lewis RJ
Conotoxins: molecular and therapeutic targets. Prog. Mol. Subcell. Biol. (2009) 46: 45-65 [P, NA]
Liu,Z., Xu,N., Hu,J., Zhao,C., Yu,Z. and Dai,Q.
Identification of novel I-superfamily conopeptides from several clades of Conus species found in the South China Sea. Peptides (2009) 30: 1782-1787 [P, NA]
Loughnan,M.L., Nicke,A., Lawrence,N. and Lewis,R.J.
Novel alphaD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry (2009) 48: 3717-3729 [P, NA]
MacRaild,C.A., Illesinghe,J., van Lierop,B.J., Townsend,A.L., Chebib,M., Livett,B.G., Robinson,A.J. and Norton,R.S.
Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an alpha-conotoxin containing a nonreducible cystine analogue. J. Med. Chem. (2009) 52: 755-762 [P, NA]
Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL
Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. J Biol Chem. (2009) 284: 4944-4951 [P, NA]
Peng,C., Chen,W., Han,Y., Sanders,T., Chew,G., Liu,J., Hawrot,E., Chi,C. and Wang,C.
Characterization of a novel alpha4/4-conotoxin, Qc1.2, from vermivorous Conus quercinus. Acta Biochim. Biophys. Sin. (Shanghai) (2009) 41: 858-864 [P, NA]
Quinton,L., Gilles,N. and De Pauw,E.
TxXIIIA, an atypical homodimeric conotoxin found in the Conus textile venom. J Proteomics (2009) 72: 219-226 [P, NA]
Turner,M., Eidemiller,S., Martin,B., Narver,A., Marshall,J., Zemp,L., Cornell,K.A., McIntosh,J.M. and McDougal,O.M.
Structural basis for alpha-conotoxin potency and selectivity. Bioorg. Med. Chem. (2009) 17: 5894-5899 [P, NA]
Twede,V.D., Miljanich,G., Olivera,B.M. and Bulaj,G.
Neuroprotective and cardioprotective conopeptides: an emerging class of drug leads. Curr Opin Drug Discov Devel (2009) 12: 231-239 [P, NA]
Twede,V.D., Teichert,R.W., Walker,C.S., Gruszczynski,P., Kazmierkiewicz,R., Bulaj,G. and Olivera,B.M.
Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor. Biochemistry (2009) 48: 4063-4073 [P, NA]
Ueberheide,B.M., Fenyö,D., Alewood,P.F. and Chait,B.T.
Rapid sensitive analysis of cysteine rich peptide venom components. Proc. Natl. Acad. Sci. U.S.A. (2009) 106: 6910-6915 [P, NA]
Walker,C.S., Jensen,S., Ellison,M., Matta,J.A., Lee,W.Y., Imperial,J.S., Duclos,N., Brockie,P.J., Madsen,D.M., Isaac,J.T., Olivera,B. and Maricq,A.V.
A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors. Curr. Biol. (2009) 19: 900-908 [P, NA]
Wang,L., Liu,J., Pi,C., Zeng,X., Zhou,M., Jiang,X., Chen,S., Ren,Z. and Xu,A.
Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents. Arch. Toxicol. (2009) [P, NA]
Yuan,D.D., Liu,L., Shao,X.X., Peng,C., Chi,C.W. and Guo,Z.Y.
New conotoxins define the novel I3-superfamily. Peptides (2009) 30: 861-865 [P, NA]
Zamora-Bustillos,R., Aguilar,M.B. and Falcón,A.
Identification, by molecular cloning, of a novel type of I(2)-superfamily conotoxin precursor and two novel I(2)-conotoxins from the worm-hunter snail Conus spurius from the Gulf of México Peptides (2009) 31: 384-393 [P, NA]
Zamora-Bustillos,R., Aguilar,M.B., Falcón,A. and Heimer de la Cotera,E.P.
Identification, by RT-PCR, of four novel T-1-superfamily conotoxins from the vermivorous snail Conus spurius from the Gulf of Mexico. Peptides (2009) 30: 1396-1404 [P, NA]

Aguilar,M.B., Luna-Rami­rez,K.S., Echeverria,D., Falcon,A., Olivera,B.M., Heimer de la Cotera,E.P. and Maillo,M.
Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks. Peptides (2008) 29: 186-195 [P, NA]
Azam,L., Yoshikami,D., and McIntosh,J.M.
Amino acid residues that confer high selectivity of the alpha6 nicotinic acetylcholine receptor subunit to alpha-conotoxin MII[S4A,E11A,L15A]. J. Biol. Chem. (2008) 283: 11625-11632 [P, NA]
Benoit,E., Favreau,P., Schlumberger,S., Cordova,M.A., Tytgat,J., Stocklin, R. abd and R. Stocklin and Molgo J.
A new mu-conotoxin from Conus consors that atypically targets sodium channels in unmyelinated and myelinated nerve fibers Abstract Book, 16th European Section Meeting of the International Society on Toxinology (2008) [P, NA]
Biggs,J.S., Olivera,B.M. and Kantor,Y.I.
alpha-Conopeptides specifically expressed in the salivary gland of Conus pulicarius. Toxicon (2008) 52: 101-105 [P, NA]
Buczek,O., Jimenez,E.C., Yoshikami,D., Imperial,J.S., Watkins,M., Morrison,A. and Olivera,B.M.
I(1)-superfamily conotoxins and prediction of single D-amino acid occurrence. Toxicon (2008) 51: 218-229 [P, NA]
Callaghan,B., Haythornthwaite,A., Berecki,G., Clark,R.J., Craik,D.J. and Adams,D.J.
Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation. J. Neurosci. (2008) 28: 10943-10951 [P, NA]
Chen,P., Garrett,J.E., Watkins,M. and Olivera,B.M.
Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins. Toxicon (2008) 52: 139-145 [P, NA]
Clark,R.J., Daly,N.L., Halai,R., Nevin,S.T., Adams,D.J. and Craik,D.J.
The three-dimensional structure of the analgesic alpha-conotoxin, RgIA. FEBS Lett. (2008) 582: 597-602 [P, NA]
Duda,T.F. Jr. and Remigio,E.A.
Variation and evolution of toxin gene expression patterns of six closely related venomous marine snails. Mol. Ecol. (2008) 17: 3018-3032 [P, NA]
Duda,T.F. Jr., Bolin,M.B., Meyer,C.P. and Kohn,A.J.
Hidden diversity in a hyperdiverse gastropod genus: discovery of previously unidentified members of a Conus species complex. Mol. Phylogenet. Evol. (2008) 49: 867-876 [P, NA]
Dutertre,S., Croker,D., Daly,N.L., Andersson,A., Muttenthaler,M., Lumsden,N.G., Craik,D.J., Alewood,P.F., Guillon,G. and Lewis,R.J.
Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. J. Biol. Chem. (2008) 283: 7100-7108 [P, NA]
Ellison,M., Feng,Z.P., Park,A.J., Zhang,X., Olivera,B.M., McIntosh,J.M. and Norton,R.S.
Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues. J. Mol. Biol. (2008) 377: 1216-1227 [P, NA]
Fiedler,B., Zhang,M.M., Buczek,O., Azam,L., Bulaj,G., Norton,R.S., Olivera,B.M. and Yoshikami,D.
Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochem. Pharmacol. (2008) 75: 2334-2344 [P, NA]
Gowd,K.H., Dewan,K.K., Iengar,P., Krishnan,K.S. and Balaram,P.
Probing peptide libraries from Conus achatinus using mass spectrometry and cDNA sequencing: identification of delta and omega-conotoxins. J Mass Spectrom (2008) 43: 791-805 [P, NA]
Gowd,K.H., Twede,V., Watkins,M., Krishnan,K.S., Teichert,R.W., Bulaj,G. and Olivera,B.M.
Conantokin-P, an unusual conantokin with a long disulfide loop. Toxicon (2008) 52: 203-213 [P, NA]
Han,Y., Huang,F., Jiang,H., Liu,L., Wang,Q., Wang,Y., Shao,X., Chi,C., Du,W. and Wang,C.
Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus. FEBS J. (2008) 275: 1976-1987 [P, NA]
Imperial,J.S., Chen,P., Sporning,A., Terlau,H., Daly,N.L., Craik,D.J. and Olivera,B.M.
Tyrosine-rich conopeptides affect voltage-gated K+ channels. J. Biol. Chem. (2008) 283: 23026-23032 [P, NA]
Innocent,N., Livingstone,P.D., Hone,A., Kimura,A., Young,T., Whiteaker,P., McIntosh,J.M. and Wonnacott,S.
Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors. J. Pharmacol. Exp. Ther. (2008) 327: 529-537 [P, NA]
Kaas,Q., Westermann,J.C., Halai,R. and Craik,D.J.
ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24: 445-446 [P, NA]
Liu,L., Wu,X., Yuan,D., Chi,C. and Wang,C.
Identification of a novel S-superfamily conotoxin from vermivorous Conus caracteristicus. Toxicon (2008) 51: 1331-1337 [P, NA]
Lluisma,A.O., López-Vera,E., Bulaj,G., Watkins,M. and Olivera,B.M.
Characterization of a novel psi-conotoxin from Conus parius Reeve. Toxicon (2008) 51: 174-180 [P, NA]
Motin,L. and Adams,D.J.
omega-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn. Neuropharmacology (2008) 55: 860-864 [P, NA]
Peng,C., Han,Y., Sanders,T., Chew,G., Liu,J., Hawrot,E., Chi,C. and Wang,C.
alpha4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors. Peptides (2008) 29: 1700-1707 [P, NA]
Peng,C., Liu,L., Shao,X., Chi,C. and Wang,C.
Identification of a novel class of conotoxins defined as V-conotoxins with a unique cysteine pattern and signal peptide sequence. Peptides (2008) 29: 985-991 [P, NA]
Remigio,E.A. and Duda,T.F. Jr.
Evolution of ecological specialization and venom of a predatory marine gastropod. Mol. Ecol. (2008) 17: 1156-1162 [P, NA]
Romeo,C., Di Francesco,L., Oliverio,M., Palazzo,P., Massilia,G.R., Ascenzi,P., Polticelli,F. and Schininà,M.E.
Conus ventricosus venom peptides profiling by HPLC-MS: a new insight in the intraspecific variation. J Sep Sci (2008) 31: 488-498 [P, NA]
Schroeder,C.I., Ekberg,J., Nielsen,K.J., Adams,D., Loughnan,M.L., Thomas,L., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Neuronally mu-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. J. Biol. Chem. (2008) 283: 21621-21628 [P, NA]
Walewska A, Skalicky JJ, Davis DR, Zhang MM, Lopez-Vera E, Watkins M, Han TS, Yoshikami D, Olivera BM, Bulaj G
NMR-based mapping of disulfide bridges in cysteine-rich peptides: application to the mu-conotoxin SxIIIA J Am Chem Soc (2008) 130: 14280-14286 [P, NA]
Wang,L., Pi,C., Liu,J., Chen,S., Peng,C., Sun,D., Zhou,M., Xiang,H., Ren,Z. and Xu,A.
Identification and characterization of a novel O-superfamily conotoxin from Conus litteratus. J. Pept. Sci. (2008) 14: 1077-1083 [P, NA]
Wang,Q., Jiang,H., Han,Y.H., Yuan,D.D. and Chi,C.W.
Two different groups of signal sequence in M-superfamily conotoxins. Toxicon (2008) 51: 813-822 [P, NA]
Wang,Y., Shao,X., Li,M., Wang,S., Chi,C. and Wang,C.
mr1e, a conotoxin from Conus marmoreus with a novel disulfide pattern. Acta Biochim. Biophys. Sin. (Shanghai) (2008) 40: 391-396 [P, NA]
Whiteaker,P., Marks,M.J., Christensen,S., Dowell,C., Collins,A.C. and McIntosh,J.M.
Synthesis and characterization of 125I-alpha-conotoxin ArIB[V11L;V16A], a selective alpha7 nicotinic acetylcholine receptor antagonist. J. Pharmacol. Exp. Ther. (2008) 325: 910-919 [P, NA]
Yao,S., Zhang,M.M., Yoshikami,D., Azam,L., Olivera,B.M., Bulaj,G. and Norton,R.S.
Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA. Biochemistry (2008) 47: 10940-10949 [P, NA]
Yuan,D.D., Liu,L., Shao,X.X., Peng,C., Chi,C.W. and Guo,Z.Y.
Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus. Peptides (2008) 29: 1521-1525 [P, NA]
Zugasti-Cruz,A., Aguilar,M.B., Falcón,A., Olivera,B.M. and Heimer de la Cotera,E.P.
Two new 4-Cys conotoxins (framework 14) of the vermivorous snail Conus austini from the Gulf of Mexico with activity in the central nervous system of mice. Peptides (2008) 29: 179-185 [P, NA]

Aguilar,M.B., López-Vera,E., Heimer de la Cotera,E.P., Falcón,A., Olivera,B.M. and Maillo,M.
I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius. Peptides (2007) 28: 18-23 [P, NA]
Biggs,J.S., Rosenfeld,Y., Shai,Y. and Olivera,B.M.
Conolysin-Mt: a conus peptide that disrupts cellular membranes. Biochemistry (2007) 46: 12586-12593 [P, NA]
Bordia,T., Grady,S.R., McIntosh,J.M. and Quik,M.
Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson Mol. Pharmacol. (2007) 72: 52-61 [P, NA]
Buczek,O., Wei,D., Babon,J.J., Yang,X., Fiedler,B., Chen,P., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S.
Structure and sodium channel activity of an excitatory I1-superfamily conotoxin. Biochemistry (2007) 46: 9929-9940 [P, NA]
Cortez,L., Marino-Buslje,C., de Jiménez Bonino,M.B. and Hellman,U.
Interactions between alpha-conotoxin MI and the Torpedo marmorata receptor alpha-delta interface. Biochem. Biophys. Res. Commun. (2007) 355: 275-279 [P, NA]
Du,W.H., Han,Y.H., Huang,F.J., Li,J., Chi,C.W. and Fang,W.H.
Solution structure of an M-1 conotoxin with a novel disulfide linkage FEBS J. (2007) 274: 2596-2602 [P, NA]
Dutertre,S., Ulens,C., Büttner,R., Fish,A., van Elk,R., Kendel,Y., Hopping,G., Alewood,P.F., Schroeder,C., Nicke,A., Smit,A.B., Sixma,T.K. and Lewis,R.J.
AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. EMBO J. (2007) 26: 3858-3867 [P, NA]
Jimenez,E.C., Olivera,B.M. and Teichert,R.W.
AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists. Biochemistry (2007) 46: 8717-8724 [P, NA]
Jin,A.H., Brandstaetter,H., Nevin,S.T., Tan,C.C., Clark,R.J., Adams,D.J., Alewood,P.F., Craik,D.J. and Daly,N.L.
Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics. BMC Struct. Biol. (2007) 7: 28-0 [P, NA]
Kang,T.S., Radic,Z., Talley,T.T., Jois,S.D., Taylor,P. and Kini,R.M.
Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins. Biochemistry (2007) 46: 3338-3355 [P, NA]
Korukottu,J., Bayrhuber,M., Montaville,P., Vijayan,V., Jung,Y.S., Becker,S. and Zweckstetter,M.
Fast high-resolution protein structure determination by using unassigned NMR data. Angew. Chem. Int. Ed. Engl. (2007) 46: 1176-1179 [P, NA]
López-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano Cassulini,R., Batista,C.V., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B. and Wanke,E.
Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. (2007) 274: 3972-3985 [P, NA]
López-Vera,E., Jacobsen,R.B., Ellison,M., Olivera,B.M. and Teichert,R.W.
A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors Toxicon (2007) 49: 1193-1199 [P, NA]
Lewis,R.J., Schroeder,C.I., Ekberg,J., Nielsen,K.J., Loughnan,M., Thomas,L., Adams,D.A., Drinkwater,R., Adams,D.J. and Alewood,P.F.
Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels Mol. Pharmacol. (2007) 71: 676-685 [P, NA]
Liu,J., Wu,Q., Pi,C., Zhao,Y., Zhou,M., Wang,L., Chen,S. and Xu,A.
Isolation and characterization of a T-superfamily conotoxin from Conus litteratus with targeting tetrodotoxin-sensitive sodium channels. Peptides (2007) 28: 2313-2319 [P, NA]
Liu,L., Chew,G., Hawrot,E., Chi,C. and Wang,C.
Two potent alpha3/5 conotoxins from piscivorous Conus achatinus. Acta Biochim. Biophys. Sin. (Shanghai) (2007) 39: 438-444 [P, NA]
Luna-Ramirez,K.S., Aguilar,M.B., Falcon,A., Heimer de la Cotera,E.P., Olivera,B.M. and Maillo,M.
An O-conotoxin from the vermivorous Conus spurius active on mice and mollusks Peptides (2007) 28: 24-30 [P, NA]
Luo,S., Zhangsun,D., Feng,J., Wu,Y., Zhu,X. and Hu,Y.
Diversity of the O-superfamily conotoxins from Conus miles J. Pept. Sci. (2007) 13: 44-53 [P, NA]
Mandal,A.K., Ramasamy,M.R., Sabareesh,V., Openshaw,M.E., Krishnan,K.S. and Balaram,P.
Sequencing of T-superfamily conotoxins from Conus virgo: pyroglutamic acid identification and disulfide arrangement by MALDI mass spectrometry. J. Am. Soc. Mass Spectrom. (2007) 18: 1396-1404 [P, NA]
Moller,C. and Mari,F.
A vasopressin/oxytocin-related conopeptide with gamma-carboxyglutamate at position 8 Biochem. J. (2007) 404: 413-419 [P, NA]
Nevin,S.T., Clark,R.J., Klimis,H., Christie,M.J., Craik,D.J. and Adams,D.J.
Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Mol. Pharmacol. (2007) 72: 1406-1410 [P, NA]
Peng,C., Wu,X., Han,Y., Yuan,D., Chi,C. and Wang,C.
Identification of six novel T-1 conotoxins from Conus pulicarius by molecular cloning. Peptides (2007) 28: 2116-2124 [P, NA]
Teichert,R.W., Jacobsen,R., Terlau,H., Yoshikami,D. and Olivera,B.M.
Discovery and characterization of the short kappaA-conotoxins: a novel subfamily of excitatory conotoxins Toxicon (2007) 49: 318-328 [P, NA]
Teichert,R.W., Jimenez,E.C., Twede,V., Watkins,M., Hollmann,M., Bulaj,G. and Olivera,B.M.
Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. J. Biol. Chem. (2007) 282: 36905-36913 [P, NA]
Thakur,S.S. and Balaram,P.
Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom. Rapid Commun. Mass Spectrom. (2007) 21: 3420-3426 [P, NA]
Watkins, M., Hillyard, D.R., McIntosh, M.J., Jones, R.M. and Olivera, B.M.
Alpha-conotoxin peptides Patent: EP 1852440-A 07-NOV-2007; University of Utah Research Foundation (US); (2007) [P, NA]
Whiteaker, P., Christensen,S., Yoshikami,D., Dowell,C., Watkins,M., Gulyas,J., Rivier,J., Olivera,B.M. and McIntosh,J.M.
Discovery, Synthesis, and Structure Activity of a Highly Selective alpha7 Nicotinic Acetylcholine Receptor Antagonist Biochemistry (2007) 46: 6628-6638 [P, NA]
Yuan,D.D., Han,Y.H., Wang,C.G. and Chi,C.W.
From the identification of gene organization of alpha conotoxins to the cloning of novel toxins Toxicon (2007) 49: 1135-1149 [P, NA]
Zhang,M.M., Green,B.R., Catlin,P., Fiedler,B., Azam,L., Chadwick,A., Terlau,H., McArthur,J.R., French,R.J., Gulyas,J., Rivier,J.E., Smith,B.J., Norton,R.S., Olivera,B.M., Yoshikami,D. and Bulaj,G.
Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J. Biol. Chem. (2007) 282: 30699-30706 [P, NA]

Aguilar,M.B., Lezama-Monfil,L., Maillo,M., Pedraza-Lara,H., Lopez-Vera,E. and Heimer de la Cotera,E.P.
A biologically active hydrophobic T-1-conotoxin from the venom of Conus spurius Peptides (2006) 27: 500-505 [P, NA]
Armishaw,C.J., Daly,N.L., Nevin,S.T., Adams,D.J., Craik,D.J. and Alewood,P.F.
Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists J. Biol. Chem. (2006) 281: 14136-14143 [P, NA]
Bulaj,G., West,P.J., Garrett,J.E., Watkins,M., Zhang,M.-M., Norton,R.S., Smith,B.J., Yoshikami,D. and Olivera,B.M.
Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity. Biochemistry (2006) 45: 3116-0 [P, NA]
Bulaj,G., Zhang,M.M., Green,B.R., Fiedler,B., Layer,R.T., Wei,S., Nielsen,J.S., Low,S.J., Klein,B.D., Wagstaff,J.D., Chicoine,L., Harty,T.P., Terlau,H., Yoshikami,D. and Olivera,B.M.
Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity Biochemistry (2006) 45: 7404-7414 [P, NA]
Chen,W.H., Han,Y.H., Wang,Q., Miao,X.W., Ou,L. and Shao,X.X.
cDNA cloning of two novel T-superfamily conotoxins from Conus leopardus Acta Biochim. Biophys. Sin. (Shanghai) (2006) 38: 287-291 [P, NA]
Chen,W.H., Han,Y.H., Wang,Q., Miao,X.W., Ou,L. and Shao,X.X.
cDNA cloning of two novel T-superfamily conotoxins from Conus leopardus Acta Biochim. Biophys. Sin. (Shanghai) (2006) 38: 287-291 [P, NA]
Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H.
Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes Biochem. Biophys. Res. Commun. (2006) 345: 248-254 [P, NA]
Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H.
NMR structure determination of alpha-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold Biochem. Biophys. Res. Commun. (2006) 349: 1228-1234 [P, NA]
Clark,R.J., Fischer,H., Nevin,S.T., Adams,D.J. and Craik,D.J.
The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1 J. Biol. Chem. (2006) 281: 23254-23263 [P, NA]
Craik,D.J., Daly,N.L. and Nielsen,K.J.
Cyclized conotoxin peptides Patent: US 7001883-A 29 21-FEB-2006; The University of Queensland; Queensland; AU; (2006) [P, NA]
Croker D., Dutertre S., Alewood P., and Lewis R.
Discovery and pharmacology of conopressin-T, a novel vasopressin-like peptide from Conus tulipa. Acta Pharmacologica Sinica (2006) 27: 351-351 [P, NA]
Czerwiec,E., Kalume,D.E., Roepstorff,P., Hambe,B., Furie,B., Furie,B.C. and Stenflo,J.
Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile. FEBS J. (2006) 273: 2779-2788 [P, NA]
Drinkwater,R.D., Lewis,R.J., Alewood,P.F. and Nielsen,K.J.
Omega.conotoxin peptides Patent: US 7101849 05-SEP-2006 (2006) [P, NA]
Dutertre,S., Lumsden,N.G., Alewood,P.F. and Lewis,R.J.
Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail. FEBS Lett. (2006) 580: 3860-3866 [P, NA]
Dy,C.Y., Buczek,P., Imperial,J.S., Bulaj,G. and Horvath,M.P.
Structure of conkunitzin-S1, a neurotoxin and Kunitz-fold disulfide variant from cone snail. Acta Crystallogr. D Biol. Crystallogr. (2006) 62: 980-990 [P, NA]
Ellison,M., Haberlandt,C., Gomez-Casati,M.E., Watkins,M., Elgoyhen,A.B., McIntosh,J.M. and Olivera,B.M.
Alpha-RgIA: a novel conotoxin that specifically and potently blocks the alpha9alpha10 nAChR Biochemistry (2006) 45: 1511-1517 [P, NA]
Franco,A., Pisarewicz,K., Moller,C., Mora,D., Fields,G.B. and Mari,F.
Hyperhydroxylation: a new strategy for neuronal targeting by venomous marine molluscs Prog. Mol. Subcell. Biol. (2006) 43: 83-0 [P, NA]
Han,Y.H., Wang,Q., Jiang,H., Liu,L., Xiao,C., Yuan,D.D., Shao,X.X., Dai,Q.Y., Cheng,J.S. and Chi,C.W.
Characterization of novel M-superfamily conotoxins with new disulfide linkage FEBS J. (2006) 273: 4972-4982 [P, NA]
Imperial,J.S., Bansal,P.S., Alewood,P.F., Daly,N.L., Craik,D.J., Sporning,A., Terlau,H., Lopez-Vera,E., Bandyopadhyay,P.K. and Olivera,B.M.
A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins Biochemistry (2006) 45: 8331-8340 [P, NA]
Jakubowski,J.A., Kelley,W.P. and Sweedler,J.V.
Screening for post-translational modifications in conotoxins using liquid chromatography/mass spectrometry: an important component of conotoxin discovery Toxicon (2006) 47: 688-699 [P, NA]
Jiang,H., Wang,C.Z., Xu,C.Q., Fan,C.X., Dai,X.D., Chen,J.S. and Chi,C.W.
A novel M-superfamily conotoxin with a unique motif from Conus vexillum Peptides (2006) 27: 682-689 [P, NA]
Jiang,H., Xu,C.Q., Wang,C.Z., Fan,C.X., Zhao,T.Y., Chen,J.S. and Chi,C.W.
Two novel O-superfamily conotoxins from Conus vexillum Toxicon (2006) 47: 425-436 [P, NA]
Kang,T.S., Jois,S.D. and Kini,R.M.
Solution structures of two structural isoforms of CMrVIA chi/lambda-conotoxin Biomacromolecules (2006) 7: 2337-2346 [P, NA]
Kasheverov,I.E., Chiara,D.C., Zhmak,M.N., Maslennikov,I.V., Pashkov,V.S., Arseniev,A.S., Utkin,Y.N., Cohen,J.B. and Tsetlin,V.I.
alpha-Conotoxin GI benzoylphenylalanine derivatives. (1)H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor FEBS J. (2006) 273: 1373-1388 [P, NA]
Kelley,W.P., Schulz,J.R., Jakubowski,J.A., Gilly,W.F. and Sweedler,J.V.
Two toxins from Conus striatus that individually induce tetanic paralysis. Biochemistry (2006) 45: 14212-14222 [P, NA]
Loughnan,M., Nicke,A., Jones,A., Schroeder,C.I., Nevin,S.T., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum J. Biol. Chem. (2006) 281: 24745-24755 [P, NA]
Lovelace,E.S., Armishaw,C.J., Colgrave,M.L., Wahlstrom,M.E., Alewood,P.F., Daly,N.L. and Craik,D.J.
Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter J. Med. Chem. (2006) 49: 6561-6568 [P, NA]
Luo,S., Zhangsun,D., Lin,Q., Xie,L., Wu,Y. and Zhu,X.
Sequence diversity of O-superfamily conopetides from Conus marmoreus native to Hainan Peptides (2006) 27: 3058-3068 [P, NA]
Luo,S., Zhangsun,D., Wu,Y., Zhu,X., Xie,L., Hu,Y., Zhang,J. and Zhao,X.
Identification and molecular diversity of T-superfamily conotoxins from Conus lividus and Conus litteratus Chem Biol Drug Des (2006) 68: 97-106 [P, NA]
Luo,S., Zhangsun,D., Zhang,B., Chen,X. and Feng,J.
Direct cDNA cloning of novel conotoxins of the T-superfamily from Conus textile Peptides (2006) 27: 2640-2646 [P, NA]
Luo,S., Zhangsun,D., Zhang,B., Quan,Y. and Wu,Y.
Novel alpha-conotoxins identified by gene sequencing from cone snails native to Hainan, and their sequence diversity J. Pept. Sci. (2006) 12: 693-704 [P, NA]
Mondal,S., Babu,R.M., Bhavna,R. and Ramakumar,S.
I-conotoxin superfamily revisited J. Pept. Sci. (2006) 12: 679-685 [P, NA]
Nair,S.S., Nilsson,C.L., Emmett,M.R., Schaub,T.M., Gowd,K.H., Thakur,S.S., Krishnan,K.S., Balaram,P. and Marshall,A.G.
De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry Anal. Chem. (2006) 78: 8082-8088 [P, NA]
Conus peptides: biodiversity-based discovery and exogenomics. J. Biol. Chem. (2006) 281: 31173-31177 [P, NA]
Peng,C., Tang,S., Pi,C., Liu,J., Wang,F., Wang,L., Zhou,W. and Xu,A.
Discovery of a novel class of conotoxin from Conus litteratus, lt14a, with a unique cysteine pattern Peptides (2006) 27: 2174-2181 [P, NA]
Pi,C., Liu,J., Peng,C., Liu,Y., Jiang,X., Zhao,Y., Tang,S., Wang,L., Dong,M., Chen,S. and Xu,A.
Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus Genomics (2006) 88: 809-819 [P, NA]
Pi,C., Liu,Y., Peng,C., Jiang,X., Liu,J., Xu,B., Yu,X., Yu,Y., Jiang,X., Wang,L., Dong,M., Chen,S. and Xu,A.L.
Analysis of expressed sequence tags from the venom ducts of Conus striatus: focusing on the expression profile of conotoxins Biochimie (2006) 88: 131-140 [P, NA]
Quinton,L., Le Caer,J.P., Vinh,J., Gilles,N. and Chamot-Rooke,J.
Fourier transform mass spectrometry: a powerful tool for toxin analysis Toxicon (2006) 47: 715-726 [P, NA]
Sabareesh,V., Gowd,K.H., Ramasamy,P., Sudarslal,S., Krishnan,K.S., Sikdar,S.K. and Balaram,P.
Characterization of contryphans from Conus loroisii and Conus amadis that target calcium channels Peptides (2006) 27: 2647-2654 [P, NA]
Shiembob,D.L., Roberts,R.L., Luetje,C.W. and McIntosh,J.M.
Determinants of alpha-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor beta subunit. Biochemistry (2006) 45: 11200-11207 [P, NA]
Talley,T.T., Olivera,B.M., Han,K.H., Christensen,S.B., Dowell,C., Tsigelny,I., Ho,K.Y., Taylor,P. and McIntosh,J.M.
Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors J. Biol. Chem. (2006) 281: 24678-24686 [P, NA]
Teichert,R.W., Lopez-Vera,E., Gulyas,J., Watkins,M., Rivier,J. and Olivera,B.M.
Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor Biochemistry (2006) 45: 1304-1312 [P, NA]
Ulens,C., Hogg,R.C., Celie,P.H., Bertrand,D., Tsetlin,V., Smit,A.B. and Sixma,T.K.
Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP Proc. Natl. Acad. Sci. U.S.A. (2006) 103: 3615-3620 [P, NA]
Vincler,M., Wittenauer,S., Parker,R., Ellison,M., Olivera,B.M. and McIntosh,J.M.
Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors. Proc. Natl. Acad. Sci. U.S.A. (2006) 103: 17880-17884 [P, NA]
Wang,C.Z., Zhang,H., Jiang,H., Lu,W., Zhao,Z.Q. and Chi,C.W.
A novel conotoxin from Conus striatus, mu-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels Toxicon (2006) 47: 122-132 [P, NA]
Watkins,M. and Olivera,B.M.
Genes expressed in a turrid venom duct: divergence and similarity to conotoxins. J. Mol. Evol. (2006) 62: 247-256 [P, NA]
Zhang,M.M., Fiedler,B., Green,B.R., Catlin,P., Watkins,M., Garrett,J.E., Smith,B.J., Yoshikami,D., Olivera,B.M. and Bulaj,G.
Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels Biochemistry (2006) 45: 3723-3732 [P, NA]
Zhangsun, D., Luo, S., Wu, Y., Zhu, X., Hu, Y. and Xie, L.
Novel O-superfamily conotoxins identified by cDNA cloning from three vermivorous Conus species. Chem Biol Drug Des. (2006) 68: 256-265 [P, NA]
Zorn,S., Leipold,E., Hansel,A., Bulaj,G., Olivera,B.M., Terlau,H. and Heinemann,S.H.
The muO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3 FEBS Lett. (2006) 580: 1360-1364 [P, NA]
Zugasti-Cruz,A., Maillo,M., Lopez-Vera,E., Falcon,A., Heimer de la Cotera,E.P., Olivera,B.M. and Aguilar,M.B.
Amino acid sequence and biological activity of a gamma-conotoxin-like peptide from the worm-hunting snail Conus austini Peptides (2006) 27: 506-511 [P, NA]

Aguilar,M.B., López-Vera,E., Imperial,J.S., Falcón,A., Olivera,B.M. and de la Cotera,E.P.
Putative gamma-conotoxins in vermivorous cone snails: the case of Conus delessertii Peptides (2005) 26: 23-27 [P, NA]
Aguilar,M.B., López-Vera,E., Ortiz,E., Becerril,B., Possani,L.D., Olivera,B.M. and Heimer de la Cotera,E.P.
A novel conotoxin from Conus delessertii with posttranslationally modified lysine residues Biochemistry (2005) 44: 11130-11136 [P, NA]
Azam,L., Dowell,C., Watkins,M., Stitzel,J.A., Olivera,B.M. and McIntosh,J.M.
Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors J. Biol. Chem. (2005) 280: 80-87 [P, NA]
Bayrhuber,M., Vijayan,V., Ferber,M., Graf,R., Korukottu,J., Imperial,J., Garrett,J.E., Olivera,B.M., Terlau,H., Zweckstetter,M. and Becker,S.
Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization. J. Biol. Chem. (2005) 280: 23766-23770 [P, NA]
Bingham,J.P., Broxton,N.M., Livett,B.G., Down,J.G., Jones,A. and Moczydlowski,E.G.
Optimizing the connectivity in disulfide-rich peptides: alpha-conotoxin SII as a case study Anal. Biochem. (2005) 338: 48-61 [P, NA]
Brown,M.A., Begley,G.S., Czerwiec,E., Stenberg,L.M., Jacobs,M., Kalume,D.E., Roepstorff,P., Stenflo,J., Furie,B.C. and Furie,B.
Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation Biochemistry (2005) 44: 9150-9159 [P, NA]
Buczek,O., Yoshikami,D., Bulaj,G., Jimenez,E.C. and Olivera,B.M.
Post-translational amino acid isomerization: a functionally important D-amino acid in an excitatory peptide J. Biol. Chem. (2005) 280: 4247-4253 [P, NA]
Buczek,O., Yoshikami,D., Watkins,M., Bulaj,G., Jimenez,E.C. and Olivera,B.M.
Characterization of D-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily FEBS J. (2005) 272: 4178-4188 [P, NA]
Bulaj,G., West,P.J., Garrett,J.E., Watkins,M., Zhang,M.M., Norton,R.S., Smith,B.J., Yoshikami,D. and Olivera,B.M.
Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels Biochemistry (2005) 44: 7259-7265 [P, NA]
Celie,P.H., Kasheverov,I.E., Mordvintsev,D.Y., Hogg,R.C., van Nierop,P., van Elk,R., van Rossum-Fikkert,S.E., Zhmak,M.N., Bertrand,D., Tsetlin,V., Sixma,T.K. and Smit,A.B.
Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant Nat. Struct. Mol. Biol. (2005) 12: 582-588 [P, NA]
Chi,S.W., Lee,S.H., Kim,D.H., Kim,J.S., Olivera,B.M., McIntosh,J.M. and Han,K.H.
Solution structure of alpha-conotoxin PIA, a novel antagonist of alpha6 subunit containing nicotinic acetylcholine receptors Biochem. Biophys. Res. Commun. (2005) 338: 1990-1997 [P, NA]
Clark,R.J., Fischer,H., Dempster,L., Daly,N.L., Rosengren,K.J., Nevin,S.T., Meunier,F.A., Adams,D.J. and Craik,D.J.
Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII Proc. Natl. Acad. Sci. U.S.A. (2005) 102: 13767-13772 [P, NA]
Corpuz,G.P., Jacobsen,R.B., Jimenez,E.C., Watkins,M., Walker,C., Colledge,C., Garrett,J.E., McDougal,O., Li,W., Gray,W.R., Hillyard,D.R., Rivier,J., McIntosh,J.M., Cruz,L.J. and Olivera,B.M.
Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms Biochemistry (2005) 44: 8176-8186 [P, NA]
Dutertre,S., Nicke,A., and Lewis,R.J.
Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor. J. Biol. Chem. (2005) 280: 30460-30468 [P, NA]
Gowd,K.H., Sabareesh,V., Sudarslal,S., Iengar,P., Franklin,B., Fernando,A., Dewan,K., Ramaswami,M., Sarma,S.P., Sikdar,S., Balaram,P. and Krishnan,K.S.
Novel peptides of therapeutic promise from Indian Conidae Ann. N. Y. Acad. Sci. (2005) 1056: 462-0 [P, NA]
Han,Y.H., Wang,Q., Jiang,H., Miao,X.W., Chen,J.S. and Chi,C.W.
Sequence diversity of T-superfamily conotoxins from Conus marmoreus Toxicon (2005) 45: 481-487 [P, NA]
Hansen,S.B., Sulzenbacher,G., Huxford,T., Marchot,P., Taylor,P. and Bourne,Y.
Structures Of Aplysia Achbp Complexes With Nicotinic Agonists And Antagonists Reveal Distinctive Binding Interfaces And Conformations Embo J. (2005) 24: 3635-0 [P, NA]
Huang,X., Dong,F. and Zhou,H.X.
Electrostatic recognition and induced fit in the kappa-PVIIA toxin binding to Shaker potassium channel. J. Am. Chem. Soc. (2005) 127: 6836-6849 [P, NA]
Kauferstein,S., Melaun,C. and Mebs,D.
Direct cDNA cloning of novel conopeptide precursors of the O-superfamily Peptides (2005) 26: 361-367 [P, NA]
Lang,P.M., Burgstahler,R., Haberberger,R.V., Sippel,W. and Grafe,P.
A conus peptide blocks nicotinic receptors of unmyelinated axons in human nerves Neuroreport (2005) 16: 479-483 [P, NA]
Leipold,E., Hansel,A., Olivera,B.M., Terlau,H. and Heinemann,S.H.
Molecular interaction of delta-conotoxins with voltage-gated sodium channels FEBS Lett. (2005) 579: 3881-3884 [P, NA]
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A novel conotoxin framework with a helix-loop-helix (Cs alpha/alpha) fold Biochemistry (2005) 44: 15986-15996 [P, NA]
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Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain Pain (2005) 118: 112-124 [P, NA]
Nilsson,K.P., Lovelace,E.S., Caesar,C.E., Tynngard,N., Alewood,P.F., Johansson,H.M., Sharpe,I.A., Lewis,R.J., Daly,N.L. and Craik,D.J.
Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter Biopolymers (2005) 80: 815-823 [P, NA]
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Polypeptide chains containing D-gamma-hydroxyvaline J. Am. Chem. Soc. (2005) 127: 6207-6215 [P, NA]
Sarma,S.P., Kumar,G.S., Sudarslal,S., Iengar,P., Ramasamy,P., Sikdar,S.K., Krishnan,K.S. and Balaram,P.
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Satkunanathan,N., Livett,B., Gayler,K., Sandall,D., Down,J. and Khalil,Z.
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Teichert,R.W., Jimenez,E.C. and Olivera,B.M.
Alpha S-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors Biochemistry (2005) 44: 7897-7902 [P, NA]
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A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor J. Neurosci. (2005) 25: 732-736 [P, NA]
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Mass spectrometric and high performance liquid chromatography profiling of the venom of the Brazilian vermivorous mollusk Conus regius: feeding behavior and identification of one novel conotoxin Toxicon (2005) 45: 113-122 [P, NA]
Wen,L., Yang,S., Qiao,H., Liu,Z., Zhou,W., Zhang,Y. and Huang,P.
SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons Br. J. Pharmacol. (2005) 145: 728-739 [P, NA]
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Al-Sabi,A., Lennartz,D., Ferber,M., Gulyas,J., Rivier,J.E., Olivera,B.M., Carlomagno,T. and Terlau,H.
KappaM-conotoxin RIIIK, structural and functional novelty in a K+ channel antagonist. Biochemistry (2004) 43: 8625-8635 [P, NA]
Barbier,J., Lamthanh,H., Le Gall,F., Favreau,P., Benoit,E., Chen,H., Gilles,N., Ilan,N., Heinemann,S.H., Gordon,D., Menez,A. and Molgo,J.
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Chen,Z., Rogge,G., Hague,C., Alewood,D., Colless,B., Lewis,R.J. and Minneman,K.P.
Subtype-selective noncompetitive or competitive inhibition of human alpha1-adrenergic receptors by rho-TIA J. Biol. Chem. (2004) 279: 35326-35333 [P, NA]
Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H.
Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors Biochem. J. (2004) 380: 347-352 [P, NA]
Chierici,S., Jourdan,M., Figuet,M. and Dumy,P.
A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a [small delta]-conotoxin EVIA peptide analog Org. Biomol. Chem. (2004) 2: 2437-2441 [P, NA]
Craig,A.G., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J., Cruz,L.J., Wagstaff,J.D., Layer,R.T., Jones,R.M. and McCabe,R.T.
Contulakin-G, analogs thereof and uses therefor Patent: US 6696408 24-FEB-2004 (2004) [P, NA]
Daly,N.L., Ekberg,J.A., Thomas,L., Adams,D.J., Lewis,R.J. and Craik,D.J.
Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons J. Biol. Chem. (2004) 279: 25774-25782 [P, NA]
Duda,T.F. Jr. and Palumbi,S.R.
Gene expression and feeding ecology: evolution of piscivory in the venomous gastropod genus Conus. Proc. Biol. Sci. (2004) 271: 1165-1174 [P, NA]
Eliseo,T., Cicero,D.O., Romeo,C., Schinina,M.E., Massilia,G.R., Polticelli,F., Ascenzi,P. and Paci,M.
Solution structure of the cyclic peptide contryphan-Vn, a Ca2+-dependent K+ channel modulator Biopolymers (2004) 74: 189-198 [P, NA]
Ellison,M., Gao,F., Wang,H.L., Sine,S.M. and Olivera,B.M.
Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. Biochemistry (2004) 43: 16019-16026 [P, NA]
Everhart,D., Cartier,G.E., Malhotra,A., Gomes,A.V., McIntosh,J.M. and Luetje,C.W.
Determinants of potency on alpha-conotoxin MII, a peptide antagonist of neuronal nicotinic receptors Biochemistry (2004) 43: 2732-2737 [P, NA]
Grant,M.A., Hansson,K., Furie,B.C., Furie,B., Stenflo,J. and Rigby,A.C.
The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M J. Biol. Chem. (2004) 279: 32464-32473 [P, NA]
Hansson,K., Furie,B., Furie,B.C. and Stenflo,J.
Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern Biochem. Biophys. Res. Commun. (2004) 319: 1081-1087 [P, NA]
Hansson,K., Ma,X., Eliasson,L., Czerwiec,E., Furie,B., Furie,B.C., Rorsman,P. and Stenflo,J.
The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. J. Biol. Chem. (2004) 279: 32453-32463 [P, NA]
Hansson,K., Ma,X., Eliasson,L., Czerwiec,E., Furie,B., Furie,B.C., Rorsman,P. and Stenflo,J.
The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. J. Biol. Chem. (2004) 279: 32453-32463 [P, NA]
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Sequencing and mass profiling highly modified conotoxins using global reduction/alkylation followed by mass spectrometry Anal. Chem. (2004) 76: 6541-6547 [P, NA]
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Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry J Mass Spectrom (2004) 39: 548-557 [P, NA]
Jimenez,E.C., Watkins,M. and Olivera,B.M.
Multiple 6-bromotryptophan residues in a sleep-inducing peptide Biochemistry (2004) 43: 12343-12348 [P, NA]
Kauferstein,S., Huys,I., Kuch,U., Melaun,C., Tytgat,J. and Mebs,D.
Novel conopeptides of the I-superfamily occur in several clades of cone snails Toxicon (2004) 44: 539-548 [P, NA]
Loughnan,M.L., Nicke,A., Jones,A., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone J. Med. Chem. (2004) 47: 1234-1241 [P, NA]
McDougal,O.M. and Dale Poulter,C.
Three-dimensional structure of the mini-M conotoxin mr3a Biochemistry (2004) 43: 425-429 [P, NA]
McIntosh,J.M., Azam,L., Staheli,S., Dowell,C., Lindstrom,J.M., Kuryatov,A., Garrett,J.E., Marks,M.J. and Whiteaker,P.
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McIntosh,J.M., Olivera,B.M., Cruz,L.J., Corpuz,G.P., Jones,R.M. and Garrett,J.E.
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Ziconotide: neuronal calcium channel blocker for treating severe chronic pain Curr. Med. Chem. (2004) 11: 3029-3040 [P, NA]
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The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. J. Biol. Chem. (2004) 279: 34705-34714 [P, NA]
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The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels J. Biol. Chem. (2004) 279: 34705-34714 [P, NA]
Olivera,B.M., Cartier,G.E., Watkins,M., Hillyard,D.R., McIntosh,J.M., Layer,R.T. and Jones,R.M.
O-superfamily conotoxin peptides Patent: US 6762165-A 282 13-JUL-2004; University of Utah Research Foundation and Cognetix, Inc.; Salt Lake City, UT (2004) [P, NA]
Olivera,B.M., McIntosh,J.M., Garrett,J.E., Cruz,L.J., Jones,R.M., Cartier,G.E. and Wagstaff,J.D.
Mu-conopeptides Patent: US 6727226-A 80 27-APR-2004; University of Utah Research Foundation and Cognetix, Inc.; Salt Lake City, UT (2004) [P, NA]
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The A-superfamily of conotoxins: structural and functional divergence J. Biol. Chem. (2004) 279: 17596-17606 [P, NA]
Teichert,R.W., Rivier,J., Dykert,J., Cervini,L., Gulyas,J., Bulaj,G., Ellison,M. and Olivera,B.M.
AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors Toxicon (2004) 44: 207-214 [P, NA]
Volpon,L., Lamthanh,H., Barbier,J., Gilles,N., Molgo,J., Menez,A. and Lancelin,J.M.
NMR solution structures of delta-conotoxin EVIA from Conus ermineus that selectively acts on vertebrate neuronal Na+ channels J. Biol. Chem. (2004) 279: 21356-21366 [P, NA]
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Wang,C.Z., Ou,Z.L. and Chi,C.W.
Gene cloning and functional studies of alpha conotoxin SII (Unpublished) [P, NA]

Watkins,M., Olivera,B.M., Hillyard,D.R., McIntosh,M.J. and Jones,R.M.
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Adams,D.J., Smith,A.B., Schroeder,C.I., Yasuda,T. and Lewis,R.J.
Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals J. Biol. Chem. (2003) 278: 4057-4062 [P, NA]
Blanchfield JT, Dutton JL, Hogg RC, Gallagher OP, Craik DJ, Jones A, Adams DJ, Lewis RJ, Alewood PF, Toth I
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chi-Conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter J. Biol. Chem. (2003) 278: 40324-40329 [P, NA]
Chi,S.W., Park,K.H., Suk,J.E., Olivera,B.M., McIntosh,J.M. and Han,K.H.
Solution conformation of alphaA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineus J. Biol. Chem. (2003) 278: 42208-42213 [P, NA]
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The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus J. Nat. Prod. (2003) 66: 1276-1279 [P, NA]
Dowell,C., Olivera,B.M., Garrett,J.E., Staheli,S.T., Watkins,M., Kuryatov,A., Yoshikami,D., Lindstrom,J.M. and McIntosh,J.M.
Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors J. Neurosci. (2003) 23: 8445-8452 [P, NA]
Ellison,M.A., McIntosh,J.M. and Olivera,B.M.
alpha-Conotoxins ImI and ImII: similar alpha 7 nicotinic receptor antagonists act at different sites J. Biol. Chem. (2003) 278: 757-764 [P, NA]
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Fan,C.X., Chen,X.K., Zhang,C., Wang,L.X., Duan,K.L., He,L.L., Cao,Y., Liu,S.Y., Zhong,M.N., Ulens,C., Tytgat,J., Chen,J.S., Chi,C.W. and Zhou,Z.
A Novel Conotoxin from Conus betulinus, kappa -BtX, Unique in Cysteine Pattern and in Function as a Specific BK Channel Modulator J. Biol. Chem. (2003) 278: 12624-12633 [P, NA]
Ferber,M., Sporning,A., Jeserich,G., DeLaCruz,R., Watkins,M., Olivera,B.M. and Terlau,H.
A novel conus peptide ligand for K+ channels J. Biol. Chem. (2003) 278: 2177-2183 [P, NA]
Hillyard, D.R., Mcintosh, M.J., Jones, R.M., Cartier, E.G., Watkins, M., Olivera, B.M. and Layer, R.T.
O-Superfamily Conotoxin Peptides Patent: JP 2003533178-A 1 11-NOV-2003; (2003) [P, NA]
Hogg,R.C., Hopping,G., Alewood,P.F., Adams,D.J. and Bertrand,D.
Alpha-conotoxins PnIA and [A10L]PnIA stabilize different states of the alpha7-L247T nicotinic acetylcholine receptor. J. Biol. Chem. (2003) 278: 26908-26914 [P, NA]
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Novel excitatory Conus peptides define a new conotoxin superfamily J. Neurochem. (2003) 85: 610-621 [P, NA]
Kauferstein,S., Huys,I., Lamthanh,H., Stocklin,R., Sotto,F., Menez,A., Tytgat,J. and Mebs,D.
A novel conotoxin inhibiting vertebrate voltage-sensitive potassium channels Toxicon (2003) 42: 43-52 [P, NA]
Keizer,D.W., West,P.J., Lee,E.F., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S.
Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA J. Biol. Chem. (2003) 278: 46805-46813 [P, NA]
Kim, J.I., Song, W.K. and Park, Y.
Double mutant omega conotoxin GVIA epitope and its monoclonalantibody Patent: KR 1020030017307-A 2 20-MAR-2003; (2003) [P, NA]
Makino,K., Oshima,K., Kurokawa,K., Yokoyama,K., Uda,T., Tagomori,K., Iijima,Y., Najima,M., Nakano,M., Yamashita,A., Kubota,Y., Kimura,S., Yasunaga,T., Honda,T., Shinagawa,H., Hattori,M. and Iida,T.
Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V cholerae Lancet (2003) 361: 743-749 [P, NA]
Malmberg,A.B., Gilbert,H., McCabe,R.T. and Basbaum,A.I.
Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T Pain (2003) 101: 109-116 [P, NA]
Massilia,G.R., Eliseo,T., Grolleau,F., Lapied,B., Barbier,J., Bournaud,R., Molgo,J., Cicero,D.O., Paci,M., Schinina,M.E., Ascenzi,P. and Polticelli,F.
Contryphan-Vn: a modulator of Ca2+-dependent K+ channels Biochem. Biophys. Res. Commun. (2003) 303: 238-246 [P, NA]
Nicke,A., Loughnan,M.L., Millard,E.L., Alewood,P.F., Adams,D.J., Daly,N.L., Craik,D.J. and Lewis,R.J.
Isolation, Structure, and Activity of GID, a Novel alpha 4/7-Conotoxin with an Extended N-terminal Sequence J. Biol. Chem. (2003) 278: 3137-3144 [P, NA]
Nicke,A., Samochocki,M., Loughnan,M.L., Bansal,P.S., Maelicke,A. and Lewis,R.J.
Alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors. FEBS Lett. (2003) 554: 219-223 [P, NA]
Olivera,B.M., Layer,R.T., Watkins,M., Hillyard,D.R., Mcintosh,M.J., Jones,R.M. and Schoenfeld,R.
Alpha Conotoxin Peptides JP 2003525582-A 3 02-SEP-2003 (2003) [P, NA]
Sandall,D.W., Satkunanathan,N., Keays,D.A., Polidano,M.A., Liping,X., Pham,V., Down,J.G., Khalil,Z., Livett,B.G. and Gayler,K.R.
A novel alpha-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo Biochemistry (2003) 42: 6904-6911 [P, NA]
Sharpe,I.A., Palant,E., Schroeder,C.I., Kaye,D.M., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship J. Biol. Chem. (2003) 278: 40317-40323 [P, NA]
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Sudarslal,S., Majumdar,S., Ramasamy,P., Dhawan,R., Pal,P.P., Ramaswami,M., Lala,A.K., Sikdar,S.K., Sarma,S.P., Krishnan,K.S. and Balaram,P.
Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail FEBS Lett. (2003) 553: 209-212 [P, NA]
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An improved solution structure for psi-conotoxin PiiiE. Biochemistry (2003) 42: 6347-6352 [P, NA]
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Characterization and three-dimensional structure determination of psi-conotoxin Piiif, a novel noncompetitive antagonist of nicotinic acetylcholine receptors Biochemistry (2003) 42: 6353-6362 [P, NA]
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cDNA cloning of two A-superfamily conotoxins from Conus striatus Toxicon (2003) 42: 613-619 [P, NA]
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Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats. Exp Brain Res (2003) 153: 16-26 [P, NA]
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Three-Dimensional Solution Structure Of W-Conotoxin So3 Determined By 1h Nmr Chin.Sci.Bull. (2003) 48: 1097-0 [P, NA]
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Craig,A.G., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J., Cruz,L.J., Wagstaff,J.D., Layer,R.T., Jones,R.M. and McCabe,R.T.
Contulakin-G, analogs thereof and uses thereof Patent: US 6489298 03-DEC-2002 (2002) [P, NA]
Craig,A.Grey., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J. and Cruz,L.J.
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Craig,G.A., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J., Cruz,L.J., Wagstaff,J.D., Layer,R.T., Jones,R.M. and Mccabe,T.R.
Contulakin-G, its analogues and utilization thereof Patent: JP 2002527093-A 2 27-AUG-2002 (2002) [P, NA]
Drinkwater,R.D., Lewis,R.J., Alewood,P.F. and Nielsen,K.J.
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Dutton,J.L., Bansal,P.S., Hogg,R.C., Adams,D.J., Alewood,P.F. and Craik,D.J.
A New Level of Conotoxin Diversity, a Non-native Disulfide Bond Connectivity in alpha -Conotoxin AuIB Reduces Structural Definition but Increases Biological Activity J. Biol. Chem. (2002) 277: 48849-48857 [P, NA]
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Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency Epilepsy Res. (2002) 51: 73-80 [P, NA]
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1H NMR studies on the solution conformation of contulakin-G and analogues Can. J. Chem. (2002) 80: 1022-1031 [P, NA]
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Conorfamide, a Conus venom peptide belonging to the RFamide family of neuropeptides Toxicon (2002) 40: 401-407 [P, NA]
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Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors J. Biol. Chem. (2002) 277: 33610-33615 [P, NA]
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Structure of a Novel P-superfamily Spasmodic Conotoxin Reveals an Inhibitory Cystine Knot Motif J. Biol. Chem. (2002) 277: 43033-43040 [P, NA]
Inhibition of single Shaker K channels by kappa-conotoxin-PVIIA Biophys. J. (2002) 82: 3003-3011 [P, NA]
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Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels J. Biol. Chem. (2002) 277: 27247-27255 [P, NA]
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Mu-conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons Biochemistry (2002) 41: 15388-15393 [P, NA]
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Intrathecal CGX-1007 is neuroprotective in a rat model of focal cerebral ischemia. Neuroreport (2002) 13: 821-824 [P, NA]

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Delta-conotoxin structure/function through a cladistic analysis Biochemistry (2001) 40: 13201-13208 [P, NA]
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A new omega-conotoxin that targets N-type voltage-sensitive calcium channels with unusual specificity Biochemistry (2001) 40: 14567-14575 [P, NA]
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The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors J. Biol. Chem. (2001) 276: 26860-26867 [P, NA]
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Contryphan-Vn: a novel peptide from the venom of the Mediterranean snail Conus ventricosus Biochem. Biophys. Res. Commun. (2001) 288: 908-913 [P, NA]
Molecular simulation of the interaction of kappa-conotoxin-PVIIA with the Shaker potassium channel pore Eur. Biophys. J. (2001) 30: 528-536 [P, NA]
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Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the alpha 1/delta subunit interface of torpedo nicotinic acetylcholine receptor J. Biol. Chem. (2001) 276: 49028-49033 [P, NA]
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Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter Nat. Neurosci. (2001) 4: 902-907 [P, NA]

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Human alpha6 AChR subtypes: subunit composition, assembly, and pharmacological responses Neuropharmacology (2000) 39: 2570-2590 [P, NA]
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The spasmodic peptide defines a new conotoxin superfamily Biochemistry (2000) 39: 1583-1588 [P, NA]
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Hydrophobic amino acids define the carboxylation recognition site in the precursor of the gamma-carboxyglutamic-acid-containing conotoxin epsilon-TxIX from the marine cone snail Conus textile. Biochemistry (1999) 38: 14660-14666 [P, NA]
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Solution structure determination by two-dimensional 1H NMR of omega-conotoxin MVIID, a calcium channel blocker peptide Biochem. Biophys. Res. Commun. (1999) 254: 32-35 [P, NA]
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Contulakin-G, an O-glycosylated invertebrate neurotensin J. Biol. Chem. (1999) 274: 13752-13759 [P, NA]
Duda,T.F. Jr. and Palumbi,S.R.
Molecular genetics of ecological diversification: duplication and rapid evolution of toxin genes of the venomous gastropod Conus Proc. Natl. Acad. Sci. U.S.A. (1999) 96: 6820-6823 [P, NA]
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Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors Biochemistry (1999) 38: 6317-6326 [P, NA]
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A marine snail neurotoxin shares with scorpion toxins a convergent mechanism of blockade on the pore of voltage-gated K channels. J. Gen. Physiol. (1999) 114: 141-157 [P, NA]
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Solution structure of alpha-conotoxin ImI determined by two-dimensional NMR spectroscopy Biochim. Biophys. Acta (1999) 1431: 384-394 [P, NA]
Hogg,R.C., Miranda,L.P., Craik,D.J., Lewis,R.J., Alewood,P.F. and Adams,D.J.
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Jacobsen,R.B., Jimenez,E.C., De la Cruz,R.G., Gray,W.R., Cruz,L.J. and Olivera,B.M.
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A new conotoxin isolated from Conus consors venom acting selectively on axons and motor nerve terminals through a Na+-dependent mechanism Eur. J. Neurosci. (1999) 11: 3134-3142 [P, NA]
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Maslennikov,I.V., Shenkarev,Z.O., Zhmak,M.N., Ivanov,V.T., Methfessel,C., Tsetlin,V.I. and Arseniev,A.S.
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NMR solution conformation of an antitoxic analogue of alpha-conotoxin GI: identification of a common nicotinic acetylcholine receptor alpha 1-subunit binding surface for small ligands and alpha-conotoxins Biochemistry (1999) 38: 11895-11904 [P, NA]
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An O-glycosylated neuroexcitatory conus peptide Biochemistry (1998) 37: 16019-16025 [P, NA]
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Hu,S.H., Loughnan,M., Miller,R., Weeks,C.M., Blessing,R.H., Alewood,P.F., Lewis,R.J. and Martin,J.L.
The 1.1 A resolution crystal structure of [Tyr15]EpI, a novel alpha-conotoxin from Conus episcopatus, solved by direct methods Biochemistry (1998) 37: 11425-11433 [P, NA]
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Miljanich,G.P., Bitner,R.S., Bowersox,S.S., Fox,J.A., Valentino,K.L. and Yamashiro,D.H.
Patent: 5051403, -US 24-SEP-1991; (1991) [P, NA]
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alpha-Conotoxins, small peptide probes of nicotinic acetylcholine receptors Biochemistry (1991) 30: 9370-9377 [P, NA]
Ott,K.H., Becker,S., Gordon,R.D. and Ruterjans,H.
Solution structure of mu-conotoxin GIIIA analysed by 2D-NMR and distance geometry calculations FEBS Lett. (1991) 278: 160-166 [P, NA]

Haack,J.A., Rivier,J., Parks,T.N., Mena,E.E., Cruz,L.J. and Olivera,B.M.
Conantokin-T. A gamma-carboxyglutamate containing peptide with N-methyl-d-aspartate antagonist activity J. Biol. Chem. (1990) 265: 6025-6029 [P, NA]
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Diversity of Conus neuropeptides Science (1990) 249: 257-263 [P, NA]
Woodward,S.R., Cruz,L.J., Olivera,B.M. and Hillyard,D.R.
Constant and hypervariable regions in conotoxin propeptides EMBO J. (1990) 9: 1015-1020 [P, NA]

Hillyard,D.R., Olivera,B.M., Woodward,S., Corpuz,G.P., Gray,W.R., Ramilo,C.A. and Cruz,L.J.
A molluscivorous Conus toxin: conserved frameworks in conotoxins Biochemistry (1989) 28: 358-361 [P, NA]
Kobayashi,Y., Ohkubo,T., Kyogoku,Y., Nishiuchi,Y., Sakakibara,S., Braun,W. and Go,N.
Solution conformation of conotoxin GI determined by 1H nuclear magnetic resonance spectroscopy and distance geometry calculations Biochemistry (1989) 28: 4853-4860 [P, NA]
Pardi,A., Galdes,A., Florance,J. and Maniconte,D.
Solution structures of alpha-conotoxin G1 determined by two-dimensional NMR spectroscopy Biochemistry (1989) 28: 5494-5501 [P, NA]
Yoshikami,D. and Olivera,B.M.
The inhibitory effects of omega-conotoxins on Ca channels and synapses. Ann. N. Y. Acad. Sci. (1989) 560: 230-248 [P, NA]

Gray,W.R., Olivera,B.M. and Cruz,L.J.
Peptide toxins from venomous Conus snails Annu. Rev. Biochem. (1988) 57: 665-0 [P, NA]
Yanagawa,Y., Abe,T., Satake,M., Odani,S., Suzuki,J. and Ishikawa,K.
A novel sodium channel inhibitor from Conus geographus: purification, structure, and pharmacological properties Biochemistry (1988) 27: 6256-6262 [P, NA]
Zafaralla,G.C., Ramilo,C., Gray,W.R., Karlstrom,R., Olivera,B.M. and Cruz,L.J.
Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI Biochemistry (1988) 27: 7102-7105 [P, NA]

Cruz,L.J., de Santos,V., Zafaralla,G.C., Ramilo,C.A., Zeikus,R., Gray,W.R. and Olivera,B.M.
Invertebrate vasopressin/oxytocin homologs. Characterization of peptides from Conus geographus and Conus straitus venoms J. Biol. Chem. (1987) 262: 15821-15824 [P, NA]
Olivera,B.M., Cruz,L.J., de Santos,V., Lecheminant,G.W., Griffin,D., Zeikus,R.D., McIntosh,J.M., Galyean,R., Varga,J., Gray,W.R. and Rivier,J.E.
Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom Biochemistry (1987) 26: 2086-2090 [P, NA]
Rivier,J., Galyean,R., Gray,W.R., Azimi-Zonooz,A., McIntosh,J.M., Cruz,L.J. and Olivera,B.M.
Neuronal calcium channel inhibitors. Synthesis of omega-conotoxin GVIA and effects on 45Ca uptake by synaptosomes J. Biol. Chem. (1987) 262: 1194-1198 [P, NA]

Nishiuchi,Y., Kumagaye,K., Noda,Y., Watanabe,T.X. and Sakakibara,S.
Synthesis and secondary-structure determination of omega-conotoxin GVIA: a 27-peptide with three intramolecular disulfide bonds Biopolymers (1986) 25 Suppl [P, NA]
Thesis (1986) [P, NA]

Cruz,L.J., Gray,W.R., Olivera,B.M., Zeikus,R.D., Kerr,L., Yoshikami,D. and Moczydlowski,E.
Conus geographus toxins that discriminate between neuronal and muscle sodium channels J. Biol. Chem. (1985) 260: 9280-9288 [P, NA]
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A sleep-inducing peptide from Conus geographus venom. Toxicon (1985) 23: 277-282 [P, NA]
Olivera,B.M., Gray,W.R., Zeikus,R., McIntosh,J.M., Varga,J., Rivier,J., de Santos,V. and Cruz,L.J.
Peptide neurotoxins from fish-hunting cone snails Science (1985) 230: 1338-1343 [P, NA]

Gray,W.R., Luque,F.A., Galyean,R., Atherton,E., Sheppard,R.C., Stone,B.L., Reyes,A., Alford,J., McIntosh,M., Olivera,B.M., Cruz,L.J. and Rivier,J.
Conotoxin GI: disulfide bridges, synthesis, and preparation of iodinated derivatives Biochemistry (1984) 23: 2796-2802 [P, NA]
Kerr,L.M. and Yoshikami,D.
A venom peptide with a novel presynaptic blocking action. Nature (1984) 308: 282-284 [P, NA]
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Gamma-carboxyglutamate in a neuroactive toxin J. Biol. Chem. (1984) 259: 14343-14346 [P, NA]
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Purification and sequence of a presynaptic peptide toxin from Conus geographus venom Biochemistry (1984) 23: 5087-5090 [P, NA]

Gray,W.R., Rivier,J.E., Galyean,R., Cruz,L.J. and Olivera,B.M.
Conotoxin MI. Disulfide bonding and conformational states J. Biol. Chem. (1983) 258: 12247-12251 [P, NA]
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The amino acid sequences of homologous hydroxyproline-containing myotoxins from the marine snail Conus geographus venom FEBS Lett. (1983) 155: 277-280 [P, NA]

McIntosh,M., Cruz,L.J., Hunkapiller,M.W., Gray,W.R. and Olivera,B.M.
Isolation and structure of a peptide toxin from the marine snail Conus magus Arch. Biochem. Biophys. (1982) 218: 329-334 [P, NA]
Nishiuchi,Y. and Sakakibara,S.
Primary and secondary structure of conotoxin GI, a neurotoxic tridecapeptide from a marine snail FEBS Lett. (1982) 148: 260-262 [P, NA]

Gray,W.R., Luque,A., Olivera,B.M., Barrett,J. and Cruz,L.J.
Peptide toxins from Conus geographus venom J. Biol. Chem. (1981) 256: 4734-4740 [P, NA]
Duda,T.F. and Palumbi,S.R.
Molecular evolution of four-loop conotoxin precursors from fish-eating Conus (Unpublished) [P, NA]
Duda,T.F. Jr.
Positive selection and patterns of divergence of orthologous toxin genes among related venomous predatory gastropods (Unpublished) [P, NA]
Duda,T.F. Jr. and Palumbi,S.R.
Convergent evolution of venoms and feeding ecologies among polyphyletic piscivorous Conus species (Unpublished) [P, NA]
Gilly,W.F., Richmond,T., Elliger,C.A., Lebaric,Z.N., Schulz,J., Bingham,J.P. and Sweedler,J.V.
Extreme Diversity in a Novel Family of Peptide Toxins from Conus californicus (Unpublished) [P, NA]

Jiang, X., Pi, C. and Liu, Y.
A Novel Class of Conotoxin cDNAs with a Distinctive Cysteine Arrangement Unpublished (0) [P, NA]
Liu, L., Chi, C.W. and Wang, C.G.
cDNA of S-superfamily conotoxin precursor from Conus caracteristicus Unpublished (0) [P, NA]
Lu,B.S., Yu,F., Wang,J.H., Zhao,D., Zhao,S.Q. and Huang,P.T.
Cloning of alpha-conotoxin sequences from Conus textile venom duct (Unpublished) [P, NA]
Luo,S. and Zhangsun,D.
Hainan O-superfamily peptides (Unpublished) [P, NA]
Luo,S., Zhang,B. and Zhangsun,D.
A11GB conotoxin scaffold VI/VII precursor (Unpublished) [P, NA]
Luo,S., Zhang,B. and Zhangsun,D.
C11GB conotoxin scaffold VI/VII precursor (Unpublished) [P, NA]
Luo,S., Zhangsun,D. and Zhang,B.
Hainan O-superfamily peptides (Unpublished) [P, NA]
Luo,S., Zhangsun,D., Zhang,B. and Lin,Q.
Novel O-superfamily conotoxins, and their coding polynucleotides and use (Unpublished) [P, NA]
Luo,S., Zhangsun,D., Zhang,B. and Lin,Q.
Hainan O-superfamily peptides (Unpublished) [P, NA]

Peng, C., Wu, X., Han, Y., Yuan, D., Chi, C. and Wang, C.
Identification of six novel T-1 conotoxins from the venom ducts of Conus pulicarius by molecular cloning Unpublished (0) [P, NA]
Peng, C., Wu, X., Wang, Y., Shao, X., Chi, C. and Wang, C.
Identification and characterization of a new four-Cys conotoxin (framework 14) from the vermivorous Conus pulicarius, pu14a, a novel antagonist of nicotinic acetylcholine receptors Unpublished (0) [P, NA]
Walker,C., Shetty,R., Olivera,B.M., Hooper,D., Jacobsen,R., Steele,D. and Jones,R.M.
Tau-conotoxin peptides (Unpublished) [P, NA]

Yuan, D., Liu, L., Chi, C. and Guo, Z.
New conotoxins define a novel I3-superfamily Unpublished (0) [P, NA]
Zhao,D. and Huang,P.
Conus imperialis conotoxin ImIIA precursor mRNA (Unpublished) [P, NA]
bidon (Unpublished) [P, NA]
bidon (Unpublished) [P, NA]
Physico-chemical and pharmacological study of new toxins from the piscivorous cone snail Conus consors Thesis (1999) () [P, NA]
Physico-chemical and pharmacological study of new toxins from the piscivorous cone snail Conus consors Thesis (1999) () [P, NA]
Physico-chemical and pharmacological study of new toxins from the piscivorous cone snail Conus consors Thesis (1999) () [P, NA]