Reference List

The references are sorted by year then first author.
Each reference is followed by a 'P' link and a 'NA' link that search the corresponding protein sequences and nucleic acid sequences, respectively.


2018

Jinqin Chen, Li Liang, Huying Ning, Fengtao Cai, Zhuguo Liu, Longxiao Zhang, Liangyi Zhou and Qiuyun Dai,
Cloning, Synthesis and Functional Characterization of a Novel α-Conotoxin Lt1.3 Marine drugs (2018) 16 [P, NA]
2017

Li,Q., Barghi,N., Lu,A., Fedosov,A.E., Bandyopadhyay,P.K., Lluisma,A.O., Concepcion,G.P., Yandell,M., Olivera,B.M. and Safavi-Hemami,H.
Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus. Genome Biol Evol (2017) 9: 2211-2225 [P, NA]
2016

Bernáldez,J., Jiménez,S., González,L.J., Ferro,J.N., Soto,E., Salceda,E., Chávez,D., Aguilar,M.B. and Licea-Navarro,A.
A New Member of Gamma-Conotoxin Family Isolated from Conus princeps Displays a Novel Molecular Target. Toxins (Basel) (2016) 8: 39-0 [P, NA]
Brust A., Croker D. E., Colless B., Ragnarsson L., Andersson A., Jain K., Garcia-Caraballo S., Castro J., Brierley S. M., Alewood P. F., Lewis R. J.
Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J. Med. Chem. (2016) [P, NA]
Carstens,B.B., Berecki,G., Daniel,J.T., Lee,H.S., Jackson,K.A., Tae,H.S., Sadeghi,M., Castro,J., O
Structure-Activity Studies of Cysteine-Rich a-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew. Chem. Int. Ed. Engl (2016) 55: 4692-4696 [P, NA]
Cuny,H., Kompella,S.N., Tae,H.S., Yu,R. and Adams,D.J.
Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins. J. Biol. Chem. (2016) 291: 23779-23792 [P, NA]
De León-Nava,M.A., Romero-Núñez,E., Luna-Nophal,A., Bernáldez-Sarabia,J., Sánchez-Campos,L.N., Licea-Navarro,A.F., Morales-Montor,J. and Muñiz-Hernández,S.
In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii. Mar Drugs (2016) 14 [P, NA]
Espino,S.S., Dilanyan,T., Imperial,J.S., Aguilar,M.B., Teichert,R.W., Bandyopadhyay,P. and Olivera,B.M.
Glycine-rich conotoxins from the Virgiconus clade. Toxicon (2016) 113: 11-17 [P, NA]
Green,B.R., Gajewiak,J., Chhabra,S., Skalicky,J.J., Zhang,M.M., Rivier,J.E., Bulaj,G., Olivera,B.M., Yoshikami,D. and Norton,R.S.
Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. J. Biol. Chem. (2016) 291: 7205-7220 [P, NA]
Penggang Han, Kang Wang, Xiandong Dai, Ying Cao, Shangyi Liu, Hui Jiang, Chongxu Fan, Wenjian Wu and Jisheng Chen
The Role of Individual Disulfide Bonds of μ-Conotoxin GIIIA in the Inhibition of NaV1.4 Marine drugs (2016) 14: 213-0 [P, NA]
Prashanth,J.R., Dutertre,S., Jin,A.H., Lavergne,V., Hamilton,B., Cardoso,F.C., Griffin,J., Venter,D.J., Alewood,P.F. and Lewis,R.J.
The role of defensive ecological interactions in the evolution of conotoxins. Mol. Ecol. (2016) 25: 598-615 [P, NA]
Wang,F., Yan,Z., Liu,Z., Wang,S., Wu,Q., Yu,S., Ding,J. and Dai,Q.
Molecular basis of toxicity of N-type calcium channel inhibitor MVIIA. Neuropharmacology (2016) 101: 137-145 [P, NA]
Zhu,X., Bi,J., Yu,J., Li,X., Zhang,Y., Zhangsun,D. and Luo,S.
Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli. Mar Drugs (2016) 14 [P, NA]
2015

Aman,J.W., Imperial,J.S., Ueberheide,B., Zhang,M.M., Aguilar,M., Taylor,D., Watkins,M., Yoshikami,D., Showers-Corneli,P., Safavi-Hemami,H., Biggs,J. and Olivera,B.M.
Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus. Proc. Natl. Acad. Sci. U.S.A. (2015) 112: 5087-5092 [P, NA]
Aman,J.W., Imperial,J.S., Ueberheide,B., Zhang,M.M., Aguilar,M., Taylor,D., Watkins,M., Yoshikami,D., Showers-Corneli,P., Safavi-Hemami,H., Biggs,J., Teichert,R.W. and Olivera,B.M.
Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus. Proc. Natl. Acad. Sci. U.S.A. (2015) 112: 5087-5092 [P, NA]
Jennifer R. Deuis, Ella Whately, Andreas Brust, Marco C. Inserra, Naghmeh H. Asvadi, Richard J. Lewis, Paul F. Alewood, Peter J. Cabot, Irina Vetter
Activation of K-Opoid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia ACS Chemical Neuroscience (2015) 6: 1751-1758 [P, NA]
Jin,A.H., Israel,M.R., Inserra,M.C., Smith,J.J., Lewis,R.J., Alewood,P.F., Vetter,I. and Dutertre,S.
δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proc. Biol. Sci. (2015) 282 [P, NA]
Kancherla,A.K., Meesala,S., Jorwal,P., Palanisamy,R., Sikdar,S.K. and Sarma,S.P.
A Disulfide Stabilized β-Sandwich Defines the Structure of a New Cysteine Framework M-Superfamily Conotoxin. ACS Chem. Biol. (2015) 10: 1847-1860 [P, NA]
Li,L., Liu,N., Ding,R., Wang,S., Liu,Z., Li,H., Zheng,X. and Dai,Q.
A novel 4/6-type alpha-conotoxin ViIA selectively inhibits nAchR α3β2 subtype. Acta Biochim. Biophys. Sin. (Shanghai) (2015) 47: 1023-1028 [P, NA]
Luo,S., Zhangsun,D., Harvey,P.J., Kaas,Q., Wu,Y., Zhu,X., Hu,Y., Li,X., Tsetlin,V.I., Christensen,S., Romero,H.K., McIntyre,M., Dowell,C., Baxter,J.C., Elmslie,K.S., Craik,D.J. and McIntosh,J.M.
Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. Proc. Natl. Acad. Sci. U.S.A. (2015) 112 [P, NA]
Mueller,A., Starobova,H., Inserra,M.C., Jin,A.H., Deuis,J.R., Dutertre,S., Lewis,R.J., Alewood,P.F., Daly,N.L. and Vetter,I.
α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochem. Pharmacol. (2015) 94: 155-163 [P, NA]
Rajesh,R.P.
Novel M-Superfamily and T-Superfamily conotoxins and contryphans from the vermivorous snail Conus figulinus. J. Pept. Sci. (2015) 21: 29-39 [P, NA]
Ren,Z., Wang,L., Qin,M., You,Y., Pan,W., Zhou,L., Sun,D. and Xu,A.
Pharmacological characterization of conotoxin lt14a as a potent non-addictive analgesic. Toxicon (2015) 96: 57-67 [P, NA]
Robinson,S.D., Li,Q., Bandyopadhyay,P.K., Gajewiak,J., Yandell,M., Papenfuss,A.T., Purcell,A.W., Norton,R.S., Safavi-Hemami,H.
Hormone-like peptides in the venoms of marine cone snails Gen. Comp. Endocrinol. (2015) [In press, corrected proof] [P, NA]
Robinson,S.D., Safavi-Hemami,H., Raghuraman,S., Imperial,J.S., Papenfuss,A.T., Teichert,R.W., Purcell,A.W., Olivera,B.M. and Norton,R.S.
Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom. J Proteomics (2015) 114: 38-47 [P, NA]
Safavi-Hemami,H., Gajewiak,J., Karanth,S., Robinson,S.D., Ueberheide,B., Douglass,A.D., Schlegel,A., Imperial,J.S., Watkins,M., Bandyopadhyay,P.K., Yandell,M., Li,Q., Purcell,A.W., Norton,R.S., Ellgaard,L. and Olivera,B.M.
Specialized insulin is used for chemical warfare by fish-hunting cone snails. Proc. Natl. Acad. Sci. U.S.A. (2015) 112: 1743-1748 [P, NA]
Wilson,M.J., Zhang,M.M., Gajewiak,J., Azam,L., Rivier,J.E., Olivera,B.M. and Yoshikami,D.
Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ. J. Neurophysiol. (2015) 113: 2289-2301 [P, NA]
Xu,S., Zhang,T., Kompella,S.N., Yan,M., Lu,A., Wang,Y., Shao,X., Chi,C., Adams,D.J., Ding,J. and Wang,C.
Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci Rep (2015) 5: 14261-0 [P, NA]
Zhang,M.M., Gajewiak,J., Azam,L., Bulaj,G., Olivera,B.M. and Yoshikami,D.
Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ. Biochemistry (2015) 54: 3911-3920 [P, NA]
Zhou,M., Wang,L., Wu,Y., Liu,J., Sun,D., Zhu,X., Feng,Y., Qin,M., Chen,S. and Xu,A.
Soluble expression and sodium channel activity of lt16a, a novel framework XVI conotoxin from the M-superfamily. Toxicon (2015) 98: 5-11 [P, NA]
2014

Chen,L., Dürr,K.L. and Gouaux,E.
X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism. Science (2014) 345: 1021-1026 [P, NA]
Chen,S., Gopalakrishnan,R., Schaer,T., Marger,F., Hovius,R., Bertrand,D., Pojer,F. and Heinis,C.
Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides Nat Chem (2014) 6: 1009-1016 [P, NA]
Chhabra,S., Belgi,A., Bartels,P., van Lierop,B.J., Robinson,S.D., Kompella,S.N., Hung,A., Callaghan,B.P., Adams,D.J., Robinson,A.J. and Norton,R.S.
Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets. J. Med. Chem. (2014) 57: 9933-9944 [P, NA]
Dudel,J.
α-Conotoxin M1 (CTx) blocks αδ binding sites of adult nicotinic receptors while ACh binding at αε sites elicits only small and short quantal synaptic currents. Physiol Rep (2014) 2 [P, NA]
Dutertre,S., Jin,A.H., Vetter,I., Hamilton,B., Sunagar,K., Lavergne,V., Dutertre,V., Fry,B.G., Antunes,A., Venter,D.J., Alewood,P.F. and Lewis,R.J.
Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails Nat Commun (2014) 5: 3521- [P, NA]
Gajewiak,J., Azam,L., Imperial,J., Walewska,A., Green,B.R., Bandyopadhyay,P.K., Raghuraman,S., Ueberheide,B., Bern,M., Zhou,H.M., Minassian,N.A., Hagan,R.H., Flinspach,M., Liu,Y., Bulaj,G., Wickenden,A.D., Olivera,B.M., Yoshikami,D. and Zhang,M.M.
A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ. Proc. Natl. Acad. Sci. U.S.A. (2014) 111: 2758-2763 [P, NA]
Green,B.R., Zhang,M.M., Chhabra,S., Robinson,S.D., Wilson,M.J., Redding,A., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S.
Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3. FEBS J. (2014) 281: 2885-2898 [P, NA]
Jin,A.H., Vetter,I., Dutertre,S., Abraham,N., Emidio,N.B., Inserra,M., Murali,S.S., Christie,M.J., Alewood,P.F. and Lewis,R.J.
MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors. Biochemistry (2014) 53: 1-3 [P, NA]
Lebbe,E.K., Peigneur,S., Maiti,M., Devi,P., Ravichandran,S., Lescrinier,E., Ulens,C., Waelkens,E., D'Souza,L. and Tytgat,J.
Structure-Function Elucidation of a New α-Conotoxin, Lo1a, from Conus longurionis. J. Biol. Chem. (2014) 289: 9573-9583 [P, NA]
Lebbe,E.K., Peigneur,S., Maiti,M., Mille,B.G., Devi,P., Ravichandran,S., Lescrinier,E., Waelkens,E., D'Souza,L. and Tytgat,J.
Discovery of a new subclass of α-conotoxins in the venom of Conus australis. Toxicon (2014) 91: 145-154 [P, NA]
Lu,A., Yang,L., Xu, S. and Wang,C.
Various conotoxin diversifications revealed by a venomic study of Conus flavidus. Mol. Cell Proteomics (2014) 13: 105-118 [P, NA]
Luo,S., Zhangsun,D., Schroeder,C.I., Zhu,X., Hu,Y., Wu,Y., Weltzin,M.M., Eberhard,S., Kaas,Q., Craik,D.J., McIntosh,J.M. and Whiteaker,P.
A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors. FASEB J. (2014) 28: 1842-1853 [P, NA]
Nguyen,B., Le Caer,J.P., Aráoz,R., Thai,R., Lamthanh,H., Benoit,E. and Molgó,J.
Isolation, purification and functional characterization of alpha-BnIA from Conus bandanus venom. Toxicon (2014) 91: 155-163 [P, NA]
Platt,R.J., Curtice,K.J., Twede,V.D., Watkins,M., Gruszczyński,P., Bulaj,G., Horvath,M.P. and Olivera,B.M.
From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes. Toxicon (2014) 81: 67-79 [P, NA]
Puillandre,N., Stöcklin,R., Favreau,P., Bianchi,E., Perret,F., Rivasseau,A., Limpalaër,L. and Bouchet,P.
When everything converges: integrative taxonomy with shell, DNA and venomic data reveals Conus conco, a new species of cone snails (Gastropoda: Conoidea). Mol. Phylogenet. Evol. (2014) 80: 186-192 [P, NA]
Robinson,S.D., Safavi-Hemami,H., McIntosh,L.D., Purcell,A.W., Norton,R.S. and Papenfuss,A.T.
Diversity of Conotoxin Gene Superfamilies in the Venomous Snail, Conus victoriae. PLoS ONE (2014) 9 [P, NA]
Stock,P., Ljaschenko,D., Heckmann,M. and Dudel,J.
Agonists binding nicotinic receptors elicit specific channel-opening patterns at αγ and αδ sites. J. Physiol. (Lond.) (2014) 592: 2501-2517 [P, NA]
Wang,C.K., King,G.J., Northfield,S.E., Ojeda,P.G. and Craik,D.J.
Racemic and quasi-racemic X-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angew. Chem. Int. Ed. Engl. (2014) 53: 11236-11241 [P, NA]
Wang,S., Du,T., Liu,Z., Wang,S., Wu,Y., Ding,J., Jiang,L. and Dai,Q.
Characterization of a T-superfamily conotoxin TxVC from Conus textile that selectively targets neuronal nAChR subtypes. Biochem. Biophys. Res. Commun. (2014) 454: 151-156 [P, NA]
2013

Aguilar,M.B., Ortiz,E., Kaas,Q., López-Vera,E., Becerril,B., Possani,L.D. and de la Cotera,E.P.
Precursor De13.1 from Conus delessertii defines the novel G gene superfamily. Peptides (2013) [ahead of print] [P, NA]
Aguilar,M.B., Zugasti-Cruz,A., Falcón,A., Batista,C.V., Olivera,B.M. and Heimer de la Cotera,E.P.
A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico. Peptides (2013) [ahead of print] [P, NA]
Akcan,M., Cao,Y., Chongxu,F. and Craik,D.J.
The three-dimensional solution structure of mini-M conotoxin BtIIIA reveals a disconnection between disulfide connectivity and peptide fold. Bioorg. Med. Chem. (2013) [ahead of print] [P, NA]
Bernáldez,J., Román-González,S.A., Martínez,O., Jiménez,S., Vivas,O., Arenas,I., Corzo,G., Arreguín,R., García,D.E., Possani,L.D. and Licea,A.
A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits CaV2.2 Channels and Displays an Anti-Nociceptive Activity. Mar Drugs (2013) 11: 1188-1202 [P, NA]
Braga,M.C., Nery,A.A., Ulrich,H., Konno,K. and Pimenta,D.C.
α -RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom. Int J Pept (2013) 2013: 543028- [P, NA]
Dutertre,S., Jin,A.H., Kaas,Q., Jones,A., Alewood,P.F. and Lewis,R.J.
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Mol. Cell Proteomics (2013) 12: 312-329 [P, NA]
Gao,B., Zhangsun,D., Wu,Y., Lin,B., Zhu,X. and Luo,S.
Expression, renaturation and biological activity of recombinant conotoxin GeXIVAWT. Appl. Microbiol. Biotechnol. (2013) 97: 1223-1230 [P, NA]
Grishin,A.A., Cuny,H., Hung,A., Clark,R.J., Brust,A., Akondi,K., Alewood,P.F., Craik,D.J. and Adams,D.J.
Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. J. Biol. Chem. (2013) 288: 34428-34442 [P, NA]
Hocking,H.G., Gerwig,G.J., Dutertre,S., Violette,A., Favreau,P., Stöcklin,R., Kamerling,J.P. and Boelens,R.
Structure of the O-glycosylated conopeptide CcTx from Conus consors venom. Chemistry (2013) 19: 870-879 [P, NA]
Hone,A.J., Ruiz,M., Scadden,M., Christensen,S., Gajewiak,J., Azam,L. and McIntosh,J.M.
Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors. J. Biol. Chem. (2013) 288: 25428-25439 [P, NA]
Inserra,M.C., Kompella,S.N., Vetter,I., Brust,A., Daly,N.L., Cuny,H., Craik,D.J., Alewood,P.F., Adams,D.J. and Lewis,R.J.
Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochem. Pharmacol. (2013) 86: 791-799 [P, NA]
Jin,A.H., Dutertre,S., Kaas,Q., Lavergne,V., Kubala,P. and Alewood,P.F.
Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Mol. Cell Proteomics (2013) 12: 3824-3833 [P, NA]
Kapono,C.A., Thapa,P., Cabalteja,C.C., Guendisch,D., Collier,A.C. and Bingham,J.P.
Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus. Toxicon (2013) [P, NA]
Kuang,Z., Zhang,M.M., Gupta,K., Gajewiak,J., Gulyas,J., Balaram,P., Rivier,J.E., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S.
Mammalian Neuronal Sodium Channel Blocker μ-Conotoxin BuIIIB Has a Structured N-Terminus That Influences Potency. ACS Chem. Biol. (2013) [ahead of print] [P, NA]
Lavergne,V., Dutertre,S., Jin,A.H., Lewis,R.J. and Alewood,P.F.
Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. BMC Genomics (2013) 14: 708- [P, NA]
Lavergne,V., Dutertre,S., Jin,A.H., Lewis,R.J., Taft,R.J. and Alewood,P.F.
Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies BMC Genomics (2013) 14: 708- [P, NA]
Luo,S., Christensen,S., Zhangsun,D., Wu,Y., Hu,Y., Zhu,X., Chhabra,S., Norton,R.S. and McIntosh,J.M.
A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily. PLoS ONE (2013) 8 [P, NA]
Luo,S., Zhangsun,D., Wu,Y., Zhu,X., Hu,Y., McIntyre,M., Christensen,S., Akcan,M., Craik,D.J. and McIntosh,J.M.
Characterization of a novel α-conotoxin from conus textile that selectively targets α6/α3β2β3 nicotinic acetylcholine receptors. J. Biol. Chem. (2013) 288: 894-902 [P, NA]
Luo,S., Zhangsun,D., Zhu,X., Wu,Y., Hu,Y., Christensen,S., Harvey,P.J., Akcan,M., Craik,D.J. and McIntosh,J.M.
Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors. J. Med. Chem. (2013) 56: 9655-9663 [P, NA]
McDougal,O.M., Granum,D.M., Swartz,M., Rohleder,C. and Maupin,C.M.
pKa determination of histidine residues in α-conotoxin MII peptides by 1H NMR and constant pH molecular dynamics simulation. J Phys Chem B (2013) 117: 2653-2661 [P, NA]
Peigneur,S., Van Der Haegen,A., Möller,C., Waelkens,E., Diego-García,E., Marí,F., Naudé,R. and Tytgat,J.
Unraveling the peptidome of the South African cone snails Conus pictus and Conus natalis. Peptides (2013) 41: 8-16 [P, NA]
Petrel,C., Hocking,H.G., Reynaud,M., Upert,G., Favreau,P., Biass,D., Paolini-Bertrand,M., Peigneur,S., Tytgat,J., Gilles,N., Hartley,O., Boelens,R., Stocklin,R. and Servent,D.
Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor. Biochem. Pharmacol. (2013) [P, NA]
Quinton,L., Servent,D., Girard,E., Molgó,J., Le Caer,J.P., Malosse,C., Haidar,E.A., Lecoq,A., Gilles,N. and Chamot-Rooke,J.
Identification and functional characterization of a novel α-conotoxin (EIIA) from Conus ermineus. Anal Bioanal Chem (2013) [P, NA]
Sonti,R., Gowd,K.H., Rao,K.N., Ragothama,S., Rodriguez,A., Perez,J.J. and Balaram,P.
Conformational diversity in contryphans from Conus venom: cis-trans isomerisation and aromatic/proline interactions in the 23-membered ring of a 7-residue peptide disulfide loop. Chemistry (2013) 19: 15175-15189 [P, NA]
van Lierop,B.J., Robinson,S.D., Kompella,S.N., Belgi,A., McArthur,J.R., Hung,A., MacRaild,C.A., Adams,D.J. and Robinson,A.J.
Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. ACS Chem. Biol. (2013) 8: 1815-1821 [P, NA]
Wu,Y., Wang,L., Zhou,M., You,Y., Zhu,X., Qiang,Y., Qin,M., Luo,S., Ren,Z. and Xu,A.
Molecular evolution and diversity of Conus peptide toxins, as revealed by gene structure and intron sequence analyses. PLoS ONE (2013) 8 [P, NA]
Yu,R., Kompella,S.N., Adams,D.J., Craik,D.J. and Kaas,Q.
Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor. J. Med. Chem. (2013) [P, NA]
Zhang,M.M., Wilson,M.J., Azam,L., Gajewiak,J., Rivier,J.E., Bulaj,G., Olivera,B.M. and Yoshikami,D.
Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins. Br. J. Pharmacol. (2013) 168: 1597-1610 [P, NA]
Zhou,M., Wang,L., Wu,Y., Zhu,X., Feng,Y., Chen,Z., Li,Y., Sun,D., Ren,Z. and Xu,A.
Characterizing the evolution and functions of the M-superfamily conotoxins. Toxicon (2013) 76: 150-159 [P, NA]
2012

Balsara,R., Li,N., Weber-Adrian,D., Huang,L. and Castellino,F.J.
Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors. Neuropharmacology (2012) 62: 2227-2238 [P, NA]
Bhatia,S., Kil,Y.J., Ueberheide,B., Chait,B.T., Tayo,L., Cruz,L., Lu,B., Yates,J.R. 3rd. and Bern,M.
Constrained de novo sequencing of conotoxins. J. Proteome Res. (2012) 11: 4191-4200 [P, NA]
Chang,D. and Duda,T.F. Jr.
Extensive and continuous duplication facilitates rapid evolution and diversification of gene families. Mol. Biol. Evol. (2012) 29: 2019-2029 [P, NA]
Dobson,R., Collodoro,M., Gilles,N., Turtoi,A., De Pauw,E. and Quinton,L.
Secretion and maturation of conotoxins in the venom ducts of Conus textile. Toxicon (2012) 60: 1370-1379 [P, NA]
Favreau P, Benoit E, Hocking HG, Carlier L, D hoedt D, Leipold E, Markgraf R, Schlumberger S, Córdova MA, Gaertner H, Paolini-Bertrand M, Hartley O, Tytgat J, Heinemann SH, Bertrand D, Boelens R, Stöcklin R, Molgó J
A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors Br J Pharmacol (2012) 166: 1654-1668 [P, NA]
Franco,A., Kompella,S.N., Akondi,K.B., Melaun,C., Daly,N.L., Luetje,C.W., Alewood,P.F., Craik,D.J., Adams,D.J. and Marí,F.
RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs. Biochem. Pharmacol. (2012) 83: 419-426 [P, NA]
Gowd,K.H., Han,T.S., Twede,V., Gajewiak,J., Smith,M.D., Watkins,M., Platt,R.J., Toledo,G., White,H.S., Olivera,B.M. and Bulaj,G.
Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits. Biochemistry (2012) 51: 4685-4692 [P, NA]
Hone,A.J., Scadden,M., Gajewiak,J., Christensen,S., Lindstrom,J. and McIntosh,J.M.
α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptors. Mol. Pharmacol. (2012) 82: 972-982 [P, NA]
Hu,H., Bandyopadhyay,P.K., Olivera,B.M. and Yandell,M.
Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct. BMC Genomics (2012) 13: 284-0 [P, NA]
Kaas,Q., Yu,R., Jin,A.H., Dutertre,S. and Craik,D.J.
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Res (2012) 40 : 325-330 [P, NA]
Khoo,K.K., Gupta,K., Green,B.R., Zhang,M.M., Watkins,M., Olivera,B.M., Balaram,P., Yoshikami,D., Bulaj,G. and Norton,R.S.
Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels. Biochemistry (2012) 51: 9826-9835 [P, NA]
Knapp,O., Nevin,S.T., Yasuda,T., Lawrence,N., Lewis,R.J. and Adams,D.J.
Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB. Br. J. Pharmacol. (2012) 166: 2148-2160 [P, NA]
Liu,Z., Li,H., Liu,N., Wu,C., Jiang,J., Yue,J. and Dai,Q.
Diversity and evolution of conotoxins in Conus virgo, Conus eburneus, Conus imperialis and Conus marmoreus from the South China Sea. Toxicon (2012) 60: 982-989 [P, NA]
Lluisma,A.O., Milash,B.A., Moore,B., Olivera,B.M. and Bandyopadhyay,P.K.
Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome. Mar Genomics (2012) 5: 43-51 [P, NA]
Markgraf,R., Leipold,E., Schirmeyer,J., Paolini-Bertrand,M., Hartley,O. and Heinemann,S.H.
Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC. Br. J. Pharmacol. (2012) 167: 576-586 [P, NA]
Napier,I.A., Klimis,H., Rycroft,B.K., Jin,A.H., Alewood,P.F., Motin,L., Adams,D.J. and Christie,M.J.
Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain. Neuropharmacology (2012) 62: 2202-2207 [P, NA]
Olivera,B.M., Watkins,M., Bandyopadhyay,P., Imperial,J.S., de la Cotera,E.P., Aguilar,M.B., Vera,E.L., Concepcion,G.P. and Lluisma,A.
Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes. Ann. N. Y. Acad. Sci. (2012) 1267: 61-70 [P, NA]
Pérez-Alvarez,A., Hernández-Vivanco,A., McIntosh,J.M. and Albillos,A.
Native α6β4* nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland. FASEB J. (2012) 26: 346-354 [P, NA]
Platt,R.J., Han,T.S., Green,B.R., Smith,M.D., Skalicky,J., Gruszczynski,P., White,H.S., Olivera,B., Bulaj,G. and Gajewiak,J.
Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. J. Biol. Chem. (2012) 287: 20727-20736 [P, NA]
Puillandre,N., Koua,D., Favreau,P., Olivera,B.M. and Stocklin,R.
Molecular phylogeny, classification and evolution of conopeptides J. Mol. Evol. (2012) 74: 297-309 [P, NA]
Safavi-Hemami,H., Gorasia,D.G., Steiner,A.M., Williamson,N.A., Karas,J.A., Gajewiak,J., Olivera,B.M., Bulaj,G. and Purcell,A.W.
Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails. J. Biol. Chem. (2012) 287: 34288-34303 [P, NA]
Schroeder,C.I., Adams,D., Thomas,L., Alewood,P.F. and Lewis,R.J.
N- and C-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers (2012) 98: 161-165 [P, NA]
Schroeder,C.I., Nielsen,K.J., Adams,D.A., Loughnan,M., Thomas,L., Alewood,P.F., Lewis,R.J. and Craik,D.J.
Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers (2012) 98: 345-356 [P, NA]
Steiner,A.M., Woycechowsky,K.J., Olivera,B.M. and Bulaj,G.
Reagentless oxidative folding of disulfide-rich peptides catalyzed by an intramolecular diselenide. Angew. Chem. Int. Ed. Engl. (2012) 51: 5580-5584 [P, NA]
Terrat,Y., Biass,D., Dutertre,S., Favreau,P., Remm,M., Stöcklin,R., Piquemal,D. and Ducancel,F.
High-resolution picture of a venom gland transcriptome: case study with the marine snail Conus consors. Toxicon (2012) 59: 34-46 [P, NA]
Tietze,A.A., Tietze,D., Ohlenschläger,O., Leipold,E., Ullrich,F., Kühl,T., Mischo,A., Buntkowsky,G., Görlach,M., Heinemann,S.H. and Imhof,D.
Structurally diverse μ-conotoxin PIIIA isomers block sodium channel NaV 1.4. Angew. Chem. Int. Ed. Engl. (2012) 51: 4058-4061 [P, NA]
Van Der Haegen A, Peigneur S, Dyubankova N, Möller C, Marí F, Diego-García E, Naudé R, Lescrinier E, Herdewijn P, Tytgat J
Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity Peptides (2012) 34: 106-113 [P, NA]
Vetter,I., Dekan,Z., Knapp,O., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochem. Pharmacol. (2012) 84: 540-548 [P, NA]
Violette,A., Biass,D., Dutertre,S., Koua,D., Piquemal,D., Pierrat,F. and Favreau,P.
Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach. J Proteomics (2012) 75: 5215-5225 [P, NA]
Violette,A., Leonardi,A., Piquemal,D., Terrat,Y., Biass,D., Dutertre,S., Noguier,F., Ducancel,F., Stöcklin,R., Križaj,I. and Favreau,P.
Recruitment of glycosyl hydrolase proteins in a cone snail venomous arsenal: further insights into biomolecular features of Conus venoms. Mar Drugs (2012) 10: 258-280 [P, NA]
Ye,M., Khoo,K.K., Xu,S., Zhou,M., Boonyalai,N., Perugini,M.A., Chi,C., Galea,C.A., Wang,C. and Norton,R.S.
A Helical Conotoxin From Conus Imperialis Has A Novel Cysteine Framework And Defiines A New Superfamily J Biol Chem (2012) 287: 14973-14983 [P, NA]
Yu,R., Kaas,Q. and Craik,D.J.
Delineation of the unbinding pathway of α-conotoxin ImI from the α7 nicotinic acetylcholine receptor. J Phys Chem B (2012) 116: 6097-6105 [P, NA]
Zhang,B., Huang,F. and Du,W.
Solution structure of a novel α-conotoxin with a distinctive loop spacing pattern. Amino Acids (2012) 43: 389-396 [P, NA]
2011

Armishaw,C.J., Jensen,A.A., Balle,L.D., Scott,K.C., Sørensen,L. and Strømgaard,K.
Improving the stability of α-conotoxin AuIB through N-to-C cyclization: the effect of linker length on stability and activity at nicotinic acetylcholine receptors. Antioxid. Redox Signal. (2011) 14: 65-76 [P, NA]
Bernaldez,J., López,O., Licea,A., Salceda,E., Arellano,R.O., Vega,R. and Soto,E.
Electrophysiological characterization of a novel small peptide from the venom of Conus californicus that targets voltage-gated neuronal Ca2+ channels. Toxicon (2011) 57: 60-67 [P, NA]
Bruce,C., Fitches,E.C., Chougule,N., Bell,H.A. and Gatehouse,J.A.
Recombinant conotoxin, TxVIA, produced in yeast has insecticidal activity. Toxicon (2011) 58: 93-100 [P, NA]
Daly,N.L., Callaghan,B., Clark,R.J., Nevin,S.T., Adams,D.J. and Craik,D.J.
Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels. J. Biol. Chem. (2011) 286: 10233-10237 [P, NA]
de Araujo,A.D., Callaghan,B., Nevin,S.T., Daly,N.L., Craik,D.J., Moretta,M., Hopping,G., Christie,M.J., Adams,D.J. and Alewood,P.F.
Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angew. Chem. Int. Ed. Engl. (2011) 50: 6527-6529 [P, NA]
Elliger,C.A., Richmond,T.A., Lebaric,Z.N., Pierce,N.T., Sweedler,J.V. and Gilly,W.F.
Diversity of conotoxin types from Conus californicus reflects a diversity of prey types and a novel evolutionary history. Toxicon (2011) 57: 311-322 [P, NA]
Halai,R., Callaghan,B., Daly,N.L., Clark,R.J., Adams,D.J. and Craik,D.J.
Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor. J. Med. Chem. (2011) 54: 6984-6992 [P, NA]
Hu,H., Bandyopadhyay,P.K. and Yandell,M.
Characterization of the Conus bullatus genome and its venom-duct transcriptome. BMC Genomics (2011) 12: 60- [P, NA]
Imperial,J., Hillyard,D.R., Watkins,M., Olivera,B.M., Wagstaff,J.D., Jones,R.M., Mccabe,R.T., Cruz,L.J., Layer,R.T., Griffen,D. and Craig,A.G.
Contulakin-G, Analogs Thereof and Uses Therefor Patent: JP 2011024579-A (2011) [P, NA]
Kauferstein,S., Porth,C., Kendel,Y., Wunder,C., Nicke,A., Kordis,D., Favreau,P., Koua,D., Stöcklin,R. and Mebs,D.
Venomic study on cone snails (Conus spp.) from South Africa. Toxicon (2011) 57: 28-34 [P, NA]
Khoo,K.K., Wilson,M.J., Smith,B.J., Zhang,M.M., Gulyas,J., Yoshikami,D., Rivier,J.E., Bulaj,G. and Norton,R.S.
Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA. J. Med. Chem. (2011) 54: 7558-7566 [P, NA]
Klimis,H., Adams,D.J., Callaghan,B., Nevin,S., Alewood,P.F., Vaughan,C.W., Mozar,C.A. and Christie,M.J.
A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain. Pain (2011) 152: 259-266 [P, NA]
Leipold,E., Markgraf,R., Miloslavina,A., Kijas,M., Schirmeyer,J. , Imhof,D., and Heinemann,S.H
Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels. Neuropharmacology (2011) 61: 105-111 [P, NA]
Lovelace,E.S., Gunasekera,S., Alvarmo,C., Clark,R.J., Nevin,S.T., Grishin,A.A., Adams,D.J., Craik,D.J., and Daly,N.L.
Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization. Antioxid. Redox Signal. (2011) 14: 87-95 [P, NA]
Möller,C. and Marí,F.
9.3 KDa components of the injected venom of Conus purpurascens define a new five-disulfide conotoxin framework. Biopolymers (2011) 96: 158-165 [P, NA]
McArthur,J.R., Singh,G., McMaster,D., Winkfein,R., Tieleman,D.P. and French,R.J.
Interactions of key charged residues contributing to selective block of neuronal sodium channels by μ-conotoxin KIIIA. Mol. Pharmacol. (2011) 80: 573-584 [P, NA]
McArthur,J.R., Singh,G., O Mara,M.L., McMaster,D., Ostroumov,V., Tieleman,D.P. and French,R.J
Orientation of {micro}-Conotoxin PIIIA in a Sodium Channel Vestibule, Based on Voltage Dependence of Its Binding. Mol. Pharmacol. (2011) 80: 219-227 [P, NA]
Pucci,L., Grazioso,G., Dallanoce,C., Rizzi,L., De Micheli,C., Clementi,F., Bertrand,S., Bertrand,D., Longhi,R., De Amici,M. and Gotti,C.
Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors. FASEB J. (2011) 25: 3775-3789 [P, NA]
Safavi-Hemami,H., Siero,W.A., Kuang,Z., Williamson,N.A., Karas,J.A., Page,L.R., MacMillan,D., Callaghan,B., Kompella,S.N., Adams,D.J., Norton,R.S., and Purcell,A.W.
Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? J. Biol. Chem. (2011) 286: 22546-22557 [P, NA]
Sun,D., Ren,Z., Zeng,X., You,Y., Pan,W., Zhou,M., Wang,L. and Xu,A.
Structure-function relationship of conotoxin lt14a, a potential analgesic with low cytotoxicity. Peptides (2011) 32: 300-305 [P, NA]
Van Der Haegen,A., Peigneur,S. and Tytgat,J.
Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity. FEBS J. (2011) 278: 3408-3418 [P, NA]
Wilson,M.J., Yoshikami,D., Azam,L., Gajewiak,J., Olivera,B.M., Bulaj,G. and Zhang,M.M.
μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc. Natl. Acad. Sci. U.S.A. (2011) 108: 10302-10307 [P, NA]
Wilson,M.J., Zhang,M.M., Azam,L., Olivera,B.M., Bulaj,G. and Yoshikami,D.
NaV{beta} Subunits Modulate the Inhibition of NaV1.8 by the Analgesic Gating Modifier {micro}O-Conotoxin MrVIB. J. Pharmacol. Exp. Ther. (2011) 338: 687-693 [P, NA]
Ye,M., Hong,J., Zhou,M., Huang,L., Shao,X., Yang,Y., Sigworth,F.J., Chi,C., Lin,D. and Wang,C.
A novel conotoxin, qc16a, with a unique cysteine framework and folding. Peptides (2011) 32: 1159-1165 [P, NA]
Yu,R., Craik,D.J. and Kaas,Q.
Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PLoS Comput. Biol. (2011) 7 [P, NA]
2010

Armishaw,C.J., Singh,N., Medina-Franco,J.L., Clark,R.J., Scott,K.C., Houghten,R.A. and Jensen,A.A.
A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists. J. Biol. Chem. (2010) 285: 1809-1821 [P, NA]
Azam,L., Maskos,U., Changeux,J.P., Dowell,C.D., Christensen,S., De Biasi,M. and McIntosh,J.M.
α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. FASEB J. (2010) 24: 5113-5123 [P, NA]
Berecki,G., Motin,L., Haythornthwaite,A., Vink,S., Bansal,P., Drinkwater,R., Wang,C.I., Moretta,M., Lewis,R.J., Alewood,P.F. and Adams,D.J.
Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Mol. Pharmacol. (2010) 77: 139-148 [P, NA]
Biggs,J.S., Watkins,M., Puillandre,N., Ownby,J.P., Lopez-Vera,E., Christensen,S., Moreno,K.J., Bernaldez,J., Licea-Navarro,A. and Olivera,B.M.
Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. Mol. Phylogenet. Evol. (2010) 56: 1-12 [P, NA]
Chen,P., Dendorfer,A., Finol-Urdaneta,R.K., Terlau,H. and Olivera,B.M.
Biochemical characterization of kM-RIIIJ, a KV1.2 channel blocker: Evaluation of cardioprotective effects of kM-conotoxins. J Biol Chem (2010) 285: 14882-14889 [P, NA]
Clark,R.J., Jensen,J., Nevin,S.T., Callaghan,B.P. and Craik,D.J.
The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angew. Chem. Int. Ed. Engl. (2010) 49: 6545-6548 [P, NA]
Gowd,K.H., Watkins,M., Twede,V.D., Bulaj,G.W. and Olivera,B.M.
Characterization of conantokin Rl-A: molecular phylogeny as structure/function study. J. Pept. Sci. (2010) 16: 375-382 [P, NA]
Grishin,A.A., Wang,C.I., Muttenthaler,M., Alewood,P.F., Lewis,R.J. and Adams,D.J.
Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors. J. Biol. Chem. (2010) 285: 22254-22263 [P, NA]
Gupta,K. and Balaram,P.
Disulfide bond assignments by mass spectrometry of native natural peptides: cysteine pairing in disulfide bonded conotoxins. Anal. Chem. (2010) 82: 8313-8319 [P, NA]
Jimenez,E.C. and Olivera,B.M.
Divergent M- and O-superfamily peptides from venom of fish-hunting Conus parius. Peptides (2010) 31: 1678-1683 [P, NA]
Kaas,Q., Westermann, J. and Craik,D.J.
Conopeptide characterization and classifications: an analysis using ConoServer. Toxicon (2010) 55: 1491-1509 [P, NA]
Lee,S., Kim,Y., Back,S.K., Choi,H.W., Lee,J.Y., Jung,H.H., Ryu,J.H., Suh,H.W., Na,H.S., Kim,H.J. and Kim,J.I.
Analgesic effect of highly reversible ω-conotoxin FVIA on N type Ca2+ channels. Mol Pain (2010) 6: 97-0 [P, NA]
Liu,Z., Yu,Z., Liu,N., Zhao,C., Hu,J. and Dai,Q.
cDNA cloning of conotoxins with framework XII from several Conus species. Acta Biochim. Biophys. Sin. (Shanghai) (2010) 42: 656-661 [P, NA]
Luo,S., Akondi,K.B., Zhangsun,D., Wu,Y., Zhu,X., Hu,Y., Christensen,S., Dowell,C., Daly,N.L., Craik,D.J., Wang,C.I., Lewis,R.J., Alewood,P.F. and Michael McIntosh,J.
Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor. J. Biol. Chem. (2010) 285: 12355-12366 [P, NA]
Peng,C., Chen,W., Sanders,T., Chew,G., Liu,J., Hawrot,E. and Chi,C.
Chemical synthesis and characterization of two α4/7-conotoxins. Acta Biochim. Biophys. Sin. (Shanghai) (2010) 42: 745-753 [P, NA]
Peng,C., Ye,M., Wang,Y., Shao,X., Yuan,D., Liu,J., Hawrot,E. and Chi,C.
A new subfamily of conotoxins belonging to the A-superfamily. Peptides (2010) 31: 2009-2016 [P, NA]
Puillandre,N. and Olivera,B.M.
Evolution of Conus Peptide Genes: Duplication and Positive Selection in the A-Superfamily. J Mol Evol (2010) [P, NA]
Wu,X.C., Zhou,M., Peng,C., Shao,X.X. and Chi,C.W.
Novel conopeptides in a form of disulfide-crosslinked dimer. Peptides (2010) 31: 1001-1006 [P, NA]
Xu,J., Wang,Y., Zhang,B. and Du,W.
Stereochemistry of 4-hydroxyproline affects the conformation of conopeptides. Chem. Commun. (Camb.) (2010) 46: 5467-5469 [P, NA]
Zhang,L., Shao,X., Chi,C. and Wang,C.
Two short D-Phe-containing cysteine-free conopeptides from Conus marmoreus. Peptides (2010) 31: 177-179 [P, NA]
2009

Aguilar,M.B., Flores-Torres,A., Batista,C.V., Falcon,A., Lopez-Vera,E. and de la Cotera,E.P.
Structural characterization of five post-translationally modified isomorphs of a novel putative delta-conotoxin from the vermivorous snail Conus delessertii from the Mexican Caribbean Sea. Peptides (2009) 30: 458-466 [P, NA]
Armishaw,C., Jensen,A.A., Balle,T., Clark,R.J., Harpsøe,K., Skonberg,C., Liljefors,T. and Strømgaard,K.
Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives. J. Biol. Chem. (2009) 284: 9498-9512 [P, NA]
Biass,D., Dutertre,S., Gerbault,A., Menou,J.L., Offord,R., Favreau,P. and Stöcklin,R.
Comparative proteomic study of the venom of the piscivorous cone snail Conus consors. J Proteomics (2009) 72: 210-218 [P, NA]
Brust,A., Palant,E., Croker,D.E., Colless,B., Drinkwater,R., Patterson,B., Schroeder,C.I., Wilson,D., Nielsen,C.K., Smith,M.T., Alewood,D., Alewood,P.F. and Lewis,R.J.
chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. J. Med. Chem. (2009) 52: 6991-7002 [P, NA]
Davis,J., Jones,A. and Lewis,R.J.
Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS. Peptides (2009) 30: 1222-1227 [P, NA]
Duda,T.F. Jr. and Lee,T.
Ecological release and venom evolution of a predatory marine snail at Easter Island. PLoS ONE (2009) 4 [P, NA]
Duda,T.F. Jr., Chang,D., Lewis,B.D. and Lee,T.
Geographic variation in venom allelic composition and diets of the widespread predatory marine gastropod Conus ebraeus. PLoS ONE (2009) 4 [P, NA]
Halai,R., Clark,R.J., Nevin,S.T., Jensen,J.E., Adams,D.J. and Craik,D.J.
Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor. J. Biol. Chem. (2009) [P, NA]
Han TS, Zhang MM, Walewska A, Gruszczynski P, Robertson CR, Cheatham TE 3rd, Yoshikami D, Olivera BM, Bulaj G
Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics. ChemMedChem (2009) 4: 406-414 [P, NA]
Holford,M., Zhang,M.M., Gowd,K.H., Azam,L., Green,B.R., Watkins,M., Ownby,J.P., Yoshikami,D., Bulaj,G. and Olivera,B.M.
Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon (2009) 53: 90-98 [P, NA]
Hone,A.J., Whiteaker,P., Christensen,S., Xiao,Y., Meyer,E.L. and McIntosh,J.M.
A novel fluorescent alpha-conotoxin for the study of alpha7 nicotinic acetylcholine receptors. J. Neurochem. (2009) 111: 80-89 [P, NA]
Huang,F. and Du,W.
Solution Structure of Hyp10Pro variant of conomarphin, a cysteine-free and D-amino-acid containing conopeptide. Toxicon (2009) [P, NA]
Kasheverov,I.E., Zhmak,M.N., Fish,A., Rucktooa,P., Khruschov,A.Y., Osipov,A.V., Ziganshin,R.H., D'hoedt,D., Bertrand,D., Sixma,T.K., Smit,A.B. and Tsetlin,V.I.
Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor. J. Neurochem. (2009) 111: 934-944 [P, NA]
Kauferstein,S., Kendel,Y., Nicke,A., Coronas,F.I., Possani,L.D., Favreau,P., Krizaj,I., Wunder,C., Kauert,G. and Mebs,D.
New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors. Toxicon (2009) 54: 295-301 [P, NA]
Khoo,K.K., Feng,Z.P., Smith,B.J., Zhang,M.M., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S.
Structure of the Analgesic mu-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion. Biochemistry (2009) 6: 1210-1219 [P, NA]
Lewis RJ
Conotoxins: molecular and therapeutic targets. Prog. Mol. Subcell. Biol. (2009) 46: 45-65 [P, NA]
Liu,Z., Xu,N., Hu,J., Zhao,C., Yu,Z. and Dai,Q.
Identification of novel I-superfamily conopeptides from several clades of Conus species found in the South China Sea. Peptides (2009) 30: 1782-1787 [P, NA]
Loughnan,M.L., Nicke,A., Lawrence,N. and Lewis,R.J.
Novel alphaD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry (2009) 48: 3717-3729 [P, NA]
MacRaild,C.A., Illesinghe,J., van Lierop,B.J., Townsend,A.L., Chebib,M., Livett,B.G., Robinson,A.J. and Norton,R.S.
Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an alpha-conotoxin containing a nonreducible cystine analogue. J. Med. Chem. (2009) 52: 755-762 [P, NA]
Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL
Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. J Biol Chem. (2009) 284: 4944-4951 [P, NA]
Peng,C., Chen,W., Han,Y., Sanders,T., Chew,G., Liu,J., Hawrot,E., Chi,C. and Wang,C.
Characterization of a novel alpha4/4-conotoxin, Qc1.2, from vermivorous Conus quercinus. Acta Biochim. Biophys. Sin. (Shanghai) (2009) 41: 858-864 [P, NA]
Quinton,L., Gilles,N. and De Pauw,E.
TxXIIIA, an atypical homodimeric conotoxin found in the Conus textile venom. J Proteomics (2009) 72: 219-226 [P, NA]
Turner,M., Eidemiller,S., Martin,B., Narver,A., Marshall,J., Zemp,L., Cornell,K.A., McIntosh,J.M. and McDougal,O.M.
Structural basis for alpha-conotoxin potency and selectivity. Bioorg. Med. Chem. (2009) 17: 5894-5899 [P, NA]
Twede,V.D., Miljanich,G., Olivera,B.M. and Bulaj,G.
Neuroprotective and cardioprotective conopeptides: an emerging class of drug leads. Curr Opin Drug Discov Devel (2009) 12: 231-239 [P, NA]
Twede,V.D., Teichert,R.W., Walker,C.S., Gruszczynski,P., Kazmierkiewicz,R., Bulaj,G. and Olivera,B.M.
Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor. Biochemistry (2009) 48: 4063-4073 [P, NA]
Ueberheide,B.M., Fenyö,D., Alewood,P.F. and Chait,B.T.
Rapid sensitive analysis of cysteine rich peptide venom components. Proc. Natl. Acad. Sci. U.S.A. (2009) 106: 6910-6915 [P, NA]
Walker,C.S., Jensen,S., Ellison,M., Matta,J.A., Lee,W.Y., Imperial,J.S., Duclos,N., Brockie,P.J., Madsen,D.M., Isaac,J.T., Olivera,B. and Maricq,A.V.
A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors. Curr. Biol. (2009) 19: 900-908 [P, NA]
Wang,L., Liu,J., Pi,C., Zeng,X., Zhou,M., Jiang,X., Chen,S., Ren,Z. and Xu,A.
Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents. Arch. Toxicol. (2009) [P, NA]
Yuan,D.D., Liu,L., Shao,X.X., Peng,C., Chi,C.W. and Guo,Z.Y.
New conotoxins define the novel I3-superfamily. Peptides (2009) 30: 861-865 [P, NA]
Zamora-Bustillos,R., Aguilar,M.B. and Falcón,A.
Identification, by molecular cloning, of a novel type of I(2)-superfamily conotoxin precursor and two novel I(2)-conotoxins from the worm-hunter snail Conus spurius from the Gulf of México Peptides (2009) 31: 384-393 [P, NA]
Zamora-Bustillos,R., Aguilar,M.B., Falcón,A. and Heimer de la Cotera,E.P.
Identification, by RT-PCR, of four novel T-1-superfamily conotoxins from the vermivorous snail Conus spurius from the Gulf of Mexico. Peptides (2009) 30: 1396-1404 [P, NA]
2008

Aguilar,M.B., Luna-Rami­rez,K.S., Echeverria,D., Falcon,A., Olivera,B.M., Heimer de la Cotera,E.P. and Maillo,M.
Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks. Peptides (2008) 29: 186-195 [P, NA]
Azam,L., Yoshikami,D., and McIntosh,J.M.
Amino acid residues that confer high selectivity of the alpha6 nicotinic acetylcholine receptor subunit to alpha-conotoxin MII[S4A,E11A,L15A]. J. Biol. Chem. (2008) 283: 11625-11632 [P, NA]
Benoit,E., Favreau,P., Schlumberger,S., Cordova,M.A., Tytgat,J., Stocklin, R. abd and R. Stocklin and Molgo J.
A new mu-conotoxin from Conus consors that atypically targets sodium channels in unmyelinated and myelinated nerve fibers Abstract Book, 16th European Section Meeting of the International Society on Toxinology (2008) [P, NA]
Biggs,J.S., Olivera,B.M. and Kantor,Y.I.
alpha-Conopeptides specifically expressed in the salivary gland of Conus pulicarius. Toxicon (2008) 52: 101-105 [P, NA]
Buczek,O., Jimenez,E.C., Yoshikami,D., Imperial,J.S., Watkins,M., Morrison,A. and Olivera,B.M.
I(1)-superfamily conotoxins and prediction of single D-amino acid occurrence. Toxicon (2008) 51: 218-229 [P, NA]
Callaghan,B., Haythornthwaite,A., Berecki,G., Clark,R.J., Craik,D.J. and Adams,D.J.
Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation. J. Neurosci. (2008) 28: 10943-10951 [P, NA]
Chen,P., Garrett,J.E., Watkins,M. and Olivera,B.M.
Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins. Toxicon (2008) 52: 139-145 [P, NA]
Clark,R.J., Daly,N.L., Halai,R., Nevin,S.T., Adams,D.J. and Craik,D.J.
The three-dimensional structure of the analgesic alpha-conotoxin, RgIA. FEBS Lett. (2008) 582: 597-602 [P, NA]
Duda,T.F. Jr. and Remigio,E.A.
Variation and evolution of toxin gene expression patterns of six closely related venomous marine snails. Mol. Ecol. (2008) 17: 3018-3032 [P, NA]
Duda,T.F. Jr., Bolin,M.B., Meyer,C.P. and Kohn,A.J.
Hidden diversity in a hyperdiverse gastropod genus: discovery of previously unidentified members of a Conus species complex. Mol. Phylogenet. Evol. (2008) 49: 867-876 [P, NA]
Dutertre,S., Croker,D., Daly,N.L., Andersson,A., Muttenthaler,M., Lumsden,N.G., Craik,D.J., Alewood,P.F., Guillon,G. and Lewis,R.J.
Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. J. Biol. Chem. (2008) 283: 7100-7108 [P, NA]
Ellison,M., Feng,Z.P., Park,A.J., Zhang,X., Olivera,B.M., McIntosh,J.M. and Norton,R.S.
Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues. J. Mol. Biol. (2008) 377: 1216-1227 [P, NA]
Fiedler,B., Zhang,M.M., Buczek,O., Azam,L., Bulaj,G., Norton,R.S., Olivera,B.M. and Yoshikami,D.
Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochem. Pharmacol. (2008) 75: 2334-2344 [P, NA]
Gowd,K.H., Dewan,K.K., Iengar,P., Krishnan,K.S. and Balaram,P.
Probing peptide libraries from Conus achatinus using mass spectrometry and cDNA sequencing: identification of delta and omega-conotoxins. J Mass Spectrom (2008) 43: 791-805 [P, NA]
Gowd,K.H., Twede,V., Watkins,M., Krishnan,K.S., Teichert,R.W., Bulaj,G. and Olivera,B.M.
Conantokin-P, an unusual conantokin with a long disulfide loop. Toxicon (2008) 52: 203-213 [P, NA]
Han,Y., Huang,F., Jiang,H., Liu,L., Wang,Q., Wang,Y., Shao,X., Chi,C., Du,W. and Wang,C.
Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus. FEBS J. (2008) 275: 1976-1987 [P, NA]
Imperial,J.S., Chen,P., Sporning,A., Terlau,H., Daly,N.L., Craik,D.J. and Olivera,B.M.
Tyrosine-rich conopeptides affect voltage-gated K+ channels. J. Biol. Chem. (2008) 283: 23026-23032 [P, NA]
Innocent,N., Livingstone,P.D., Hone,A., Kimura,A., Young,T., Whiteaker,P., McIntosh,J.M. and Wonnacott,S.
Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors. J. Pharmacol. Exp. Ther. (2008) 327: 529-537 [P, NA]
Kaas,Q., Westermann,J.C., Halai,R. and Craik,D.J.
ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24: 445-446 [P, NA]
Liu,L., Wu,X., Yuan,D., Chi,C. and Wang,C.
Identification of a novel S-superfamily conotoxin from vermivorous Conus caracteristicus. Toxicon (2008) 51: 1331-1337 [P, NA]
Lluisma,A.O., López-Vera,E., Bulaj,G., Watkins,M. and Olivera,B.M.
Characterization of a novel psi-conotoxin from Conus parius Reeve. Toxicon (2008) 51: 174-180 [P, NA]
Motin,L. and Adams,D.J.
omega-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn. Neuropharmacology (2008) 55: 860-864 [P, NA]
Peng,C., Han,Y., Sanders,T., Chew,G., Liu,J., Hawrot,E., Chi,C. and Wang,C.
alpha4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors. Peptides (2008) 29: 1700-1707 [P, NA]
Peng,C., Liu,L., Shao,X., Chi,C. and Wang,C.
Identification of a novel class of conotoxins defined as V-conotoxins with a unique cysteine pattern and signal peptide sequence. Peptides (2008) 29: 985-991 [P, NA]
Remigio,E.A. and Duda,T.F. Jr.
Evolution of ecological specialization and venom of a predatory marine gastropod. Mol. Ecol. (2008) 17: 1156-1162 [P, NA]
Romeo,C., Di Francesco,L., Oliverio,M., Palazzo,P., Massilia,G.R., Ascenzi,P., Polticelli,F. and Schininà,M.E.
Conus ventricosus venom peptides profiling by HPLC-MS: a new insight in the intraspecific variation. J Sep Sci (2008) 31: 488-498 [P, NA]
Schroeder,C.I., Ekberg,J., Nielsen,K.J., Adams,D., Loughnan,M.L., Thomas,L., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Neuronally mu-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. J. Biol. Chem. (2008) 283: 21621-21628 [P, NA]
Walewska A, Skalicky JJ, Davis DR, Zhang MM, Lopez-Vera E, Watkins M, Han TS, Yoshikami D, Olivera BM, Bulaj G
NMR-based mapping of disulfide bridges in cysteine-rich peptides: application to the mu-conotoxin SxIIIA J Am Chem Soc (2008) 130: 14280-14286 [P, NA]
Wang,L., Pi,C., Liu,J., Chen,S., Peng,C., Sun,D., Zhou,M., Xiang,H., Ren,Z. and Xu,A.
Identification and characterization of a novel O-superfamily conotoxin from Conus litteratus. J. Pept. Sci. (2008) 14: 1077-1083 [P, NA]
Wang,Q., Jiang,H., Han,Y.H., Yuan,D.D. and Chi,C.W.
Two different groups of signal sequence in M-superfamily conotoxins. Toxicon (2008) 51: 813-822 [P, NA]
Wang,Y., Shao,X., Li,M., Wang,S., Chi,C. and Wang,C.
mr1e, a conotoxin from Conus marmoreus with a novel disulfide pattern. Acta Biochim. Biophys. Sin. (Shanghai) (2008) 40: 391-396 [P, NA]
Whiteaker,P., Marks,M.J., Christensen,S., Dowell,C., Collins,A.C. and McIntosh,J.M.
Synthesis and characterization of 125I-alpha-conotoxin ArIB[V11L;V16A], a selective alpha7 nicotinic acetylcholine receptor antagonist. J. Pharmacol. Exp. Ther. (2008) 325: 910-919 [P, NA]
Yao,S., Zhang,M.M., Yoshikami,D., Azam,L., Olivera,B.M., Bulaj,G. and Norton,R.S.
Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA. Biochemistry (2008) 47: 10940-10949 [P, NA]
Yuan,D.D., Liu,L., Shao,X.X., Peng,C., Chi,C.W. and Guo,Z.Y.
Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus. Peptides (2008) 29: 1521-1525 [P, NA]
Zugasti-Cruz,A., Aguilar,M.B., Falcón,A., Olivera,B.M. and Heimer de la Cotera,E.P.
Two new 4-Cys conotoxins (framework 14) of the vermivorous snail Conus austini from the Gulf of Mexico with activity in the central nervous system of mice. Peptides (2008) 29: 179-185 [P, NA]
2007

Aguilar,M.B., López-Vera,E., Heimer de la Cotera,E.P., Falcón,A., Olivera,B.M. and Maillo,M.
I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius. Peptides (2007) 28: 18-23 [P, NA]
Biggs,J.S., Rosenfeld,Y., Shai,Y. and Olivera,B.M.
Conolysin-Mt: a conus peptide that disrupts cellular membranes. Biochemistry (2007) 46: 12586-12593 [P, NA]
Bordia,T., Grady,S.R., McIntosh,J.M. and Quik,M.
Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson Mol. Pharmacol. (2007) 72: 52-61 [P, NA]
Buczek,O., Wei,D., Babon,J.J., Yang,X., Fiedler,B., Chen,P., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S.
Structure and sodium channel activity of an excitatory I1-superfamily conotoxin. Biochemistry (2007) 46: 9929-9940 [P, NA]
Cortez,L., Marino-Buslje,C., de Jiménez Bonino,M.B. and Hellman,U.
Interactions between alpha-conotoxin MI and the Torpedo marmorata receptor alpha-delta interface. Biochem. Biophys. Res. Commun. (2007) 355: 275-279 [P, NA]
Du,W.H., Han,Y.H., Huang,F.J., Li,J., Chi,C.W. and Fang,W.H.
Solution structure of an M-1 conotoxin with a novel disulfide linkage FEBS J. (2007) 274: 2596-2602 [P, NA]
Dutertre,S., Ulens,C., Büttner,R., Fish,A., van Elk,R., Kendel,Y., Hopping,G., Alewood,P.F., Schroeder,C., Nicke,A., Smit,A.B., Sixma,T.K. and Lewis,R.J.
AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. EMBO J. (2007) 26: 3858-3867 [P, NA]
Jimenez,E.C., Olivera,B.M. and Teichert,R.W.
AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists. Biochemistry (2007) 46: 8717-8724 [P, NA]
Jin,A.H., Brandstaetter,H., Nevin,S.T., Tan,C.C., Clark,R.J., Adams,D.J., Alewood,P.F., Craik,D.J. and Daly,N.L.
Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics. BMC Struct. Biol. (2007) 7: 28-0 [P, NA]
Kang,T.S., Radic,Z., Talley,T.T., Jois,S.D., Taylor,P. and Kini,R.M.
Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins. Biochemistry (2007) 46: 3338-3355 [P, NA]
Korukottu,J., Bayrhuber,M., Montaville,P., Vijayan,V., Jung,Y.S., Becker,S. and Zweckstetter,M.
Fast high-resolution protein structure determination by using unassigned NMR data. Angew. Chem. Int. Ed. Engl. (2007) 46: 1176-1179 [P, NA]
López-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano Cassulini,R., Batista,C.V., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B. and Wanke,E.
Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. (2007) 274: 3972-3985 [P, NA]
López-Vera,E., Jacobsen,R.B., Ellison,M., Olivera,B.M. and Teichert,R.W.
A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors Toxicon (2007) 49: 1193-1199 [P, NA]
Lewis,R.J., Schroeder,C.I., Ekberg,J., Nielsen,K.J., Loughnan,M., Thomas,L., Adams,D.A., Drinkwater,R., Adams,D.J. and Alewood,P.F.
Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels Mol. Pharmacol. (2007) 71: 676-685 [P, NA]
Liu,J., Wu,Q., Pi,C., Zhao,Y., Zhou,M., Wang,L., Chen,S. and Xu,A.
Isolation and characterization of a T-superfamily conotoxin from Conus litteratus with targeting tetrodotoxin-sensitive sodium channels. Peptides (2007) 28: 2313-2319 [P, NA]
Liu,L., Chew,G., Hawrot,E., Chi,C. and Wang,C.
Two potent alpha3/5 conotoxins from piscivorous Conus achatinus. Acta Biochim. Biophys. Sin. (Shanghai) (2007) 39: 438-444 [P, NA]
Luna-Ramirez,K.S., Aguilar,M.B., Falcon,A., Heimer de la Cotera,E.P., Olivera,B.M. and Maillo,M.
An O-conotoxin from the vermivorous Conus spurius active on mice and mollusks Peptides (2007) 28: 24-30 [P, NA]
Luo,S., Zhangsun,D., Feng,J., Wu,Y., Zhu,X. and Hu,Y.
Diversity of the O-superfamily conotoxins from Conus miles J. Pept. Sci. (2007) 13: 44-53 [P, NA]
Mandal,A.K., Ramasamy,M.R., Sabareesh,V., Openshaw,M.E., Krishnan,K.S. and Balaram,P.
Sequencing of T-superfamily conotoxins from Conus virgo: pyroglutamic acid identification and disulfide arrangement by MALDI mass spectrometry. J. Am. Soc. Mass Spectrom. (2007) 18: 1396-1404 [P, NA]
Moller,C. and Mari,F.
A vasopressin/oxytocin-related conopeptide with gamma-carboxyglutamate at position 8 Biochem. J. (2007) 404: 413-419 [P, NA]
Nevin,S.T., Clark,R.J., Klimis,H., Christie,M.J., Craik,D.J. and Adams,D.J.
Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Mol. Pharmacol. (2007) 72: 1406-1410 [P, NA]
Peng,C., Wu,X., Han,Y., Yuan,D., Chi,C. and Wang,C.
Identification of six novel T-1 conotoxins from Conus pulicarius by molecular cloning. Peptides (2007) 28: 2116-2124 [P, NA]
Teichert,R.W., Jacobsen,R., Terlau,H., Yoshikami,D. and Olivera,B.M.
Discovery and characterization of the short kappaA-conotoxins: a novel subfamily of excitatory conotoxins Toxicon (2007) 49: 318-328 [P, NA]
Teichert,R.W., Jimenez,E.C., Twede,V., Watkins,M., Hollmann,M., Bulaj,G. and Olivera,B.M.
Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. J. Biol. Chem. (2007) 282: 36905-36913 [P, NA]
Thakur,S.S. and Balaram,P.
Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom. Rapid Commun. Mass Spectrom. (2007) 21: 3420-3426 [P, NA]
Watkins, M., Hillyard, D.R., McIntosh, M.J., Jones, R.M. and Olivera, B.M.
Alpha-conotoxin peptides Patent: EP 1852440-A 07-NOV-2007; University of Utah Research Foundation (US); (2007) [P, NA]
Whiteaker, P., Christensen,S., Yoshikami,D., Dowell,C., Watkins,M., Gulyas,J., Rivier,J., Olivera,B.M. and McIntosh,J.M.
Discovery, Synthesis, and Structure Activity of a Highly Selective alpha7 Nicotinic Acetylcholine Receptor Antagonist Biochemistry (2007) 46: 6628-6638 [P, NA]
Yuan,D.D., Han,Y.H., Wang,C.G. and Chi,C.W.
From the identification of gene organization of alpha conotoxins to the cloning of novel toxins Toxicon (2007) 49: 1135-1149 [P, NA]
Zhang,M.M., Green,B.R., Catlin,P., Fiedler,B., Azam,L., Chadwick,A., Terlau,H., McArthur,J.R., French,R.J., Gulyas,J., Rivier,J.E., Smith,B.J., Norton,R.S., Olivera,B.M., Yoshikami,D. and Bulaj,G.
Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J. Biol. Chem. (2007) 282: 30699-30706 [P, NA]
2006

Aguilar,M.B., Lezama-Monfil,L., Maillo,M., Pedraza-Lara,H., Lopez-Vera,E. and Heimer de la Cotera,E.P.
A biologically active hydrophobic T-1-conotoxin from the venom of Conus spurius Peptides (2006) 27: 500-505 [P, NA]
Armishaw,C.J., Daly,N.L., Nevin,S.T., Adams,D.J., Craik,D.J. and Alewood,P.F.
Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists J. Biol. Chem. (2006) 281: 14136-14143 [P, NA]
Bulaj,G., West,P.J., Garrett,J.E., Watkins,M., Zhang,M.-M., Norton,R.S., Smith,B.J., Yoshikami,D. and Olivera,B.M.
Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity. Biochemistry (2006) 45: 3116-0 [P, NA]
Bulaj,G., Zhang,M.M., Green,B.R., Fiedler,B., Layer,R.T., Wei,S., Nielsen,J.S., Low,S.J., Klein,B.D., Wagstaff,J.D., Chicoine,L., Harty,T.P., Terlau,H., Yoshikami,D. and Olivera,B.M.
Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity Biochemistry (2006) 45: 7404-7414 [P, NA]
Chen,W.H., Han,Y.H., Wang,Q., Miao,X.W., Ou,L. and Shao,X.X.
cDNA cloning of two novel T-superfamily conotoxins from Conus leopardus Acta Biochim. Biophys. Sin. (Shanghai) (2006) 38: 287-291 [P, NA]
Chen,W.H., Han,Y.H., Wang,Q., Miao,X.W., Ou,L. and Shao,X.X.
cDNA cloning of two novel T-superfamily conotoxins from Conus leopardus Acta Biochim. Biophys. Sin. (Shanghai) (2006) 38: 287-291 [P, NA]
Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H.
Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes Biochem. Biophys. Res. Commun. (2006) 345: 248-254 [P, NA]
Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H.
NMR structure determination of alpha-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold Biochem. Biophys. Res. Commun. (2006) 349: 1228-1234 [P, NA]
Clark,R.J., Fischer,H., Nevin,S.T., Adams,D.J. and Craik,D.J.
The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1 J. Biol. Chem. (2006) 281: 23254-23263 [P, NA]
Craik,D.J., Daly,N.L. and Nielsen,K.J.
Cyclized conotoxin peptides Patent: US 7001883-A 29 21-FEB-2006; The University of Queensland; Queensland; AU; (2006) [P, NA]
Croker D., Dutertre S., Alewood P., and Lewis R.
Discovery and pharmacology of conopressin-T, a novel vasopressin-like peptide from Conus tulipa. Acta Pharmacologica Sinica (2006) 27: 351-351 [P, NA]
Czerwiec,E., Kalume,D.E., Roepstorff,P., Hambe,B., Furie,B., Furie,B.C. and Stenflo,J.
Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile. FEBS J. (2006) 273: 2779-2788 [P, NA]
Drinkwater,R.D., Lewis,R.J., Alewood,P.F. and Nielsen,K.J.
Omega.conotoxin peptides Patent: US 7101849 05-SEP-2006 (2006) [P, NA]
Dutertre,S., Lumsden,N.G., Alewood,P.F. and Lewis,R.J.
Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail. FEBS Lett. (2006) 580: 3860-3866 [P, NA]
Dy,C.Y., Buczek,P., Imperial,J.S., Bulaj,G. and Horvath,M.P.
Structure of conkunitzin-S1, a neurotoxin and Kunitz-fold disulfide variant from cone snail. Acta Crystallogr. D Biol. Crystallogr. (2006) 62: 980-990 [P, NA]
Ellison,M., Haberlandt,C., Gomez-Casati,M.E., Watkins,M., Elgoyhen,A.B., McIntosh,J.M. and Olivera,B.M.
Alpha-RgIA: a novel conotoxin that specifically and potently blocks the alpha9alpha10 nAChR Biochemistry (2006) 45: 1511-1517 [P, NA]
Franco,A., Pisarewicz,K., Moller,C., Mora,D., Fields,G.B. and Mari,F.
Hyperhydroxylation: a new strategy for neuronal targeting by venomous marine molluscs Prog. Mol. Subcell. Biol. (2006) 43: 83-0 [P, NA]
Han,Y.H., Wang,Q., Jiang,H., Liu,L., Xiao,C., Yuan,D.D., Shao,X.X., Dai,Q.Y., Cheng,J.S. and Chi,C.W.
Characterization of novel M-superfamily conotoxins with new disulfide linkage FEBS J. (2006) 273: 4972-4982 [P, NA]
Imperial,J.S., Bansal,P.S., Alewood,P.F., Daly,N.L., Craik,D.J., Sporning,A., Terlau,H., Lopez-Vera,E., Bandyopadhyay,P.K. and Olivera,B.M.
A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins Biochemistry (2006) 45: 8331-8340 [P, NA]
Jakubowski,J.A., Kelley,W.P. and Sweedler,J.V.
Screening for post-translational modifications in conotoxins using liquid chromatography/mass spectrometry: an important component of conotoxin discovery Toxicon (2006) 47: 688-699 [P, NA]
Jiang,H., Wang,C.Z., Xu,C.Q., Fan,C.X., Dai,X.D., Chen,J.S. and Chi,C.W.
A novel M-superfamily conotoxin with a unique motif from Conus vexillum Peptides (2006) 27: 682-689 [P, NA]
Jiang,H., Xu,C.Q., Wang,C.Z., Fan,C.X., Zhao,T.Y., Chen,J.S. and Chi,C.W.
Two novel O-superfamily conotoxins from Conus vexillum Toxicon (2006) 47: 425-436 [P, NA]
Kang,T.S., Jois,S.D. and Kini,R.M.
Solution structures of two structural isoforms of CMrVIA chi/lambda-conotoxin Biomacromolecules (2006) 7: 2337-2346 [P, NA]
Kasheverov,I.E., Chiara,D.C., Zhmak,M.N., Maslennikov,I.V., Pashkov,V.S., Arseniev,A.S., Utkin,Y.N., Cohen,J.B. and Tsetlin,V.I.
alpha-Conotoxin GI benzoylphenylalanine derivatives. (1)H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor FEBS J. (2006) 273: 1373-1388 [P, NA]
Loughnan,M., Nicke,A., Jones,A., Schroeder,C.I., Nevin,S.T., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum J. Biol. Chem. (2006) 281: 24745-24755 [P, NA]
Lovelace,E.S., Armishaw,C.J., Colgrave,M.L., Wahlstrom,M.E., Alewood,P.F., Daly,N.L. and Craik,D.J.
Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter J. Med. Chem. (2006) 49: 6561-6568 [P, NA]
Luo,S., Zhangsun,D., Lin,Q., Xie,L., Wu,Y. and Zhu,X.
Sequence diversity of O-superfamily conopetides from Conus marmoreus native to Hainan Peptides (2006) 27: 3058-3068 [P, NA]
Luo,S., Zhangsun,D., Wu,Y., Zhu,X., Xie,L., Hu,Y., Zhang,J. and Zhao,X.
Identification and molecular diversity of T-superfamily conotoxins from Conus lividus and Conus litteratus Chem Biol Drug Des (2006) 68: 97-106 [P, NA]
Luo,S., Zhangsun,D., Zhang,B., Chen,X. and Feng,J.
Direct cDNA cloning of novel conotoxins of the T-superfamily from Conus textile Peptides (2006) 27: 2640-2646 [P, NA]
Luo,S., Zhangsun,D., Zhang,B., Quan,Y. and Wu,Y.
Novel alpha-conotoxins identified by gene sequencing from cone snails native to Hainan, and their sequence diversity J. Pept. Sci. (2006) 12: 693-704 [P, NA]
Mondal,S., Babu,R.M., Bhavna,R. and Ramakumar,S.
I-conotoxin superfamily revisited J. Pept. Sci. (2006) 12: 679-685 [P, NA]
Nair,S.S., Nilsson,C.L., Emmett,M.R., Schaub,T.M., Gowd,K.H., Thakur,S.S., Krishnan,K.S., Balaram,P. and Marshall,A.G.
De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry Anal. Chem. (2006) 78: 8082-8088 [P, NA]
Olivera,B.M.
Conus peptides: biodiversity-based discovery and exogenomics. J. Biol. Chem. (2006) 281: 31173-31177 [P, NA]
Peng,C., Tang,S., Pi,C., Liu,J., Wang,F., Wang,L., Zhou,W. and Xu,A.
Discovery of a novel class of conotoxin from Conus litteratus, lt14a, with a unique cysteine pattern Peptides (2006) 27: 2174-2181 [P, NA]
Pi,C., Liu,J., Peng,C., Liu,Y., Jiang,X., Zhao,Y., Tang,S., Wang,L., Dong,M., Chen,S. and Xu,A.
Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus Genomics (2006) 88: 809-819 [P, NA]
Pi,C., Liu,Y., Peng,C., Jiang,X., Liu,J., Xu,B., Yu,X., Yu,Y., Jiang,X., Wang,L., Dong,M., Chen,S. and Xu,A.L.
Analysis of expressed sequence tags from the venom ducts of Conus striatus: focusing on the expression profile of conotoxins Biochimie (2006) 88: 131-140 [P, NA]
Quinton,L., Le Caer,J.P., Vinh,J., Gilles,N. and Chamot-Rooke,J.
Fourier transform mass spectrometry: a powerful tool for toxin analysis Toxicon (2006) 47: 715-726 [P, NA]
Sabareesh,V., Gowd,K.H., Ramasamy,P., Sudarslal,S., Krishnan,K.S., Sikdar,S.K. and Balaram,P.
Characterization of contryphans from Conus loroisii and Conus amadis that target calcium channels Peptides (2006) 27: 2647-2654 [P, NA]
Shiembob,D.L., Roberts,R.L., Luetje,C.W. and McIntosh,J.M.
Determinants of alpha-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor beta subunit. Biochemistry (2006) 45: 11200-11207 [P, NA]
Talley,T.T., Olivera,B.M., Han,K.H., Christensen,S.B., Dowell,C., Tsigelny,I., Ho,K.Y., Taylor,P. and McIntosh,J.M.
Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors J. Biol. Chem. (2006) 281: 24678-24686 [P, NA]
Teichert,R.W., Lopez-Vera,E., Gulyas,J., Watkins,M., Rivier,J. and Olivera,B.M.
Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor Biochemistry (2006) 45: 1304-1312 [P, NA]
Ulens,C., Hogg,R.C., Celie,P.H., Bertrand,D., Tsetlin,V., Smit,A.B. and Sixma,T.K.
Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP Proc. Natl. Acad. Sci. U.S.A. (2006) 103: 3615-3620 [P, NA]
Vincler,M., Wittenauer,S., Parker,R., Ellison,M., Olivera,B.M. and McIntosh,J.M.
Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors. Proc. Natl. Acad. Sci. U.S.A. (2006) 103: 17880-17884 [P, NA]
Wang,C.Z., Zhang,H., Jiang,H., Lu,W., Zhao,Z.Q. and Chi,C.W.
A novel conotoxin from Conus striatus, mu-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels Toxicon (2006) 47: 122-132 [P, NA]
Watkins,M. and Olivera,B.M.
Genes expressed in a turrid venom duct: divergence and similarity to conotoxins. J. Mol. Evol. (2006) 62: 247-256 [P, NA]
Zhang,M.M., Fiedler,B., Green,B.R., Catlin,P., Watkins,M., Garrett,J.E., Smith,B.J., Yoshikami,D., Olivera,B.M. and Bulaj,G.
Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels Biochemistry (2006) 45: 3723-3732 [P, NA]
Zhangsun, D., Luo, S., Wu, Y., Zhu, X., Hu, Y. and Xie, L.
Novel O-superfamily conotoxins identified by cDNA cloning from three vermivorous Conus species. Chem Biol Drug Des. (2006) 68: 256-265 [P, NA]
Zorn,S., Leipold,E., Hansel,A., Bulaj,G., Olivera,B.M., Terlau,H. and Heinemann,S.H.
The muO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3 FEBS Lett. (2006) 580: 1360-1364 [P, NA]
Zugasti-Cruz,A., Maillo,M., Lopez-Vera,E., Falcon,A., Heimer de la Cotera,E.P., Olivera,B.M. and Aguilar,M.B.
Amino acid sequence and biological activity of a gamma-conotoxin-like peptide from the worm-hunting snail Conus austini Peptides (2006) 27: 506-511 [P, NA]
2005

Aguilar,M.B., López-Vera,E., Imperial,J.S., Falcón,A., Olivera,B.M. and de la Cotera,E.P.
Putative gamma-conotoxins in vermivorous cone snails: the case of Conus delessertii Peptides (2005) 26: 23-27 [P, NA]
Aguilar,M.B., López-Vera,E., Ortiz,E., Becerril,B., Possani,L.D., Olivera,B.M. and Heimer de la Cotera,E.P.
A novel conotoxin from Conus delessertii with posttranslationally modified lysine residues Biochemistry (2005) 44: 11130-11136 [P, NA]
Azam,L., Dowell,C., Watkins,M., Stitzel,J.A., Olivera,B.M. and McIntosh,J.M.
Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors J. Biol. Chem. (2005) 280: 80-87 [P, NA]
Bayrhuber,M., Vijayan,V., Ferber,M., Graf,R., Korukottu,J., Imperial,J., Garrett,J.E., Olivera,B.M., Terlau,H., Zweckstetter,M. and Becker,S.
Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization. J. Biol. Chem. (2005) 280: 23766-23770 [P, NA]
Bingham,J.P., Broxton,N.M., Livett,B.G., Down,J.G., Jones,A. and Moczydlowski,E.G.
Optimizing the connectivity in disulfide-rich peptides: alpha-conotoxin SII as a case study Anal. Biochem. (2005) 338: 48-61 [P, NA]
Brown,M.A., Begley,G.S., Czerwiec,E., Stenberg,L.M., Jacobs,M., Kalume,D.E., Roepstorff,P., Stenflo,J., Furie,B.C. and Furie,B.
Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation Biochemistry (2005) 44: 9150-9159 [P, NA]
Buczek,O., Yoshikami,D., Bulaj,G., Jimenez,E.C. and Olivera,B.M.
Post-translational amino acid isomerization: a functionally important D-amino acid in an excitatory peptide J. Biol. Chem. (2005) 280: 4247-4253 [P, NA]
Buczek,O., Yoshikami,D., Watkins,M., Bulaj,G., Jimenez,E.C. and Olivera,B.M.
Characterization of D-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily FEBS J. (2005) 272: 4178-4188 [P, NA]
Bulaj,G., West,P.J., Garrett,J.E., Watkins,M., Zhang,M.M., Norton,R.S., Smith,B.J., Yoshikami,D. and Olivera,B.M.
Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels Biochemistry (2005) 44: 7259-7265 [P, NA]
Celie,P.H., Kasheverov,I.E., Mordvintsev,D.Y., Hogg,R.C., van Nierop,P., van Elk,R., van Rossum-Fikkert,S.E., Zhmak,M.N., Bertrand,D., Tsetlin,V., Sixma,T.K. and Smit,A.B.
Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant Nat. Struct. Mol. Biol. (2005) 12: 582-588 [P, NA]
Chi,S.W., Lee,S.H., Kim,D.H., Kim,J.S., Olivera,B.M., McIntosh,J.M. and Han,K.H.
Solution structure of alpha-conotoxin PIA, a novel antagonist of alpha6 subunit containing nicotinic acetylcholine receptors Biochem. Biophys. Res. Commun. (2005) 338: 1990-1997 [P, NA]
Clark,R.J., Fischer,H., Dempster,L., Daly,N.L., Rosengren,K.J., Nevin,S.T., Meunier,F.A., Adams,D.J. and Craik,D.J.
Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII Proc. Natl. Acad. Sci. U.S.A. (2005) 102: 13767-13772 [P, NA]
Corpuz,G.P., Jacobsen,R.B., Jimenez,E.C., Watkins,M., Walker,C., Colledge,C., Garrett,J.E., McDougal,O., Li,W., Gray,W.R., Hillyard,D.R., Rivier,J., McIntosh,J.M., Cruz,L.J. and Olivera,B.M.
Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms Biochemistry (2005) 44: 8176-8186 [P, NA]
Dutertre,S., Nicke,A., and Lewis,R.J.
Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor. J. Biol. Chem. (2005) 280: 30460-30468 [P, NA]
Gowd,K.H., Sabareesh,V., Sudarslal,S., Iengar,P., Franklin,B., Fernando,A., Dewan,K., Ramaswami,M., Sarma,S.P., Sikdar,S., Balaram,P. and Krishnan,K.S.
Novel peptides of therapeutic promise from Indian Conidae Ann. N. Y. Acad. Sci. (2005) 1056: 462-0 [P, NA]
Han,Y.H., Wang,Q., Jiang,H., Miao,X.W., Chen,J.S. and Chi,C.W.
Sequence diversity of T-superfamily conotoxins from Conus marmoreus Toxicon (2005) 45: 481-487 [P, NA]
Hansen,S.B., Sulzenbacher,G., Huxford,T., Marchot,P., Taylor,P. and Bourne,Y.
Structures Of Aplysia Achbp Complexes With Nicotinic Agonists And Antagonists Reveal Distinctive Binding Interfaces And Conformations Embo J. (2005) 24: 3635-0 [P, NA]
Huang,X., Dong,F. and Zhou,H.X.
Electrostatic recognition and induced fit in the kappa-PVIIA toxin binding to Shaker potassium channel. J. Am. Chem. Soc. (2005) 127: 6836-6849 [P, NA]
Kauferstein,S., Melaun,C. and Mebs,D.
Direct cDNA cloning of novel conopeptide precursors of the O-superfamily Peptides (2005) 26: 361-367 [P, NA]
Lang,P.M., Burgstahler,R., Haberberger,R.V., Sippel,W. and Grafe,P.
A conus peptide blocks nicotinic receptors of unmyelinated axons in human nerves Neuroreport (2005) 16: 479-483 [P, NA]
Leipold,E., Hansel,A., Olivera,B.M., Terlau,H. and Heinemann,S.H.
Molecular interaction of delta-conotoxins with voltage-gated sodium channels FEBS Lett. (2005) 579: 3881-3884 [P, NA]
Lima,V., Mueller,A., Kamikihara,S.Y., Raymundi,V., Alewood,D., Lewis,R.J., Chen,Z., Minneman,K.P. and Pupo,A.S.
Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta Eur. J. Pharmacol. (2005) 508: 183-192 [P, NA]
McIntosh,J.M., Plazas,P.V., Watkins,M., Gomez-Casati,M.E., Olivera,B.M. and Elgoyhen,A.B.
A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors J. Biol. Chem. (2005) 280: 30107-30112 [P, NA]
Moller,C., Rahmankhah,S., Lauer-Fields,J., Bubis,J., Fields,G.B. and Mari,F.
A novel conotoxin framework with a helix-loop-helix (Cs alpha/alpha) fold Biochemistry (2005) 44: 15986-15996 [P, NA]
Mondal,S., Vijayan,R., Shichina,K., Babu,R.M. and Ramakumar,S.
I-superfamily conotoxins: sequence and structure analysis In Silico Biol. (Gedrukt) (2005) 5: 557-571 [P, NA]
Nielsen,C.K., Lewis,R.J., Alewood,D., Drinkwater,R., Palant,E., Patterson,M., Yaksh,T.L., McCumber,D. and Smith,M.T.
Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain Pain (2005) 118: 112-124 [P, NA]
Nilsson,K.P., Lovelace,E.S., Caesar,C.E., Tynngard,N., Alewood,P.F., Johansson,H.M., Sharpe,I.A., Lewis,R.J., Daly,N.L. and Craik,D.J.
Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter Biopolymers (2005) 80: 815-823 [P, NA]
Olivera,B.M., Layer,R.T., McIntosh,J.M., Nielsen,J.S. and Jones,R.M.
Alpha.-conotoxin peptides Patent: US 6855805 15-FEB-2005 (2005) [P, NA]
Olivera,B.M., McIntosh,J.M., Yoshikami,D., Cartier,G.E. and Luo,S.
Uses of .alpha.-conotoxin peptides Patent: US 6958323 25-OCT-2005 (2005) [P, NA]
Pisarewicz,K., Mora,D., Pflueger,F.C., Fields,G.B. and Mari,F.
Polypeptide chains containing D-gamma-hydroxyvaline J. Am. Chem. Soc. (2005) 127: 6207-6215 [P, NA]
Sarma,S.P., Kumar,G.S., Sudarslal,S., Iengar,P., Ramasamy,P., Sikdar,S.K., Krishnan,K.S. and Balaram,P.
Solution structure of delta-Am2766: a highly hydrophobic delta-conotoxin from Conus amadis that inhibits inactivation of neuronal voltage-gated sodium channels. Chem. Biodivers. (2005) 2: 535-556 [P, NA]
Satkunanathan,N., Livett,B., Gayler,K., Sandall,D., Down,J. and Khalil,Z.
Alpha-conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones Brain Res. (2005) 1059: 149-158 [P, NA]
Teichert,R.W., Jimenez,E.C. and Olivera,B.M.
Alpha S-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors Biochemistry (2005) 44: 7897-7902 [P, NA]
Teichert,R.W., Rivier,J., Torres,J., Dykert,J., Miller,C. and Olivera,B.M.
A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor J. Neurosci. (2005) 25: 732-736 [P, NA]
Vianna Braga,M.C., Konno,K., Portaro,F.C., de Freitas,J.C., Yamane,T., Olivera,B.M. and Pimenta,D.C.
Mass spectrometric and high performance liquid chromatography profiling of the venom of the Brazilian vermivorous mollusk Conus regius: feeding behavior and identification of one novel conotoxin Toxicon (2005) 45: 113-122 [P, NA]
Wen,L., Yang,S., Qiao,H., Liu,Z., Zhou,W., Zhang,Y. and Huang,P.
SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons Br. J. Pharmacol. (2005) 145: 728-739 [P, NA]
Zhao,T.-Y., Cao,Y., Dai,X.-D., Fan,C.-X. and Chen,J.-S.
Purification, sequence and disulfide bonding pattern of a novel conotoxin BtIIIB Acta Chim. Sin. (2005) 63: 163-0 [P, NA]
2004

Al-Sabi,A., Lennartz,D., Ferber,M., Gulyas,J., Rivier,J.E., Olivera,B.M., Carlomagno,T. and Terlau,H.
KappaM-conotoxin RIIIK, structural and functional novelty in a K+ channel antagonist. Biochemistry (2004) 43: 8625-8635 [P, NA]
Barbier,J., Lamthanh,H., Le Gall,F., Favreau,P., Benoit,E., Chen,H., Gilles,N., Ilan,N., Heinemann,S.H., Gordon,D., Menez,A. and Molgo,J.
A delta-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels but not in skeletal and cardiac muscles J. Biol. Chem. (2004) 279: 4680-4685 [P, NA]
Chen,Z., Rogge,G., Hague,C., Alewood,D., Colless,B., Lewis,R.J. and Minneman,K.P.
Subtype-selective noncompetitive or competitive inhibition of human alpha1-adrenergic receptors by rho-TIA J. Biol. Chem. (2004) 279: 35326-35333 [P, NA]
Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H.
Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors Biochem. J. (2004) 380: 347-352 [P, NA]
Chierici,S., Jourdan,M., Figuet,M. and Dumy,P.
A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a [small delta]-conotoxin EVIA peptide analog Org. Biomol. Chem. (2004) 2: 2437-2441 [P, NA]
Craig,A.G., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J., Cruz,L.J., Wagstaff,J.D., Layer,R.T., Jones,R.M. and McCabe,R.T.
Contulakin-G, analogs thereof and uses therefor Patent: US 6696408 24-FEB-2004 (2004) [P, NA]
Daly,N.L., Ekberg,J.A., Thomas,L., Adams,D.J., Lewis,R.J. and Craik,D.J.
Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons J. Biol. Chem. (2004) 279: 25774-25782 [P, NA]
Duda,T.F. Jr. and Palumbi,S.R.
Gene expression and feeding ecology: evolution of piscivory in the venomous gastropod genus Conus. Proc. Biol. Sci. (2004) 271: 1165-1174 [P, NA]
Eliseo,T., Cicero,D.O., Romeo,C., Schinina,M.E., Massilia,G.R., Polticelli,F., Ascenzi,P. and Paci,M.
Solution structure of the cyclic peptide contryphan-Vn, a Ca2+-dependent K+ channel modulator Biopolymers (2004) 74: 189-198 [P, NA]
Ellison,M., Gao,F., Wang,H.L., Sine,S.M. and Olivera,B.M.
Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. Biochemistry (2004) 43: 16019-16026 [P, NA]
Everhart,D., Cartier,G.E., Malhotra,A., Gomes,A.V., McIntosh,J.M. and Luetje,C.W.
Determinants of potency on alpha-conotoxin MII, a peptide antagonist of neuronal nicotinic receptors Biochemistry (2004) 43: 2732-2737 [P, NA]
Grant,M.A., Hansson,K., Furie,B.C., Furie,B., Stenflo,J. and Rigby,A.C.
The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M J. Biol. Chem. (2004) 279: 32464-32473 [P, NA]
Hansson,K., Furie,B., Furie,B.C. and Stenflo,J.
Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern Biochem. Biophys. Res. Commun. (2004) 319: 1081-1087 [P, NA]
Hansson,K., Ma,X., Eliasson,L., Czerwiec,E., Furie,B., Furie,B.C., Rorsman,P. and Stenflo,J.
The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. J. Biol. Chem. (2004) 279: 32453-32463 [P, NA]
Hansson,K., Ma,X., Eliasson,L., Czerwiec,E., Furie,B., Furie,B.C., Rorsman,P. and Stenflo,J.
The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus J. Biol. Chem. (2004) 279: 32453-32463 [P, NA]
Jakubowski,J.A. and Sweedler, J.V.
Sequencing and mass profiling highly modified conotoxins using global reduction/alkylation followed by mass spectrometry Anal. Chem. (2004) 76: 6541-6547 [P, NA]
Jakubowski,J.A., Keays,D.A., Kelley,W.P., Sandall,D.W., Bingham,J.P., Livett,B.G., Gayler,K.R. and Sweedler,J.V.
Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry J Mass Spectrom (2004) 39: 548-557 [P, NA]
Jimenez,E.C., Watkins,M. and Olivera,B.M.
Multiple 6-bromotryptophan residues in a sleep-inducing peptide Biochemistry (2004) 43: 12343-12348 [P, NA]
Kauferstein,S., Huys,I., Kuch,U., Melaun,C., Tytgat,J. and Mebs,D.
Novel conopeptides of the I-superfamily occur in several clades of cone snails Toxicon (2004) 44: 539-548 [P, NA]
Loughnan,M.L., Nicke,A., Jones,A., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone J. Med. Chem. (2004) 47: 1234-1241 [P, NA]
McDougal,O.M. and Dale Poulter,C.
Three-dimensional structure of the mini-M conotoxin mr3a Biochemistry (2004) 43: 425-429 [P, NA]
McIntosh,J.M., Azam,L., Staheli,S., Dowell,C., Lindstrom,J.M., Kuryatov,A., Garrett,J.E., Marks,M.J. and Whiteaker,P.
Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors. Mol. Pharmacol. (2004) 65: 944-952 [P, NA]
McIntosh,J.M., Olivera,B.M., Cruz,L.J., Corpuz,G.P., Jones,R.M. and Garrett,J.E.
Conotoxin peptides Patent: US 6767896 27-JUL-2004 (2004) [P, NA]
Miljanich,G.P.
Ziconotide: neuronal calcium channel blocker for treating severe chronic pain Curr. Med. Chem. (2004) 11: 3029-3040 [P, NA]
Mould,J., Yasuda,T., Schroeder,C.I., Beedle,A.M., Doering,C.J., Zamponi,G.W., Adams,D.J. and Lewis,R.J.
The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. J. Biol. Chem. (2004) 279: 34705-34714 [P, NA]
Mould,J., Yasuda,T., Schroeder,C.I., Beedle,A.M., Doering,C.J., Zamponi,G.W., Adams,D.J. and Lewis,R.J.
The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels J. Biol. Chem. (2004) 279: 34705-34714 [P, NA]
Olivera,B.M., Cartier,G.E., Watkins,M., Hillyard,D.R., McIntosh,J.M., Layer,R.T. and Jones,R.M.
O-superfamily conotoxin peptides Patent: US 6762165-A 282 13-JUL-2004; University of Utah Research Foundation and Cognetix, Inc.; Salt Lake City, UT (2004) [P, NA]
Olivera,B.M., McIntosh,J.M., Garrett,J.E., Cruz,L.J., Jones,R.M., Cartier,G.E. and Wagstaff,J.D.
Mu-conopeptides Patent: US 6727226-A 80 27-APR-2004; University of Utah Research Foundation and Cognetix, Inc.; Salt Lake City, UT (2004) [P, NA]
Santos,A.D., McIntosh,J.M., Hillyard,D.R., Cruz,L.J. and Olivera,B.M.
The A-superfamily of conotoxins: structural and functional divergence J. Biol. Chem. (2004) 279: 17596-17606 [P, NA]
Teichert,R.W., Rivier,J., Dykert,J., Cervini,L., Gulyas,J., Bulaj,G., Ellison,M. and Olivera,B.M.
AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors Toxicon (2004) 44: 207-214 [P, NA]
Volpon,L., Lamthanh,H., Barbier,J., Gilles,N., Molgo,J., Menez,A. and Lancelin,J.M.
NMR solution structures of delta-conotoxin EVIA from Conus ermineus that selectively acts on vertebrate neuronal Na+ channels J. Biol. Chem. (2004) 279: 21356-21366 [P, NA]
Walker,C.S., Shetty,R., Jimenez,E.C., McIntosh,J.M., Olivera,B.M., Watkins,M., Jones,R.M. and Shen,G.S.
I-superfamily conotoxins Patent: US 6767895-A 440 27-JUL-2004; Cognetix, Inc. and University of Utah Research Foundation; Salt Lake City, UT (2004) [P, NA]
Wang,C.Z., Ou,Z.L. and Chi,C.W.
Gene cloning and functional studies of alpha conotoxin SII (Unpublished) [P, NA]
2004

Watkins,M., Olivera,B.M., Hillyard,D.R., McIntosh,M.J. and Jones,R.M.
Patent: 6797808 -US 28-SEP-2004 Patent: 6797808 (2004) [P, NA]
2003

Adams,D.J., Smith,A.B., Schroeder,C.I., Yasuda,T. and Lewis,R.J.
Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals J. Biol. Chem. (2003) 278: 4057-4062 [P, NA]
Blanchfield JT, Dutton JL, Hogg RC, Gallagher OP, Craik DJ, Jones A, Adams DJ, Lewis RJ, Alewood PF, Toth I
Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. J Med Chem (2003) 46: 1266-1272 [P, NA]
Bryan-Lluka,L.J., Bonisch,H. and Lewis,R.J.
chi-Conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter J. Biol. Chem. (2003) 278: 40324-40329 [P, NA]
Chi,S.W., Park,K.H., Suk,J.E., Olivera,B.M., McIntosh,J.M. and Han,K.H.
Solution conformation of alphaA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineus J. Biol. Chem. (2003) 278: 42208-42213 [P, NA]
Dai,Q., Liu,F., Zhou,Y., Lu,B., Yu,F. and Huang,P.
The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus J. Nat. Prod. (2003) 66: 1276-1279 [P, NA]
Dowell,C., Olivera,B.M., Garrett,J.E., Staheli,S.T., Watkins,M., Kuryatov,A., Yoshikami,D., Lindstrom,J.M. and McIntosh,J.M.
Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors J. Neurosci. (2003) 23: 8445-8452 [P, NA]
Ellison,M.A., McIntosh,J.M. and Olivera,B.M.
alpha-Conotoxins ImI and ImII: similar alpha 7 nicotinic receptor antagonists act at different sites J. Biol. Chem. (2003) 278: 757-764 [P, NA]
Fainzilber,M., Kits,K.S., Burlingame,A.L., Olivera,B.M., Walker,C., Watkins,M., Shetty,R., Cruz,L.J., Imperial,J. and Colledge,C.
Gamma-conopeptides Patent: US 6624288-A 25 23-SEP-2003; Cognetix, Inc. and University of Utah Research Foundation; Salt Lake City, UT (2003) [P, NA]
Fan,C.X., Chen,X.K., Zhang,C., Wang,L.X., Duan,K.L., He,L.L., Cao,Y., Liu,S.Y., Zhong,M.N., Ulens,C., Tytgat,J., Chen,J.S., Chi,C.W. and Zhou,Z.
A Novel Conotoxin from Conus betulinus, kappa -BtX, Unique in Cysteine Pattern and in Function as a Specific BK Channel Modulator J. Biol. Chem. (2003) 278: 12624-12633 [P, NA]
Ferber,M., Sporning,A., Jeserich,G., DeLaCruz,R., Watkins,M., Olivera,B.M. and Terlau,H.
A novel conus peptide ligand for K+ channels J. Biol. Chem. (2003) 278: 2177-2183 [P, NA]
Hillyard, D.R., Mcintosh, M.J., Jones, R.M., Cartier, E.G., Watkins, M., Olivera, B.M. and Layer, R.T.
O-Superfamily Conotoxin Peptides Patent: JP 2003533178-A 1 11-NOV-2003; (2003) [P, NA]
Hogg,R.C., Hopping,G., Alewood,P.F., Adams,D.J. and Bertrand,D.
Alpha-conotoxins PnIA and [A10L]PnIA stabilize different states of the alpha7-L247T nicotinic acetylcholine receptor. J. Biol. Chem. (2003) 278: 26908-26914 [P, NA]
Jimenez,E.C., Shetty,R.P., Lirazan,M., Rivier,J., Walker,C., Abogadie,F.C., Yoshikami,D., Cruz,L.J. and Olivera,B.M.
Novel excitatory Conus peptides define a new conotoxin superfamily J. Neurochem. (2003) 85: 610-621 [P, NA]
Kauferstein,S., Huys,I., Lamthanh,H., Stocklin,R., Sotto,F., Menez,A., Tytgat,J. and Mebs,D.
A novel conotoxin inhibiting vertebrate voltage-sensitive potassium channels Toxicon (2003) 42: 43-52 [P, NA]
Keizer,D.W., West,P.J., Lee,E.F., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S.
Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA J. Biol. Chem. (2003) 278: 46805-46813 [P, NA]
Kim, J.I., Song, W.K. and Park, Y.
Double mutant omega conotoxin GVIA epitope and its monoclonalantibody Patent: KR 1020030017307-A 2 20-MAR-2003; (2003) [P, NA]
Makino,K., Oshima,K., Kurokawa,K., Yokoyama,K., Uda,T., Tagomori,K., Iijima,Y., Najima,M., Nakano,M., Yamashita,A., Kubota,Y., Kimura,S., Yasunaga,T., Honda,T., Shinagawa,H., Hattori,M. and Iida,T.
Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V cholerae Lancet (2003) 361: 743-749 [P, NA]
Malmberg,A.B., Gilbert,H., McCabe,R.T. and Basbaum,A.I.
Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T Pain (2003) 101: 109-116 [P, NA]
Massilia,G.R., Eliseo,T., Grolleau,F., Lapied,B., Barbier,J., Bournaud,R., Molgo,J., Cicero,D.O., Paci,M., Schinina,M.E., Ascenzi,P. and Polticelli,F.
Contryphan-Vn: a modulator of Ca2+-dependent K+ channels Biochem. Biophys. Res. Commun. (2003) 303: 238-246 [P, NA]
Nicke,A., Loughnan,M.L., Millard,E.L., Alewood,P.F., Adams,D.J., Daly,N.L., Craik,D.J. and Lewis,R.J.
Isolation, Structure, and Activity of GID, a Novel alpha 4/7-Conotoxin with an Extended N-terminal Sequence J. Biol. Chem. (2003) 278: 3137-3144 [P, NA]
Nicke,A., Samochocki,M., Loughnan,M.L., Bansal,P.S., Maelicke,A. and Lewis,R.J.
Alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors. FEBS Lett. (2003) 554: 219-223 [P, NA]
Olivera,B.M., Layer,R.T., Watkins,M., Hillyard,D.R., Mcintosh,M.J., Jones,R.M. and Schoenfeld,R.
Alpha Conotoxin Peptides JP 2003525582-A 3 02-SEP-2003 (2003) [P, NA]
Sandall,D.W., Satkunanathan,N., Keays,D.A., Polidano,M.A., Liping,X., Pham,V., Down,J.G., Khalil,Z., Livett,B.G. and Gayler,K.R.
A novel alpha-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo Biochemistry (2003) 42: 6904-6911 [P, NA]
Sharpe,I.A., Palant,E., Schroeder,C.I., Kaye,D.M., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship J. Biol. Chem. (2003) 278: 40317-40323 [P, NA]
Sharpe,I.A., Thomas,L., Loughnan,M., Motin,L., Palant,E., Croker,D.E., Alewood,D., Chen,S., Graham,R.M., Alewood,P.F., Adams,D.J. and Lewis,R.J.
Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA J. Biol. Chem. (2003) 278: 34451-34457 [P, NA]
Sudarslal,S., Majumdar,S., Ramasamy,P., Dhawan,R., Pal,P.P., Ramaswami,M., Lala,A.K., Sikdar,S.K., Sarma,S.P., Krishnan,K.S. and Balaram,P.
Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail FEBS Lett. (2003) 553: 209-212 [P, NA]
Van Wagoner,R.M. and Ireland,C.M.
An improved solution structure for psi-conotoxin PiiiE. Biochemistry (2003) 42: 6347-6352 [P, NA]
Van Wagoner,R.M., Jacobsen,R.B., Olivera,B.M. and Ireland,C.M.
Characterization and three-dimensional structure determination of psi-conotoxin Piiif, a novel noncompetitive antagonist of nicotinic acetylcholine receptors Biochemistry (2003) 42: 6353-6362 [P, NA]
Walker,C., Shetty,R., Olivera,B.M., Hooper,D., Jacobsen,R., Steele,D. and Jones,R.
Tau-conotoxin peptides Patent: US 6630573 07-OCT-2003 (2003) [P, NA]
Walker,C., Shetty,R., Olivera,B.M., Hooper,D., Jacobsen,R., Steele,D. and Jones,R.M.
Patent: 6630573, -US 07-OCT-2003; (2003) [P, NA]
Wang,C.Z., Jiang,H., Ou,Z.L., Chen,J.S. and Chi,C.W.
cDNA cloning of two A-superfamily conotoxins from Conus striatus Toxicon (2003) 42: 613-619 [P, NA]
Williams,A.J., Ling,G., Berti,R., Moffett,J.R., Yao,C., Lu,X.M. and Tortella,F.C.
Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats. Exp Brain Res (2003) 153: 16-26 [P, NA]
Yan,Y., Tu,G., Luo,X., Dai,Q., Huang,P. and Zhang,R.
Three-Dimensional Solution Structure Of W-Conotoxin So3 Determined By 1h Nmr Chin.Sci.Bull. (2003) 48: 1097-0 [P, NA]
Yan,Y.B., Tu,G.Z., Luo,X.C., Dai,Q.Y., Huang,P.T. and Zhang,R.Q.
Three dimensional solution structure of omega-conotoxin SO3 determined by NMR Chin. Sci. Bull. (2003) 48: 1097-0 [P, NA]
2002

Craig,A.G., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J., Cruz,L.J., Wagstaff,J.D., Layer,R.T., Jones,R.M. and McCabe,R.T.
Contulakin-G, analogs thereof and uses thereof Patent: US 6489298 03-DEC-2002 (2002) [P, NA]
Craig,A.Grey., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J. and Cruz,L.J.
Contulakin-G, analogs thereof and uses therefor Patent: US 6369193 09-APR-2002 (2002) [P, NA]
Craig,G.A., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J., Cruz,L.J., Wagstaff,J.D., Layer,R.T., Jones,R.M. and Mccabe,T.R.
Contulakin-G, its analogues and utilization thereof Patent: JP 2002527093-A 2 27-AUG-2002 (2002) [P, NA]
Drinkwater,R.D., Lewis,R.J., Alewood,P.F. and Nielsen,K.J.
Novel omega-conotoxin peptides Patent: JP 2002512254-A 2 23-APR-2002 (2002) [P, NA]
Dutton,J.L., Bansal,P.S., Hogg,R.C., Adams,D.J., Alewood,P.F. and Craik,D.J.
A New Level of Conotoxin Diversity, a Non-native Disulfide Bond Connectivity in alpha -Conotoxin AuIB Reduces Structural Definition but Increases Biological Activity J. Biol. Chem. (2002) 277: 48849-48857 [P, NA]
Jimenez,E.C., Donevan,S., Walker,C., Zhou,L.M., Nielsen,J., Cruz,L.J., Armstrong,H., White,H.S. and Olivera,B.M.
Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency Epilepsy Res. (2002) 51: 73-80 [P, NA]
Jimenez,E.C., Olivera,B.M., Gray,W.R. and Cruz,L.
Contryphan peptides Patent: US 6441132 27-AUG-2002 (2002) [P, NA]
Kindahl, L., Sandström, C., Craig, A.G., Norberg, T., Kenne, L.
1H NMR studies on the solution conformation of contulakin-G and analogues Can. J. Chem. (2002) 80: 1022-1031 [P, NA]
Kohno,T., Sasaki,T., Kobayashi,K., Fainzilber,M. and Sato,K.
Three-dimensional solution structure of the sodium channel agonist/antagonist delta-conotoxin TxVIA J. Biol. Chem. (2002) 277: 36387-36391 [P, NA]
Lirazan,M., Jimenez,E.C., Grey Craig,A., Olivera,B.M. and Cruz,L.J.
Conophysin-R, a Conus radiatus venom peptide belonging to the neurophysin family. Toxicon (2002) 40: 901-908 [P, NA]
Maillo,M., Aguilar,M.B., Lopez-Vera,E., Craig,A.G., Bulaj,G., Olivera,B.M. and Heimer de la Cotera,E.P.
Conorfamide, a Conus venom peptide belonging to the RFamide family of neuropeptides Toxicon (2002) 40: 401-407 [P, NA]
McIntosh,J.M., Dowell,C., Watkins,M., Garrett,J.E., Yoshikami,D. and Olivera,B.M.
Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors J. Biol. Chem. (2002) 277: 33610-33615 [P, NA]
Miles,L.A., Dy,C.Y., Nielsen,J., Barnham,K.J., Hinds,M.G., Olivera,B.M., Bulaj,G. and Norton,R.S.
Structure of a Novel P-superfamily Spasmodic Conotoxin Reveals an Inhibitory Cystine Knot Motif J. Biol. Chem. (2002) 277: 43033-43040 [P, NA]
Naranjo,D.
Inhibition of single Shaker K channels by kappa-conotoxin-PVIIA Biophys. J. (2002) 82: 3003-3011 [P, NA]
Nielsen,K.J., Watson,M., Adams,D.J., Hammarstroem,A.K., Gage,P.W., Hill,J.M., Craik,D.J., Thomas,L., Adams,D., Alewood,P.F. and Lewis,R.J.
Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels J. Biol. Chem. (2002) 277: 27247-27255 [P, NA]
Watkins,M., Olivera,B.M., Hillyard,D.R., McIntosh,J.M. and Jones,R.M.
Alpha-conotoxin peptides JP 2002534996-A 11 22-OCT-2002 (2002) [P, NA]
Watkins,M., Olivera,B.M., Hillyard,D.R., Mcintosh,M.J. and Jones,R.M.
Alpha-conotoxin peptides JP 2002534996-A 11 22-OCT-2002 (2002) [P, NA]
West,P.J., Bulaj,G., Garrett,J.E., Olivera,B.M. and Yoshikami,D.
Mu-conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons Biochemistry (2002) 41: 15388-15393 [P, NA]
Williams,A.J., Ling,G. and Tortella,F.C.
Intrathecal CGX-1007 is neuroprotective in a rat model of focal cerebral ischemia. Neuroreport (2002) 13: 821-824 [P, NA]
2001

Bulaj,G., DeLaCruz,R., Azimi-Zonooz,A., West,P., Watkins,M., Yoshikami,D. and Olivera,B.M.
Delta-conotoxin structure/function through a cladistic analysis Biochemistry (2001) 40: 13201-13208 [P, NA]
Conticello,S.G., Gilad,Y., Avidan,N., Ben-Asher,E., Levy,Z. and Fainzilber,M.
Mechanisms for evolving hypervariability: the case of conopeptides Mol. Biol. Evol. (2001) 18: 120-131 [P, NA]
Espiritu,D.J., Watkins,M., Dia-Monje,V., Cartier,G.E. and Olivera,B.M.
Venomous cone snails: molecular phylogeny and the generation of toxin diversity. Toxicon (2001) 39: 1899-1916 [P, NA]
Favreau,P., Gilles,N., Lamthanh,H., Bournaud,R., Shimahara,T., Bouet,F., Laboute,P., Letourneux,Y., Menez,A., Molgo,J. and Le Gall,F.
A new omega-conotoxin that targets N-type voltage-sensitive calcium channels with unusual specificity Biochemistry (2001) 40: 14567-14575 [P, NA]
Goldenberg,D.P., Koehn,R.E., Gilbert,D.E. and Wagner,G.
Solution structure and backbone dynamics of an omega-conotoxin precursor Protein Sci. (2001) 10: 538-550 [P, NA]
Jimenez,E.C., Watkins,M., Juszczak,L.J., Cruz,L.J. and Olivera,B.M.
Contryphans from Conus textile venom ducts Toxicon (2001) 39: 803-808 [P, NA]
Klein,R.C., Prorok,M., Galdzicki,Z. and Castellino,F.J.
The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors J. Biol. Chem. (2001) 276: 26860-26867 [P, NA]
Kobayashi,K., Sasaki,T., Sato,K. and Kohno,T.
Three-Dimensional Solution Structure Of The Analogue Peptide Of Omega-Conotoxin Mviic NMR Toronkai Koen Yoshishu [japanese] (2001) 40: 324-324 [P, NA]
Massilia,G.R., Schinina,M.E., Ascenzi,P. and Polticelli,F.
Contryphan-Vn: a novel peptide from the venom of the Mediterranean snail Conus ventricosus Biochem. Biophys. Res. Commun. (2001) 288: 908-913 [P, NA]
Moran,O.
Molecular simulation of the interaction of kappa-conotoxin-PVIIA with the Shaker potassium channel pore Eur. Biophys. J. (2001) 30: 528-536 [P, NA]
Park,K.H., Suk,J.E., Jacobsen,R., Gray,W.R., McIntosh,J.M. and Han,K.H.
Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the alpha 1/delta subunit interface of torpedo nicotinic acetylcholine receptor J. Biol. Chem. (2001) 276: 49028-49033 [P, NA]
Sharpe,I.A., Gehrmann,J., Loughnan,M.L., Thomas,L., Adams,D.A., Atkins,A., Palant,E., Craik,D.J., Adams,D.J., Alewood,P.F. and Lewis,R.J.
Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter Nat. Neurosci. (2001) 4: 902-907 [P, NA]
2000

Atkinson,R.A., Kieffer,B., Dejaegere,A., Sirockin,F. and Lefevre,J.F.
Structural and dynamic characterization of omega-conotoxin MVIIA: the binding loop exhibits slow conformational exchange Biochemistry (2000) 39: 3908-3919 [P, NA]
Balaji,R.A., Ohtake,A., Sato,K., Gopalakrishnakone,P., Kini,R.M., Seow,K.T. and Bay,B.H.
lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding. Isolation and characterization from the venom of Conus marmoreus J. Biol. Chem. (2000) 275: 39516-39522 [P, NA]
Benie,A.J., Whitford,D., Hargittai,B., Barany,G. and Janes,R.W.
Solution structure of alpha-conotoxin SI FEBS Lett. (2000) 476: 287-295 [P, NA]
Blandl,T., Warder,S.E., Prorok,M. and Castellino,F.J.
Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R FEBS Lett. (2000) 470: 139-146 [P, NA]
Cho,J.H., Mok,K.H., Olivera,B.M., McIntosh,J.M., Park,K.H. and Han,K.H.
Nuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonist J. Biol. Chem. (2000) 275: 8680-8685 [P, NA]
Donevan,S.D. and McCabe,R.T.
Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol. Pharmacol. (2000) 58: 614-623 [P, NA]
Duda,T.F. Jr. and Palumbi,S.R.
Evolutionary diversification of multigene families: allelic selection of toxins in predatory cone snails Mol. Biol. Evol. (2000) 17: 1286-1293 [P, NA]
Hill,J.M., Alewood,P.F. and Craik,D.J.
Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 2. Three-dimensional solution structure Eur. J. Biochem. (2000) 267: 4649-4657 [P, NA]
Hill,J.M., Atkins,A.R., Loughnan,M.L., Jones,A., Adams,D.A., Martin,R.C., Lewis,R.J., Craik,D.J. and Alewood,P.F.
Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 1. Isolation, characterization and chemical synthesis Eur. J. Biochem. (2000) 267: 4642-4648 [P, NA]
Jacobsen, R., Jimenez, E., Cruz, L.J., Olivera, B.M., Gray, W.R., Grilley, M., Watkins, M. and Hillyard, D.R.
Contryphan peptides Patent: US 6153738-A 28 28-NOV-2000; (2000) [P, NA]
Jacobsen,R., Jimenez,E., Cruz,L.J., Olivera,B.M., Gray,W.R., Grilley,M., Watkins,M. and Hillyard,D.R.
Contryphan peptides Patent: US 6077934 20-JUN-2000 (2000) [P, NA]
Jacobsen,R.B., Koch,E.D., Lange-Malecki,B., Stocker,M., Verhey,J., Van Wagoner,R.M., Vyazovkina,A., Olivera,B.M. and Terlau,H.
Single amino acid substitutions in kappa-conotoxin PVIIA disrupt interaction with the shaker K+ channel J. Biol. Chem. (2000) 275: 24639-24644 [P, NA]
Kalume,D.E., Stenflo,J., Czerwiec,E., Hambe,B., Furie,B.C., Furie,B. and Roepstorff,P.
Structure determination of two conotoxins from Conus textile by a combination of matrix-assisted laser desorption/ionization time-of-flight and electrospray ionization mass spectrometry and biochemical methods J Mass Spectrom (2000) 35: 145-156 [P, NA]
Kobayashi,K., Sasaki,T., Sato,K. and Kohno,T.
Three-dimensional solution structure of omega-conotoxin TxVII, an L-type calcium channel blocker Biochemistry (2000) 39: 14761-14767 [P, NA]
Kuryatov,A., Olale,F., Cooper,J., Choi,C. and Lindstrom,J.
Human alpha6 AChR subtypes: subunit composition, assembly, and pharmacological responses Neuropharmacology (2000) 39: 2570-2590 [P, NA]
Lewis,R.J., Nielsen,K.J., Craik,D.J., Loughnan,M.L., Adams,D.A., Sharpe,I.A., Luchian,T., Adams,D.J., Bond,T., Thomas,L., Jones,A., Matheson,J.L., Drinkwater,R., Andrews,P.R. and Alewood,P.F.
Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes J. Biol. Chem. (2000) 275: 35335-35344 [P, NA]
Lirazan,M.B., Hooper,D., Corpuz,G.P., Ramilo,C.A., Bandyopadhyay,P., Cruz,L.J. and Olivera,B.M.
The spasmodic peptide defines a new conotoxin superfamily Biochemistry (2000) 39: 1583-1588 [P, NA]
McIntosh,J.M., Corpuz,G.O., Layer,R.T., Garrett,J.E., Wagstaff,J.D., Bulaj,G., Vyazovkina,A., Yoshikami,D., Cruz,L.J. and Olivera,B.M.
Isolation and characterization of a novel conus peptide with apparent antinociceptive activity J. Biol. Chem. (2000) 275: 32391-32397 [P, NA]
Nasu,H., Iida,T., Sugahara,T., Yamaichi,Y., Park,K.S., Yokoyama,K., Makino,K., Shinagawa,H. and Honda,T.
A filamentous phage associated with recent pandemic Vibrio parahaemolyticus O3:K6 strains J. Clin. Microbiol. (2000) 38: 2156-2161 [P, NA]
Nielsen,K.J., Schroeder,T. and Lewis,R.
Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels J. Mol. Recognit. (2000) 13: 55-70 [P, NA]
Pallaghy,P.K. and Norton,R.S.
The cyclic contryphan motif CPxXPXC, a robust scaffold potentially useful as an omega-conotoxin mimic Biopolymers (2000) 54: 173-179 [P, NA]
Pallaghy,P.K., He,W., Jimenez,E.C., Olivera,B.M. and Norton,R.S.
Structures of the contryphan family of cyclic peptides. Role of electrostatic interactions in cis-trans isomerism Biochemistry (2000) 39: 12845-12852 [P, NA]
Rogers,J.P., Luginbuhl,P., Pemberton,K., Harty,P., Wemmer,D.E. and Stevens,R.C.
Structure-activity relationships in a peptidic alpha7 nicotinic acetylcholine receptor antagonist J. Mol. Biol. (2000) 304: 911-926 [P, NA]
Safo,P., Rosenbaum,T., Shcherbatko,A., Choi,D.Y., Han,E., Toledo-Aral,J.J., Olivera,B.M., Brehm,P. and Mandel,G.
Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA J. Neurosci. (2000) 20: 76-80 [P, NA]
White,H.S., McCabe,R.T., Armstrong,H., Donevan,S.D., Cruz,L.J., Abogadie,F.C., Torres,J., Rivier,J.E., Paarmann,I., Hollmann,M. and Olivera,B.M.
In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus J. Pharmacol. Exp. Ther. (2000) 292: 425-432 [P, NA]
Williams,A.J., Dave,J.R., Phillips,J.B., Lin,Y. and Tortella,F.C.
Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J. Pharmacol. Exp. Ther. (2000) 294: 378-386 [P, NA]
Zhao,D. and Huang,P.
Cloning of novel conotoxin precursor sequences from Conus pulicarius. Progress in Natural Science (2000) 10: 33-36 [P, NA]
1999

Blandl,T., Warder,S.E., Prorok,M. and Castellino,F.J.
Binding of cations to individual gamma-carboxyglutamate residues of conantokin-G and conantokin-T J. Pept. Res. (1999) 53: 453-464 [P, NA]
Bush,K.A., Stenflo,J., Roth,D.A., Czerwiec,E., Harrist,A., Begley,G.S., Furie,B.C. and Furie,B.
Hydrophobic amino acids define the carboxylation recognition site in the precursor of the gamma-carboxyglutamic-acid-containing conotoxin epsilon-TxIX from the marine cone snail Conus textile. Biochemistry (1999) 38: 14660-14666 [P, NA]
Chen,J.S., Fan,C.X., Hu,K.P., Wei,K.H. and Zhong,M.N.
Studies on conotoxins of Conus betulinus J Nat Toxins (1999) 8: 341-349 [P, NA]
Civera,C., Vazquez,A., Sevilla,J.M., Bruix,M., Gago,F., Garcia,A.G. and Sevilla,P.
Solution structure determination by two-dimensional 1H NMR of omega-conotoxin MVIID, a calcium channel blocker peptide Biochem. Biophys. Res. Commun. (1999) 254: 32-35 [P, NA]
Craig,A.G., Norberg,T., Griffin,D., Hoeger,C., Akhtar,M., Schmidt,K., Low,W., Dykert,J., Richelson,E., Navarro,V., Mazella,J., Watkins,M., Hillyard,D., Imperial,J., Cruz,L.J. and Olivera,B.M.
Contulakin-G, an O-glycosylated invertebrate neurotensin J. Biol. Chem. (1999) 274: 13752-13759 [P, NA]
Duda,T.F. Jr. and Palumbi,S.R.
Molecular genetics of ecological diversification: duplication and rapid evolution of toxin genes of the venomous gastropod Conus Proc. Natl. Acad. Sci. U.S.A. (1999) 96: 6820-6823 [P, NA]
Favreau,P., Krimm,I., le Gall,F., Bobenrieth,M.J., Lamthanh,H., Bouet,F., Servent,D., Molgo,J., Menez,A., Letourneux,Y. and Lancelin,J.-M.
Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors Biochemistry (1999) 38: 6317-6326 [P, NA]
Flinn,J.P., Pallaghy,P.K., Lew,M.J., Murphy,R. and Norton,R.S.
Role of disulfide bridges in the folding, structure and biological activity of omega-conotoxin GVIA. Biochim. Biophys. Acta (1999) 1434: 177-190 [P, NA]
García,E., Scanlon,M. and Naranjo,D.
A marine snail neurotoxin shares with scorpion toxins a convergent mechanism of blockade on the pore of voltage-gated K channels. J. Gen. Physiol. (1999) 114: 141-157 [P, NA]
Gehrmann,J., Daly,N.L., Alewood,P.F. and Craik,D.J.
Solution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonance J. Med. Chem. (1999) 42: 2364-2372 [P, NA]
Gouda,H. and Hirono,S.
Solution structure of alpha-conotoxin ImI determined by two-dimensional NMR spectroscopy Biochim. Biophys. Acta (1999) 1431: 384-394 [P, NA]
Hogg,R.C., Miranda,L.P., Craik,D.J., Lewis,R.J., Alewood,P.F. and Adams,D.J.
Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor. J. Biol. Chem. (1999) 274: 36559-36564 [P, NA]
Jacobsen,R.B., DelaCruz,R.G., Grose,J.H., McIntosh,J.M., Yoshikami,D. and Olivera,B.M.
Critical residues influence the affinity and selectivity of alpha-conotoxin MI for nicotinic acetylcholine receptors Biochemistry (1999) 38: 13310-13315 [P, NA]
Jacobsen,R.B., Jimenez,E.C., De la Cruz,R.G., Gray,W.R., Cruz,L.J. and Olivera,B.M.
A novel D-leucine-containing Conus peptide: diverse conformational dynamics in the contryphan family J. Pept. Res. (1999) 54: 93-99 [P, NA]
Lamthanh,H., Jegou-Matheron,C., Servent,D., Menez,A. and Lancelin,J.M.
Minimal conformation of the alpha-conotoxin ImI for the alpha7 neuronal nicotinic acetylcholine receptor recognition: correlated CD, NMR and binding studies FEBS Lett. (1999) 454: 293-298 [P, NA]
Le Gall,F., Favreau,P., Benoit,E., Mattei,C., Bouet,F., Menou,J.L., Menez,A., Letourneux,Y. and Molgo,J.
A new conotoxin isolated from Conus consors venom acting selectively on axons and motor nerve terminals through a Na+-dependent mechanism Eur. J. Neurosci. (1999) 11: 3134-3142 [P, NA]
Lu,B.S., Yu,F., Zhao,D., Huang,P.T. and Huang,C.F.
Conopeptides from Conus striatus and Conus textile by cDNA cloning Peptides (1999) 20: 1139-1144 [P, NA]
Luo,S., Nguyen,T.A., Cartier,G.E., Olivera,B.M., Yoshikami,D. and McIntosh,J.M.
Single-residue alteration in alpha-conotoxin PnIA switches its nAChR subtype selectivity Biochemistry (1999) 38: 14542-14548 [P, NA]
Maslennikov,I.V., Shenkarev,Z.O., Zhmak,M.N., Ivanov,V.T., Methfessel,C., Tsetlin,V.I. and Arseniev,A.S.
NMR spatial structure of alpha-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors FEBS Lett. (1999) 444: 275-280 [P, NA]
Mok,K.H. and Han,K.H.
NMR solution conformation of an antitoxic analogue of alpha-conotoxin GI: identification of a common nicotinic acetylcholine receptor alpha 1-subunit binding surface for small ligands and alpha-conotoxins Biochemistry (1999) 38: 11895-11904 [P, NA]
Nielsen,K.J., Adams,D., Thomas,L., Bond,T., Alewood,P.F., Craik,D.J. and Lewis,R.J.
Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels J. Mol. Biol. (1999) 289: 1405-1421 [P, NA]
Pallaghy,P.K. and Norton,R.S.
Refined solution structure of omega-conotoxin GVIA: implications for calcium channel binding J. Pept. Res. (1999) 53: 343-351 [P, NA]
Pallaghy,P.K., Melnikova,A.P., Jimenez,E.C., Olivera,B.M. and Norton,R.S.
Solution structure of contryphan-R, a naturally occurring disulfide-bridged octapeptide containing D-tryptophan: comparison with protein loops Biochemistry (1999) 38: 11553-11559 [P, NA]
Pang,I.-H., Kapin,M. and Hellberg,M.
Use of .omega.-conotoxin analogs for treating retinal and optic nerve head damage Patent: US 5965534-A 7 12-OCT-1999; (1999) [P, NA]
Quiram,P.A., Jones,J.J. and Sine,S.M.
Pairwise interactions between neuronal alpha7 acetylcholine receptors and alpha-conotoxin ImI. J. Biol. Chem. (1999) 274: 19517-19524 [P, NA]
Rigby,A.C., Lucas-Meunier,E., Kalume,D.E., Czerwiec,E., Hambe,B., Dahlqvist,I., Fossier,P., Baux,G., Roepstorff,P., Baleja,J.D., Furie,B.C., Furie,B. and Stenflo,J.
A conotoxin from Conus textile with unusual posttranslational modifications reduces presynaptic Ca2+ influx Proc. Natl. Acad. Sci. U.S.A. (1999) 96: 5758-5763 [P, NA]
Rogers,J.P., Luginbuhl,P., Shen,G.S., McCabe,R.T., Stevens,R.C. and Wemmer,D.E.
NMR solution structure of alpha-conotoxin ImI and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors Biochemistry (1999) 38: 3874-3882 [P, NA]
Shon,K.-J., Gray,W.R., Dykert,J., Yoshikami,D., Watkins,M., Hillyard,D.R., Rivier,J.E.F. and Olivera,B.M.
Conotoxin peptides Patent: US 5969096-A 1 19-OCT-1999; (1999) [P, NA]
Shon,K.-J., Olivera,B.M. and McIntosh,J.Michael.
Conotoxin peptides Patent: US 5990295 23-NOV-1999 (1999) [P, NA]
Terlau,H., Boccaccio,A., Olivera,B.M. and Conti,F.
The block of Shaker K+ channels by kappa-conotoxin PVIIA is state dependent J. Gen. Physiol. (1999) 114: 125-140 [P, NA]
Utkin,Y.N., Zhmak,M.N., Methfessel,C. and Tsetlin,V.I.
Aromatic substitutions in alpha-conotoxin ImI. Synthesis of iodinated photoactivatable derivative. Toxicon (1999) 37: 1683-1695 [P, NA]
Walker,C.S., Steel,D., Jacobsen,R.B., Lirazan,M.B., Cruz,L.J., Hooper,D., Shetty,R., DelaCruz,R.C., Nielsen,J.S., Zhou,L.M., Bandyopadhyay,P., Craig,A.G. and Olivera,B.M.
The T-superfamily of conotoxins J. Biol. Chem. (1999) 274: 30664-30671 [P, NA]
Wolfender,J.L., Chu,F., Ball,H., Wolfender,F., Fainzilber,M., Baldwin,M.A. and Burlingame,A.L.
Identification of tyrosine sulfation in Conus pennaceus conotoxins alpha-PnIA and alpha-PnIB: further investigation of labile sulfo- and phosphopeptides by electrospray, matrix-assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI mass spectrometry J Mass Spectrom (1999) 34: 447-454 [P, NA]
1998

Bandyopadhyay,P.K., Colledge,C.J., Walker,C.S., Zhou,L.M., Hillyard,D.R. and Olivera,B.M.
Conantokin-G precursor and its role in gamma-carboxylation by a vitamin K-dependent carboxylase from a Conus snail J. Biol. Chem. (1998) 273: 5447-5450 [P, NA]
Craig,A.G., Zafaralla,G., Cruz,L.J., Santos,A.D., Hillyard,D.R., Dykert,J., Rivier,J.E., Gray,W.R., Imperial,J., DelaCruz,R.G., Sporning,A., Terlau,H., West,P.J., Yoshikami,D. and Olivera,B.M.
An O-glycosylated neuroexcitatory conus peptide Biochemistry (1998) 37: 16019-16025 [P, NA]
England,L.J., Imperial,J., Jacobsen,R., Craig,A.G., Gulyas,J., Akhtar,M., Rivier,J., Julius,D. and Olivera,B.M.
Inactivation of a serotonin-gated ion channel by a polypeptide toxin from marine snails Science (1998) 281: 575-578 [P, NA]
Fainzilber,M., Nakamura,T., Lodder,J.C., Zlotkin,E., Kits,K.S. and Burlingame,A.L.
gamma-Conotoxin-PnVIIA, a gamma-carboxyglutamate-containing peptide agonist of neuronal pacemaker cation currents Biochemistry (1998) 37: 1470-1477 [P, NA]
Gehrmann,J., Alewood,P.F. and Craik,D.J.
Structure determination of the three disulfide bond isomers of alpha-conotoxin GI: a model for the role of disulfide bonds in structural stability J. Mol. Biol. (1998) 278: 401-415 [P, NA]
Hill,J.M., Oomen,C.J., Miranda,L.P., Bingham,J.P., Alewood,P.F. and Craik,D.J.
Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity Biochemistry (1998) 37: 15621-15630 [P, NA]
Hu,S.H., Loughnan,M., Miller,R., Weeks,C.M., Blessing,R.H., Alewood,P.F., Lewis,R.J. and Martin,J.L.
The 1.1 A resolution crystal structure of [Tyr15]EpI, a novel alpha-conotoxin from Conus episcopatus, solved by direct methods Biochemistry (1998) 37: 11425-11433 [P, NA]
Jacobsen,R., Jimenez,E.C., Grilley,M., Watkins,M., Hillyard,D., Cruz,L.J. and Olivera,B.M.
The contryphans, a D-tryptophan-containing family of Conus peptides: interconversion between conformers J. Pept. Res. (1998) 51: 173-179 [P, NA]
Loughnan,M., Bond,T., Atkins,A., Cuevas,J., Adams,D.J., Broxton,N.M., Livett,B.G., Down,J.G., Jones,A., Alewood,P.F. and Lewis,R.J.
alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors J. Biol. Chem. (1998) 273: 15667-15674 [P, NA]
Luo,S., Kulak,J.M., Cartier,G.E., Jacobsen,R.B., Yoshikami,D., Olivera,B.M. and McIntosh,J.M.
alpha-conotoxin AuIB selectively blocks alpha3 beta4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release J. Neurosci. (1998) 18: 8571-8579 [P, NA]
Maslennikov,I.V., Sobol,A.G., Gladky,K.V., Lugovskoy,A.A., Ostrovsky,A.G., Tsetlin,V.I., Ivanov,V.T. and Arseniev,A.S.
Two distinct structures of alpha-conotoxin GI in aqueous solution Eur. J. Biochem. (1998) 254: 238-247 [P, NA]
Mitchell,S.S., Shon,K.J., Foster,M.P., Davis,D.R., Olivera,B.M. and Ireland,C.M.
Three-dimensional solution structure of conotoxin psi-PIIIE, an acetylcholine gated ion channel antagonist Biochemistry (1998) 37: 1215-1220 [P, NA]
Price-Carter,M. and Goldenberg,D.P.
Roles of individual disulfide bonds in the stability and folding of an omega-conotoxin. Biochemistry (1998) 37: 9851-9861 [P, NA]
Quiram,P.A. and Sine,S.M.
Identification of residues in the neuronal alpha7 acetylcholine receptor that confer selectivity for conotoxin ImI J. Biol. Chem. (1998) 273: 11001-11006 [P, NA]
Quiram,P.A. and Sine,S.M.
Structural elements in alpha-conotoxin ImI essential for binding to neuronal alpha7 receptors. J. Biol. Chem. (1998) 273: 11007-11011 [P, NA]
Savarin,P., Guenneugues,M., Gilquin,B., Lamthanh,H., Gasparini,S., Zinn-Justin,S. and Menez,A.
Three-dimensional structure of kappa-conotoxin PVIIA, a novel potassium channel-blocking toxin from cone snails Biochemistry (1998) 37: 5407-5416 [P, NA]
Servent,D., Lamthanh,H., Antil,S., Bertrand,D., Corringer,P.J., Changeux,J.P. and Menez,A.
Functional Determinants By Which Snake And Cone Snail Toxins Block The Alpha 7 Neuronal Nicotinic Acetylcholine Receptors J.Physiol. Paris (1998) 92: 107-111 [P, NA]
Shon,K.-J., Grilley,M.M. and Olivera,B.M.
Conotoxin peptides Patent: US 5739276 14-APR-1998 (1998) [P, NA]
Shon,K.-J., Olivera,B.M., McIntosh,J.Michael., Hasson,A. and Spira,M.E.
Conotoxin peptides Patent: US 5719264 17-FEB-1998 (1998) [P, NA]
Shon,K.-J., Olivera,B.M., Watkins,M., Jacobsen,R.B., Gray,W.R., Floresca,C.Z., Cruz,L.J., Hillyard,D.R., Brink,A., Terlau,H. and Yoshikami,D.
mu-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes J. Neurosci. (1998) 18: 4473-4481 [P, NA]
Shon,K.-J., Stocker,M., Terlau,H., Stuehmer,W., Jacobsen,R.B., Walker,C.S., Grilley,M.M., Watkins,M., Hillyard,D.R., Gray,W.R. and Olivera,B.M.
kappa-Conotoxin PVIIA is a peptide inhibiting the shaker K+ channel J. Biol. Chem. (1998) 273: 33-38 [P, NA]
1997

Craig,A.G., Jimenez,E.C., Dykert,J., Nielsen,D.B., Gulyas,J., Abogadie,F.C., Porter,J., Rivier,J.E., Cruz,L.J., Olivera,B.M. and McIntosh,J.M.
A novel post-translational modification involving bromination of tryptophan. Identification of the residue, L-6-bromotryptophan, in peptides from Conus imperialis and Conus radiatus venom J. Biol. Chem. (1997) 272: 4689-4698 [P, NA]
De Bolle,M., Broekaert,W.Frans., Cammue,B.Philippe.Angelo., Rees,S.Bronwen. and Vanderleyden,J.
Biocidal proteins Patent: US 5689048-A 5 18-NOV-1997; (1997) [P, NA]
Groebe,D.R., Gray,W.R., and Abramson,S.N.
Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors Biochemistry (1997) 36: 6469-6474 [P, NA]
Han,K.H., Hwang,K.J., Kim,S.M., Kim,S.K., Gray,W.R., Olivera,B.M., Rivier,J. and Shon,K.J.
NMR structure determination of a novel conotoxin, [Pro 7,13] alpha A-conotoxin PIVA Biochemistry (1997) 36: 1669-1677 [P, NA]
Harvey,S.C., McIntosh,J.M., Cartier,G.E., Maddox,F.N. and Luetje,C.W.
Determinants of specificity for alpha-conotoxin MII on alpha3beta2 neuronal nicotinic receptors. Mol. Pharmacol. (1997) 51: 336-342 [P, NA]
Hill,J.M., Alewood,P.F. and Craik,D.J.
Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry Structure (1997) 5: 571-583 [P, NA]
Hu,S.H., Gehrmann,J., Alewood,P.F., Craik,D.J. and Martin,J.L.
Crystal structure at 1.1 A resolution of alpha-conotoxin PnIB: comparison with alpha-conotoxins PnIA and GI Biochemistry (1997) 36: 11323-11330 [P, NA]
Jacobsen,R.B., Yoshikami,D., Ellison,M., Martinez,J., Gray,W.R., Cartier,G.E., Shon,K.-J., Groebe,D.R., Abramson,S.N., Olivera,B.M. and McIntosh,J.M.
Differential targeting of nicotinic acetylcholine receptors by novel alphaA-conotoxins J. Biol. Chem. (1997) 272: 22531-22537 [P, NA]
Jimenez,E.C., Craig,A.G., Watkins,M., Hillyard,D.R., Gray,W.R., Gulyas,J., Rivier,J.E., Cruz,L.J. and Olivera,B.M.
Bromocontryphan: post-translational bromination of tryptophan Biochemistry (1997) 36: 989-994 [P, NA]
Lew,M.J., Flinn,J.P., Pallaghy,P.K., Murphy,R., Whorlow,S.L., Wright,C.E., Norton,R.S. and Angus,J.A.
Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues J. Biol. Chem. (1997) 272: 12014-12023 [P, NA]
Olivera,B.M., Cruz,L.J., Hillyard,D.R., McIntosh,J.Michael. and Santos,A.O.
Conotoxin peptides Patent: US 5633347 27-MAY-1997 (1997) [P, NA]
Olivera,B.M., Hillyard,D.R., Imperial,J.S. and Monje,V.D.
Omega-conotoxin peptides Patent: US 5591821 07-JAN-1997 (1997) [P, NA]
Rigby,A.C., Baleja,J.D., Furie,B.C. and Furie,B.
Three-dimensional structure of a gamma-carboxyglutamic acid-containing conotoxin, conantokin G, from the marine snail Conus geographus: the metal-free conformer Biochemistry (1997) 36: 6906-6914 [P, NA]
Rigby,A.C., Baleja,J.D., Li,L., Pedersen,L.G., Furie,B.C. and Furie,B.
Role of gamma-carboxyglutamic acid in the calcium-induced structural transition of conantokin G, a conotoxin from the marine snail Conus geographus Biochemistry (1997) 36: 15677-15684 [P, NA]
Scanlon,M.J., Naranjo,D., Thomas,L., Alewood,P.F., Lewis,R.J. and Craik,D.J.
Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA Structure (1997) 5: 1585-1597 [P, NA]
Shon,K.-J., Yoshikami,D., Marsh,M., Cruz,L.J., Hillyard,D.R. and Olivera,B.M.
Conotoxin peptide PIIIA Patent: US 5670622 23-SEP-1997 (1997) [P, NA]
Shon,K.J., Grilley,M., Jacobsen,R., Cartier,G.E., Hopkins,C., Gray,W.R., Watkins,M., Hillyard,D.R., Rivier,J., Torres,J., Yoshikami,D. and Olivera,B.M.
A noncompetitive peptide inhibitor of the nicotinic acetylcholine receptor from Conus purpurascens venom Biochemistry (1997) 36: 9581-9587 [P, NA]
Shon,K.J., Koerber,S.C., Rivier,J.E., Olivera,B.M. and McIntosh,J.M.
Three-dimensional solution structure of alpha-conotoxin MII, an alpha3beta2 neuronal nicotinic acetylcholine receptor-targeted ligand Biochemistry (1997) 36: 15693-15700 [P, NA]
Skjaerbaek,N., Nielsen,K.J., Lewis,R.J., Alewood,P. and Craik,D.J.
Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy J. Biol. Chem. (1997) 272: 2291-2299 [P, NA]
Warder,S.E., Chen,Z., Zhu,Y., Prorok,M., Castellino,F.J. and Ni,F.
The NMR solution structure of the NMDA receptor antagonist, conantokin-T, in the absence of divalent metal ions FEBS Lett. (1997) 411: 19-26 [P, NA]
1996

Cartier,G.E., Yoshikami,D., Gray,W.R., Luo,S., Olivera,B.M. and McIntosh,J.M.
A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors J. Biol. Chem. (1996) 271: 7522-7528 [P, NA]
De Bolle,M., Broekaert,W.F., Cammue,B.P.A., Rees,S.B. and Vanderleyden,J.
Biocidal proteins Patent: US 5482928-A 5 09-JAN-1996; (1996) [P, NA]
Fainzilber,M., Lodder,J.C., van der Schors,R.C., Li,K.W., Yu,Z., Burlingame,A.L., Geraerts,W.P. and Kits,K.S.
A novel hydrophobic omega-conotoxin blocks molluscan dihydropyridine-sensitive calcium channels Biochemistry (1996) 35: 8748-8752 [P, NA]
Guddat,L.W., Martin,J.A., Shan,L., Edmundson,A.B. and Gray,W.R.
Three-dimensional structure of the alpha-conotoxin GI at 1.2 A resolution Biochemistry (1996) 35: 11329-11335 [P, NA]
Hill,J.M., Alewood,P.F. and Craik,D.J.
Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels Biochemistry (1996) 35: 8824-8835 [P, NA]
Hu,S.H., Gehrmann,J., Guddat,L.W., Alewood,P.F., Craik,D.J. and Martin,J.L.
The 1.1 A crystal structure of the neuronal acetylcholine receptor antagonist, alpha-conotoxin PnIA from Conus pennaceus Structure (1996) 4: 417-423 [P, NA]
Jimenez,E.C., Olivera,B.M., Gray,W.R. and Cruz,L.J.
Contryphan is a D-tryptophan-containing Conus peptide J. Biol. Chem. (1996) 271: 28002-28005 [P, NA]
Kits,K.S., Lodder,J.C., van der Schors,R.C., Li,K.W., Geraerts,W.P. and Fainzilber,M.
Novel omega-conotoxins block dihydropyridine-insensitive high voltage-activated calcium channels in molluscan neurons J. Neurochem. (1996) 67: 2155-2163 [P, NA]
Nakamura,T., Yu,Z., Fainzilber,M. and Burlingame,A.L.
Mass spectrometric-based revision of the structure of a cysteine-rich peptide toxin with gamma-carboxyglutamic acid, TxVIIA, from the sea snail, Conus textile Protein Sci. (1996) 5: 524-530 [P, NA]
Nielsen,K.J., Thomas,L., Lewis,R.J., Alewood,P.F. and Craik,D.J.
A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202 J. Mol. Biol. (1996) 263: 297-310 [P, NA]
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Conotoxin peptides Patent: US 5514774 07-MAY-1996 (1996) [P, NA]
Olivera,B.M., Cruz,L.J., Hillyard,D.R., McIntosh,J.Michael. and Santos,A.D.
Process and primers for identifying nucleic acids encoding A-lineage conotoxin peptides Patent: US 5589340 31-DEC-1996 (1996) [P, NA]
Price-Carter,M., Gray,W.R. and Goldenberg,D.P.
Folding of omega-conotoxins. 2. Influence of precursor sequences and protein disulfide isomerase Biochemistry (1996) 35: 15547-15557 [P, NA]
Terlau,H., Shon,K.J., Grilley,M., Stocker,M., Stuhmer,W. and Olivera,B.M.
Strategy for rapid immobilization of prey by a fish-hunting marine snail Nature (1996) 381: 148-151 [P, NA]
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MicroO-conotoxin MrVIA inhibits mammalian sodium channels, but not through site I J. Neurophysiol. (1996) 76: 1423-1429 [P, NA]
van Kesteren,R.E., Tensen,C.P., Smit,A.B., van Minnen,J., Kolakowski,L.F., Meyerhof,W., Richter,D., van Heerikhuizen,H., Vreugdenhil,E. and Geraerts,W.P.
Co-evolution of ligand-receptor pairs in the vasopressin/oxytocin superfamily of bioactive peptides J. Biol. Chem. (1996) 271: 3619-3626 [P, NA]
1995

Basus,V.J., Nadasdi,L., Ramachandran,J. and Miljanich,G.P.
Solution structure of omega-conotoxin MVIIA using 2D NMR spectroscopy FEBS Lett. (1995) 370: 163-169 [P, NA]
Chung,D., Gaur,S., Bell,J.R., Ramachandran,J. and Nadasdi,L.
Determination of disulfide bridge pattern in omega-conopeptides Int. J. Pept. Protein Res. (1995) 46: 320-325 [P, NA]
Fainzilber,M., Lodder,J.C., Kits,K.S., Kofman,O., Vinnitsky,I., Van Rietschoten,J., Zlotkin,E. and Gordon,D.
A new conotoxin affecting sodium current inactivation interacts with the delta-conotoxin receptor site J. Biol. Chem. (1995) 270: 1123-1129 [P, NA]
Fainzilber,M., Nakamura,T., Gaathon,A., Lodder,J.C., Kits,K.S., Burlingame,A.L. and Zlotkin,E.
A new cysteine framework in sodium channel blocking conotoxins Biochemistry (1995) 34: 8649-8656 [P, NA]
Fainzilber,M., van der Schors,R., Lodder,J.C., Li,K.W., Geraerts,W.P. and Kits,K.S.
New sodium channel-blocking conotoxins also affect calcium currents in Lymnaea neurons Biochemistry (1995) 34: 5364-5371 [P, NA]
Farr-Jones,S., Miljanich,G.P., Nadasdi,L., Ramachandran,J. and Basus,V.J.
Solution structure of omega-conotoxin MVIIC, a high affinity ligand of P-type calcium channels, using 1H NMR spectroscopy and complete relaxation matrix analysis J. Mol. Biol. (1995) 248: 106-124 [P, NA]
Groebe,D.R., Dumm,J.M., Levitan,E.S. and Abramson,S.N.
alpha-Conotoxins selectively inhibit one of the two acetylcholine binding sites of nicotinic receptors Mol. Pharmacol. (1995) 48: 105-111 [P, NA]
Hasson,A., Fainzilber,M., Zlotkin,E. and Spira,M.
Electrophysiological characterization of a novel conotoxin that blocks molluscan sodium channels Eur. J. Neurosci. (1995) 7: 815-818 [P, NA]
Hasson,A., Shon,K.J., Olivera,B.M. and Spira,M.E.
Alterations of voltage-activated sodium current by a novel conotoxin from the venom of Conus gloriamaris J. Neurophysiol. (1995) 73: 1295-1301 [P, NA]
Hopkins,C., Grilley,M., Miller,C., Shon,K.J., Cruz,L.J., Gray,W.R., Dykert,J., Rivier,J., Yoshikami,D. and Olivera,B.M.
A new family of Conus peptides targeted to the nicotinic acetylcholine receptor J. Biol. Chem. (1995) 270: 22361-22367 [P, NA]
Johnson,D.S., Martinez,J., Elgoyhen,A.B., Heinemann,S.F. and McIntosh,J.M.
alpha-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric alpha 7 and alpha 9 receptors Mol. Pharmacol. (1995) 48: 194-199 [P, NA]
Kim,J.I., Takahashi,M., Martin-Moutot,N., Seagar,M.J., Ohtake,A. and Sato,K.
Tyr13 is essential for the binding of omega-conotoxin MVIIC to the P/Q-type calcium channel Biochem. Biophys. Res. Commun. (1995) 214: 305-309 [P, NA]
Kim,J.I., Takahashi,M., Ohtake,A., Wakamiya,A. and Sato,K.
Tyr13 is essential for the activity of omega-conotoxin MVIIA and GVIA, specific N-type calcium channel blockers Biochem. Biophys. Res. Commun. (1995) 206: 449-454 [P, NA]
Kohno,T., Kim,J.I., Kobayashi,K., Kodera,Y., Maeda,T. and Sato,K.
Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin MVIIA Biochemistry (1995) 34: 10256-10265 [P, NA]
Martinez,J.S., Olivera,B.M., Gray,W.R., Craig,A.G., Groebe,D.R., Abramson,S.N. and McIntosh,J.M.
alpha-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity Biochemistry (1995) 34: 14519-14526 [P, NA]
McIntosh,J.M., Ghomashchi,F., Gelb,M.H., Dooley,D.J., Stoehr,S.J., Giordani,A.B., Naisbitt,S.R. and Olivera,B.M.
Conodipine-M, a novel phospholipase A2 isolated from the venom of the marine snail Conus magus. J. Biol. Chem. (1995) 270: 3518-3526 [P, NA]
McIntosh,J.M., Hasson,A., Spira,M.E., Gray,W.R., Li,W., Marsh,M., Hillyard,D.R. and Olivera,B.M.
A new family of conotoxins that blocks voltage-gated sodium channels J. Biol. Chem. (1995) 270: 16796-16802 [P, NA]
Miljanich,G.P. and Ramachandran,J.
Antagonists of neuronal calcium channels: structure, function, and therapeutic implications Annu. Rev. Pharmacol. Toxicol. (1995) 35: 707-0 [P, NA]
Nadasdi L, Yamashiro D, Chung D, Tarczy-Hornoch K, Adriaenssens P, Ramachandran J.
Structure-activity analysis of a Conus peptide blocker of N-type neuronal calcium channels. Biochemistry (1995) 34: 8076-8081 [P, NA]
Shon,K.J., Grilley,M.M., Marsh,M., Yoshikami,D., Hall,A.R., Kurz,B., Gray,W.R., Imperial,J.S., Hillyard,D.R. and Olivera,B.M.
Purification, characterization, synthesis, and cloning of the lockjaw peptide from Conus purpurascens venom Biochemistry (1995) 34: 4913-4918 [P, NA]
Sine,S.M., Kreienkamp,H.J., Bren,N., Maeda,R. and Taylor,P.
Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of alpha-conotoxin M1 selectivity. Neuron (1995) 15: 205-211 [P, NA]
Van Kesteren,R.E., Smit,A.B., De Lange,R.P., Kits,K.S., Van Golen,F.A., Van Der Schors,R.C., De With,N.D., Burke,J.F. and Geraerts,W.P.
Structural and functional evolution of the vasopressin/oxytocin superfamily: vasopressin-related conopressin is the only member present in Lymnaea, and is involved in the control of sexual behavior J. Neurosci. (1995) 15: 5989-5998 [P, NA]
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A novel G protein-coupled receptor mediating both vasopressin- and oxytocin-like functions of Lys-conopressin in Lymnaea stagnalis Neuron (1995) 15: 897-908 [P, NA]
1994

Fainzilber,M., Hasson,A., Oren,R., Burlingame,A.L., Gordon,D., Spira,M.E. and Zlotkin,E.
New mollusc-specific alpha-conotoxins block Aplysia neuronal acetylcholine receptors Biochemistry (1994) 33: 9523-9529 [P, NA]
Fainzilber,M., Kofman,O., Zlotkin,E. and Gordon,D.
A new neurotoxin receptor site on sodium channels is identified by a conotoxin that affects sodium channel inactivation in molluscs and acts as an antagonist in rat brain J. Biol. Chem. (1994) 269: 2574-2580 [P, NA]
Hann,R.M., Pagan,O.R. and Eterovic,V.A.
The alpha-conotoxins GI and MI distinguish between the nicotinic acetylcholine receptor agonist sites while SI does not Biochemistry (1994) 33: 14058-14063 [P, NA]
Kim,J.I., Takahashi,M., Ogura,A., Kohno,T., Kudo,Y. and Sato,K.
Hydroxyl group of Tyr13 is essential for the activity of omega-conotoxin GVIA, a peptide toxin for N-type calcium channel J. Biol. Chem. (1994) 269: 23876-23878 [P, NA]
McIntosh,J.M., Yoshikami,D., Mahe,E., Nielsen,D.B., Rivier,J.E., Gray,W.R. and Olivera,B.M.
A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI J. Biol. Chem. (1994) 269: 16733-16739 [P, NA]
Miller,R., Gallo,S.M., Khalak,H.G. and Weeks,C.M.
Snb: Crystal Structure Determination Via Shake-And-Bake J. Appl. Crystallogr. (1994) 27: 613-621 [P, NA]
Nielsen,D.B., Dykert,J., Rivier,J.E. and McIntosh,J.M.
Isolation of Lys-conopressin-G from the venom of the worm-hunting snail, Conus imperialis Toxicon (1994) 32: 845-848 [P, NA]
Shon,K.J., Hasson,A., Spira,M.E., Cruz,L.J., Gray,W.R. and Olivera,B.M.
Delta-conotoxin GmVIA, a novel peptide from the venom of Conus gloriamaris Biochemistry (1994) 33: 11420-11425 [P, NA]
1993

Davis,J.H., Bradley,E.K., Miljanich,G.P., Nadasdi,L., Ramachandran,J. and Basus,V.J.
Solution structure of omega-conotoxin GVIA using 2-D NMR spectroscopy and relaxation matrix analysis Biochemistry (1993) 32: 7396-7405 [P, NA]
Hasson,A., Fainzilber,M., Gordon,D., Zlotkin,E. and Spira,M.E.
Alteration of sodium currents by new peptide toxins from the venom of a molluscivorous Conus snail Eur. J. Neurosci. (1993) 5: 56-64 [P, NA]
Lampe,R.A., Lo,M.M., Keith,R.A., Horn,M.B., McLane,M.W. and Spreen,R.C.
Effects of site-specific acetylation on omega-conotoxin GVIA binding and function. Biochemistry (1993) 32: 3255-3260 [P, NA]
Miljanich,G.P., Bitner,R.S., Bowersox,S.S., Fox,J.A., Valentino,K.L., Yamashiro,D.H. and Tsubokawa,M.
Method of reducing neuronal damage using omega conotoxin peptides Patent: US 5189020-A 29 23-FEB-1993; Neurex Corporation; Menlo Park, CA (1993) [P, NA]
Miljanich,G.P., Bowersox,S.S., Fox,J.A., Valentino,K.L., Bitner,R.S. and Yamashiro,D.H.
Compositions for Delayed Treatment of Ischemia-related Neuronal Damage. Patent: PCT/US92 09766; Classification, C07K 7/10, A61K 37/02. (1993) [P, NA]
Monje,V.D., Haack,J.A., Naisbitt,S.R., Miljanich,G., Ramachandran,J., Nasdasdi,L., Olivera,B.M., Hillyard,D.R. and Gray,W.R.
A new Conus peptide ligand for Ca channel subtypes Neuropharmacology (1993) 32: 1141-1149 [P, NA]
Pallaghy,P.K., Duggan,B.M., Pennington,M.W. and Norton,R.S.
Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin J. Mol. Biol. (1993) 234: 405-420 [P, NA]
Sato,K., Park,N.G., Kohno,T., Maeda,T., Kim,J.I., Kato,R. and Takahashi,M.
Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels Biochem. Biophys. Res. Commun. (1993) 194: 1292-1296 [P, NA]
Sevilla,P., Bruix,M., Santoro,J., Gago,F., Garcia,A.G. and Rico,M.
Three-dimensional structure of omega-conotoxin GVIA determined by 1H NMR Biochem. Biophys. Res. Commun. (1993) 192: 1238-1244 [P, NA]
Skalicky,J.J., Metzler,W.J., Ciesla,D.J., Galdes,A. and Pardi,A.
Solution structure of the calcium channel antagonist omega-conotoxin GVIA Protein Sci. (1993) 2: 1591-1603 [P, NA]
1992

Colledge,C.J., Hunsperger,J.P., Imperial,J.S. and Hillyard,D.R.
Precursor structure of omega-conotoxin GVIA determined from a cDNA clone Toxicon (1992) 30: 1111-1116 [P, NA]
Cruz,L.J., Ramilo,C.A., Corpuz,G.P. and Olivera,B.M.
Conus peptides: phylogenetic range of biological activity Biol. Bull. (1992) 183: 159-0 [P, NA]
Hillyard,D.R., Monje,V.D., Mintz,I.M., Bean,B.P., Nadasdi,L., Ramachandran,J., Miljanich,G., Azimi-Zoonooz,A., McIntosh,J.M., Cruz,L.J. et al.
A new Conus peptide ligand for mammalian presynaptic Ca2+ channels Neuron (1992) 9: 69-77 [P, NA]
Olivera,B.M., Johnson,D.S., Azimi-Zonooz,A. and Cruz,L.J.
Peptides in the venom of the geography cone, Conus geographus (in) Waters,D., Lavin,M., Maguire,D. and Pearn,J. (Eds.); TOXINS AND TARGETS; Harwood Academic (1992) : 19-28 [P, NA]
Ramilo,C., Zafaralla,G.C., Nadasdi,L., Hammerland,L.G., Yoshikami,D., Gray,W.R., Kristipati,R., Ramachandran,J., Miljanich,G.P., Olivera,B.M. and Cruz,L.J.
Novel alpha- and omega-conotoxins from Conus striatus venom Biochemistry (1992) 31: 9919-9926 [P, NA]
van Kesteren,R.E., Smit,A.B., Dirks,R.W., de With,N.D., Geraerts,W.P. and Joosse,J.
Evolution of the vasopressin/oxytocin superfamily: characterization of a cDNA encoding a vasopressin-related precursor, preproconopressin, from the mollusc Lymnaea stagnalis Proc. Natl. Acad. Sci. U.S.A. (1992) 89: 4593-4597 [P, NA]
Wakamatsu,K., Kohda,D., Hatanaka,H., Lancelin,J.M., Ishida,Y., Oya,M., Nakamura,H., Inagaki,F. and Sato,K.
Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations Biochemistry (1992) 31: 12577-12584 [P, NA]
1991

Fainzilber,M., Gordon,D., Hasson,A., Spira,M.E. and Zlotkin,E.
Mollusc-specific toxins from the venom of Conus textile neovicarius Eur. J. Biochem. (1991) 202: 589-595 [P, NA]
Horne,W.A., Hawrot,E. and Tsien,R.W.
omega-Conotoxin GVIA receptors of Discopyge electric organ. Characterization of omega-conotoxin binding to the nicotinic acetylcholine receptor. J. Biol. Chem. (1991) 266: 13719-13725 [P, NA]
Lancelin,J.M., Kohda,D., Tate,S., Yanagawa,Y., Abe,T., Satake,M. and Inagaki,F.
Tertiary structure of conotoxin GIIIA in aqueous solution Biochemistry (1991) 30: 6908-6916 [P, NA]
Miljanich,G.P., Bitner,R.S., Bowersox,S.S., Fox,J.A., Valentino,K.L. and Yamashiro,D.H.
Patent: 5051403, -US 24-SEP-1991; (1991) [P, NA]
Myers,R.A., Zafaralla,G.C., Gray,W.R., Abbott,J., Cruz,L.J. and Olivera,B.M.
alpha-Conotoxins, small peptide probes of nicotinic acetylcholine receptors Biochemistry (1991) 30: 9370-9377 [P, NA]
Ott,K.H., Becker,S., Gordon,R.D. and Ruterjans,H.
Solution structure of mu-conotoxin GIIIA analysed by 2D-NMR and distance geometry calculations FEBS Lett. (1991) 278: 160-166 [P, NA]
1990

Haack,J.A., Rivier,J., Parks,T.N., Mena,E.E., Cruz,L.J. and Olivera,B.M.
Conantokin-T. A gamma-carboxyglutamate containing peptide with N-methyl-d-aspartate antagonist activity J. Biol. Chem. (1990) 265: 6025-6029 [P, NA]
Hidaka,Y., Sato,K., Nakamura,H., Kobayashi,J., Ohizumi,Y. and Shimonishi,Y.
Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus FEBS Lett. (1990) 264: 29-32 [P, NA]
Olivera,B.M., Rivier,J., Clark,C., Ramilo,C.A., Corpuz,G.P., Abogadie,F.C., Mena,E.E., Woodward,S.R., Hillyard,D.R. and Cruz,L.J.
Diversity of Conus neuropeptides Science (1990) 249: 257-263 [P, NA]
Woodward,S.R., Cruz,L.J., Olivera,B.M. and Hillyard,D.R.
Constant and hypervariable regions in conotoxin propeptides EMBO J. (1990) 9: 1015-1020 [P, NA]
1989

Hillyard,D.R., Olivera,B.M., Woodward,S., Corpuz,G.P., Gray,W.R., Ramilo,C.A. and Cruz,L.J.
A molluscivorous Conus toxin: conserved frameworks in conotoxins Biochemistry (1989) 28: 358-361 [P, NA]
Kobayashi,Y., Ohkubo,T., Kyogoku,Y., Nishiuchi,Y., Sakakibara,S., Braun,W. and Go,N.
Solution conformation of conotoxin GI determined by 1H nuclear magnetic resonance spectroscopy and distance geometry calculations Biochemistry (1989) 28: 4853-4860 [P, NA]
Pardi,A., Galdes,A., Florance,J. and Maniconte,D.
Solution structures of alpha-conotoxin G1 determined by two-dimensional NMR spectroscopy Biochemistry (1989) 28: 5494-5501 [P, NA]
Yoshikami,D. and Olivera,B.M.
The inhibitory effects of omega-conotoxins on Ca channels and synapses. Ann. N. Y. Acad. Sci. (1989) 560: 230-248 [P, NA]
1988

Gray,W.R., Olivera,B.M. and Cruz,L.J.
Peptide toxins from venomous Conus snails Annu. Rev. Biochem. (1988) 57: 665-0 [P, NA]
Yanagawa,Y., Abe,T., Satake,M., Odani,S., Suzuki,J. and Ishikawa,K.
A novel sodium channel inhibitor from Conus geographus: purification, structure, and pharmacological properties Biochemistry (1988) 27: 6256-6262 [P, NA]
Zafaralla,G.C., Ramilo,C., Gray,W.R., Karlstrom,R., Olivera,B.M. and Cruz,L.J.
Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI Biochemistry (1988) 27: 7102-7105 [P, NA]
1987

Cruz,L.J., de Santos,V., Zafaralla,G.C., Ramilo,C.A., Zeikus,R., Gray,W.R. and Olivera,B.M.
Invertebrate vasopressin/oxytocin homologs. Characterization of peptides from Conus geographus and Conus straitus venoms J. Biol. Chem. (1987) 262: 15821-15824 [P, NA]
Olivera,B.M., Cruz,L.J., de Santos,V., Lecheminant,G.W., Griffin,D., Zeikus,R.D., McIntosh,J.M., Galyean,R., Varga,J., Gray,W.R. and Rivier,J.E.
Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom Biochemistry (1987) 26: 2086-2090 [P, NA]
Rivier,J., Galyean,R., Gray,W.R., Azimi-Zonooz,A., McIntosh,J.M., Cruz,L.J. and Olivera,B.M.
Neuronal calcium channel inhibitors. Synthesis of omega-conotoxin GVIA and effects on 45Ca uptake by synaptosomes J. Biol. Chem. (1987) 262: 1194-1198 [P, NA]
1986

Nishiuchi,Y., Kumagaye,K., Noda,Y., Watanabe,T.X. and Sakakibara,S.
Synthesis and secondary-structure determination of omega-conotoxin GVIA: a 27-peptide with three intramolecular disulfide bonds Biopolymers (1986) 25 Suppl [P, NA]
Ramilo,C.A.
Thesis (1986) [P, NA]
1985

Cruz,L.J., Gray,W.R., Olivera,B.M., Zeikus,R.D., Kerr,L., Yoshikami,D. and Moczydlowski,E.
Conus geographus toxins that discriminate between neuronal and muscle sodium channels J. Biol. Chem. (1985) 260: 9280-9288 [P, NA]
Olivera BM, McIntosh JM, Clark C, Middlemas D, Gray WR, Cruz LJ.
A sleep-inducing peptide from Conus geographus venom. Toxicon (1985) 23: 277-282 [P, NA]
Olivera,B.M., Gray,W.R., Zeikus,R., McIntosh,J.M., Varga,J., Rivier,J., de Santos,V. and Cruz,L.J.
Peptide neurotoxins from fish-hunting cone snails Science (1985) 230: 1338-1343 [P, NA]
1984

Gray,W.R., Luque,F.A., Galyean,R., Atherton,E., Sheppard,R.C., Stone,B.L., Reyes,A., Alford,J., McIntosh,M., Olivera,B.M., Cruz,L.J. and Rivier,J.
Conotoxin GI: disulfide bridges, synthesis, and preparation of iodinated derivatives Biochemistry (1984) 23: 2796-2802 [P, NA]
Kerr,L.M. and Yoshikami,D.
A venom peptide with a novel presynaptic blocking action. Nature (1984) 308: 282-284 [P, NA]
McIntosh,J.M., Olivera,B.M., Cruz,L.J. and Gray,W.R.
Gamma-carboxyglutamate in a neuroactive toxin J. Biol. Chem. (1984) 259: 14343-14346 [P, NA]
Olivera,B.M., McIntosh,J.M., Cruz,L.J., Luque,F.A. and Gray,W.R.
Purification and sequence of a presynaptic peptide toxin from Conus geographus venom Biochemistry (1984) 23: 5087-5090 [P, NA]
1983

Gray,W.R., Rivier,J.E., Galyean,R., Cruz,L.J. and Olivera,B.M.
Conotoxin MI. Disulfide bonding and conformational states J. Biol. Chem. (1983) 258: 12247-12251 [P, NA]
Sato,S., Nakamura,H., Ohizumi,Y., Kobayashi,J. and Hirata,Y.
The amino acid sequences of homologous hydroxyproline-containing myotoxins from the marine snail Conus geographus venom FEBS Lett. (1983) 155: 277-280 [P, NA]
1982

McIntosh,M., Cruz,L.J., Hunkapiller,M.W., Gray,W.R. and Olivera,B.M.
Isolation and structure of a peptide toxin from the marine snail Conus magus Arch. Biochem. Biophys. (1982) 218: 329-334 [P, NA]
Nishiuchi,Y. and Sakakibara,S.
Primary and secondary structure of conotoxin GI, a neurotoxic tridecapeptide from a marine snail FEBS Lett. (1982) 148: 260-262 [P, NA]
1981

Gray,W.R., Luque,A., Olivera,B.M., Barrett,J. and Cruz,L.J.
Peptide toxins from Conus geographus venom J. Biol. Chem. (1981) 256: 4734-4740 [P, NA]
Duda,T.F. and Palumbi,S.R.
Molecular evolution of four-loop conotoxin precursors from fish-eating Conus (Unpublished) [P, NA]
Duda,T.F. Jr.
Positive selection and patterns of divergence of orthologous toxin genes among related venomous predatory gastropods (Unpublished) [P, NA]
Duda,T.F. Jr. and Palumbi,S.R.
Convergent evolution of venoms and feeding ecologies among polyphyletic piscivorous Conus species (Unpublished) [P, NA]
Gilly,W.F., Richmond,T., Elliger,C.A., Lebaric,Z.N., Schulz,J., Bingham,J.P. and Sweedler,J.V.
Extreme Diversity in a Novel Family of Peptide Toxins from Conus californicus (Unpublished) [P, NA]
0

Jiang, X., Pi, C. and Liu, Y.
A Novel Class of Conotoxin cDNAs with a Distinctive Cysteine Arrangement Unpublished (0) [P, NA]
Liu, L., Chi, C.W. and Wang, C.G.
cDNA of S-superfamily conotoxin precursor from Conus caracteristicus Unpublished (0) [P, NA]
Lu,B.S., Yu,F., Wang,J.H., Zhao,D., Zhao,S.Q. and Huang,P.T.
Cloning of alpha-conotoxin sequences from Conus textile venom duct (Unpublished) [P, NA]
Luo,S. and Zhangsun,D.
Hainan O-superfamily peptides (Unpublished) [P, NA]
Luo,S., Zhang,B. and Zhangsun,D.
A11GB conotoxin scaffold VI/VII precursor (Unpublished) [P, NA]
Luo,S., Zhang,B. and Zhangsun,D.
C11GB conotoxin scaffold VI/VII precursor (Unpublished) [P, NA]
Luo,S., Zhangsun,D. and Zhang,B.
Hainan O-superfamily peptides (Unpublished) [P, NA]
Luo,S., Zhangsun,D., Zhang,B. and Lin,Q.
Novel O-superfamily conotoxins, and their coding polynucleotides and use (Unpublished) [P, NA]
Luo,S., Zhangsun,D., Zhang,B. and Lin,Q.
Hainan O-superfamily peptides (Unpublished) [P, NA]
0

Peng, C., Wu, X., Han, Y., Yuan, D., Chi, C. and Wang, C.
Identification of six novel T-1 conotoxins from the venom ducts of Conus pulicarius by molecular cloning Unpublished (0) [P, NA]
Peng, C., Wu, X., Wang, Y., Shao, X., Chi, C. and Wang, C.
Identification and characterization of a new four-Cys conotoxin (framework 14) from the vermivorous Conus pulicarius, pu14a, a novel antagonist of nicotinic acetylcholine receptors Unpublished (0) [P, NA]
Walker,C., Shetty,R., Olivera,B.M., Hooper,D., Jacobsen,R., Steele,D. and Jones,R.M.
Tau-conotoxin peptides (Unpublished) [P, NA]
0

Yuan, D., Liu, L., Chi, C. and Guo, Z.
New conotoxins define a novel I3-superfamily Unpublished (0) [P, NA]
Zhao,D. and Huang,P.
Conus imperialis conotoxin ImIIA precursor mRNA (Unpublished) [P, NA]
Favreau,P.
Physico-chemical and pharmacological study of new toxins from the piscivorous cone snail Conus consors Thesis (1999) () [P, NA]
Favreau,P.
Physico-chemical and pharmacological study of new toxins from the piscivorous cone snail Conus consors Thesis (1999) () [P, NA]
Favreau,P.
Physico-chemical and pharmacological study of new toxins from the piscivorous cone snail Conus consors Thesis (1999) () [P, NA]