About ConoServer
ConoServer was created end 2007 in the laboratory of David Craik [1]. The database gives access to protein sequences, nucleic acid sequences and structural information on conopeptides. ConoServer's data are first collected from the peer reviewed literature and from publicly available databases, including UniProtKB/Swiss-Prot, NCBI nucleotide (nt), and the World Wide Protein Data Bank. The data are then curated manually, which include the addition of references, the analysis of sequence regions, the identification of cysteine frameworks and gene superfamilies, and the identification of mature peptides in the precusor sequences. The database is updated several times a year, at irregular intervals.
The help page for the database and tools can be found here.
If you use the database in your publications and found it has been useful to your research, please cite the corresponding peer reviewed article. Citing the ConoServer reference will help us to get credits for it and continue its development. Thank you.
| [1] | Kaas,Q. et al. (2008) Bioinformatics 24:445-446 |
Features
- Multi-criteria search: conopeptide classification schemes, organism names, organism clades, cone snail diet, organism geographic location, and sequence.
- Protein, nucleic acid and structure cards.
- Classification schemes: conopeptides are classified using several classification schemes, which are constantly evolving, and ConoServer allows to keep track of their recent evolutions.
- Statistics: some automatocally updated statistics are provided for sequence and structures of conopeptides [2].
- Analysis of conopeptide precursor sequences: prediction of ORF, identification of sequence regions in the precursor, determination of close homologues and classification scheme analysis.
- Analysis of mass spectrometry data: mass with differential post-translational modifications, search of mass lists with predicted masses from database or from a list provided by user.
| [2] | Kaas,Q. et al. (2010) Toxicon 55:1491-1509 |
Credits
- Quentin Kaas: design of database, design of website, curator.
- Jan-Christoph Westermann: original idea, (retired) curator.
- David Craik: head of laboratory.
Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6
ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.
The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).
Contacts:
David Craik
Quentin Kaas
Last updated: Tuesday 5 December 2023