Vr3a (P10151) Protein Card

General Information

Name	Vr3a
Alternative name(s)	Vr3-NPPP01
Organism	Conus varius
Protein Type	Wild type
Protein precursor	Vr3a precursor (10152)

Classification

Conopeptide class	conotoxin
Gene superfamily	M superfamily
Cysteine framework	III
Pharmacological family

Sequence

QGCCPPGVCQMAACNPPPCCP
Sequence evidence	nucleic acid level
Average Mass	2070.44
Monoisotopic Mass	2068.72
Isoelectric Point	7.00
Extinction Coefficient [280nm]	NA

Activity

Percentage inhibition: Voltage-Gated Calcium Channels

Target	Organism	% inhibition		Concentration	Ref
Cav1.2	H. sapiens	15.32	+/-5.41	10 μM	Yang,M. et al. (2021)
Cav2.2	H. sapiens	12.86	+/-4.93	10 μM	Yang,M. et al. (2021)

References

Yang,M., Li,Y., Liu,L., Zhou,M. (2021) A novel proline-rich M-superfamily conotoxin that can simultaneously affect sodium, potassium and calcium currents J Venom Anim Toxins Incl Trop Dis 27

Internal links

Protein Precursor	Vr3a precursor (10152)
Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 26 September 2023