LvIB (P10267) Protein Card

General Information
Name LvIB
Organism Conus lividus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
QCCSNPPCAHEHCR
Sequence evidence nucleic acid level
Average Mass 1580.74
Monoisotopic Mass 1579.55
Isoelectric Point 8.09
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β2R. norvegicus>10000 nM100 μM AChWang et al. (2021)
α6/α3β2β3R. norvegicus5300 nM[2570-10950]0.88100 μM AChWang et al. (2021)
α6/α3β4R. norvegicus>10000 nM100 μM AChWang et al. (2021)
α7R. norvegicus1760 nM[1330-2340]0.97200 μM AChWang et al. (2021)

Synthetic variants
LvIB[Q1G,del14]GCCSNPPCAHEHC(nh2)
LvIB[Q1G]GCCSNPPCAHEHCR
LvIB[del1,14]CCSNPPCAHEHC(nh2)
LvIB[del14]QCCSNPPCAHEHC(nh2)

References
Wang, S., Zhu, X., Zhangsun, M., Wu, Y., Yu, J., Harvey, P. J., Kaas, Q., Zhangsun, D., Craik, D. J., & Luo, S. (2021) Engineered Conotoxin Differentially Blocks and Discriminates Rat and Human α7 Nicotinic Acetylcholine Receptors Journal of Medicinal Chemistry 64:5620-5631

Internal links
Nucleic acids
Structure

External links

Tools