LvIB[Q1G,del14] (P10269) Protein Card

General Information
Name LvIB[Q1G,del14]
Organism synthetic construct
Protein Type Synthetic
Parent LvIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSNPPCAHEHC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Average Mass 1352.49
Monoisotopic Mass 1351.43
Isoelectric Point 6.81
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β2R. norvegicus350 nM[280-440]0.82100 μM AChWang et al. (2021)
α6/α3β2β3R. norvegicus150 nM[100-240]0.64100 μM AChWang et al. (2021)
α6/α3β4R. norvegicus1410 nM[1100-1780]1.38100 μM AChWang et al. (2021)
α7H. sapiens1570 nM[1280-1910]1.5200 μM AChWang et al. (2021)
R. norvegicus97 nM[82-110]1.25200 μM AChWang et al. (2021)

References
Wang, S., Zhu, X., Zhangsun, M., Wu, Y., Yu, J., Harvey, P. J., Kaas, Q., Zhangsun, D., Craik, D. J., & Luo, S. (2021) Engineered Conotoxin Differentially Blocks and Discriminates Rat and Human α7 Nicotinic Acetylcholine Receptors Journal of Medicinal Chemistry 64:5620-5631

Internal links
Nucleic acids
Structure

External links

Tools