RgIA[Y10(Ity)] (P10373) Protein Card

General Information
Name RgIA[Y10(Ity)]
Alternative name(s) RgIA1
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCR(Ity)RCR
Modified residues
positionsymbolname
10Ity3-iodotyrosine
Average Mass 1696.69
Monoisotopic Mass 1695.51
Isoelectric Point 12.50
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α9α10H. sapiens8.4 nM+/-2.80.8110 μM AChRomero,H.K. et al. (2017)
R. norvegicus0.3 nM+/-0.10.910 μM AChRomero,H.K. et al. (2017)

References
Romero,H.K., Christensen,S.B., Di Cesare Mannelli,L., Gajewiak,J., Ramachandra,R., Elmslie,K.S., Vetter,D.E., Ghelardini,C., Iadonato,S.P., Mercado,J.L., Olivera,B.M. and McIntosh,J.M. (2017) Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. Proc Natl Acad Sci U S A 114

Internal links
Nucleic acids
Structure

External links

Tools