RgIA[S4T,R9(Cit),Y10(Ity),R11Q] (P10374) Protein Card

General Information
Name RgIA[S4T,R9(Cit),Y10(Ity),R11Q]
Alternative name(s) RgIA2
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
GCCTDPRC(Cit)(Ity)QCR
Modified residues
positionsymbolname
9CitCitrulline
10Ity3-iodotyrosine
Average Mass 1683.64
Monoisotopic Mass 1682.47
Isoelectric Point 10.99
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α9α10H. sapiens6.1 nM+/-1.81.110 μM AChRomero,H.K. et al. (2017)
R. norvegicus1.7 nM+/-0.50.7310 μM AChRomero,H.K. et al. (2017)

References
Romero,H.K., Christensen,S.B., Di Cesare Mannelli,L., Gajewiak,J., Ramachandra,R., Elmslie,K.S., Vetter,D.E., Ghelardini,C., Iadonato,S.P., Mercado,J.L., Olivera,B.M. and McIntosh,J.M. (2017) Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. Proc Natl Acad Sci U S A 114

Internal links
Nucleic acids
Structure

External links

Tools