RgIA [S4T,R9(Cit),Y10(Ity),R11Q,C12(Pen),R13Y] (P10380) Protein Card

General Information
Name RgIA [S4T,R9(Cit),Y10(Ity),R11Q,C12(Pen),R13Y] (named by ConoServer)
Alternative name(s) RgIA-5409
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
GCCTDPRC(Cit)(Ity)Q(Pen)Y
Modified residues
positionsymbolname
9CitCitrulline
10Ity3-iodotyrosine
12PenL-Penicillamine
Average Mass 1737.71
Monoisotopic Mass 1736.48
Isoelectric Point 8.09
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α9α10H. sapiens24[11-50]100 μM AChGajewiak J et al. (2021)

References
Gajewiak J, Christensen SB, Dowell C, Hararah F, Fisher F, Huynh PN, Olivera BM, McIntosh JM (2021) Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism J Med Chem 64:9271-9278

Internal links
Nucleic acids
Structure

External links

Tools