RgIA [C3(Pen),S4T,Y10(Ity),R11Q,R13(β3hY),insC_r] (P10387) Protein Card

General Information
Name RgIA [C3(Pen),S4T,Y10(Ity),R11Q,R13(β3hY),insC_r] (named by ConoServer)
Alternative name(s) RgIA-5477
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
GC(Pen)TDPRCR(Ity)QC(β3hY)r
Modified residues
positionsymbolname
3PenL-Penicillamine
10Ity3-iodotyrosine
13β3hYβ3-homotyrosine
14rD-arginine
Average Mass 1920.97
Monoisotopic Mass 1919.63
Isoelectric Point 12.20
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α9α10H. sapiens0.36 nM[0.28-0.46]100 μM AChGajewiak J et al. (2021)

References
Gajewiak J, Christensen SB, Dowell C, Hararah F, Fisher F, Huynh PN, Olivera BM, McIntosh JM (2021) Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism J Med Chem 64:9271-9278

Internal links
Nucleic acids
Structure

External links

Tools