RgIA [C3(Pen),S4T,Y10(Ity),R11Q,R13(β3hY),insC_E] (P10391) Protein Card

General Information

Name	RgIA [C3(Pen),S4T,Y10(Ity),R11Q,R13(β3hY),insC_E] (named by ConoServer)
Alternative name(s)	RgIA-5687
Organism	synthetic construct
Protein Type	Synthetic
Parent	RgIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Pharmacological family	alpha conotoxin

Sequence

GC(Pen)TDPRCR(Ity)QC(β3hY)E

Modified residues

position	symbol	name
3	Pen	L-Penicillamine
10	Ity	3-iodotyrosine
13	β3hY	β3-homotyrosine

Average Mass

1893.89

Monoisotopic Mass

1892.57

Isoelectric Point

7.00

Extinction Coefficient [280nm]

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Agonist	Ref
α9α10	H. sapiens	1.4 nM	[0.6-3.5]	100 μM ACh	Gajewiak J et al. (2021)

References

Gajewiak J, Christensen SB, Dowell C, Hararah F, Fisher F, Huynh PN, Olivera BM, McIntosh JM (2021) Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism J Med Chem 64:9271-9278

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Saturday 1 April 2023