Cy3-RgIA-5727 (P10392) Protein Card

General Information
Name Cy3-RgIA-5727
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
(Cy3Trz)GC(Pen)TDPRCR(Ity)QC(β3hY)R
Modified residues
positionsymbolname
Average Mass 2474.74
Monoisotopic Mass 2473.00
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50Ref
α1β1δεM. musculus>1000 nMFisher,F. et al. (2021)
α2β2M. musculus>1000 nMFisher,F. et al. (2021)
α2β4M. musculus>1000 nMFisher,F. et al. (2021)
α3β2M. musculus>1000 nMFisher,F. et al. (2021)
α3β4M. musculus>1000 nMFisher,F. et al. (2021)
>1000 nMFisher,F. et al. (2021)
α4β2M. musculus>1000 nMFisher,F. et al. (2021)
α4β4M. musculus>1000 nMFisher,F. et al. (2021)
α6/α3β2β3M. musculus>1000 nMFisher,F. et al. (2021)
α6/α3β4M. musculus>1000 nMFisher,F. et al. (2021)
α7M. musculus6.8 nM[5.8-7.9]Fisher,F. et al. (2021)
α9α10M. musculus0.023 nM[0.02-0.028]Fisher,F. et al. (2021)

References
Fisher,F., Zhang,Y., Vincent,P.F.Y., Gajewiak,J., Gordon,T.J., Glowatzki,E., Fuchs,P.A. and McIntosh,J.M. (2021) Cy3-RgIA-5727 Labels and Inhibits α9-Containing nAChRs of Cochlear Hair Cells. Front Cell Neurosci 15:697560

Internal links
Nucleic acids
Structure

External links

Tools