Bu8[S12M] (P10405) Protein Card

General Information

Name	Bu8[S12M]
Organism	synthetic construct
Protein Type	Synthetic
Parent	Bu8

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	VI/VII
Pharmacological family	omega conotoxin

Sequence

CKRKGSSCRRTMYDCCTGSCRNGKC(nh2)
Modified residues	position symbol name 26 nh2 C-term amidation
Average Mass	2797.24
Monoisotopic Mass	2795.15
Isoelectric Point	12.55
Extinction Coefficient [280nm]	1490.00

Activity

IC50: Voltage-Gated Calcium Channels

Target	Organism	IC50		Ref
Cav2.2	R. norvegicus	172 nM	[145-204]	Chen J et al. (2021)

References

Chen J, Liu X, Yu S, Liu J, Chen R, Zhang Y, Jiang L, Dai Q (2021) A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity. Acta Pharm Sin B 11:2685-2693

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Thursday 28 September 2023