AusIA[ribbon] (P10418) Protein Card

General Information
Name AusIA[ribbon]
Alternative name(s) rAusIA
Organism synthetic construct
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
SCCARNPACRHNHPCV
Average Mass 1764.00
Monoisotopic Mass 1762.70
Isoelectric Point 12.50
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α7G. gallus9.67 uM+/-0.01200 uM AchLebbe,E.K. et al. (2014)
H. sapiens26.0 uM+/-530 uM cholineHo,T.N.T. et al. (2021)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α1β1δεR. norvegicus0 10 uM AchLebbe,E.K. et al. (2014)
α1β1γδR. norvegicus0 10 uM AchLebbe,E.K. et al. (2014)
α3β4H. sapiens070 uM AchLebbe,E.K. et al. (2014)
α4β2H. sapiens050 uM AchLebbe,E.K. et al. (2014)
α4β4H. sapiens050 uM AchLebbe,E.K. et al. (2014)
α7G. gallus51200 uM AchLebbe,E.K. et al. (2014)

Synthetic variants
AusIA[A4S, del5, ribbon]SCCSNPACRHNHPCV
AusIA[A4S, ribbon]SCCSRNPACRHNHPCV
AusIA[H11L, ribbon]SCCARNPACRLNHPCV
AusIA[P7A, ribbon]SCCARNAACRHNHPCV
AusIA[R10A, ribbon]SCCARNPACAHNHPCV
AusIA[R5A, ribbon]SCCAANPACRHNHPCV
AusIA[R5S, ribbon]SCCASNPACRHNHPCV
AusIA[S1G, ribbon]GCCARNPACRHNHPCV
AusIA[del16, ribbon]SCCARNPACRHNHPC
AusIA[del4, ribbon]SCCRNPACRHNHPCV
AusIA[del5, del16, ribbon]SCCANPACRHNHPC
AusIA[del5, ribbon]SCCANPACRHNHPCV

References
Lebbe,E.K., Peigneur,S., Maiti,M., Mille,B.G., Devi,P., Ravichandran,S., Lescrinier,E., Waelkens,E., D'Souza,L. and Tytgat,J. (2014) Discovery of a new subclass of α-conotoxins in the venom of Conus australis. Toxicon 91:145-154
Ho,T.N.T., Abraham,N., Lewis,R.J. (2021) Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA Sci Rep 11:21928

Internal links
Nucleic acids
Structure

External links

Tools