AusIA[R5S, ribbon] (P10425) Protein Card

General Information
Name AusIA[R5S, ribbon] (named by ConoServer)
Alternative name(s) rAusIA[R5S]
Organism synthetic construct
Protein Type Synthetic
Parent AusIA[ribbon]

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
SCCASNPACRHNHPCV
Average Mass 1694.89
Monoisotopic Mass 1693.63
Isoelectric Point 10.94
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α7H. sapiens70.0 uM+/-1030 uM cholineHo,T.N.T. et al. (2021)

References
Ho,T.N.T., Abraham,N., Lewis,R.J. (2021) Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA Sci Rep 11:21928

Internal links
Nucleic acids
Structure

External links

Tools