TxIA[ins5_A, A10L, ribbon] (P10443) Protein Card

General Information

Name	TxIA[ins5_A, A10L, ribbon]
Alternative name(s)	rTxIA[insA5; A10L]
Organism	synthetic construct
Protein Type	Synthetic
Parent	TxIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family

Sequence

GCCSARPPCILNNPDLC(nh2)
Modified residues	position symbol name 18 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	1771.07
Monoisotopic Mass	1769.75
Isoelectric Point	7.00
Extinction Coefficient [280nm]	NA

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Agonist	Ref
α7	H. sapiens	39.0 uM	+/-10.3	30 uM choline	Ho,T.N.T. et al. (2021)

References

Ho,T.N.T., Abraham,N., Lewis,R.J. (2021) Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA Sci Rep 11:21928

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Saturday 1 April 2023