EpI [sTy15Y]-OH (P10444) Protein Card

General Information
Name EpI [sTy15Y]-OH
Alternative name(s) EpI[Y(SO3)15Y]-OH
Organism synthetic construct
Protein Type Synthetic
Parent EpI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCNMNNPDYC
Average Mass 1787.94
Monoisotopic Mass 1786.56
Isoelectric Point 5.63
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β4H. sapiens1348.96 nM[891.25-2137.96]30 uM nicotineHo,T.N.T. et al. (2021)

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
AChBPA. californica1000.00 nM[512.86-1698.24]1 nM [3H]-epibatidineHo,T.N.T. et al. (2021)
L. stagnalis>100 uM1 nM [3H]-epibatidineHo,T.N.T. et al. (2021)

References
Ho,T.N.T., Lee,H.S., Swaminathan,S., Goodwin,L., Rai,N., Ushay,B., Lewis,R.J. and Conibear,A.C. (2021) Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Med Chem 12:1574-1584

Internal links
Nucleic acids
Structure NMR structure of EpI[Y(SO3)15Y]-OH

External links

Tools