AnIB-OH (P10446) Protein Card

General Information
Name AnIB-OH
Organism synthetic construct
Protein Type Synthetic
Parent AnIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GGCCSHPACAANNQD(sTy)C
Modified residues
positionsymbolname
16sTySulfotyrosine
Average Mass 1788.85
Monoisotopic Mass 1787.50
Isoelectric Point 5.63
Extinction Coefficient [280nm] 1490.00

Activity

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
AChBPA. californica2.19 nM[1.41-3.63]1 nM [3H]-epibatidineHo,T.N.T. et al. (2021)
L. stagnalis>100 uM1 nM [3H]-epibatidineHo,T.N.T. et al. (2021)

References
Ho,T.N.T., Lee,H.S., Swaminathan,S., Goodwin,L., Rai,N., Ushay,B., Lewis,R.J. and Conibear,A.C. (2021) Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Med Chem 12:1574-1584

Internal links
Nucleic acids
Structure NMR structure of AnIB-OH

External links

Tools