AnIB [sTy16Y]-OH (P10447) Protein Card

General Information
Name AnIB [sTy16Y]-OH
Alternative name(s) AnIB[Y(SO3)16Y]-OH
Organism synthetic construct
Protein Type Synthetic
Parent AnIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GGCCSHPACAANNQDYC
Average Mass 1709.81
Monoisotopic Mass 1708.55
Isoelectric Point 6.60
Extinction Coefficient [280nm] 1490.00

Activity

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
AChBPA. californica10.00 nM[6.46-16.22]1 nM [3H]-epibatidineHo,T.N.T. et al. (2021)
L. stagnalis>100 uM1 nM [3H]-epibatidineHo,T.N.T. et al. (2021)

References
Ho,T.N.T., Lee,H.S., Swaminathan,S., Goodwin,L., Rai,N., Ushay,B., Lewis,R.J. and Conibear,A.C. (2021) Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Med Chem 12:1574-1584

Internal links
Nucleic acids
Structure NMR structure of AnIB[Y(SO3)16Y]-OH

External links

Tools