BuIA[Y12F] (P10453) Protein Card

General Information
Name BuIA[Y12F]
Organism synthetic construct
Protein Type Synthetic
Parent BuIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSTPPCAVLFC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Average Mass 1295.56
Monoisotopic Mass 1294.50
Isoelectric Point 7.00
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2H. sapiens449.8 nM+/-195.7100 uM AChWei,N. et al. (2021)

References
Wei,N., Chu,Y., Liu,H., Xu,Q. and Yu,R. (2021) Antagonistic Mechanism of α-Conotoxin BuIA toward the Human α3β2 Nicotinic Acetylcholine Receptor. ACS Chem Neurosci 12:4535-4545

Internal links
Nucleic acids
Structure

External links

Tools