RgIA [C2(Smc),S4T,C8,R9(Cit),Y10(Ity),R11Q,R13Y] (P10455) Protein Card

General Information
Name RgIA [C2(Smc),S4T,C8,R9(Cit),Y10(Ity),R11Q,R13Y] (named by ConoServer)
Alternative name(s) RgIA-5617
Organism synthetic construct
Protein Type Synthetic
Parent RgIA
Notes A methylene thioacetal bond is formed between (Smc)2 and C8 (Zheng et al., 2021).

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
G(Smc)CTDPRC(Cit)(Ity)QCY
Modified residues
positionsymbolname
2SmcS-Methylcystine
9CitCitrulline
10Ity3-iodotyrosine
Average Mass 1705.66
Monoisotopic Mass 1704.46
Isoelectric Point 8.09
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α9α10H. sapiens882 nM[678-1146]100 uM AChZheng N et al. (2021)

References
Zheng N, Christensen SB, Dowell C, Purushottam L, Skalicky JJ, McIntosh JM, Chou DH. (2021) Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9β10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain J Med Chem 64:9513-9524

Internal links
Nucleic acids
Structure

External links

Tools