RgIA [C2(Smc),C3(Smc),S4T,R9(Cit),Y10(Ity),R11Q,R13Y] (P10457) Protein Card

General Information
Name RgIA [C2(Smc),C3(Smc),S4T,R9(Cit),Y10(Ity),R11Q,R13Y] (named by ConoServer)
Alternative name(s) RgIA-5618
Organism synthetic construct
Protein Type Synthetic
Parent RgIA
Notes Methylene thioacetal bonds are formed between (Smc)2 and C8 and between (Smc)3 and C12 (Zheng et al., 2021).

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
G(Smc)(Smc)TDPRC(Cit)(Ity)QCY
Modified residues
positionsymbolname
2SmcS-Methylcystine
3SmcS-Methylcystine
9CitCitrulline
10Ity3-iodotyrosine
Average Mass 1722.72
Monoisotopic Mass 1721.50
Isoelectric Point 7.33
Extinction Coefficient [280nm] 1740.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α9α10H. sapiens>1000 nM100 uM AChZheng N et al. (2021)

References
Zheng N, Christensen SB, Dowell C, Purushottam L, Skalicky JJ, McIntosh JM, Chou DH. (2021) Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9β10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain J Med Chem 64:9513-9524

Internal links
Nucleic acids
Structure

External links

Tools