GI[ins13_A] (P10464) Protein Card

General Information
Name GI[ins13_A] (named by ConoServer)
Alternative name(s) GI[+13A]
Organism synthetic construct
Protein Type Synthetic
Parent GI
Notes

The dose of 120 µg/kg had no effect on the mortality rate in mice, while the dose of 200 µg/kg of GI[ins13_A] resulted in a death rate of 20% in mice after 1356 +/- 41 seconds (Ma et al. 2021).


Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
ECCNPACGRHYSAC(nh2)
Modified residues
positionsymbolname
15nh2C-term amidation
Average Mass 1508.67
Monoisotopic Mass 1507.52
Isoelectric Point 8.31
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1γδR. norvegicus45.4 nM[41.7-49.3]200 uM AChMa X et al. (2021)

References
Ma X, Huang Q, Yu S, Xu S, Huang Y, Zhao Z, Xiao X, Dai Q. (2021) The 3/4- and 3/6-Subfamily Variants of α-Conotoxins GI and MI Exhibit Potent Inhibitory Activity against Muscular Nicotinic Acetylcholine Receptors Mar Drugs 19:705

Internal links
Nucleic acids
Structure

External links

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