GI[ins13_R] (P10465) Protein Card

General Information
Name GI[ins13_R] (named by ConoServer)
Alternative name(s) GI[+13R]
Organism synthetic construct
Protein Type Synthetic
Parent GI
Notes

The dose of 40 µg/kg of GI[ins13_R] had no effect on the mortality rate in mice, while the doses of 80, 120 and 160 µg/kg resulted in a death rate of 80%, 90% and 100% in mice after 1442 +/- 231, 929 +/- 297 and 705 +/- 58 seconds, respectively (Ma et al. 2021).


Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
ECCNPACGRHYSRC(nh2)
Modified residues
positionsymbolname
15nh2C-term amidation
Average Mass 1593.78
Monoisotopic Mass 1592.58
Isoelectric Point 10.94
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1γδR. norvegicus73.5 nM[69.2-78.1]200 uM AChMa X et al. (2021)

References
Ma X, Huang Q, Yu S, Xu S, Huang Y, Zhao Z, Xiao X, Dai Q. (2021) The 3/4- and 3/6-Subfamily Variants of α-Conotoxins GI and MI Exhibit Potent Inhibitory Activity against Muscular Nicotinic Acetylcholine Receptors Mar Drugs 19:705

Internal links
Nucleic acids
Structure

External links

Tools