QuIA (P10477) Protein Card

General Information
Name QuIA
Organism synthetic construct
Protein Type Synthetic
Parent Qc1.16

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
DECCSNPSCAQTHPEIC(nh2)
Modified residues
positionsymbolname
18nh2C-term amidation
Average Mass 1831.97
Monoisotopic Mass 1830.64
Isoelectric Point 4.20
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α1β1δεM. musculus>10000 nM10 uM AChWang,L. et al. (2022)
α3β2R. norvegicus55.7 nM[39.7-79.8]0.8100 uM AChWang,L. et al. (2022)
α3β4R. norvegicus>10000 nM100 uM AChWang,L. et al. (2022)
α4β2R. norvegicus>10000 nM100 uM AChWang,L. et al. (2022)
α6/α3β2β3R. norvegicus>10000 nM100 uM AChWang,L. et al. (2022)
α6/α3β4R. norvegicus90.7 nM[67.7-122]0.8100 uM AChWang,L. et al. (2022)
α7R. norvegicus>20000 nM200 uM AChWang,L. et al. (2022)
α9α10H. sapiens>10000 nM10 uM AChWang,L. et al. (2022)
R. norvegicus>10000 nM10 uM AChWang,L. et al. (2022)

References
Wang,L., Wu,X., Zhu,X., Zhangsun,D., Wu,Y., Luo,S. (2022) A Novel α4/7-Conotoxin QuIA Selectively Inhibits α3β2 and α6/α3β4 Nicotinic Acetylcholine Receptor Subtypes with High Efficacy Mar Drugs 20:146

Internal links
Nucleic acids
Structure

External links

Tools