Ile-SII(3-14)-OH (P10490) Protein Card

General Information
Name Ile-SII(3-14)-OH
Organism synthetic construct
Protein Type Synthetic
Parent SII

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
ICCNPACGPNYGC
Average Mass 1310.49
Monoisotopic Mass 1309.43
Isoelectric Point 8.09
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50Ref
α1β1δεR. norvegicus(mouse epsilon subunit)3800 nM+/-400Wilhelm,P. et al. (2022)
α1β1γδR. norvegicus7700 nM+/-900Wilhelm,P. et al. (2022)

References
Wilhelm,P., Luna-Ramirez,K., Chin,Y.K., Dekan,Z., Abraham,N., Tae,H.S., Chow,C.Y., Eagles,D.A., King,G.F., Lewis,R.J., Adams,D.J., and Alewood,P.F. (2022) Cysteine-Rich α-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. ACS Chemical Neurosci 13:1245-1250

Internal links
Nucleic acids
Structure NMR structure of truncated alpha conotoxin SII: Ile-SII(3-14)

External links

Tools