conomarphin-Mr3 (P10492) Protein Card

General Information

Name	conomarphin-Mr3
Alternative name(s)	Mr-1
Organism	Conus marmoreus
Organism region	Indo-Pacific
Organism diet	molluscivorous
Protein Type	Patent

Classification

Conopeptide class	conomarphin
Gene superfamily
Pharmacological family

Sequence

DWEYHAHPKPNSFWT
Sequence evidence	protein level
Average Mass	1915.06
Monoisotopic Mass	1913.85
Isoelectric Point	6.99
Extinction Coefficient [280nm]	12490.00

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

Target	Organism	% inhibition		Concentration	Agonist	Ref
α1β1δε	R. norvegicus	0		100 uM	10 uM ACh	Fu,Y. et al. (2022)
α3β4	R. norvegicus	0		100 uM	100 uM ACh	Fu,Y. et al. (2022)
α4β2	R. norvegicus	20.0	+/-8.5	100 uM	100 uM ACh	Fu,Y. et al. (2022)

References

Fu,Y., Zhang,Y., Ju,S., Ma,B., Huang,W., and Luo,S. (2022) Isolation and characterization of five novel disulfide-poor conopeptides from Conus marmoreus venom. J Venom Anim Toxins Incl Trop Dis. 28

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Wednesday 22 March 2023