SIIID (P10493) Protein Card

General Information
Name SIIID
Organism synthetic construct
Protein Type Synthetic
Parent S3-G02
Notes

According to Wang et al.(2022): (i) SIIID (1–4, 2–5, 3–6) was the most active isomer among the three isomers; (ii) 10 uM SIIID had less than 15% inhibitory effects on the sodium, potassium and calcium currents in rat DRG neurons; (iii) 10 uM SIIID had no obvious effect on the human α3β4 nicotinic acetylcholine receptor currents.

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family alpha conotoxin

Sequence
CCGEGSSCPKYFKNNFICGCC
Average Mass 2257.57
Monoisotopic Mass 2255.80
Isoelectric Point 10.69
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α7H. sapiens(5 uM PNU-120596 was coapplied with acetylcholine)880.71 nM+/-271.9130 uM AChWang,H. et al. (2022)

References
Wang,H., Li,Y., Yang, M., and Zhou,M. (2022) Synthesis and characterization of αM-conotoxin SIIID, a reversible human α7 nicotinic acetylcholine receptor antagonist. Toxicon 210:141-147

Internal links
Nucleic acids
Structure

External links

Tools