SIVC (P10735) Protein Card

General Information

Name	SIVC
Organism	Conus striatus (Striated cone)
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Patent
Notes	L4 and L24 are not confirmed. They correspond to either leucine or isoleucine (Saintmont et al., 2022). O2, O18, O22 correspond to 3 or 4-hydroxyproline (Saintmont et al., 2022).

Classification

Conopeptide class	conotoxin
Gene superfamily
Pharmacological family

Sequence

AOALVV(gTr)A(gTr)TNCCGYTGOACHOCLCTQTC(nh2)
Modified residues	position symbol name 2 O 4-Hydroxyproline 7 gTr glycosylated threonine 9 gTr glycosylated threonine 18 O 4-Hydroxyproline 22 O 4-Hydroxyproline 30 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	3672.01
Monoisotopic Mass	3669.45
Isoelectric Point	8.31
Extinction Coefficient [280nm]	1490.00

References

Saintmont,F., Cazals,G., Bich,C., and Dutertre,S. (2022) Proteomic Analysis of the Predatory Venom of Conus striatus Reveals Novel and Population-Specific κA-Conotoxin SIVC Toxins 14:799

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Sunday 11 June 2023