LvIC (P10736) Protein Card

General Information

Name	LvIC
Organism	Conus lividus
Organism region	Indo-Pacific
Organism diet	vermivorous
Protein Type	Patent

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family

Sequence

DCCANPVCNGKHCQ(nh2)
Modified residues	position symbol name 15 nh2 C-term amidation
Sequence evidence	nucleic acid level
Average Mass	1486.67
Monoisotopic Mass	1485.54
Isoelectric Point	8.31
Extinction Coefficient [280nm]	NA

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		nhill	Agonist	Ref
α1β1δε	M. musculus	>10000 nM			10 uM ACh	Zhu,X. et al. (2023)
α2β2	R. norvegicus	>10000 nM			100 uM ACh	Zhu,X. et al. (2023)
α2β4	R. norvegicus	>10000 nM			100 uM ACh	Zhu,X. et al. (2023)
α3β2	R. norvegicus	>10000 nM			100 uM ACh	Zhu,X. et al. (2023)
α3β4	R. norvegicus	>10000 nM			100 uM ACh	Zhu,X. et al. (2023)
α4β2	R. norvegicus	>10000 nM			100 uM ACh	Zhu,X. et al. (2023)
α4β4	R. norvegicus	>10000 nM			100 uM ACh	Zhu,X. et al. (2023)
α6/α3β2β3	R. norvegicus	>10000 nM			100 uM	Zhu,X. et al. (2023)
α6/α3β4	R. norvegicus	3300 nM	[2300-4600]	0.91	100 uM ACh	Zhu,X. et al. (2023)
α7	R. norvegicus	>10000 nM			200 uM ACh	Zhu,X. et al. (2023)
α9α10	R. norvegicus	>10000 nM			10 uM ACh	Zhu,X. et al. (2023)

Synthetic variants

LvIC[D1G,del14]	GCCANPVCNGKHC
LvIC[del14]	DCCANPVCNGKHC

References

Zhu,X., Wang,S., Kaas,Q., Yu,J., Wu,Y., Harvey,P.J., Zhangsun,D., Craik,D.J., and Luo,S. (2023) Characterization, and Engineering of LvIC, an α4/4-Conotoxin That Selectively Blocks Rat α6/α3β4 Nicotinic Acetylcholine Receptors. J Med Chem 66:2020-2031

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Monday 5 June 2023