conotoxin-GS (P01268) Protein Card

General Information
Name conotoxin-GS
Organism Conus geographus (Geography cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor conotoxin-GS precursor (5752)
Notes lethal upon ic injection (Na+ channel)

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family mu conotoxin

Sequence
ACSGRGSRCOOQCCMGLRCGRGNPQKCIGAH(Gla)DV
Modified residues
positionsymbolname
10O4-Hydroxyproline
11O4-Hydroxyproline
32GlaGamma carboxylic glutamic acid
Sequence evidence protein level
Average Mass 3618.05
Monoisotopic Mass 3615.49
Isoelectric Point 12.08
Extinction Coefficient [280nm] NA

References
Yanagawa,Y., Abe,T., Satake,M., Odani,S., Suzuki,J. and Ishikawa,K. (1988) A novel sodium channel inhibitor from Conus geographus: purification, structure, and pharmacological properties Biochemistry 27:6256-6262
Hill,J.M., Alewood,P.F. and Craik,D.J. (1997) Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry Structure 5:571-583

Internal links
Protein Precursor conotoxin-GS precursor (5752)
Nucleic acids
Structure CONOTOXIN GS, NMR, 20 STRUCTURES

External links
UniProtKB/Swiss-Prot P15472
Ncbi 1AG7, 1AG7_A, P15472

Tools