Contryphan-Lo1 (P01272) Protein Card

General Information

Name	Contryphan-Lo1
Alternative name(s)	Lo959
Organism	Conus loroisii
Organism region	Indo-Pacific
Organism diet	vermivorous
Protein Type	Wild type
Notes	According to Sabareesh et al. (2006), contryphan-Lo1 increases the Ca2+ current.

Classification

Conopeptide class	contryphan
Gene superfamily
Pharmacological family

Sequence

GCPwDPWC(nh2)
Modified residues	position symbol name 4 w D-tryptophan 9 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	960.09
Monoisotopic Mass	959.34
Isoelectric Point	2.19
Extinction Coefficient [280nm]	11000.00

References

Gowd,K.H., Sabareesh,V., Sudarslal,S., Iengar,P., Franklin,B., Fernando,A., Dewan,K., Ramaswami,M., Sarma,S.P., Sikdar,S., Balaram,P. and Krishnan,K.S. (2005) Novel peptides of therapeutic promise from Indian Conidae Ann. N. Y. Acad. Sci. 1056:462

Sabareesh,V., Gowd,K.H., Ramasamy,P., Sudarslal,S., Krishnan,K.S., Sikdar,S.K. and Balaram,P. (2006) Characterization of contryphans from Conus loroisii and Conus amadis that target calcium channels Peptides 27:2647-2654

Sonti,R., Gowd,K.H., Rao,K.N., Ragothama,S., Rodriguez,A., Perez,J.J. and Balaram,P. (2013) Conformational diversity in contryphans from Conus venom: cis-trans isomerisation and aromatic/proline interactions in the 23-membered ring of a 7-residue peptide disulfide loop. Chemistry 19:15175-15189

Thakur,S.S. and Balaram,P. (2007) Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom. Rapid Commun. Mass Spectrom. 21:3420-3426

Vijayasarathy,M., Basheer,S.M., Franklin,J.B. and Balaram,P. (2017) Contryphan Genes and Mature Peptides in the Venom of Nine Cone Snail Species by Transcriptomic and Mass Spectrometric Analysis. J. Proteome Res. 16:763-772

Internal links

Nucleic acids
Structure	Solution structure of cis(C2-P3) trans (D5-P6) form of lO959 in water Solution structure of trans(C2-P3) trans (D5-P6) of LO959 in methanol

External links

UniProtKB/Swiss-Prot	P0C250
Ncbi	P0C250

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023