Contryphan-Lo1 (P01272) Protein Card

General Information
Name Contryphan-Lo1
Alternative name(s) Lo959
Organism Conus loroisii
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Notes According to Sabareesh et al. (2006), contryphan-Lo1 increases the Ca2+ current.

Conopeptide class contryphan
Gene superfamily
Pharmacological family

Modified residues
9nh2C-term amidation
Sequence evidence protein level
Average Mass 960.09
Monoisotopic Mass 959.34
Isoelectric Point 2.19
Extinction Coefficient [280nm] 11000.00

Gowd,K.H., Sabareesh,V., Sudarslal,S., Iengar,P., Franklin,B., Fernando,A., Dewan,K., Ramaswami,M., Sarma,S.P., Sikdar,S., Balaram,P. and Krishnan,K.S. (2005) Novel peptides of therapeutic promise from Indian Conidae Ann. N. Y. Acad. Sci. 1056:462
Sabareesh,V., Gowd,K.H., Ramasamy,P., Sudarslal,S., Krishnan,K.S., Sikdar,S.K. and Balaram,P. (2006) Characterization of contryphans from Conus loroisii and Conus amadis that target calcium channels Peptides 27:2647-2654
Sonti,R., Gowd,K.H., Rao,K.N., Ragothama,S., Rodriguez,A., Perez,J.J. and Balaram,P. (2013) Conformational diversity in contryphans from Conus venom: cis-trans isomerisation and aromatic/proline interactions in the 23-membered ring of a 7-residue peptide disulfide loop. Chemistry 19:15175-15189
Thakur,S.S. and Balaram,P. (2007) Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom. Rapid Commun. Mass Spectrom. 21:3420-3426
Vijayasarathy,M., Basheer,S.M., Franklin,J.B. and Balaram,P. (2017) Contryphan Genes and Mature Peptides in the Venom of Nine Cone Snail Species by Transcriptomic and Mass Spectrometric Analysis. J. Proteome Res. 16:763-772

Internal links
Nucleic acids
Structure Solution structure of cis(C2-P3) trans (D5-P6) form of lO959 in water
Solution structure of trans(C2-P3) trans (D5-P6) of LO959 in methanol

External links
UniProtKB/Swiss-Prot P0C250
Ncbi P0C250