PVIIA precursor (P01331) Protein Card

General Information
Name PVIIA precursor
Organism Conus purpurascens
Organism region Eastern Pacific
Organism diet piscivorous
Protein Type Precursor

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Pharmacological family

Sequence
MKLTCVVIVVVLFLTACQLITA
DDSRRTQKHRALRSTTKLS
LSTR
CRIPNQKCFQHLDDCCSRKCNRFNKCV
Sequence region
[1-22]signal sequence
[46-72]mature peptidePVIIA

References
Shon,K.-J., Stocker,M., Terlau,H., Stuehmer,W., Jacobsen,R.B., Walker,C.S., Grilley,M.M., Watkins,M., Hillyard,D.R., Gray,W.R. and Olivera,B.M. (1998) kappa-Conotoxin PVIIA is a peptide inhibiting the shaker K+ channel J. Biol. Chem. 273:33-38
Terlau,H., Shon,K.J., Grilley,M., Stocker,M., Stuhmer,W. and Olivera,B.M. (1996) Strategy for rapid immobilization of prey by a fish-hunting marine snail Nature 381:148-151
Scanlon,M.J., Naranjo,D., Thomas,L., Alewood,P.F., Lewis,R.J. and Craik,D.J. (1997) Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA Structure 5:1585-1597
Savarin,P., Guenneugues,M., Gilquin,B., Lamthanh,H., Gasparini,S., Zinn-Justin,S. and Menez,A. (1998) Three-dimensional structure of kappa-conotoxin PVIIA, a novel potassium channel-blocking toxin from cone snails Biochemistry 37:5407-5416
Jacobsen,R.B., Koch,E.D., Lange-Malecki,B., Stocker,M., Verhey,J., Van Wagoner,R.M., Vyazovkina,A., Olivera,B.M. and Terlau,H. (2000) Single amino acid substitutions in kappa-conotoxin PVIIA disrupt interaction with the shaker K+ channel J. Biol. Chem. 275:24639-24644
Terlau,H., Boccaccio,A., Olivera,B.M. and Conti,F. (1999) The block of Shaker K+ channels by kappa-conotoxin PVIIA is state dependent J. Gen. Physiol. 114:125-140
Moran,O. (2001) Molecular simulation of the interaction of kappa-conotoxin-PVIIA with the Shaker potassium channel pore Eur. Biophys. J. 30:528-536
Naranjo,D. (2002) Inhibition of single Shaker K channels by kappa-conotoxin-PVIIA Biophys. J. 82:3003-3011

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P56633
Ncbi P56633

Tools