PIIIA precursor (P01407) Protein Card

General Information
Name PIIIA precursor
Organism Conus purpurascens
Organism region Eastern Pacific
Organism diet piscivorous
Protein Type Precursor

Classification
Conopeptide class conotoxin
Gene superfamily M superfamily
Pharmacological family

Sequence
MSKLGVLLTICLLLFPITA
LPMDGDQPADRLAERMQDNISS
EEHPFEKR
QRLCCGFPKSCRSRQCKPHRCC
GR
Sequence region
[1-19]signal sequence
[50-71]mature peptidePIIIA

References
Corpuz,G.P., Jacobsen,R.B., Jimenez,E.C., Watkins,M., Walker,C., Colledge,C., Garrett,J.E., McDougal,O., Li,W., Gray,W.R., Hillyard,D.R., Rivier,J., McIntosh,J.M., Cruz,L.J. and Olivera,B.M. (2005) Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms Biochemistry 44:8176-8186
Shon,K.-J., Olivera,B.M., Watkins,M., Jacobsen,R.B., Gray,W.R., Floresca,C.Z., Cruz,L.J., Hillyard,D.R., Brink,A., Terlau,H. and Yoshikami,D. (1998) mu-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes J. Neurosci. 18:4473-4481
Safo,P., Rosenbaum,T., Shcherbatko,A., Choi,D.Y., Han,E., Toledo-Aral,J.J., Olivera,B.M., Brehm,P. and Mandel,G. (2000) Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA J. Neurosci. 20:76-80
Nielsen,K.J., Watson,M., Adams,D.J., Hammarstroem,A.K., Gage,P.W., Hill,J.M., Craik,D.J., Thomas,L., Adams,D., Alewood,P.F. and Lewis,R.J. (2002) Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels J. Biol. Chem. 277:27247-27255

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P58925
Ncbi P58925

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